Tag: M.W=250-300

Haydl, Alexander M. published the artcilePalladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters, HPLC of Formula: 942069-73-0, the publication is Organic Letters (2019), 21(5), 1337-1341, database is CAplus and MEDLINE.

A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu₂Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biol. active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.

Organic Letters published new progress about 942069-73-0. 942069-73-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(3,5-Dichloro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H17BCl2O2, HPLC of Formula: 942069-73-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Wen-Shan published the artcileBridging Chiral de-tert-Butylcalix[4]arenes: Diastereomeric Crystallization-Based Optical Resolution and Determination of Absolute Configuration, Formula: C10H15ClO3S, the publication is ChemistrySelect (2018), 3(36), 10153-10156, database is CAplus.

A pair of diastereomers were synthesized from the conjugation of bridging chiral de-tert-butylcalix[4]arene racemate and (1S)-(+)-10-camphorsulfonyl chloride. The diastereomeric separation by crystallization was explored in different solvents, temperature and time. The optimal crystallization procedures afforded them in a desirable yield, de and purity. A pair of enantiomers of tert-butylcalix[4]arene were subsequently obtained after their hydrolysis. Moreover, their absolute configurations were determined by X-ray crystallog. anal. The crystallization results can match the large-scale preparation of optically pure de-tert-butylcalix[4]arene in laboratory and industry.

ChemistrySelect published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Formula: C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jian published the artcilePurine Nucleoside Derivatives Containing a Sulfa Ethylamine Moiety: Design, Synthesis, Antiviral Activity, and Mechanism, Quality Control of 32333-53-2, the publication is Journal of Agricultural and Food Chemistry (2021), 69(20), 5575-5582, database is CAplus and MEDLINE.

To find efficient and broad-spectrum viral agents, a series of purine nucleoside derivatives containing sulfa ethylamine moieties was designed and synthesized, and their antiviral activities against tobacco mosaic virus (TMV), cucumber mosaic virus (CMV), and potato virus Y (PVY) were evaluated. Some target compounds displayed good antiviral activities. Among them, compound I showed excellent protective activity against CMV and PVY with 50% effective concentration values (EC₅₀) of 137 and 209μg/mL, resp., which were better than that of the control agent ningnanmycin (508 and 431μg/mL). Moreover, the EC₅₀ value of compound I for the inactivating activity against TMV was 48μg/mL, which was better than that of ningnanmycin (88μg/mL). In addition, compound I not only destroyed the structure of the TMV virus but also had a good interaction with the coat protein of the TMV virus. Therefore, compound I may further destroy the structure of the virus by binding to the coat protein of the TMV virus, thereby weakening the infectivity of the virus.

Journal of Agricultural and Food Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C11H24O3, Quality Control of 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Hao published the artcileDesign and Synthesis of Bridging Chiral p-t-Butylcalix[4]arene Tetrahydroisoquinolines and Their Application in Henry Reaction as Chiral Organocatalysts, Application In Synthesis of 21286-54-4, the publication is ChemistrySelect (2019), 4(15), 4642-4646, database is CAplus.

A pair of bridging chiral p-t-butylcalix[4]arenes (2a and 2b) (were) synthesized from 1 through homologous anionic ortho-Fries rearrangement, and optically resolved with (1S)-(+)-10-camphorsulfonyl chloride as chiral auxiliary. Bridging chiral p-t-butylcalix[4]arene tetrahydroisoquinolines (9a and 9b) as chiral organocatalysts for Henry reaction were designed and synthesized through the structural modification of 2a and 2b, resp. Compared to the catalytic enantioselectivity of the unmodified tertiary amine (4b: �% ee and 63% yield), those of the tetrahydroisoquinoline derivatives (9b: up to 13.4% ee and 96% yield) were distinctly enhanced. Although the increase magnitude of the catalytic ee is not remarkable, these catalytic results prove that the conformation inversion of calix[4]arene skeleton and the rotational freedom reduction of catalytic amine group indeed bring beneficial effects on the catalytic stereoselectivity.

ChemistrySelect published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Gren Z. published the artcileCCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood, Synthetic Route of 32333-53-2, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(24), 7291-7294, database is CAplus and MEDLINE.

A series of N,S-diarylsulfonamides was identified as hCCR2 receptor antagonists but suffered from high plasma protein binding resulting in a >100 fold shift in activity in a functional GTPγS assay run in tandem in the presence and absence of human serum albumin. Introduction of an aryl amide with ethylenediamine linker led to compounds with reduced shifts and improved activity in whole blood.

Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C9H20Cl2Si, Synthetic Route of 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Seyferth, Dietmar published the artcilePreparation of functional alkylidynetricobalt nonacarbonyl complexes from dicobalt octacarbonyl, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Journal of Organometallic Chemistry (1973), 50(1), 265-75, database is CAplus.

Cobalt cluster compounds RCCo3(CO)9 (R = D, Me3Si, PhMe2Si, (MeO)2P(O), (EtO)2P(O), Me3COC(O), Me3SiOC(O), Et2NC(O), Me3CC(O), EtC(O), PrC(O), Me2CHC(O), BuC(O), Me3CC(O), PhC(O), p-MeC6H4C(O), p-BrC6H4C(O), HOCH2, HC(O), MeO, Me2N, were prepared by reaction of Co2(CO)8 with the appropriate RCX3 or RCHX2 (X = Cl or Br) compound

Journal of Organometallic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C3H5BN2O2, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ramsbeck, Daniel published the artcileFirst insight into structure-activity relationships of selective meprin β inhibitors, SDS of cas: 32333-53-2, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(11), 2428-2431, database is CAplus and MEDLINE.

The astacin proteases meprin α and β are emerging drug targets for treatment of disorders such as kidney failure, fibrosis or inflammatory bowel disease. However, there are only few inhibitors of both proteases reported to date. Starting from NNGH as lead structure, a detailed elaboration of the structure-activity relationship of meprin β inhibitors was performed, leading to compounds with activities in the lower nanomolar range. Considering the preference of meprin β for acidic residues in the P1′ position, the compounds were optimized. Acidic modifications induced potent inhibition and >100-fold selectivity over other structurally related metalloproteases such as MMP-2 or ADAM10.

Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, SDS of cas: 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chai, Guo-Li published the artcileHydroxytetraphenylenes as Chiral Ligands: Application to Asymmetric Darzens Reaction of Diazoacetamide with Aldehydes, Name: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Synthesis (2017), 49(1), 181-187, database is CAplus.

Hydroxytetraphenylenes with rigid conformations are potential candidates for employment as chiral ligands in asym. synthesis. Highly diastereo- and enantioselective Darzens reactions between aldehydes and diazo-N,N-dimethylacetamide are catalyzed by a chiral titanium complex formed in situ from Ti(OⁱPr)₄ and chiral 1,16-dihydroxytetraphenylene, giving cis-glycidic amides in moderate to high yields with excellent enantiomeric purities (40-99% yield, up to 99% ee).

Synthesis published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Name: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Jing-Xing published the artcileSynthesis and Chiroptical Properties of Double-Helical (M)- and (P)-o-Oligophenylenes, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Organic Letters (2015), 17(17), 4296-4299, database is CAplus and MEDLINE.

All of the M and P isomers of optically pure oligophenylenes with 6, 8, 10, and 12 Ph rings were synthesized and fully characterized. The Suzuki cross-coupling reaction has been revealed to be a viable strategy in the syntheses of tetraphenylene derivatives, which, together with the copper-mediated oxidative cross-coupling reaction, were employed in the quest for the oligophenylenes [e.g., (S,S)-I + (M)-II â†?(M)-III (5%) + (M)-IV (6%) + (M)-V (9%) using t-BuLi/CuCl₂]. X-ray diffraction anal. in combination with sp. rotation and CD spectroscopy unambiguously identified the unique covalent double-helical frameworks of these oligophenylene mols.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gross, Raymond S. published the artcileDesign and Synthesis of Tricyclic Corticotropin-Releasing Factor-1 Antagonists, SDS of cas: 765917-27-9, the publication is Journal of Medicinal Chemistry (2005), 48(18), 5780-5793, database is CAplus and MEDLINE.

Antagonists of the corticotropin-releasing factor (CRF) neuropeptide should prove to be effective in treating stress and anxiety-related disorders. In an effort to identify antagonists with improved physicochem. properties, new tricyclic CRF₁ antagonists were designed, synthesized, and tested for biol. activity. As a result of studies aimed at establishing a relationship between structure and CRF₁ binding affinity, NBI 35965 [i.e., (7S)-6-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene (I)] was identified as a high-affinity antagonist with a pK_i value of 8.5. I proved to be a functional CRF₁ antagonist with pIC₅₀ values of 7.1 and 6.9 in the in vitro CRF-stimulated cAMP accumulation and ACTH production assays, resp., and I also reduced CRF or stress induced ACTH production in vivo.

Journal of Medicinal Chemistry published new progress about 765917-27-9. 765917-27-9 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Boronate Esters, name is 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C12H15BClFO2, SDS of cas: 765917-27-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics