Tag: M.W=250-300

Jain, Nikita published the artcileOxidative Cyclization of Naphtholic Sulfonamides Mediated by a Chiral Hypervalent Iodine Reagent: Asymmetric Synthesis versus Resolution, HPLC of Formula: 21286-54-4, the publication is Synlett (2019), 30(10), 1222-1227, database is CAplus.

A chiral aryl iodide e.g., I promotes the enantioselective oxidative cyclization of 1-naphtholic sulfonamides II (R¹ = H, Cl, Ph, 3,5-di(trifluoromethyl)phenyl, etc.; R² = Me, Bn, 4-methylphenyl, 4-nitrophenyl) and III (R = H, OMe), albeit in moderate ee and low yield. The products (R)/(S)-IV and V tend to crystallize as conglomerates. Recrystallization thus increases their ee to > 99% ee. This highly enantioenriched material provides seed crystals for the resolution of racemate (±)-1′-(methylsulfonyl)-1H-spiro[naphthalene-2,2′-pyrrolidine]-1-one (prepared in high yield by oxidative cyclization with (diacetoxyiodo)benzene in trifluoroacetic acid) by coupled preferential crystallization This enables the production of significant quantities of highly enantioenriched products, despite the low efficiency of the enantioselective reaction.

Synlett published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Stutz, Helmut published the artcilePhostones with potential alkylating properties, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Zeitschrift fuer Chemie (1975), 15(2), 52-4, database is CAplus.

The reaction of (EtO)2PR with HO(CH2)4Cl gave phostones I [n = 2, R = EtO (II), Ph]. The cyclization of XCH2(CH2)nCH2P(O)(OEt)R (X = halo) gave phostones I (n = 1, 2; R = PhO, Cl3C). II was chlorinated with PCl5 to give I (n = 2, R = Cl). Thiourea and 2-mercaptobenzimidazole were S-alkylated and aniline and piperidine were N-alkylated with I.

Zeitschrift fuer Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C44H28ClFeN4, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Axer, Alexander published the artcileHarnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design, Application In Synthesis of 21286-54-4, the publication is ChemMedChem (2018), 13(3), 241-250, database is CAplus and MEDLINE.

Diagnosis and localization of bacterial infections remains a significant clin. challenge. Harnessing bacteria-specific metabolic pathways, such as the maltodextrin transport mechanism, may allow specific localization and imaging of small or hidden colonies. This requires that the intrabacterial tracer accumulation provided by the transporter is matched by high serum stability of the tracer mol. Herein, radiolabeled maltodextrins of varying chain lengths and with free nonreducing/reducing ends are reported and their behavior against starch-degrading enzymes in the blood, which compromise their serum stability, is evaluated. Successful single-photon emission computed tomog. (SPECT) imaging is shown in a footpad infection model in vivo by using the newly developed model tracer, [^99mTc]MB1143, and the signal is compared with that of ¹⁸F-fluorodeoxyglucose positron emission tomog. ([¹⁸F]FDG-PET) as a nonbacterial specific marker for inflammation. Although the [^99mTc]MB1143 imaging signal is highly specific, it is low, most probably due to insufficient serum stability of the tracer. A series of stability tests with different ¹⁸F-labeled maltodextrins finally yielded clear structural guidelines regarding substitution patterns and chain lengths of maltodextrin-based tracers for nuclear imaging of bacterial infections.

ChemMedChem published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bailey, William J. published the artcilePyrolysis of esters. XXII. Synthesis of bisdienes from 2-hydroxymethyl-1,3-butadiene, Quality Control of 866-23-9, the publication is Journal of Organic Chemistry (1962), 2732-6, database is CAplus.

cf. CA 57, 4529d. A new synthesis of 2-hydroxymethyl-1,3-butadiene was developed, starting from commercially available 2-amino-2-ethyl-1,3-propanediol and involving a pyrolysis of an amine oxide as well as the pyrolysis of an ester. Hydroxymethylbutadiene treated with vinyl acetate in the presence of a mercuric oxide-boron trifluoride etherate mixture gave 38% bis(2-butadienylmethyl) acetal. Treatment of the hydroxymethylbutadiene with hexamethylene diisocyanate gave 76% solid bis(2-butadienylmethyl) hexamethylenecarbamate, while treatment with m-xylylene diisocyanate gave 91% solid bis(2-butadienylmethyl) m-xylylenecarbamate.

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, S. published the artcileReactions of chloro-substituted methanephosphonic acid dialkyl esters with dialkyl phosphites, trialkyl phosphites, or alcohol/sodium alcoholate, Quality Control of 866-23-9, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1986), 207-11, database is CAplus.

(RO)₂P(O)CCl₃ (R = Et, Bu) react with dialkyl phosphites and alc. in the presence of tertiary amines or with trialkyl phosphites and alc. yielding diesters of dichloromethanephosphonic acids and triesters of phosphoric acid. When esters of trichloromethane- or dichloromethanephosphonic acid react with alcs. in the presence of sodium alcoholates, a quant. cleavage of P-C bond occurs, and triesters of phosphoric acid and CHCl₃ or CH₂Cl₂ are formed.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, S. published the artcileReaction of the two-component system trialkyl phosphite/carbon tetrachloride with nucleophiles. 3. Reaction in presence of trialkylammonium salts, SDS of cas: 866-23-9, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1987), 132-46, database is CAplus.

Alkali pseudohalides (KSCN, NaN₃, KCN) react with the 2-component system trialkyl phosphite/carbon tetrachloride in the presence of trialkylammonium halides. Isothiocyanates of dialkylphosphoric acid, N-alkyl phosphoric acid diester amides, N-dialkoxyphosphoryl trialkoxyphosphazenes and tricyanophosphine oxide resp., are obtained. In the system (RO)₃P/CCl₄/R₃NHI the dialkoxyphosphoryl chloride is formed.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Steinbach, J. published the artcileReaction of the two-component system trialkyl phosphite/carbon tetrachloride with nucleophiles containing hydrogen. 2. Reaction with ammonia and amines, Name: Diethyltrichloromethylphosphonate, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1985), 180-6, database is CAplus.

RNH₂ (R = H, Pr, Bu, PhCH₂, Ph) reacted 1:1 with (R¹O)₃P (R¹ = Et, Bu) and CCl₄ to give (R¹O)₂P(O)NHR. If excess RNH₂ was used, R¹OP(O)(NHR)₂ and OP(NHR)₃ also formed. The reaction of (R¹O)₃P/CCl₄ in the presence of secondary and tertiary amines gave (R¹O)₂P(O)CCl₃, which reacted with the amine to give [Cl₃CP(O)(O^–)(OR¹)][⁺NRR²R³R⁴].

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C14H10O4S2, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, Steffen published the artcileDirect synthesis of dialkyl N,N-diorganophosphoramidates from trialkyl phosphites, Application In Synthesis of 866-23-9, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1991), 62(1-4), 189-92, database is CAplus.

Amidation of (RO)₃P (R = Et, Bu) with secondary amines R¹R²NH (R¹ = R² = Bu, Et; R¹ = Ph, R² = Me, Et) in the presence of amine hydrochloride catalysts and CCl₄ in MeCN as solvent gave title compounds, (RO)₂P(O)(NR¹R²). The mechanism is discussed.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boutevin, B. published the artcileSynthesis of phosphonic compounds with chlorofluorinated chains. Part I, Formula: C5H10Cl3O3P, the publication is Phosphorus and Sulfur and the Related Elements (1981), 11(3), 373-81, database is CAplus.

The redox catalysis and free-radical telomerizations of di- and trichloromethylphosphonyl dichlorides and their esters with chlorotrifluoroethylene (I) [79-38-9] were studied. Also investigated was phosphonation of telomers of I and CCl₄ using Kinnear-Perren and Michaelis-Arbuzov methods. Phosphonic compounds containing chlorofluorinated blocks are obtained with these two methods. By-products are described and explained using known mechanisms.

Phosphorus and Sulfur and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boebel, Timothy A. published the artcileIridium-Catalyzed Preparation of Silylboranes by Silane Borylation and Their Use in the Catalytic Borylation of Arenes, Category: chlorides-buliding-blocks, the publication is Organometallics (2008), 27(22), 6013-6019, database is CAplus.

Silylboranes are versatile reagents for transition metal-catalyzed reactions of unsaturated organic mols. These reagents are typically prepared by the addition of a silyl lithium species to a boron electrophile. However, the need to generate anionic silane reagents limits the scope of silylboranes that can be readily obtained. Here, the synthesis of trialkylsilylboranes by borylation of silanes catalyzed by iridium complexes is described. The reaction of trialkylhydrosilanes with B₂pin₂ catalyzed by the combination of [Ir(OMe)cod]₂ and 4,4′-di-tert-butylbipyridine forms trialkylsilylboronic esters. In addition, these trialkylsilylboranes serve as boron sources for iridium-catalyzed borylation of aryl C-H bonds. In contrast to diboron reagents, the silylboranes react with methylarenes at both the aryl and Me C-H bonds.

Organometallics published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics