Tag: M.W=250-300

Sokolova, A. S. published the artcileSynthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of filovirus infections, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Russian Chemical Bulletin (2019), 68(5), 1041-1046, database is CAplus.

N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A mol. modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.

Russian Chemical Bulletin published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C18H24N6O6S4, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Yeosan published the artcileChemoselective Coupling of 1,1-Bis[(pinacolato)boryl]alkanes for the Transition-Metal-Free Borylation of Aryl and Vinyl Halides: A Combined Experimental and Theoretical Investigation, Recommanded Product: 2-(3-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Journal of the American Chemical Society (2017), 139(2), 976-984, database is CAplus and MEDLINE.

A new transition-metal-free borylation of aryl and vinyl halides using 1,1-bis[(pinacolato)boryl]alkanes as boron sources is described. In this transformation one of the boron groups from 1,1-bis[(pinacolato)boryl]alkanes is selectively transferred to aryl and vinyl halides in the presence of sodium tert-butoxide as the only activator to form organoboronate esters. Under the developed borylation conditions, a broad range of organohalides are borylated with excellent chemoselectivity and functional group compatibility, thus offering a rare example of a transition-metal-free borylation protocol. Exptl. and theor. studies have been performed to elucidate the reaction mechanism, revealing the unusual formation of Lewis acid/base adduct between organohalides and α-borylcarbanion, generated in situ from the reaction of 1,1-bis[(pinacolato)boryl]alkanes with an alkoxide base, to facilitate the borylation reactions.

Journal of the American Chemical Society published new progress about 1688649-04-8. 1688649-04-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronate Esters, name is 2-(3-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO2, Recommanded Product: 2-(3-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Fei-Le published the artcilePd-Catalyzed Allylic Alkylation of gem-Alkyl,Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers, COA of Formula: C10H15ClO3S, the publication is ACS Catalysis (2018), 8(4), 3317-3321, database is CAplus.

(E)-gem-Alkyl,aryl-disubstituted allyl carbonates can react with ketones under Pd catalysis using a com. available NHC ligand by suppressing the β-H elimination. Ketones with α-tertiary, β-quaternary carbon stereocenters were produced in high yields with high regio- and diastereoselectivities. Kinetic resolution of the reaction product via CBS reduction afforded the optically active ketone I as well as the alc. II with high enantioselectivity (S-factor = 35). The utility of the methodol. was also demonstrated by transformations of the reaction products.

ACS Catalysis published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C9H8BF3O2, COA of Formula: C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Roy, Debayan published the artcileEvidence for Atropisomerism in Polycyclic γ-Butenolides: Synthesis, Scope, and Spectroscopic Studies, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemistry – A European Journal (2021), 27(12), 4009-4015, database is CAplus and MEDLINE.

Design and development of a domino cyclative approach for the synthesis of new polycyclic γ-butenolides from β-aryl-Z-enoate propargylic alcs., through the interception of an intermediate of the Z-enoate-assisted Meyer-Schuster rearrangement, has been reported. A systematic NMR anal. of various derivatives of this class revealed and supported the potential atropisomerism associated with them. These mols. represent first examples of butenolide ring-based atropisomeric compounds in organic chem. The synthetic process involves a synchronous construction of both rings with concurrent creation of the potential stereogenic rotational axis.

Chemistry – A European Journal published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bel’skii, V. E. published the artcileHydrogen bonding of phenol and tert-butyl alcohol with phosphonates, Product Details of C5H10Cl3O3P, the publication is Zhurnal Obshchei Khimii (1975), 45(12), 2606-9, database is CAplus.

H bonding between Me3COH or PhOH and 27 RP(O)(OEt)2 (R = e.g., Et, piperidinomethyl, ClCH2CH2, vinyl, Ph) in CCl4 was studied by ir; compounds with 2 acceptor groups formed H bonds preferentially with the PO group. The heat of H bonding between PhOH and the phosphonates was correlated with Taft ρ* constants and 31P NMR chem. shifts.

Zhurnal Obshchei Khimii published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kaboudin, B. published the artcileSurface-mediated solid phase reactions: microwave assisted Arbuzov rearrangement on the solid surface, HPLC of Formula: 866-23-9, the publication is Synthetic Communications (2001), 31(18), 2773-2776, database is CAplus.

Microwave assisted Arbuzov rearrangement under solvent-free condition is an efficient method for the preparation of dialkyl alkylphosphonates of alkyl halides. This method is an easy, rapid, and high-yielding reactions for the Arbuzov rearrangement. E.g., PhCH₂Cl reacts with P(OEt)₃ in the presence of Al₂O₃ under solvent-free conditions using microwave irradiation to give 85% yield of PhCH₂P(O)(OEt)₂.

Synthetic Communications published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, HPLC of Formula: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rosin, Hadassa published the artcileAddition of trichloromethane phosphonyldichloride and its derivatives to vinylic monomers and other olefins, SDS of cas: 866-23-9, the publication is Journal of Organic Chemistry (1975), 40(22), 3298-9, database is CAplus.

Trichloromethanephosphonyl dichloride adds to vinylic monomers and other olefins under iron or copper chloride catalysis by a redox chain mechanism, giving RCH(Cl)CH2CCl2POCl2. Under forcing conditions, ethylene adds to its own monoadduct to give (ClCH2CH2)2CClPOCl2. Diphenyl trichloromethanephosphonate reacts in the same fashion, but with the dimethyl and diethyl ester the addition stops far short of completion.

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Del Grosso, Alessandro published the artcileRegioselective electrophilic borylation of haloarenes, SDS of cas: 765917-27-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(14), 2878-2881, database is CAplus and MEDLINE.

Haloarenes undergo direct borylation using amine : BCl₃ : AlCl₃ in the ratio of 1 : 1 : 2. After esterification the pinacol boronate esters are isolated in good yield with regioselectivity controlled by steric and electronic effects.

Chemical Communications (Cambridge, United Kingdom) published new progress about 765917-27-9. 765917-27-9 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Boronate Esters, name is 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C12H15BClFO2, SDS of cas: 765917-27-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Devaud, Marguerite published the artcileElectrochemical reduction of 1-chloroalkylphosphonates in the presence of various electrophiles, Application of Diethyltrichloromethylphosphonate, the publication is Journal of Chemical Research, Synopses (1991), 120-1, database is CAplus.

The electroreduction of dichloromethylene bis(di-Et phosphonate) was studied in the presence of various electrophiles protons, alkyl iodides and carbonyl compounds The electroreduction of di-Et (trichloromethyl)phosphonate with and without benzaldehyde is also described.

Journal of Chemical Research, Synopses published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rosch, Andrea published the artcileHow Biotransformation Influences Toxicokinetics of Azole Fungicides in the Aquatic Invertebrate Gammarus pulex, Quality Control of 67747-01-7, the publication is Environmental Science & Technology (2016), 50(13), 7175-7188, database is CAplus and MEDLINE.

Biotransformation is a key process that can greatly influence the bioaccumulation potential and toxicity of organic compounds In this study, biotransformation of seven frequently used azole fungicides (triazoles: cyproconazole, epoxiconazole, fluconazole, propiconazole, tebuconazole and imidazoles: ketoconazole, prochloraz) was investigated in the aquatic invertebrate Gammarus pulex in a 24 h exposure experiment Addnl., temporal trends of the whole body internal concentrations of epoxiconazole, prochloraz, and their resp. biotransformation products (BTPs) were studied to gain insight into toxicokinetic processes such as uptake, elimination and biotransformation. By the use of high resolution tandem mass spectrometry in total 37 BTPs were identified. Between one (ketoconazole) and six (epoxiconazole) BTPs were identified per parent compound except for prochloraz, which showed extensive biotransformation reactions with 18 BTPs detected that were mainly formed through ring cleavage or ring loss. In general, most BTPs were formed by oxidation and conjugation reactions. Ring loss or ring cleavage was only observed for the imidazoles as expected from the general mechanism of oxidative ring openings of imidazoles, likely affecting the bioactivity of these BTPs. Overall, internal concentrations of BTPs were up to 3 orders of magnitude lower than that of the corresponding parent compound Thus, biotransformation did not dominate toxicokinetics and only played a minor role in elimination of the resp. parent compound, with the exception of prochloraz.

Environmental Science & Technology published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C11H14Cl3NO, Quality Control of 67747-01-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics