Fawzy, Ahmed published the artcileDegradation of Ampicillin and Flucloxacillin Antibiotics via Oxidation by Alkaline Hexacyanoferrate(III): Kinetics and Mechanistic Aspects, Category: chlorides-buliding-blocks, the publication is Industrial & Engineering Chemistry Research (2020), 59(37), 16217-16224, database is CAplus.
The kinetics and mechanistic aspects of the oxidation of two beta-lactam antibiotics (A), ampicillin and flucloxacillin, by alk. hexacyanoferrate(III) (HCF(III)) were examined using spectrophotometry at a fixed temperature The oxidation reactions showed a 1:4 (A: HCF(III)) stoichiometry. The reaction kinetics were found to follow first-order dependence for the oxidant and fractional first-order dependence for [A] and [OH–]. The enhancement of the ionic strength and dielec. constant was found to increase the oxidation rates. Free radical tests of the reactions showed pos. results. The addition of HCF(II) as a predicted oxidation product did not considerably change the oxidation rates. Under the same exptl. conditions, the oxidation rate of ampicillin was found to be slightly lower than that of flucloxacillin. The acquired oxidation products were recognized using spot testing and Fourier transform IR spectra. A conceivable oxidation mechanism was suggested. A derived rate law expression was found to be consistent with the exptl. results. The activation parameters were assessed and discussed.
Industrial & Engineering Chemistry Research published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Category: chlorides-buliding-blocks.
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