Binaschi, Monica published the artcileAntiproliferative and Differentiating Activities of a Novel Series of Histone Deacetylase Inhibitors, COA of Formula: C13H9ClN2O4, the publication is ACS Medicinal Chemistry Letters (2010), 1(8), 411-415, database is CAplus and MEDLINE.
Histone deacetylases are promising mol. targets for the development of antitumor agents. A novel series of histone deacetylase inhibitors of the hydroxamic acid type were synthesized for structure-activity studies. Thirteen tricyclic dibenzo-diazepine, -oxazepine, and -thiazepine analogs were studied and shown to induce variable degrees of histone H3/H4 and tubulin acetylation in a cellular model of myeloid leukemia sensitive to all-trans retinoic acid (ATRA). Multiparametric correlations between acetylation of the three substrates, tumor cell growth inhibition, and ATRA-dependent cytodifferentiation were performed, providing information on the chem. functionalities governing these activities. For two analogs, antitumor activity in the animal was demonstrated.
ACS Medicinal Chemistry Letters published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, COA of Formula: C13H9ClN2O4.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics