Tag: M.W=250-300

Witt, A. published the artcileSynthesis and Reactions of some 2-Vinyl-3H-quinazolin-4-ones, HPLC of Formula: 18791-02-1, the publication is Tetrahedron (2000), 56(37), 7245-7253, database is CAplus.

A simple, high-yielding synthesis of 2-vinyl-3H-quinazolin-4-one, 2-(1-chlorovinyl)-3H-quinazolin-4-one, and 2-(1-bromovinyl)-3H-quinazolin-4-one is reported. The 2-vinylquinazolinones participate readily in nucleophilic addition reactions. Treatment with both carbon and nitrogen nucleophiles results in a clean conversion into a variety of 2-substituted 3H-quinazolin-4-one derivatives 2-(1-Halovinyl)-3H-quinazolin-4-ones reacted with carbon nucleophiles to give several derivatives of 2-substituted 3H-quinazolin-4-one.

Tetrahedron published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C6H13NO2, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zanella, Yannick published the artcileNew route to 1-formylalkylphosphonates using diethyl trichloromethylphosphonate as a precursor, Name: Diethyltrichloromethylphosphonate, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1995), 2835-8, database is CAplus.

(EtO)₂P(O)CCl₃ and Me₃SiCl were converted by a three-step sequence beginning with BuLi into α-phosphorylated α-silylated α-substituted carbanions, (EtO)₂P(O)CRLiSiMe₃ [I; R = Pr, C₅H₁₁, C₇H₁₅, C₁₂H₂₅, CH:CH₂, crotyl, ClCH₂(CH₂)_n, n = 2,3]. I reacts with Et formate in the presence of Me₃SiCl to give transient silylated acetals, (EtO)₂P(O)CR(SiMe₃)CH(OEt)(OTMS), which readily undergo acid hydrolysis to afford 1-formylalkylphosphonates, (EtO)₂P(O)CHRCHO, in good yield.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C11H22N2O4, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Filonenko, L. P. published the artcileSilylation of compounds containing trichloromethyl groups, SDS of cas: 866-23-9, the publication is Zhurnal Obshchei Khimii (1987), 57(10), 2320-4, database is CAplus.

Compounds containing the Cl₃C group are silylated under mild conditions by the binary system P(NMe₂)₃/ClSiMe₃. Thus, silylation of (Cl₃C)₂CO gave 50% Cl₂C:C(CCl₃)OSiMe₃.

Zhurnal Obshchei Khimii published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shakhnazaryan, G. M. published the artcileSelectivity of bromine migration in oxidation of gem-bromochlorovinyl compounds by oxygen, Application In Synthesis of 18791-02-1, the publication is Armyanskii Khimicheskii Zhurnal (1979), 32(2), 149-50, database is CAplus.

trans-XCH₂CH:CClBr (X = H, Cl, Br, HO) oxidation with 2 L/h O₂ or 10 L/h air gave polyperoxides which were heated to give mixtures of the corresponding XCH₂CHBrCOCl (I) and XCH₂CHClCOBr in ∼93% combined yield, with I predominating in all cases.

Armyanskii Khimicheskii Zhurnal published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C8H8O3, Application In Synthesis of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gramstad, Thor published the artcileNMR Studies of hydrogen bonding of phenol with several proton acceptors, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Journal of Molecular Structure (1970), 5(4), 253-61, database is CAplus.

PMR studies are reported of self-association of PhOH in CCl4 and in cyclohexane, and of H bonding between PhOH and 2 carbonyl and several phosphoryl compounds The NMR chem. shift, δx, of a proton in a H bond is dependent on both the temperature and the concentration of the proton acceptor. Furthermore, the chem. shift data at low concentration of proton acceptor suggest the presence of a 2:1 proton donor-acceptor complex in addition to a 1:1 complex. A linear relation exists between the change in chem. shift and O-H stretching frequency shift upon complexation of PhOH with phosphoryl compounds

Journal of Molecular Structure published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Baldwin, Jack E. published the artcile5-Isothiazolidinonyl and 5-isoxazolidinonyl radicals. Approaches to the biogenetic-type synthesis of β-lactams, SDS of cas: 18791-02-1, the publication is Tetrahedron (1981), 37(11), 2181-9, database is CAplus.

A possible mechanism for penicillin biosynthesis involves the rearrangement of a 5-isothiazolidinonyl radical I [R = NHCO(CH₂)₃CH(N⁺H₃)CO₂^–, R¹ = H, R² = CH(CO₂H)CHMe₂] to a β-lactam. However, the model radicals I (R = R¹ = Ph, R² = CMe₃; R = Br₃C, R¹ = H, R² = CMe₃), generated in the conversion of II (R = Br, R¹ = R² = Ph) to II (R = H, R¹, R² as before) and II (RR¹ = bond, R² = H) to II (RR¹ = bond, R² = Br₃C), resp., failed to give β-lactams. The analogous reaction of a 5-isoxazolidinonyl radical is the basis for a potential synthesis of clavulanic acid, but again the rearrangement was not observed in the model radical III (R = H, R¹ = absent) generated in the conversion of III (R = H, R¹ = CO₂OCMe₃) to III (RR¹ = bond).

Tetrahedron published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, SDS of cas: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yongzhu published the artcilePalladium-catalyzed reductive desulfonative aminocarbonylation of benzylsulfonyl chlorides with nitroarenes towards arylacetamides, HPLC of Formula: 21286-54-4, the publication is Organic Chemistry Frontiers (2022), 9(8), 2079-2083, database is CAplus.

A new palladium-catalyzed reductive desulfonative aminocarbonylation reaction with benzylsulfonyl chlorides RCH₂S(O)₂Cl (R = Ph, 3,4-dimethylphenyl, 2,4-dichlorophenyl, etc.) as C(sp³) electrophiles has been developed. Using nitroarenes R¹NO₂ (R¹ = Ph, quinolin-8-yl, 2H-1,3-benzodioxol-5-yl, etc.) as readily accessible and stable nitrogen surrogates, a wide range of arylacetamides RCH₂C(O)NHR¹ were easily prepared in high yields with very good functional group compatibility. Mo(CO)₆ plays a dual role as both a CO source and reductant. Moreover, a late-stage modification of natural products was also achieved via this aminocarbonylation strategy.

Organic Chemistry Frontiers published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qi, Xinxin published the artcilePalladium-catalyzed carbonylative transformation of aryl iodides and sulfonyl chlorides: convenient access to thioesters, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Organic Chemistry Frontiers (2020), 7(6), 885-889, database is CAplus.

A palladium-catalyzed carbonylative transformation of aryl iodides RI (R = Ph, naphthalen-2-yl, thiophen-3-yl, etc.) and sulfonyl chlorides R¹S(O)₂Cl (R¹ = 4-methylphenyl, i-Pr, cyclohexyl, etc.) has been studied. Both aryl and alkyl sulfonyl chlorides were all successfully transformed into the desired thioesters RC(O)SR¹ with sulfonyl chlorides as the sulfur source. Mo(CO)₆ played a dual role as both CO surrogate and reductant in this reaction.

Organic Chemistry Frontiers published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qi, Xinxin published the artcileNickel-Catalyzed Thiocarbonylation of Arylboronic Acids with Sulfonyl Chlorides for the Synthesis of Thioesters, Computed Properties of 21286-54-4, the publication is Organic Letters (2020), 22(16), 6671-6676, database is CAplus and MEDLINE.

An interesting procedure for thioesters synthesis via nickel-catalyzed thiocarbonylation of arylboronic acids with sulfonyl chlorides as the sulfur source has been explored. Using Mo(CO)₆ as a solid CO surrogate and reductant, a broad range of thioesters ArC(O)SR (Ar = Ph, naphthalen-2-yl, furan-2-yl, etc., R = Et, cyclohexyl, naphthalen-1-yl, etc.) were obtained in moderate to good yields with good functional group tolerance.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Wei published the artcileNickel-Catalyzed One-Pot Carbonylative Synthesis of 2-Mono- and 2,3-Disubstituted Thiochromenones from 2-Bromobenzenesulfonyl Chlorides and Alkynes, Application In Synthesis of 21286-54-4, the publication is Organic Letters (2021), 23(16), 6589-6593, database is CAplus and MEDLINE.

A nickel-catalyzed one-pot carbonylation reaction of 2-bromobenzenesulfonyl chlorides I (R = H, Me, OMe; R¹ = H, OMe; RR¹ = -OCH₂O-, -O(CH₂)₂O-) with alkynes R²CCR³ (R² = Me, Ph, 2-thienyl, etc.; R³ = Ph, 3-thienyl, 2-naphthyl, etc.) for the synthesis of thiochromenones II has been established. The alkynes were suitable substrates in this carbonylative transformation, and a broad range of 2-mono- and 2,3-disubstituted thiochromenone products II were obtained in moderate to good yields with quite high functional group compatibility. Notably, this procedure presents the first example of nickel-catalyzed carbonylative synthesis of thiochromenones II with 2-bromobenzenesulfonyl chlorides as a promising sulfur precursor.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C7H9BO3, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics