Unsinn, Andreas published the artcileDirected Magnesiation of Polyhaloaromatics using the Tetramethylpiperidylmagnesium Reagents TMP2Mg.2LiCl and TMPMgCl.LiCl, COA of Formula: C9H8Cl2O2, the main research area is regioselective magnesium halo arene magnesium amide Grignard reagent preparation; chlorophenethylphenol antimicrobial natural product preparation.
A convenient and efficient functionalization of polyhaloaroms. via regioselective magnesiation has been developed. Starting from simple, inexpensive but structurally challenging arenes, metalation by magnesium amide bases was achieved under mild conditions. The desired Grignard reagents were stable towards aryne formation, were obtained in good yields within short reaction times and could be reacted with a variety of typical electrophiles, providing attractive, functionalized building blocks in good to excellent yields. As an application we have prepared the antimicrobial natural product 2,6-dichloro-3-phenethylphenol isolated from the New Zealand liverwort Riccardia marginata. This synthesis involves a mixed bimetallic compound prepared via metalation of a phenylboronic acid pinacol ester derivative and subsequent selective cross-coupling.
Advanced Synthesis & Catalysis published new progress about Amides Role: RGT (Reagent), RACT (Reactant or Reagent) (Mg amide magnesiation agents). 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, COA of Formula: C9H8Cl2O2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics