Ranjitkar, Pratistha published the artcileAffinity reagents that target a specific inactive form of protein kinases, SDS of cas: 6313-54-8, the publication is Chemistry & Biology (Cambridge, MA, United States) (2010), 17(2), 195-206, database is CAplus and MEDLINE.
A number of small-mol. inhibitors have been developed that target the catalytic domains of protein kinases that are not in an active conformation. An inactive form that has been observed in several kinases is the DFG-out conformation. This conformation is characterized by an almost 180° rotation of the conserved Asp-Phe-Gly (DFG) motif in the ATP-binding cleft relative to the active form. However, the sequence and structural determinants that allow a kinase to stably adopt the DFG-out conformation are not known. Here, we characterize a series of inhibitors based on a general pharmacophore for this inactive form. We demonstrate that modified versions of these inhibitors can be used to study the thermodn. and kinetics of ligand binding to DFG-out-adopting kinases and for enriching these kinases from complex protein mixtures
Chemistry & Biology (Cambridge, MA, United States) published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics