Tag: M.W=150-200

Ramazani, A. published the artcileIn silico analysis and development of anti-malarial compounds against dihydroorotate dehydrogenase using chem-bioinformatic tools, Category: chlorides-buliding-blocks, the publication is International Journal of Pharma and Bio Sciences (2011), 2(2), 122-131, database is CAplus.

Computational studies have been developed to unravel the mechanism of action of the anti-malarial drugs and to give guidelines for the development of new derivatives with improved efficiency. In this study, dihydroorotate dehydrogenase (DHOD), a key enzyme in de novo pyrimidine biosynthesis and the major source of electrons for the mitochondrial electron transport chain of intraerythrocytic malaria parasites, was selected as a target for potential inhibitors. Beginning with the natural inhibitors found in crystallographed mols. representing *.pdb file, a general similarity search were done in PDB, NCI and PUBMED databases resemble probable anti-malarial compounds This made it possible to dock these ligand libraries with DHOD by FlexX 3.2, 2007 software and comparing the inter-mol. interactions and scores which are given to them by the software. The highest absolute value of interactions energies were considered be the best and proper ligands. These ligands were used for second 95% similarity search in PUBCHEM for proposed anti-malarial compound which have the same mechanism as A26. As an interesting point among 400 found mols. was presence of quinolines. This could propose a new mechanism for these important anti-malarial agents.

International Journal of Pharma and Bio Sciences published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Han, Byung Hee published the artcileOrganic sonochemistry. Ultrasonic acceleration of the hydrosilation reaction, Name: Dichloro(hexyl)(methyl)silane, the publication is Organometallics (1983), 2(6), 769-71, database is CAplus.

Ultrasonic waves dramatically increase the activity of a Pt/C catalyst in the hydrosilylation of alkenes or alkynes, e.g., 1-hexene, PhCCH, by hydrosilanes, e.g., HSiCl₃, HSiMeCl₂, HSiEt₃, HSi(OEt)₃. The reaction was carried out at -30°.

Organometallics published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Name: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Benouargha, A. published the artcileRedistribution of dichlorosilanes and dihydridosilanes. Synthesis of chloro hydridosilanes, Related Products of chlorides-buliding-blocks, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1996), 113(1-4), 79-87, database is CAplus.

The redistribution of dichlorosilanes, RSiMeCl₂, and dihydridosilanes, RSiMeH₂ (prepared by reduction of the homologs dichlorosilanes), in the presence of a quaternary ammonium salt is presented. The influence of the nature of R (fluoroalkyl chain: R_FCH₂CH₂ with R_F = CF₃, C₄F₉, C₈F₁₇; alkyl chain: R = C₆H₁₃; or aromatic: R = C₆H₅) and of the temperature on the rate of the reaction was studied. The equilibrium constants and free enthalpies are calculated and discussed taking into account the nature of R. The new products described were characterized from IR, ¹H, ¹⁹F and ²⁹Si NMR spectroscopies.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Garcia, Ana M. published the artcileModulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors, Application In Synthesis of 350-30-1, the publication is Journal of Medicinal Chemistry (2014), 57(20), 8590-8607, database is CAplus and MEDLINE.

A forward chem. genetic approach was followed to discover new targets and lead compounds for Parkinson’s disease (PD) treatment. By anal. of the cell protection produced by some small mols., a di-Ph sulfide compound was revealed to be a new phosphodiesterase 7 (PDE7) inhibitor and identified as a new hit. This result allows us to confirm the utility of PDE7 inhibitors as a potential pharmacol. treatment of PD. On the basis of these data, a diverse family of di-Ph sulfides has been developed and pharmacol. evaluated in the present work. Moreover, to gain insight into the safety of PDE7 inhibitors for human chronic treatment, the authors evaluated the new compounds in a surrogate emesis model, showing nonemetic effects.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application In Synthesis of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Senczyszyn, Jemma published the artcileSpirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides, Formula: C6H4ClNO2, the publication is Organic Letters (2013), 15(8), 1922-1925, database is CAplus and MEDLINE.

On treatment with acylating or sulfonylating agents, N-alkenyl pyridinecarboxamides (N-pyridinecarbonyl enamines) undergo a dearomatizing cyclization initiated by pyridine acylation and followed by intramol. trapping of the resulting pyridinium cation (e.g., I → II). The products are spirocyclic dihydropyridines which may be further elaborated to spirocyclic heterocycles with drug-like features.

