Month: November 2022

Das, Arup Jyoti’s team published research in Organic & Biomolecular Chemistry in 18 | CAS: 7080-50-4

Organic & Biomolecular Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, HPLC of Formula: 7080-50-4.

Das, Arup Jyoti published the artcileSwitching of regioselectivity in base-mediated diastereoselective annulation of 2,3-epoxy tosylates and their N-tosylaziridine analogs with 2-mercaptobenzimidazole, HPLC of Formula: 7080-50-4, the publication is Organic & Biomolecular Chemistry (2020), 18(3), 441-449, database is CAplus and MEDLINE.

A base-mediated dinucleophilic cyclization of readily accessible 2,3-epoxy tosylates such as I with 2-mercaptobenzimidazole has been developed for the one-pot diastereoselective synthesis of benzimidazole-based tricyclic compounds such as II equipped with two stereogenic centers. With trans-substrates such as I bearing an aryl or alkyl substituent at the C3 position, the reaction involves an initial S-C1 bond-forming intermol. alkylation followed by an N-C3 bond-forming, endo-selective intramol. epoxide ring-opening cyclization reaction. A spectacular regioselectivity switching (tandem S-C3 and N-C1 bond formation reactions) was observed with related trans-N-tosylaziridine substrates III (R = H, F). Wide substrate scope, complete diastereoselectivity, high to complete regioselectivity and mild transition metal-free conditions render this protocol particularly efficient and practical.

Organic & Biomolecular Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, HPLC of Formula: 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kovtunyak, N. A.’s team published research in Farmakologiya i Toksikologiya (Moscow) in 43 | CAS: 38146-42-8

Farmakologiya i Toksikologiya (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Application In Synthesis of 38146-42-8.

Kovtunyak, N. A. published the artcileEffect of decamethoxin, decamine and levorin on the content of carbohydrate-protein components in the connective tissue of the rat liver, Application In Synthesis of 38146-42-8, the publication is Farmakologiya i Toksikologiya (Moscow) (1980), 43(1), 88-91, database is CAplus.

Decamethoxin [38146-42-8] (0.5 mg/kg/day) injected i.m. into rats for 10 days increased the concentration of hexosamines and hexuronic acid [62446-36-0] in the liver. Decamine [522-51-0] (1.0 mg/kg/day) decreased the levels of hexosamines and hexoses. Levorin [1403-17-4] (1.0 mg/kg/day) decreased the biosynthesis of hydroxyproline [51-35-4] and hexosamine.

Farmakologiya i Toksikologiya (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Application In Synthesis of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kovtunyak, N. A.’s team published research in Farmakologiya i Toksikologiya (Moscow) in 46 | CAS: 38146-42-8

Farmakologiya i Toksikologiya (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Kovtunyak, N. A. published the artcileEffect of decamethoxin, decamine and levorin on the content of cholesterol, phospholipids and triglycerides in the liver of white rats, Synthetic Route of 38146-42-8, the publication is Farmakologiya i Toksikologiya (Moscow) (1983), 46(5), 72-5, database is CAplus.

I.m. injection, of quaternary ammonium compounds (decamethoxin (I) [38146-42-8] and decamine  [522-51-0]) and levorin  [11014-70-3] changed the content of cholesterol  [57-88-5], phospholipids, and triglycerides in the liver of rats. Decamethoxin decreased the content of phospholipids and cholesterol and raised the concentration of triglycerides. Decamine decreased the level of phospholipids and raised the content of cholesterol and triglycerides, while levorin minimized the content of phospholipids, cholesterol, and triglycerides.

Farmakologiya i Toksikologiya (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Moeller, Carsten’s team published research in ChemMedChem in 13 | CAS: 7080-50-4

ChemMedChem published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, HPLC of Formula: 7080-50-4.

Moeller, Carsten published the artcileDiscovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies, HPLC of Formula: 7080-50-4, the publication is ChemMedChem (2018), 13(21), 2271-2280, database is CAplus and MEDLINE.

Progesterone plays an important role in the female reproductive system. However, there is also evidence that gynecol. disorders/diseases such as uterine fibroids and endometriosis are progesterone-dependent. Steroidal and non-steroidal selective progesterone receptor modulators (SPRMs) have shown potential for the treatment of such diseases. Steroidal SPRMs, including mifepristone and ulipristal acetate, have proven effective in clin. trials. However, several steroidal SPRMs containing a dimethylamino substituent have been associated with elevated liver enzymes in patients. An earlier drug discovery program identified lonaprisan as a highly selective SPRM that did not show drug-related change in liver enzyme activity. Building on data obtained from that work, here we describe the research program that culminated in the discovery of a novel steroidal SPRM, vilaprisan, which combines an extremely high potency with very favorable drug metabolism and pharmacokinetic properties. Vilaprisan has entered clin. development and is currently undergoing phase 3 clin. trials.

ChemMedChem published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, HPLC of Formula: 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Prosyanik, A. V.’s team published research in Khimiya Geterotsiklicheskikh Soedinenii in | CAS: 18791-02-1

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application of 2,3-Dibromopropionylchloride.

Prosyanik, A. V. published the artcileAsymmetric unbridged nitrogen. 20. New data on derivatives of 1-alkoxyaziridine-2-carboxylic acids, Application of 2,3-Dibromopropionylchloride, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1980), 212-15, database is CAplus.

Treatment of BrCH2CHBrCO2R (R = Me, Et, CHMe2, CMe3) with R1ONH2 (R1 = Me, Et, Me2CH) and Et3N gave R1ONHCH2CHBrCO2R, which cyclized upon heating in Et3N-MeCN to give I, the trans isomer being formed predominantly. Similarly prepared were II (same R1) with the trans isomer predominant or exclusive. III (trans/cis = 3:1) was also obtained. The N inversion barriers in I–III were 130-138 kJ/mol at 120°.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bonafoux, Dominique F.’s team published research in Bioorganic & Medicinal Chemistry in 18 | CAS: 6313-54-8

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Formula: C6H4ClNO2.

Bonafoux, Dominique F. published the artcileAminopyridinecarboxamide-based inhibitors: Structure-activity relationship, Formula: C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry (2010), 18(1), 403-414, database is CAplus and MEDLINE.

Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1β stimulated synovial fibroblasts. The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors with improved cellular activity.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Binaschi, Monica’s team published research in ACS Medicinal Chemistry Letters in 1 | CAS: 60091-87-4

ACS Medicinal Chemistry Letters published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, COA of Formula: C13H9ClN2O4.

Binaschi, Monica published the artcileAntiproliferative and Differentiating Activities of a Novel Series of Histone Deacetylase Inhibitors, COA of Formula: C13H9ClN2O4, the publication is ACS Medicinal Chemistry Letters (2010), 1(8), 411-415, database is CAplus and MEDLINE.

Histone deacetylases are promising mol. targets for the development of antitumor agents. A novel series of histone deacetylase inhibitors of the hydroxamic acid type were synthesized for structure-activity studies. Thirteen tricyclic dibenzo-diazepine, -oxazepine, and -thiazepine analogs were studied and shown to induce variable degrees of histone H3/H4 and tubulin acetylation in a cellular model of myeloid leukemia sensitive to all-trans retinoic acid (ATRA). Multiparametric correlations between acetylation of the three substrates, tumor cell growth inhibition, and ATRA-dependent cytodifferentiation were performed, providing information on the chem. functionalities governing these activities. For two analogs, antitumor activity in the animal was demonstrated.

ACS Medicinal Chemistry Letters published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, COA of Formula: C13H9ClN2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lysenko, V. P.’s team published research in Zhurnal Obshchei Khimii in 49 | CAS: 5034-06-0

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Lysenko, V. P. published the artcilePhosphorus-containing sulfoxonium ylides. IV. Ylides containing substituents with trivalent phosphorus, Synthetic Route of 5034-06-0, the publication is Zhurnal Obshchei Khimii (1979), 49(6), 1230-5, database is CAplus.

Reaction of Me2S(O):CH2 with FP(OEt)2 gave Me2S(O):CHP(OEt)2 which reacts with S, RX (R = Me, Et; X = halo) and Cl3CCHO to give Me2S(O):CHR1 (R1 = P(S)(OEt)2, P(O)R(OEt), P(O)(OEt)OCH:CCl2 resp.). Reaction of Me2S(O):CH2 with Cl3PX1 (X1 = -, O, S) gave X1P[CH2S+(O)Me2]3 3Cl–.

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lysenko, V. P.’s team published research in Zhurnal Obshchei Khimii in 48 | CAS: 5034-06-0

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Name: trimethyloxosulphonium chloride.

Lysenko, V. P. published the artcilePhosphorus-containing sulfoxonium ylides. II. Properties of ylides stabilized by phosphorus(V), Name: trimethyloxosulphonium chloride, the publication is Zhurnal Obshchei Khimii (1978), 48(5), 978-84, database is CAplus.

Me2S+(O)CH2P(Y)(OR)2 X– (Y = O, NSO2C6H4Me-p, R = Et, Pr, Ph; X = Cl, 2,4,6-(O2N)3C6H2O, F3CCO2) were prepared in 81-92% yields by treating Me2S+(O)C–HP(Y)(OR)2 (I) with HX. Reaction of I with PhNCO, Ac2O, and p-R1C6H4CHO (R1 = H, NO2) gave Me2S+(O)C–R2P(O)(OR)2 (R2 = CONHPh, Ac, CH(OH)C6H4R1–p) resp. Reaction of Me2S+(O)C–HP(OEt)2 with RN3 (R = Ph, p-MeC6H4SO2) and N2C(CO2Et)2 gave Me2S+(O)C–HP(:X)(OEt)2 (X = NR, NN:C(CO2Et)2] resp.

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Name: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pavlova, A. S.’s team published research in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 53 | CAS: 61551-49-3

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Synthetic Route of 61551-49-3.

Pavlova, A. S. published the artcileSynthesis of combinatorial libraries of amides, sulfonamides and ureas from 2-acylated derivatives of benzo[d]thiazole-2,5-diamine, Synthetic Route of 61551-49-3, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2010), 53(7), 11-15, database is CAplus.

Four 2-(acylamino)-5-aminobenzo[d]thiazoles (acyl = MeCO, EtCO, PhCO, 4-MeC6H4CO) were efficiently synthesized in 3 steps by cyclocondensation of 1-chloro-2,4-dinitrobenzene with thiourea followed by acylation of the intermediate 2-amino-5-nitrobenzothiazole and hydrogen reduction of the nitro group on Pd catalyst in DMF. The products were successfully used in the solution-phase parallel synthesis of combinatorial libraries of 5-amide-, 5-sulfonamide- and 5-urea-functionalized 2-(acylamino)benzothiazoles by reactions with carboxylic acids/CDI, sulfonyl chlorides and isocyanates, resp.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Synthetic Route of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics