Month: November 2022

Cho, Sung Jin published the artcileSelective 5-Hydroxytryptamine 2C Receptor Agonists Derived from the Lead Compound Tranylcypromine: Identification of Drugs with Antidepressant-Like Action, Formula: C8H6ClFO, the main research area is serotonin receptor 5HT2c agonist antidepressant tranylcypromine derivative SAR preparation.

We report here the design, synthesis, and pharmacol. properties of a series of compounds related to tranylcypromine (9), which itself was discovered as a lead compound in a high-throughput screening campaign. Starting from 9, which shows modest activity as a 5-HT2C agonist, a series of 1-aminomethyl-2-phenylcyclopropanes was investigated as 5-HT2C agonists through iterative structural modifications. Key pharmacophore feature of this new class of ligands is a 2-aminomethyl-trans-cyclopropyl side chain attached to a substituted benzene ring. Among the tested compounds, several were potent and efficacious 5-HT2C receptor agonists with selectivity over both 5-HT2A and 5-HT2B receptors in functional assays. The most promising compound is 37, with 120- and 14-fold selectivity over 5-HT2A and 5-HT2B, resp. (EC50 = 585, 65, and 4.8 nM at the 2A, 2B, and 2C subtypes, resp.). In animal studies, compound 37 (10-60 mg/kg) decreased immobility time in the mouse forced swim test.

Journal of Medicinal Chemistry published new progress about 5-HT receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 286474-59-7 belongs to class chlorides-buliding-blocks, name is 6-Chloro-2-fluoro-3-methylbenzaldehyde, and the molecular formula is C8H6ClFO, Formula: C8H6ClFO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Hao published the artcileMicroarray-Assisted High-Throughput Identification of a Cell-Permeable Small-Molecule Binder of 14-3-3 Proteins, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is cell permeable peptide library preparation microarray screening protein binding.

The authors have used a small-mol. microarray (SMM) technique to identify cell-permeable small mol.-peptide hybrids that are capable of binding to all 14-3-3 proteins and thus inhibiting protein-protein interactions (PPI). Phosphoserine-containing peptide libraries were constructed on solid-phase using 243 different carboxylic acids for conjugation with N-terminus of individual peptides in one library, and 50 different amines for conjugation with C-terminus of individual peptides in the second library. For both libraries, biotin and GlyGly linkers were introduced at either N- or C-terminus of each peptide to facilitate subsequent immobilization onto avidin-functionalized glass slides. All the peptide conjugates were characterized by liquid chromatog./mass spectrometry and most were shown to be the correct mol. weight and of sufficient purity for direct microarray applications.

Angewandte Chemie, International Edition published new progress about 14-3-3 Proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safak, Cihat published the artcileSynthesis and Myorelaxant Activity of Fused 1,4-Dihydropyridines on Isolated Rabbit Gastric Fundus, Quality Control of 93118-03-7, the main research area is dihydropyridine derivative myorelaxant gastric fundus smooth muscle calcium channel.

Strategy, Management and Health PolicyEnabling Technol., Genomics, ProteomicsPreclin. ResearchPreclin. Development Toxicol., Formulation Drug Delivery, PharmacokineticsClin. Development Phases I-III Regulatory, Quality, ManufacturingPostmarketing Phase IV In the present study, 25 novel condensed 1,4-dihydropyridine (DHP) derivatives bearing cyclopentane, cyclohexane, or tetrahydrothiopene ring with a bulky and lipophilic moiety (3-pyridylmethyl) in the ester group were synthesized via a modified Hantzsch reaction, and their calcium channel modulator activities were assayed on isolated rabbit gastric fundus smooth muscle strips. To evaluate the myorelaxant effects of the compounds, the maximum relaxant response (Emax) and pD2 values were calculated The results indicated that all compounds produced concentration-dependent relaxation and the introduction of five- or six-membered rings to the DHP nucleus and 3-pyridiylmethyl moiety to the ester group led to potent calcium antagonists.

Drug Development Research published new progress about Calcium channels Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Quality Control of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hamprecht, Dieter published the artcileIsoindolone derivatives, a new class of 5-HT2C antagonists: Synthesis and biological evaluation, COA of Formula: C9H9ClO2, the main research area is isoindolone aryl derivative preparation 5HT2C receptor inhibitory activity.

Two independent approaches resulted in the identification of a series of isoindolone derivatives, e.g., I, as potent and selective 5-HT2C antagonists. From a Medicinal Chem. perspective this template was considered interesting as it allowed the incorporation of the carbon-carbon double bond of an earlier dihydropyrrolone series in an aromatic system within a comparatively simple and compact motif. Addnl. an in silico screening approach of the corporate database using a 5-HT2C pharmacophore model resulted in the identification of a related structure containing this template. The strategy used to optimize potency at the target receptor and to improve the pharmacokinetic profile is described, resulting in mols. combining high potency with good selectivity and oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT2A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 99585-12-3 belongs to class chlorides-buliding-blocks, name is Methyl 4-chloro-2-methylbenzoate, and the molecular formula is C9H9ClO2, COA of Formula: C9H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Unsinn, Andreas published the artcileDirected Magnesiation of Polyhaloaromatics using the Tetramethylpiperidylmagnesium Reagents TMP2Mg.2LiCl and TMPMgCl.LiCl, COA of Formula: C9H8Cl2O2, the main research area is regioselective magnesium halo arene magnesium amide Grignard reagent preparation; chlorophenethylphenol antimicrobial natural product preparation.

A convenient and efficient functionalization of polyhaloaroms. via regioselective magnesiation has been developed. Starting from simple, inexpensive but structurally challenging arenes, metalation by magnesium amide bases was achieved under mild conditions. The desired Grignard reagents were stable towards aryne formation, were obtained in good yields within short reaction times and could be reacted with a variety of typical electrophiles, providing attractive, functionalized building blocks in good to excellent yields. As an application we have prepared the antimicrobial natural product 2,6-dichloro-3-phenethylphenol isolated from the New Zealand liverwort Riccardia marginata. This synthesis involves a mixed bimetallic compound prepared via metalation of a phenylboronic acid pinacol ester derivative and subsequent selective cross-coupling.

Advanced Synthesis & Catalysis published new progress about Amides Role: RGT (Reagent), RACT (Reactant or Reagent) (Mg amide magnesiation agents). 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, COA of Formula: C9H8Cl2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ilhan, Suleyman published the artcileEssential Oils from Vitex agnus castus L. Leaves Induces Caspase-Dependent Apoptosis of Human Multidrug-Resistant Lung Carcinoma Cells through Intrinsic and Extrinsic Pathways, HPLC of Formula: 18585-06-3, the main research area is Vitex agnus essential oil caspase lung carcinoma apoptosis human.

Essential oil (EO) fractions of plants are complex mixtures of volatile compounds with broad-spectrum biol. properties. In the current study, the EO content of Vitex agnus castus L. (VAC) leaves growing in the Aegean region of Turkey was extracted and identified. Then, VAC EOs were investigated for their potential antioxidant, cytotoxic and apoptotic effects in human H69AR multi-drug resistant cancer cells. EOs were isolated by hydrodistillation and chem. composition was determined by GC-MS. Cell viability was assessed via MTT and trypan blue assays. Antioxidant activity was evaluated by measuring the total antioxidant activity and free radical scavenging activity. Apoptosis was evaluated via DNA fragmentation and caspase 3/7 activity assays. Changes in the levels of apoptotic genes were determined by RT-qPCR. The results indicated strong antioxidant activity and cytotoxic effect on H69AR cancer cells but not on HEK-293 human normal cells indicating the tumor-specific effect. VAC EOs induced caspase 3/7 activation and apoptosis through triggering both extrinsic- and intrinsic-pathways by modulating Bcl-2, Bcl-XL, Bax, Bad, FADD, Caspase-8, Caspase-9, TRAIL R1/DR4 and TRAIL R2/DR5. This study revealed that VAC EOs may be a promising candidate in the development of novel therapeutic agents for multi-drug resistant lung cancer treatment.

Nutrition and Cancer published new progress about Animal gene, Bcl-2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 18585-06-3 belongs to class chlorides-buliding-blocks, name is Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate, and the molecular formula is C10H9ClF3NO2, HPLC of Formula: 18585-06-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huang, Hai-Yun published the artcilePd-Catalyzed Direct Arylations of Heteroarenes with Polyfluoroalkoxy-Substituted Bromobenzenes, COA of Formula: C7H3BrClF3O, the main research area is fluoroalkoxy bromobenzene heteroarene palladium catalyst arylation; arylated heteroarene preparation.

The reactivity of di-, tri- and tetra-fluoroalkoxy-substituted bromobenzenes in the direct arylation of 5-membered ring heteroarenes using palladium catalysis was explored. High yields in arylated heteroarenes, e.g., I, were obtained using only 1 mol-% of Pd(OAc)2 catalyst with KOAc as an inexpensive base. Similar yields were obtained with o/m/p trifluoromethoxy-, o/p difluoromethoxy-, and tetrafluoroethoxy-substituents on the aryl bromide. A bromo-substituted difluorobenzo[d][1,3]dioxole was successfully coupled. The major side-products of the reaction are HBr/KOAc. Therefore, this synthetic scheme is very attractive for the access to such polyfluoroalkoxy-containing arylated heteroaromatics in terms of cost, simplicity, and low environmental impact, compared to reactions involving arylation of heteroarenes with bromophenols followed by polyfluoroalkylation.

European Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent) (fluoroalkoxy). 468075-00-5 belongs to class chlorides-buliding-blocks, name is 2-Bromo-1-chloro-4-(trifluoromethoxy)benzene, and the molecular formula is C7H3BrClF3O, COA of Formula: C7H3BrClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thorat, Raviraj Ananda published the artcileSynthesis of Chiral-Substituted 2-Aryl-ferrocenes by the Catellani Reaction, Product Details of C6H3ClFI, the main research area is palladium catalyzed three component coupling iodoarene acrylate iodoferrocencarboxamide; chiral aryl ferroceneamide preparation.

A Pd-catalyzed and norbornene-mediated methodol. was developed for the synthesis of chiral 2-aryl-ferroceneamides from chiral 2-iodo-N,N-diisopropylferrocencarboxamide, iodoarenes, and alkenes using a JohnPhos ligand and K carbonate as a base in DMF at 105°. The developed three-component coupling protocol allows the compatibility of electron-withdrawing fluoro, chloro, ester, and nitro and electron-donating Me, methoxy, dimethoxy, benzyl ether-substituted iodo-benzenes, other iodoarenes, such as iodo-naphthalene, heteroarenes, such as iodothiophene, and terminating substrates, such as Me, Et, tert-Bu acrylates, and substituted styrenes with 2-iodo-N,N-diisopropylferrocencarboxamide. Also, the developed three-component Catellani method proceeded with the retention of the configuration of the planar chiral ferrocene, which depends on the role of the participating C-I bond in ferrocene. Consequently, the developed protocol enabled the formation of densely substituted chiral 2-aryl ferroceneamides, exhibiting good to excellent enantioselectivity. The conversion of an ester of the synthesized chiral 2-aryl ferroceneamides also was carried out to further accommodate the easily expendable acid and alc. functionalities.

Journal of Organic Chemistry published new progress about Alkynylation catalysts (Pd complexes). 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, Product Details of C6H3ClFI.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Marino, Joseph P. published the artcileThe discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages, COA of Formula: C8H4ClF3O, the main research area is tertiary amine preparation reductive amination nucleophilic substitution; liver X receptor LXR agonist cholesterol efflux macrophage pharmacokinetics; structure activity coronary heart disease cholesterol homeostasis lipid metabolism.

The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism SAR studies around tertiary-amine lead mol. I, an LXR full agonist, revealed that steric and conformational changes to the acetic acid and propanolamine groups produce dramatic effects on agonist efficacy and potency. The new analogs possess good functional activity, demonstrating the ability to upregulate LXR target genes, as well as promote cholesterol efflux in macrophages.

Bioorganic & Medicinal Chemistry Letters published new progress about Liver X receptor β Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (agonists). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, COA of Formula: C8H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mooibroek, Tiddo J. published the artcileA threading receptor for polysaccharides, Safety of Pyrene-2-carboxylic acid, the main research area is receptor polysaccharide cellulose oligosaccharide monosaccharide preparation polypseudorotaxane chitosan.

Cellulose, chitin and related polysaccharides are key renewable sources of organic mols. and materials. However, poor solubility tends to hamper their exploitation. Synthetic receptors could aid dissolution provided they are capable of cooperative action, for example by multiple threading on a single polysaccharide mol. Here we report a synthetic receptor designed to form threaded complexes (polypseudorotaxanes) with these natural polymers. The receptor binds fragments of the polysaccharides in aqueous solution with high affinities (Ka up to 19,000 M-1), and is shown-by nuclear Overhauser effect spectroscopy-to adopt the threading geometry. Evidence from induced CD and at. force microscopy implies that the receptor also forms polypseudorotaxanes with cellulose and its polycationic analog chitosan. The results hold promise for polysaccharide solubilization under mild conditions, as well as for new approaches to the design of biol. active mols.

Nature Chemistry published new progress about Oligosaccharides Role: FMU (Formation, Unclassified), PRP (Properties), FORM (Formation, Nonpreparative). 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Safety of Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics