Tag: M.W=150-200

Licciardi, Mariano’s team published research in Biomaterials in 27 | CAS: 6249-56-5

Biomaterials published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Licciardi, Mariano published the artcileSynthesis and characterization of polyaminoacidic polycations for gene delivery, Related Products of chlorides-buliding-blocks, the publication is Biomaterials (2006), 27(9), 2066-2075, database is CAplus and MEDLINE.

The properties as non viral gene vector of a protein-like polymer, the α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) were exploited after its derivatization with 3-(carboxypropyl)trimethyl-ammonium chloride (CPTA) as mol. bearing a cationic group, in order to obtain stable polycations able to condense DNA. PHEA was firstly functionalized with aminic pendant groups by reaction with ethylenediamine (EDA) obtaining the α,β-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-D,L-aspartamide (PHEA-EDA) copolymer. We demonstrated that polymer functionalization degree is easily modulable by varying reaction conditions, so allowing to produce two PHEA-EDA derivatives at different molar percentage of amine groups. Subsequently, the condensation reaction of PHEA-EDA copolymers with CPTA yielded α,β-poly(N-2-hydroxyethyl)(2-[3-(trimethylammonium chloride)propylamide]-amidoethylcarbamate)-D,L-aspartamide (PHEA-EDA-CPTA) polycation derivatives In vitro studies were carried out to evaluate polycations ability to complex DNA and to protect it from nuclease degradation Obtained results demonstrated the good ability of our new PHEA polycationic derivatives, PHEA-EDA-CPTA, to complex and condense genomic material, neutralizing its anionic charge even at very low polycation/DNA weight ratio. Finally, PHEA-EDA-CPTA polycations were characterized by in vitro cytotoxicity studies to evaluate their effects on the viability of HuH-6 human hepatocellular carcinoma cells by MTS assay. No cytotoxicity was evidenced by both polycationic derivatives after 48 h of incubation at all tested concentrations

Biomaterials published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Licciardi, Mariano’s team published research in European Polymer Journal in 42 | CAS: 6249-56-5

European Polymer Journal published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Licciardi, Mariano published the artcileNovel cationic polyaspartamide with covalently linked carboxypropyl-trimethyl ammonium chloride as a candidate vector for gene delivery, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is European Polymer Journal (2006), 42(4), 823-834, database is CAplus.

The non-viral gene vector properties of a protein-like polymer, the α,β-poly(N-2-hydroxyethyl)-,-aspartamide (PHEA) were investigated after its derivatization with 3-(carboxypropyl)trimethyl-ammonium chloride (CPTA) as mol. bearing cationic groups, in order to obtain stable polycations able to condense DNA. PHEA was firstly functionalized with hydrazide pendant groups by reaction with hydrazine monohydrate (HYD), obtaining the polyhydrazide α,β-poly(N-2-hydroxyethyl/carbazate)-,-aspartamide (PHEA-HYD). In this paper we reported that polymer functionalization degree can be easily modulated by varying reaction conditions, so allowing us to produce two PHEA derivatives at different molar percentage of hydrazide groups. Subsequently, condensation reaction of PHEA-HYD copolymers with CPTA yielded α,β-poly(N-2-hydroxyethyl)-N-carbazate[N’-(3-trimethylammonium chloride)propylhydrazide]-,-aspartamide (PHEA-HYD-CPTA) polycation derivatives In vitro studies were carried out to evaluate polycations ability to complex DNA and to protect it from nuclease degradation Obtained results demonstrated the good efficiency of our new PHEA-polycations derivatives, PHEA-HYD-CPTA, to complex and condense genomic material even at very low polycation/DNA weight ratio.

European Polymer Journal published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun’s team published research in Journal of Luminescence in 233 | CAS: 620-20-2

Journal of Luminescence published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Cao, Chaotun published the artcileQuantifying and fine adjusting the solid-state fluorescence wavelength of 1-thienyl-2-arylethylene, Recommanded Product: 3-Chlorobenzylchloride, the publication is Journal of Luminescence (2021), 117895, database is CAplus.

Thirty two 1-thienyl-2-arylethylene derivatives (XAEY) were synthesized and their solid-state fluorescence emission wavelengths Em (nm) were determined The effects of substituents X and Y on the fluorescence wavelengths were analyzed in detail. The quant. correlation anal. for the Em was carried out by employing the ground-state polarity parameters and excited-state parameters of the substituents X and Y. A quant. equation was obtained and its reliability was verified by the leave-one-out (LOO) method. The obtained results show: (1) For the compounds XAEY, when the group Y on the aryl group is fixed, the Em order is 2′-methyl-2-thienyl-AEY > 3-thienyl-AEY > 2-thienyl-AEY; when thienyl (X) is fixed, the Em of XAEY with electron-withdrawing group Y is longer than that of XAEY with electron-donating group Y; (2) The Em of XAEY can be finely adjusted by changing groups X and Y. That is, one can obtain a series of compounds with continuous fluorescence emission wavelength in range of 450-600 nm via selecting different groups X or Y. (3) The 2′-Me has an addnl. red shift effect on the Em of 2′- methyl-2-thienyl-AEY. The results of this paper can provide an important reference for studying theor. solid-state fluorescence emission spectra of organic compounds and designing corresponding fluorescent material mols.

Journal of Luminescence published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun’s team published research in Journal of Luminescence in 233 | CAS: 939-99-1

Journal of Luminescence published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Cao, Chaotun published the artcileQuantifying and fine adjusting the solid-state fluorescence wavelength of 1-thienyl-2-arylethylene, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of Luminescence (2021), 117895, database is CAplus.

Thirty two 1-thienyl-2-arylethylene derivatives (XAEY) were synthesized and their solid-state fluorescence emission wavelengths Em (nm) were determined The effects of substituents X and Y on the fluorescence wavelengths were analyzed in detail. The quant. correlation anal. for the Em was carried out by employing the ground-state polarity parameters and excited-state parameters of the substituents X and Y. A quant. equation was obtained and its reliability was verified by the leave-one-out (LOO) method. The obtained results show: (1) For the compounds XAEY, when the group Y on the aryl group is fixed, the Em order is 2′-methyl-2-thienyl-AEY > 3-thienyl-AEY > 2-thienyl-AEY; when thienyl (X) is fixed, the Em of XAEY with electron-withdrawing group Y is longer than that of XAEY with electron-donating group Y; (2) The Em of XAEY can be finely adjusted by changing groups X and Y. That is, one can obtain a series of compounds with continuous fluorescence emission wavelength in range of 450-600 nm via selecting different groups X or Y. (3) The 2′-Me has an addnl. red shift effect on the Em of 2′- methyl-2-thienyl-AEY. The results of this paper can provide an important reference for studying theor. solid-state fluorescence emission spectra of organic compounds and designing corresponding fluorescent material mols.

Journal of Luminescence published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gan, Haifeng’s team published research in ChemistrySelect in 5 | CAS: 620-20-2

ChemistrySelect published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Gan, Haifeng published the artcileSynthesis of 2-Arylbenzoselenazoles from Se-mediated Redox Condensation of 2-Chloronitrobenzene and Arylmethyl Chlorides, Category: chlorides-buliding-blocks, the publication is ChemistrySelect (2020), 5(15), 4548-4551, database is CAplus.

A selenium-mediated redox condensation of 2-chloronitrobenzenes 2-Cl-RC6H3NO2 (R = H, 4-Me, 5-F, 5-CF3, etc.) and arylmethyl chlorides R1CH2Cl (R1 = Ph, naphthalen-1-yl, pyridin-3-yl, etc.) to obtain 2-arylbenzoselenazoles I (R2 = H, 6-Me, 5-F, 5-Br, etc.) has been realized under metal-free condition. The reactions proceeded in moderate-to-good yields with good functional compatibility and gram-scale achievement. Primarily mechanistic investigation suggested that key intermediate Bn(Se)nBn II, was first isolated and confirmed by NMR.

ChemistrySelect published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gan, Haifeng’s team published research in ChemistrySelect in 5 | CAS: 939-99-1

ChemistrySelect published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Related Products of chlorides-buliding-blocks.

Gan, Haifeng published the artcileSynthesis of 2-Arylbenzoselenazoles from Se-mediated Redox Condensation of 2-Chloronitrobenzene and Arylmethyl Chlorides, Related Products of chlorides-buliding-blocks, the publication is ChemistrySelect (2020), 5(15), 4548-4551, database is CAplus.

A selenium-mediated redox condensation of 2-chloronitrobenzenes 2-Cl-RC6H3NO2 (R = H, 4-Me, 5-F, 5-CF3, etc.) and arylmethyl chlorides R1CH2Cl (R1 = Ph, naphthalen-1-yl, pyridin-3-yl, etc.) to obtain 2-arylbenzoselenazoles I (R2 = H, 6-Me, 5-F, 5-Br, etc.) has been realized under metal-free condition. The reactions proceeded in moderate-to-good yields with good functional compatibility and gram-scale achievement. Primarily mechanistic investigation suggested that key intermediate Bn(Se)nBn II, was first isolated and confirmed by NMR.

ChemistrySelect published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Prabhu, Vilas A.’s team published research in Journal of Pharmaceutical Sciences in 70 | CAS: 4584-49-0

Journal of Pharmaceutical Sciences published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Prabhu, Vilas A. published the artcileSynthesis and structure-activity relationships of selected tricyclic oxime O-ethers as potential anticholinergic agents, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Journal of Pharmaceutical Sciences (1981), 70(5), 558-62, database is CAplus and MEDLINE.

The thioxanthone oximes I [R = CH2CH2NMe2, 1-methyl-4-piperidinyl, (CH2)3NMe2, CH2CHMeNMe2, CHMeCH2NMe2], prepared by alkylation of thioxanthone oxime with the appropriate aminoalkyl halides in the presence of NaH, exhibited significant antimuscarinic activity in rat ileum. However, (±)-I (R = CH2CHMeNMe2) was at least 5 times more potent than the corresponding O-(α-methylcholine) ether derivative of benzophenone oxime whereas (±)-I (R = CHMeCH2NMe2) was the least active among I.

Journal of Pharmaceutical Sciences published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Davies, Nicholas G. M.’s team published research in Bioorganic & Medicinal Chemistry in 20 | CAS: 209919-30-2

Bioorganic & Medicinal Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Safety of 4-Chloro-2-methylphenylboronic acid.

Davies, Nicholas G. M. published the artcileTargeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization, Safety of 4-Chloro-2-methylphenylboronic acid, the publication is Bioorganic & Medicinal Chemistry (2012), 20(22), 6770-6789, database is CAplus and MEDLINE.

Inhibitors of the Hsp90 mol. chaperone are showing promise as anti-cancer agents. Here the authors describe a series of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine ATP competitive Hsp90 inhibitors that were identified following structure-driven optimization of purine hits revealed by NMR based screening of a proprietary fragment library. Ligand-Hsp90 x-ray structures combined with mol. modeling led to the rational displacement of a conserved water mol. leading to enhanced affinity for Hsp90 as measured by fluorescence polarization, isothermal titration calorimetry and surface plasmon resonance assays. This displacement was achieved with a nitrile group, presenting an example of efficient gain in binding affinity with minimal increase in mol. weight Some compounds in this chem. series inhibit the proliferation of human cancer cell lines in vitro and cause depletion of oncogenic Hsp90 client proteins and concomitant elevation of the co-chaperone Hsp70. In addition, one compound was demonstrated to be orally bioavailable in the mouse. This work demonstrates the power of structure-based design for the rapid evolution of potent Hsp90 inhibitors and the importance of considering conserved water mols. in drug design.

Bioorganic & Medicinal Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Safety of 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Adouama, Cherif’s team published research in Organic Letters in 21 | CAS: 145349-62-8

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, SDS of cas: 145349-62-8.

Adouama, Cherif published the artcileRoom-Temperature and Transition-Metal-Free Intramolecular α-Arylation of Ketones: A Mild Access to Tetracyclic Indoles and 7-Azaindoles, SDS of cas: 145349-62-8, the publication is Organic Letters (2019), 21(1), 320-324, database is CAplus and MEDLINE.

A novel approach for the synthesis of tetracyclic indoles and 7-azaindoles is reported. The strategy involves four steps, with a fast rt intramol. α-arylation of ketones as key step. The reaction was inspected synthetically to achieve the synthesis of 11 novel tetracyclic structures with moderate to very good yields (39-85%). Theor. combined with exptl. studies led us to propose a probable polar mechanism (concerted SNAr).

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, SDS of cas: 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Price, Charles C.’s team published research in Journal of Organic Chemistry in 12 | CAS: 1002-41-1

Journal of Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Formula: C4H8Cl2S2.

Price, Charles C. published the artcileHydrolysis and oxidation of mustard gas and related compounds in aqueous solution, Formula: C4H8Cl2S2, the publication is Journal of Organic Chemistry (1947), 238-48, database is CAplus and MEDLINE.

cf. following abstract The hydrolysis and oxidation of S(CH2CH2Cl)2 (I) are studied to evaluate its hazard as a H2O contaminant. To 400 cc. H2O through which O containing O3 is bubbled, 40 cc. Cellosolve containing 1.6 cc. I is added dropwise over a period of 1 hr. The solution is evaporated to dryness to give 53% OS(CH2CH2Cl)2 (II), m. 105-8°. When to 100 cc. H2O containing 0.25 mol. NaOCl, adjusted to pH 7.5, 25 cc. MeOH containing 2 cc. I is added, 57% II, m. 105-8°, is isolated. I and chloramine-T (III) give 83% N-(p-tolylsulfonyl) – S,S’ – bis(2-chloroethyl) sulfilimine, m. 139-42°. I and Halazone (p-HO2CC6H4SO2NCl2) (IV) give 40% II, m. 104-7°. When II is shaken with NaHCO3, Cl is very slowly split off. II and NaOCl in NaHCO3-buffered solution give 37% O2S(CH2CH2Cl)2 (V), m. 54-6°. To 200 g. II in 7.5 l. H2O, 4.5 l. 0.612 N NaOCl contg: 100 g. NaHCO3 is added with stirring, and the mixture kept overnight and extracted exhaustively with CHCl3. From the residue of the CHCl3 extract (205 g.), 37 g. II, m. 103-7°, is filtered off. The filtrate is subjected to a rapid vacuum distillation, giving a distillate (VI), b1 73-145°, and leaving 30 g. residue from which 9 g. light tan crystals, m. 107-8°, are isolated. VI is fractionally distilled through a 12-in. column and the presence of OS(CH:CH2)2, b16 81°, nD20 1.5100, O2S(CH:CH2)2 (VII), b16 109°, nD20 1.4782, CH2:CHSOCH2CH2Cl, b15 126°, nD20 1.5232, and CH2:CHSO2CH2CH2Cl, b16 143°, nD20 1.4952, is indicated. V, after repeated crystallization from EtOH, m. 55-5.2° and dissolves in H2O to 1.115%. When 10 g. V in 1 l. H2O containing 16.8 g. NaHCO3 is kept overnight and the mixture extracted 16 hrs. with ether, 1.6 g. VII, b17 110°, nD20 1.4750, is isolated. O2S(CH2CH2OH)2 (VIII) could not be prepared according to Gilman and Beaber (C.A. 19, 1850) from S(CH2CH2OH)2 (IX) and H2O2 in AcOH, as distillation of the reaction product gave thioxane sulfone (X), m. 129-30°, b1 130-40°. Following the method of Levin (C.A. 24, 4257), VIII, m. 54-5°, is obtained. Into a solution of 1.6 g. IX in 100 cc. H2O, O containing 2.5% O3 is passed at a rate of 200 cc./min. After 0.02 mol. O3 has been introduced, 95% OS(CH2CH2OH)2 (XI), m. 106-8°, is obtained. On further treatment of XI with O3, VIII, m. 36-43°, is formed. When IX is treated with III, 50% XI, m. 108°, is obtained. IX and IV give 76% XI, m. 106-8°. IX and NaOCl at pH 7 give 60% XI. On treatment of IX with Cl, neutralizing the reaction mixture with NaHCO3, evaporating to dryness in vacuo, and extracting with dioxane, X is obtained in good yield. For the detection of sulfonium salt [(HOCH2CH2)2S+CH2CH2]2S 2Cl– (XII) in H2O, a solution of 26 g. KI and 45 g. HgI2 in 20 cc. H2O is used. Addition of 0.02 cc. of this solution to 2 cc. of a solution of 10 g. XII in 1 l. H2O causes a white cloudiness after 5-10 sec. Oxidation of 20 g. XII with 5.7 g. 30% H2O2 gives [(HOCH2CH2)2S+CH2CH2]2SO 2Cl–, rosettes of needles, m. 63.5-5° (sealed tube). When XII is treated with III, 92% p-toluenesulfonamide, m. 133-4°, is formed. When 20 g. XII is treated with 17 g. 30% H2O2 and the mixture evaporated at room temperature, an oil is obtained which is dried in vacuo over P2O5. The oil does not crystallize and its aqueous solution gives a heavy oily precipitate (XIII) with KHgI3. Assuming the composition of XIII to be XIIIa, the yield of XIII is 97%. Attempts to prepare crystalline salts of XIII with picric acid, etc., failed. When 1 g. IX is shaken with 3,5-(O2N)2C6H3COCl with dropwise addition of 0.7 g. NaOH in 10 cc. H2O, bis[2-(3,5-dinitrobenzoxy)ethyl] sulfide, m. 161-2°, is formed; the corresponding sulfoxide, crystals from BuOH, m. 185-6°. Oxidation of 10 g. IX with an excess of 30% H2O2 according to G. and B. (cf. loc. cit.) and treating the resulting oil with Ac2O give bis(2-hydroxyethyl) sulfone diacetate (XIV), b2 170-5°, in addition to a small amount of X, m. 130°. XIV is readily saponified Distillation of washed Levinstein mustard gas (XV) in vacuo gives 69.5% almost pure I, b1 59°, nD20 1.5281, and 9% fairly pure (ClCH2CH2)2S2 (XVI) in addition to a small amount of dithiane, m. 110-11°. Distillation of 750 g. unwashed XV gives 432 g. I, b0.13 57°, nD20 1.5273-1.5278, of a yellow-brown color, in addition to some higher-boiling material. The decomposition of XV in H2O and the Cl demand of XVI, (ClCH2CH2)2S3, and (ClCH2CH2)2S5 in aqueous solution with III are studied and the results given in tables.

Journal of Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics