Das, Arup Jyoti published the artcileSwitching of regioselectivity in base-mediated diastereoselective annulation of 2,3-epoxy tosylates and their N-tosylaziridine analogs with 2-mercaptobenzimidazole, HPLC of Formula: 7080-50-4, the publication is Organic & Biomolecular Chemistry (2020), 18(3), 441-449, database is CAplus and MEDLINE.
A base-mediated dinucleophilic cyclization of readily accessible 2,3-epoxy tosylates such as I with 2-mercaptobenzimidazole has been developed for the one-pot diastereoselective synthesis of benzimidazole-based tricyclic compounds such as II equipped with two stereogenic centers. With trans-substrates such as I bearing an aryl or alkyl substituent at the C3 position, the reaction involves an initial S-C1 bond-forming intermol. alkylation followed by an N-C3 bond-forming, endo-selective intramol. epoxide ring-opening cyclization reaction. A spectacular regioselectivity switching (tandem S-C3 and N-C1 bond formation reactions) was observed with related trans-N-tosylaziridine substrates III (R = H, F). Wide substrate scope, complete diastereoselectivity, high to complete regioselectivity and mild transition metal-free conditions render this protocol particularly efficient and practical.
Organic & Biomolecular Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, HPLC of Formula: 7080-50-4.
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