Organic Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C17H37NO3, Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Camargo Solorzano, Patricia published the artcilePhotoinduced Synthesis of Dibenzofurans: Intramolecular and Intermolecular Comparative Methodologies, Quality Control of 145349-62-8, the publication is Journal of Organic Chemistry (2018), 83(15), 7867-7877, database is CAplus and MEDLINE.

The S_RN1 reaction has been used as a powerful tool for the synthesis of heterocycles, and only a few studies about photoinduced intramol. cyclization to generate a new C-O bond by a radical pathway have been reported. This work introduces two strategies for the synthesis of substituted dibenzofurans by electron transfer (eT) reactions. The first one is a three-step process that comprises bromination of o-arylphenols, Suzuki-Miyaura cross-coupling and photoinduced cyclization in order to obtain the above-mentioned products. The second one is a metal-free procedure and does not require any photocatalyst. Different solvents were tested, and the yields ranged from low to moderate. A comparison was established between both methodologies, showing that the second one is the most suitable for the synthesis of dibenzofurans.

Journal of Organic Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Quality Control of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ranjitkar, Pratistha published the artcileAffinity reagents that target a specific inactive form of protein kinases, SDS of cas: 6313-54-8, the publication is Chemistry & Biology (Cambridge, MA, United States) (2010), 17(2), 195-206, database is CAplus and MEDLINE.

A number of small-mol. inhibitors have been developed that target the catalytic domains of protein kinases that are not in an active conformation. An inactive form that has been observed in several kinases is the DFG-out conformation. This conformation is characterized by an almost 180° rotation of the conserved Asp-Phe-Gly (DFG) motif in the ATP-binding cleft relative to the active form. However, the sequence and structural determinants that allow a kinase to stably adopt the DFG-out conformation are not known. Here, we characterize a series of inhibitors based on a general pharmacophore for this inactive form. We demonstrate that modified versions of these inhibitors can be used to study the thermodn. and kinetics of ligand binding to DFG-out-adopting kinases and for enriching these kinases from complex protein mixtures

Chemistry & Biology (Cambridge, MA, United States) published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Deltour, G. published the artcileDetermination of carnitine in biologic media, HPLC of Formula: 6249-56-5, the publication is Clinica Chimica Acta (1960), 181-5, database is CAplus and MEDLINE.

Carnitine, after extraction by appropriate solvents or liberation from biol. materials by acid hydrolysis, is separated electrophoretically. Separation is carried out on Whatman 3 MM paper at 400 v. by means of buffer prepared by adding pyridine to 0.3M AcOH to give a final pH of 4.1. Position of the carnitine spot is located with I vapor; the spot is cut out and eluted with HCl-EtOH, and carnitine is estimated by the method of Friedman (CA 52, 12978a) in which the ethyl ester is complexed in alk. medium with bromophenol blue. The procedure gives an error of the order of 10%. Application of the method to several betaines and the results are described.

Clinica Chimica Acta published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Charles, Mark D. published the artcileDiscovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties, SDS of cas: 145349-62-8, the publication is Journal of Medicinal Chemistry (2015), 58(20), 8309-8313, database is CAplus and MEDLINE.

As part of a program to develop a small mol. inhibitor of LIMK, a series of aminothiazole inhibitors were discovered by high throughput screening. Scaffold hopping and subsequent SAR directed development led to a series of low nanomolar inhibitors of LIMK1 and LIMK2 that also inhibited the direct biomarker p-cofilin in cells and inhibited the invasion of MDA MB-231-luc cells in a matrigel inverse invasion assay.

Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, SDS of cas: 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Waring, Michael J. published the artcileOptimisation of biphenyl acetic acid inhibitors of diacylglycerol acetyl transferase 1 – the discovery of AZD2353, Formula: C8H7ClO3, the publication is MedChemComm (2013), 4(1), 159-164, database is CAplus.

Inhibition of diacylglycerol acetyl transferase 1 is of great interest in the treatment of diabetes, obesity and other diseases that constitute the metabolic syndrome. Small mol. inhibitors of the enzyme are often dogged with physicochem. property-related problems such as poor solubility Herein, the optimization of a series of biphenyl acetic acid inhibitors is reported. Focus on ligand efficiency and ligand lipophilicity efficiency and a strategy based on conformational restriction led to compounds with excellent potency and ADMET properties, culminating in the discovery of AZD2353.

MedChemComm published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C7H8O3, Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics