M.W=250-300 Archives - Page 48 of 75 - Chlorides-buliding-blocks

Amin, Kamelia M.’s team published research in International Journal of Pharmacy and Technology in 8 | CAS: 21286-54-4

International Journal of Pharmacy and Technology published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, SDS of cas: 21286-54-4.

Amin, Kamelia M. published the artcileSynthesis, antibreast cancer activity and docking study of some novel 4-(benzo [d] thiazol-2-yl) phenyl moiety as CDK2 inhibitors, SDS of cas: 21286-54-4, the publication is International Journal of Pharmacy and Technology (2016), 8(1), 10853-10871, database is CAplus.

Some novel sulfonamides, Schiff’s bases and pyrrole derivatives attached to 4-benzo[d]thiazol-2-yl were prepared Some of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF-7) in comparison with doxorubicin; the urea derivative 6a exhibited the highest activity. Mol. docking into CDK2 has been done for lead optimization of the compounds in study as potential CDK2 inhibitors; compound 8b showed the lowest binding score.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fawzy, A.’s team published research in Journal of Molecular Liquids in 325 | CAS: 3919-74-2

Journal of Molecular Liquids published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Category: chlorides-buliding-blocks.

Fawzy, A. published the artcileMechanistic and thermodynamic aspects of oxidative removal of flucloxacillin by different oxidants in an acidic medium, Category: chlorides-buliding-blocks, the publication is Journal of Molecular Liquids (2021), 115160, database is CAplus.

The mechanism of oxidative removal of flucloxacillin antibiotic (Flx) by two different oxidants (Ox), potassium bromate (KBrO3) and potassium iodate (KIO3), were studied using a spectrophotometric technique in sulfuric acid medium. The stoichiometry of the oxidation reactions of flucloxacillin by both oxidants was set to be a 2: 3 (Ox: Flx). The oxidation products of flucloxacillin were identified utilizing spot tests and FT-IR spectroscopy. The reactions followed a first order credence in [Flx] and lesser than unit order kinetics regarding to both [Ox] and [H+]. Negligible impacts of both ionic strength and dielec. constant of the reactions medium on the rates of reactions were observed The dependence of the oxidation rates on mercuric acetate concentration which works as a scavenger for any bromide or iodide ion composed during the reactions was investigated. Credence of reaction rates on temperature was studied, and the activation parameters were assessed and discussed. Tests for free radicals involvement throughout the oxidation reactions were neg. The reactions mechanism was elucidated and the rate law expressions were derived.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fawzy, Ahmed’s team published research in Industrial & Engineering Chemistry Research in 59 | CAS: 3919-74-2

Industrial & Engineering Chemistry Research published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Category: chlorides-buliding-blocks.

Fawzy, Ahmed published the artcileDegradation of Ampicillin and Flucloxacillin Antibiotics via Oxidation by Alkaline Hexacyanoferrate(III): Kinetics and Mechanistic Aspects, Category: chlorides-buliding-blocks, the publication is Industrial & Engineering Chemistry Research (2020), 59(37), 16217-16224, database is CAplus.

The kinetics and mechanistic aspects of the oxidation of two beta-lactam antibiotics (A), ampicillin and flucloxacillin, by alk. hexacyanoferrate(III) (HCF(III)) were examined using spectrophotometry at a fixed temperature The oxidation reactions showed a 1:4 (A: HCF(III)) stoichiometry. The reaction kinetics were found to follow first-order dependence for the oxidant and fractional first-order dependence for [A] and [OH^–]. The enhancement of the ionic strength and dielec. constant was found to increase the oxidation rates. Free radical tests of the reactions showed pos. results. The addition of HCF(II) as a predicted oxidation product did not considerably change the oxidation rates. Under the same exptl. conditions, the oxidation rate of ampicillin was found to be slightly lower than that of flucloxacillin. The acquired oxidation products were recognized using spot testing and Fourier transform IR spectra. A conceivable oxidation mechanism was suggested. A derived rate law expression was found to be consistent with the exptl. results. The activation parameters were assessed and discussed.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Washburn, Alex’s team published research in Bioorganic & Medicinal Chemistry Letters in 29 | CAS: 32333-53-2

Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C15H21BO2, Category: chlorides-buliding-blocks.

Washburn, Alex published the artcileDual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections, Category: chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(13), 1665-1672, database is CAplus and MEDLINE.

Benzoxazolylphenyl sulfonamides I (R = Me, Ph, 2-thienyl, 2-FC₆H₄, 3-FC₆H₄, 4-FC₆H₄, 2-ClC₆H₄, 3-ClC₆H₄, 4-ClC₆H₄, 5-chloro-2-thienyl, 2-F₃CC₆H₄, 3-F₃CC₆H₄, 4-F₃CC₆H₄, 3,4-Cl₂C₆H₃, 4-F-3-F₃CC₆H₃, 4-Cl-3-F₃CC₆H₃, 4-Cl-3-O₂NC₆H₃, 5-Cl-2-MeOC₆H₃, 2-MeC₆H₄, 3-MeC₆H₄, 4-MeC₆H₄, 4-EtC₆H₄, 4-H₂C:CHC₆H₄, 2-MeOC₆H₄, 3-MeOC₆H₄, 4-MeOC₆H₄, 2-HOC₆H₄, 3-HOC₆H₄, 4-HOC₆H₄) and phenylbenzoxazolyl sulfonamides II (R = Me, Ph, 2-thienyl, 2-FC₆H₄, 3-FC₆H₄, 4-FC₆H₄, 2-ClC₆H₄, 3-ClC₆H₄, 4-ClC₆H₄, 5-chloro-2-thienyl, 2-F₃CC₆H₄, 3-F₃CC₆H₄, 4-F₃CC₆H₄, 3,4-Cl₂C₆H₃, 4-F-3-F₃CC₆H₃, 4-Cl-3-F₃CC₆H₃, 4-Cl-3-O₂NC₆H₃, 5-Cl-2-MeOC₆H₃, 2-MeC₆H₄, 3-MeC₆H₄, 4-MeC₆H₄, 4-EtC₆H₄, 4-H₂C:CHC₆H₄, 2-MeOC₆H₄, 3-MeOC₆H₄, 4-MeOC₆H₄, 2-HOC₆H₄, 3-HOC₆H₄, 4-HOC₆H₄) were prepared as dual inhibitors of GroEL/ES and the virulence factor protein tyrosine phosphatase B (PtpB) for the treatment of Mycobacterium tuberculosis infection at all stages of bacterial infection.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tenthorey, Paul A.’s team published research in Journal of Medicinal Chemistry in 24 | CAS: 18791-02-1

Journal of Medicinal Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C13H10N2S, Related Products of chlorides-buliding-blocks.

Tenthorey, Paul A. published the artcileNew antiarrhythmic agents. 7. 2,3-Diaminopropionanilides, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (1981), 24(9), 1059-63, database is CAplus and MEDLINE.

Ten 2,3-diaminopropionanilides I (R and R¹ = Me, Et, Pr, etc.; R²,R³,R⁴, and R⁵ = H, OMe, OEt, etc.) were synthesized by acylation of mono- and disubstituted aniline derivatives with 2,3-dibromopropionyl chloride [18791-02-1] and subsequent amination with the appropriate secondary amines. I were evaluated in mice for antiarrhythmic efficacy against chloroform-induced tachycardia and for central nervous system toxicity. Several of the active agents had much higher antiarrhythmic potencies than lidocaine, but they were also toxic. Evaluation of the target compounds for local anesthetic activity in the form of sciatic nerve block in rats showed that most compounds had durations of block similar to that of lidocaine; none exhibited the long duration of block seen with etidocaine.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sandham, David A.’s team published research in Bioorganic & Medicinal Chemistry Letters in 19 | CAS: 32333-53-2

Sandham, David A. published the artcile7-Azaindole-3-acetic acid derivatives: Potent and selective CRTh2 receptor antagonists, COA of Formula: C7H3Cl2F3O2S, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(16), 4794-4798, database is CAplus and MEDLINE.

High throughput screening identified a 7-azaindole-3-acetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimized to furnish a highly selective compound with good functional potency for inhibition of human eosinophil shape change in whole blood and oral bioavailability in the rat.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Das, Somnath’s team published research in Chemistry – A European Journal in 2017 | CAS: 18585-06-3

Chemistry – A European Journal published new progress about Amination. 18585-06-3 belongs to class chlorides-buliding-blocks, name is Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate, and the molecular formula is C10H9ClF3NO2, Application of Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate.

Das, Somnath published the artcileTeaching Old Compounds New Tricks: DDQ-Photocatalyzed C-H Amination of Arenes with Carbamates, Urea, and N-Heterocycles, Application of Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate, the main research area is DDQ photocatalyst amination arene carbamate urea amine heterocycle; C−H amination; charge-transfer complexes; electron-deficient arenes; heterocycles; photocatalysis.

The C-H amination of benzene derivatives was achieved using DDQ as photocatalyst and BocNH2 as the amine source under aerobic conditions and visible light irradiation Electron-deficient and electron-rich benzenes react as substrates with moderate to good product yields. The amine scope of the reaction comprises Boc-amine, carbamates, pyrazoles, sulfonimides and urea. Preliminary mechanistic studies indicate arene oxidation by the triplet of DDQ to radical cations with different electrophilicity and a charge transfer complex between the amine and DDQ as intermediate of the reaction.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sidique, Shyama’s team published research in Journal of Medicinal Chemistry in 2012-11-26 | CAS: 6797-79-1

Journal of Medicinal Chemistry published new progress about Allosterism. 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, SDS of cas: 6797-79-1.

Sidique, Shyama published the artcileOrally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure-Activity Relationships and Assessment in a Rat Model of Nicotine Dependence, SDS of cas: 6797-79-1, the main research area is benzisothiazolone isoindolinone metabotropic glutamate receptor pos allosteric modulator preparation; structure activity relationship mGlu2 receptor modulator treatment nicotine dependence.

Compounds that modulate metabotropic glutamate subtype 2 (mGlu2) receptors have the potential to treat several disorders of the central nervous system (CNS) including drug dependence. Herein the authors describe the synthesis and structure-activity relationship (SAR) studies around a series of mGlu2 receptor pos. allosteric modulators (PAMs). The effects of N-substitution and substitutions on the aryl ring were identified as key areas for SAR exploration. Investigation of the effects of varying substituents in both the isoindolinone (I) and benzisothiazolone (II) series led to compounds with improved in vitro potency and/or efficacy. In addition, several analogs exhibited promising pharmacokinetic (PK) properties. Furthermore, compound I was shown to dose-dependently decrease nicotine self-administration in rats following oral administration. Our data, showing for the first time efficacy of an mGlu2 receptor PAM in this in vivo model, suggest potential utility for the treatment of nicotine dependence in humans.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Petigara, R. B.’s team published research in Journal of Heterocyclic Chemistry in 1974 | CAS: 52927-98-7

Journal of Heterocyclic Chemistry published new progress about Cyclization. 52927-98-7 belongs to class chlorides-buliding-blocks, name is 2-Bromo-1-(2-bromoethyl)-4-chlorobenzene, and the molecular formula is C8H7Br2Cl, Category: chlorides-buliding-blocks.

Petigara, R. B. published the artcileNovel polycyclic heterocycles. XI. Synthesis of 11,12-dihydropyrido[2,1-b][1,3]benzodiazepines, 6H-pyrido[1,2-c][1,3,5]benzoxadiazepines, and 6H-pyrido[1,2-c][1,3,5]benzothiadiazepines, Category: chlorides-buliding-blocks, the main research area is cyclization iminobromoanilinomethylpyridine; pyridobenzodiazepine; pyridobenzoxadiazepine; pyridobenzothiadiazepine; pyridine imino bromoanilinomethyl cyclization.

An unusually facile dehydrobromination, involving the ortho Br atom and the NH proton of the iminopyridines I (X = CH2, O, S, R = H, Cl) gave the 11,12-dihydropyrido[2,1-b] [1,3]benzodiazepines II (X = CH2), 6H-pyrido[1,2-c] [1,3,5]benzoxadiazepines II (X = O), and 6H-pyrido-[1,2-c] [1,3,5]benzothiadiazepines II (X = S). These cyclizations required a base, e.g., potassium carbonate, and a catalyst, e.g., copper bronze. The reactions occurred in methanol or propanol at reflux, either under anhydrous conditions or in the presence of large amounts of water.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Klatt, Thomas’s team published research in Organic Letters in 2014-02-21 | CAS: 6797-79-1

Organic Letters published new progress about Coupling reaction. 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, Name: 4-Chloro-2-fluoroiodobenzene.

Klatt, Thomas published the artcileTMP-Magnesium and TMP-Zinc Bases for the Regioselective Metalation of the Cinnoline Scaffold, Name: 4-Chloro-2-fluoroiodobenzene, the main research area is cinnoline regioselective preparation; regioselective metalation cinnoline methylpiperidinylmagnesium reagent alkylation coupling.

Cinnolines I [R = H, 4-EtO2CC6H4, 4-MeOC6H4, 3-MeO2CC6H4, 3-Me2NC6H4, 3-TBDMSOC6H4, Br, I, MeS, 3-ClC6H4CO, cyclopropanecarbonyl, 2-furanylcarbonyl; R1 = H, 4-MeOC6H4, 3-BocOC6H4, 4-Cl-2-FC6H3, 4-MeO2CC6H4, (E)-BuCH2CH2CH:CH, EtO2CC(:CH2)CH2, 2-cyclohexen-1-yl, Br, I, 3-MeOC6H4, (E)-Me3SiCH:CH; R2 = H, NC, EtO2C] were prepared by regioselective metalation of cinnoline, 6-cinnolinecarbonitrile, or Et 6-cinnolinecarboxylate with tetramethylpiperidinylmagnesium reagents and boron trifluoride etherate or zinc chloride followed by reaction with electrophiles (either alone or using a copper catalyst) or by palladium-catalyzed coupling reactions with aryl bromides or iodides or alkenyl iodides. The use of a frustrated Lewis pair derived from cinnoline, BF3·Et2O, and TMP2Mg·2LiCl yielded 3-substituted cinnolines while the use of the in situ-generated base TMP2Zn·2MgCl2·2LiCl yielded 8-substituted cinnolines; successive metalations allowed the preparation of 3,8-disubstituted cinnolines.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics