Tag: M.W=250-300

Markushyna, Yevheniia published the artcileSynthesis of Sulfonyl Chlorides from Aryldiazonium Salts Mediated by a Heterogeneous Potassium Poly(heptazine imide) Photocatalyst, HPLC of Formula: 32333-53-2, the publication is ACS Organic & Inorganic Au (2022), 2(2), 153-158, database is CAplus.

A heterogeneous transition metal-free material, a type of carbon nitride photocatalyst, potassium poly(heptazine imide), was employed to produce sulfonyl chlorides from arenediazonium salts under mild conditions (visible light irradiation, room temperature) with 50-95% yields. The method was suitable for the synthesis of both electron rich and electron deficient compounds and it showed high tolerance toward different functional groups (halides, ester, nitro, cyano groups). Thus, a sustainable photocatalytic alternative to the Meerwein chlorosulfonylation reaction was offered.

ACS Organic & Inorganic Au published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, HPLC of Formula: 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abbasi, Muhammad Athar published the artcileSynthesis, enzyme inhibition and molecular docking studies of 1-Arylsulfonyl-4-phenylpiperazine derivatives, Computed Properties of 21286-54-4, the publication is Pakistan Journal of Pharmaceutical Sciences (2017), 30(5), 1715-1724, database is CAplus and MEDLINE.

Heterocyclic mols. have been frequently investigated to possess various biol. activities during the last few decades. The present work elaborates the synthesis and enzymic inhibition potentials of a series of sulfonamides. A series of 1-arylsulfonyl-4-Phenylpiperazine (3a-n) geared up by the reaction of 1-phenylpiperazine (1) and different (un)substituted alkyl/arylsulfonyl chlorides (2a-n), under defined pH control using water as a reaction medium. The synthesized mols. were characterized by ¹H-NMR, ¹³C-NMR, IR and EI-MS spectral data. The enzyme inhibition study was carried on a-glucosidase, lipoxygenase (LOX), acetyl cholinesterase (AChE) and butyryl cholinesterase (BChE) enzymes supported by docking simulation studies and the IC₅₀ values rendered a few of the synthesized mols. as moderate inhibitors of these enzymes where, the compound 3e exhibited comparatively better potency against α-glucosidase enzyme. The synthesized compounds showed weak or no inhibition against LOX, AChE and BChE enzymes.

Pakistan Journal of Pharmaceutical Sciences published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Berry, James P. published the artcileFluoride-induced cleavage of the carbon-phosphorus bond in diethyl trichloromethylphosphonate. Source of dichlorocarbene and dialkyl phosphorofluoridates, COA of Formula: C5H10Cl3O3P, the publication is Journal of Organic Chemistry (1968), 33(4), 1664-5, database is CAplus.

Di-Et trichloromethylphosphonate (I) is heated with KF.2H2O to give CHCl3; I is heated with anhydrous KF to give (EtO)2P(O)F. I is treated with anhydrous KF in cyclohexene and the dichlorocarbene obtained adds to cyclohexene to give 7,7-dichlorobicyclo[4.1.0]heptane (II). I is treated with KF in MeOH to give (EtO)2POMe.

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, COA of Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ando, Ryoichi published the artcileDesign, synthesis, and evaluation of novel kazusamycin A derivatives as potent antitumor agents, Product Details of C5H10Cl3O3P, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(12), 3315-3318, database is CAplus and MEDLINE.

Novel kazusamycin A derivatives I (R = R¹ = Me, R² = H; R = R² = Me, R¹ = H; R = R¹ = H, R² = Me; R = R¹ = R² = Me) were designed in the viewpoint of decrease of reactivity at the α,β-unsaturated δ-lactone moiety against Michael-type addition Although 25-30 steps were required for the synthesis of each compound, their syntheses were achieved. Cytotoxicity against HPAC cell line was evaluated, and two of them, I (R = R¹ = Me, R² = H; R = R¹ = H, R² = Me), exhibited comparable potency to kazusamycin A. Hepatic toxicity of these designed compounds was much lower than that of kazusamycin A.

Bioorganic & Medicinal Chemistry Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Mingxue published the artcileSimulation degradation of bromophenolic compounds in chlorine-based advanced oxidation processes: Mechanism, microscopic and apparent kinetics, and toxicity assessment, Category: chlorides-buliding-blocks, the publication is Chemosphere (2022), 291(Part_3), 133034, database is CAplus and MEDLINE.

Chlorine-based advanced oxidation processes (AOPs) have been extensively studied to remove contaminants through generating HO• and reactive chlorine species, including ClO• and Cl•. In this work, 2,4,6-tribromoanisole (246TBA) and 2,4,6-tribromophenol (246TBP) were selected as model to investigate the reaction mechanisms and micro-kinetics of brominated contaminants with HO•, ClO• and Cl• in chlorine-based AOPs. Also, the apparent degradation kinetics of two compounds were simulated at pH 3.0-9.5 under UV/H₂O₂, UV/chlorine and UV/NH₂Cl. Calculated results showed that neutral 246TBA and 246TBP exhibited similar reactivity to HO• and ClO•, which was different from anionic 2,4,6-tribromophenolate (246TBPT): radical adduct formation (RAF) and H atom abstraction (HAA) were predominant mechanisms for the HO• and ClO• initiated reactions of 246TBA and 246TBP, while RAF and single electron transfer (SET) for 246TBPT; the reaction rate constants of 246TBA and 246TBP with HO• and ClO• were lower than 107 M^-1 s^-1, and such rate constants dramatically increased to 1010 M^-1 s^-1 once 246TBP was deprotonated to 246TBPT. The apparent degradation kinetics of 246TBA at pH 3.0-9.5 was simulated in the order of UV/NH₂Cl > UV/chlorine > UV/H₂O₂, and UV/chlorine and UV/NH₂Cl were more effective for the removal of 246TBP and 246TBPT than UV/H₂O₂. UV and/or Cl• dominated 246 TBA degradation under three AOPs. The main radicals mediating 246TBP and 246TBPT degradation are resp. HO• under UV/H₂O₂, ClO• under UV/chlorine, and HO• and Cl• under UV/NH₂Cl. The transformation products of 246TBA, 246TBP and 246TBPT, especially methoxylated and hydroxylated polybrominated di-Ph ethers (MeO-PBDEs and HO-PBDEs), were still toxic pollutants.

Chemosphere published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bennett, D. Jonathan published the artcileNovel water soluble 2,6-dimethoxyphenyl ester derivatives with intravenous anaesthetic activity, Computed Properties of 18791-02-1, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(12), 1971-1975, database is CAplus and MEDLINE.

A number of water soluble bis-amino-2,6-dimethoxyphenyl ester derivatives were found to exhibit improved anesthetic activity in mice relative to propofol. Of the analogs disclosed, 44 was further profiled in rodents and a superior agent to propofol for the induction and maintenance of anesthesia.

Bioorganic & Medicinal Chemistry Letters published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Computed Properties of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Charlesworth, E. H. published the artcileAction of zinc on α,β-dibromopropionyl halides, Formula: C3H3Br2ClO, the publication is Canadian Journal of Research, Section B: Chemical Sciences (1950), 1-4, database is CAplus.

BrCH₂CHBrCOBr (I) reacts vigorously with Zn in absolute Et₂O to give CH₂:CHCO₂Et (II) (55%), EtBr (6-8%), and HBr (42%). Steps for the reaction have been suggested. I was prepared by treating BrCH₂CHBrCO₂H with P and Br. The Hell-Volhard-Zelinskii reaction on BrCH₂CH₂CO₂H (anilide, m. 119-20°; Pr β-bromopropionate, b. 76-8°, n_D²⁰ 1.467), gave only BrCH₂CH₂COBr (III). Zn with BrCH₂CHBrCOCl gave II also. Zn and III yielded 60% BrCH₂CH₂CO₂Et.

Canadian Journal of Research, Section B: Chemical Sciences published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Formula: C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lowen, Gregory T. published the artcileA Novel Synthesis of Phosphonates from Diethyl (Trichloromethyl)phosphonate, Application In Synthesis of 866-23-9, the publication is Journal of Organic Chemistry (1994), 59(16), 4548-50, database is CAplus.

Com. available di-Et (trichloromethyl)phosphonate was reacted with aldehydes and ketones to generate (chlorovinyl)phosphonates, e.g., PhCH:CClPO(OEt)₂, in a single step. These intermediates could be hydrogenated in high yields to the corresponding saturated phosphonates..

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pujala, Brahmam published the artcileDiscovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ, COA of Formula: C12H16BClO3, the publication is ACS Medicinal Chemistry Letters (2016), 7(12), 1161-1166, database is CAplus and MEDLINE.

The aberrant activation of B-cells has been implicated in several types of cancers and hematol. disorders. BTK and PI3Kδ are kinases responsible for B-cell signal transduction, and inhibitors of these enzymes have demonstrated clin. benefit in certain types of lymphoma. Simultaneous inhibition of these pathways could result in more robust responses or overcome resistance as observed in single agent use. The authors report a series of novel compounds that have low nanomolar potency against both BTK and PI3Kδ as well as acceptable PK properties that could be useful in the development of treatments against B-cell related diseases.

ACS Medicinal Chemistry Letters published new progress about 960388-56-1. 960388-56-1 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters, name is 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, and the molecular formula is C12H16BClO3, COA of Formula: C12H16BClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kamlet, Mortimer J. published the artcileLinear solvation energy relationships. 23. A comprehensive collection of the solvatochromic parameters, π^*, α, and β, and some methods for simplifying the generalized solvatochromic equation, SDS of cas: 866-23-9, the publication is Journal of Organic Chemistry (1983), 48(17), 2877-87, database is CAplus.

A generalized equation for linear solvation energy relations or complexation energy relations is developed which involves 6 terms: π^* (a solvent dipolarity-polarizability term), α (solvent hydrogen-bond acceptor term), β (solvent hydrogen-bond donor term), δ (solvent polarizability correction term), δ_H (Hildebrand solubility parameter), and ξ. This equation is reduced to a more manageable form by a judicious choice of solvents and reactants or indicators. One-, two- or three-parameter LFER involving different combinations of the above parameters and various types of physicochem. properties are observed A comprehensive collection of π^*, α, and β for 217 solvents is presented.

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics