Month: November 2022

Poltavskii, V. P. published the artcileChanges in mitotic regimen of permanent amniotic human cell cultures (line Ai) exposed to decamethoxin, Computed Properties of 38146-42-8, the publication is Antibiotiki (Moscow) (1975), 20(6), 506-9, database is CAplus.

Decamethoxin [38146-42-8] (0.1-10 μg/ml) added to cultures of a permanent line of amniotic human cells suppressed mitotic activity and arrested cells in telophase. At 50-500 μg/ml, decamethoxin caused cell destruction and at 1000 μg/ml had a fixation effect.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Computed Properties of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Newby, James A. published the artcileDesign and Application of a Low-Temperature Continuous Flow Chemistry Platform, Name: (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, the publication is Organic Process Research & Development (2014), 18(10), 1211-1220, database is CAplus.

A flow reactor platform technol. applicable to a broad range of low temperature chem. is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor.

Organic Process Research & Development published new progress about 944129-07-1. 944129-07-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester,, name is (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H7BClFO3, Name: (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Newby, James A. published the artcileReconfiguration of a Continuous Flow Platform for Extended Operation: Application to a Cryogenic Fluorine-Directed ortho-Lithiation Reaction, Quality Control of 944129-07-1, the publication is Organic Process Research & Development (2014), 18(10), 1221-1228, database is CAplus.

A flow platform for preparing various aromatic scaffolds using a low-temperature fluorine-directed ortho-lithiation reaction has been successfully reconfigured to allow large-scale processing over extended reaction periods. During the course of this work several key factors have resulted in the development of new technol. such as stainless steel y-piece fittings capable of hosting a thermocouple at the point of mixing which directly controls the power output of a cryogenic cooling device. These developments have enabled the continuous processing of an industrially relevant product, where adequate mixing, cooling, and exotherm control are important for successful operation. The configuration culminates in a large-scale campaign where the flow platform is utilized to process over 100 g of pure product over 7 h, in a yield of 80% after workup.

Organic Process Research & Development published new progress about 944129-07-1. 944129-07-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester,, name is (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H7BClFO3, Quality Control of 944129-07-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Newby, James A. published the artcileDesign and Application of a Low-Temperature Continuous Flow Chemistry Platform, Application In Synthesis of 1628684-10-5, the publication is Organic Process Research & Development (2014), 18(10), 1211-1220, database is CAplus.

A flow reactor platform technol. applicable to a broad range of low temperature chem. is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor.

Organic Process Research & Development published new progress about 1628684-10-5. 1628684-10-5 belongs to chlorides-buliding-blocks, auxiliary class Boronic Acids,Boronic Acids,Boronic acid and ester, name is (4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid, and the molecular formula is C7H7BClFO3, Application In Synthesis of 1628684-10-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rostoll-Berenguer, Jaume published the artcilePhotocatalytic Giese Addition of 1,4-Dihydroquinoxalin-2-ones to Electron-Poor Alkenes Using Visible Light, Formula: C8H6ClF3, the publication is Organic Letters (2020), 22(20), 8012-8017, database is CAplus and MEDLINE.

The visible-light photoredox-catalyzed coupling of 1,4-dihydroquinoxalin-2-ones and Michael acceptors was achieved using Ru(bpy)₃Cl₂ as the photocatalyst and (PhO)₂PO₂H as an additive. The optimized reaction conditions provide a good yield for the radical conjugate addition products (44 examples) with a wide range of structurally different Michael acceptors. A gram scale reaction using sunlight irradiation is also described. Furthermore, several transformations were carried out with the Giese addition products.

Organic Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Deyi published the artcileDiscovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT_1F receptor agonists: Evolution from bicyclic to monocyclic cores, Product Details of C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(19), 4337-4341, database is CAplus and MEDLINE.

Preclin. experiments and clin. observations suggest the potential effectiveness of selective 5-HT_1F receptor agonists in migraine. Identifying compounds with enhanced selectivity is crucial to assess its therapeutic value. Replacement of the indole nucleus in LY334370 (I) with a monocyclic Ph ketone moiety generated potent and more selective 5-HT_1F receptor agonists. Focused SAR studies around this central Ph ring demonstrated that the electrostatic and steric interactions of the substituent with both the amide CONH group and the ketone C=O group play pivotal roles in affecting the adopted conformation and thus the 5-HT_1F receptor selectivity. Computational studies confirmed the observed results and provide a useful tool in the understanding of the conformational requirements for 5-HT_1F receptor agonist activity and selectivity. Through this effort, the 2-F-Ph and N-2-pyridyl series were also identified as potent and selective 5-HT_1F receptor agonists.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C14H12O2, Product Details of C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Djerourou, Abdelhafid published the artcileReactivity of dichlorosilanes with lithium ester enolates: synthesis of 3,3-disubstituted 3-silaglutarates, Name: Dichloro(methyl)(octyl)silane, the publication is Journal of Organometallic Chemistry (1995), 485(1-2), 63-8, database is CAplus.

3,3-Disubstituted 3-silaglutarates were synthesized by reaction of the lithium enolate of Et acetate with dichlorosilanes at -94°. When a Ph group is linked to the silicon atom the reaction in THF gave mainly the silaglutarate. In other cases alkylsilyl ketene acetals were formed in proportions similar to or greater than that of the silaglutarate. The presence of HMPA increased the ratio of C- to O-silylated products and allowed the preparation of 3,3-dialkyl 3-silaglutarates in good yield.

Journal of Organometallic Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Name: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sorokin, V. A. published the artcileStudies on the complex formation of DNA with the antibacterial drug (decamethoxine), Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Molekulyarnaya Biologiya (Moscow) (1990), 24(1), 214-19, database is CAplus.

The interactions of the antibacterial drug decamethoxine with natural calf thymus DNA were studied by differential UV-spectroscopy. Decamethoxine showed a nucleotide specificity. It decreased the cooperativity of melting and the thermal stability of DNA parts enriched by AT pairs. The characteristics of the helix-coil transition in the DNA parts enriched by GC-pairs were invariable. Interactions with AT-pairs resulted in their partial or complete melting at room temperature, followed by intermol. aggregation. By interacting with phosphates decamethoxine behaves not as a dication but as two single-charged ions.

Molekulyarnaya Biologiya (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C5H5N3S, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chimenti, Franco published the artcileSynthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides, COA of Formula: C7H4BrClO2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(16), 4922-4926, database is CAplus and MEDLINE.

N-substituted-3-carboxamido-coumarin derivatives, e.g. I, were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clin. strains, including five metronidazole resistant ones. Some of them possessed the best activity against H. pylori metronidazole resistant strains with MIC values lower than the drug reference (metronidazole). Furthermore, anti-inflammatory activity through the inhibition of the IL-8 production was investigated.

Bioorganic & Medicinal Chemistry Letters published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, COA of Formula: C7H4BrClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Waring, Michael J. published the artcileOptimisation of biphenyl acetic acid inhibitors of diacylglycerol acetyl transferase 1 – the discovery of AZD2353, Formula: C8H7ClO3, the publication is MedChemComm (2013), 4(1), 159-164, database is CAplus.

Inhibition of diacylglycerol acetyl transferase 1 is of great interest in the treatment of diabetes, obesity and other diseases that constitute the metabolic syndrome. Small mol. inhibitors of the enzyme are often dogged with physicochem. property-related problems such as poor solubility Herein, the optimization of a series of biphenyl acetic acid inhibitors is reported. Focus on ligand efficiency and ligand lipophilicity efficiency and a strategy based on conformational restriction led to compounds with excellent potency and ADMET properties, culminating in the discovery of AZD2353.

MedChemComm published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C7H8O3, Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics