Tag: M.W=250-300

Zheng, Yuxin published the artcileRegiodivergent Desymmetrization Reaction of meso-Azabicycloheptene Providing Two Enantioenriched Structural Isomers, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Organic Letters, database is CAplus and MEDLINE.

A novel catalytic asym. reaction uses the regiodivergent desymmetrization of 7-tosyl-7-azabicyclo[4.1.0]hept-3-ene via allylic oxidation using a single chiral copper catalyst to produce two different, enantioenriched structural isomers in high optical purity starting from a single compound The enantioselectivity of the two structurally isomeric compounds was enriched to >99.5%ee after derivatization.

Organic Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C26H26N4O7, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rojas Cabrera, Haydee published the artcileHomochiral L-prolinamido-sulfonamides and their use as organocatalysts in aldol reactions, Computed Properties of 21286-54-4, the publication is Tetrahedron: Asymmetry (2015), 26(4), 163-172, database is CAplus.

The synthesis of new homochiral L-prolinamido-sulfonamides 1-7 from enantiomerically pure (R,R)-11,12-diamino-9,10-dihydro-9,10-ethanoanthracene (R,R)-8 is reported. The L-prolinamido-sulfonamides 1-7 were tested as organocatalysts (10 mol %) in the aldol reaction of p-nitrobenzaldehyde and acetone in dichloromethane at room temperature in the presence of water (1 equiv) and acetic acid (20 mol %) giving good to high yields and enantioselectivities. Catalyst I (10 mol %) afforded the best results in the aldol reaction of acetone with p-substituted-benzaldehydes with electron withdrawing groups (i.e., nitro, cyano, bromo and chloro, up to 97% yield and 90% ee). The origin of the enantioselective induction was modeled using DFT methods. The estimated enantioselectivity for the model system is consistent with the exptl. data.

Tetrahedron: Asymmetry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sweis, Ramzi F. published the artcile2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy, HPLC of Formula: 18791-02-1, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(6), 1890-1895, database is CAplus and MEDLINE.

The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark mol. I. Reversing the connectivity of the central aniline lead to a new class of 2-(4-carbonylphenyl)benzoxazoles. Structure-activity studies at the C-7 and terminal pyridine ring allowed for the optimization of potency and HDLc-raising efficacy in this new class of inhibitors. These efforts lead to the discovery of benzoxazole II, which raised HDLc by 24 mg/dL in the transgenic mouse PD model.

Bioorganic & Medicinal Chemistry Letters published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C10H17N3O2, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Oh, Keimei published the artcileSynthesis and structure-activity relationships of new pyrazole derivatives that induce triple response in Arabidopsis seedlings, Name: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Journal of Pesticide Science (Tokyo, Japan) (2019), 44(4), 233-241, database is CAplus and MEDLINE.

Twenty-seven analogs of pyrazole derivatives I (R¹ = Me, Ph, allyl, tert-butyl; R² = 2-fluorophenyl, 3-chloro-4-fluorophenyl, 4-phenylazo, etc.) were synthesized and subjected to structure-activity relationship studies on inducing the triple response in Arabidopsis seedlings. The compound I (R¹ = allyl; R² = 3,4-dichlorophenyl) (II) has been found to exhibit potent activity on inducing the triple response in Arabidopsis seedlings. Compound II (10μM) induced an exaggerated apical hook in Arabidopsis seedlings. The curvature of the hook of the Arabidopsis seedlings was found to be 300 ± 23°, while ethephon (10μM), a prodrug of ethylene, and a non-chem. treated control were found to be 128 ± 19 and 58 ± 16°, resp. Compound II also exhibited potent activity on reducing stem elongation. The hypocotyl length of Arabidopsis seedlings treated with compound II (10μM) was found to be 0.25 ± 0.02 cm, while those of ethephon-treated (10μM) and treated controls were found to be 0.69 ± 0.06 and 1.15 ± 0.01 cm, resp. Compound II displayed potency inhibiting the root growth of Arabidopsis seedlings similar to that of ethephon.

Journal of Pesticide Science (Tokyo, Japan) published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Name: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ng, Wing-Hin published the artcileZwitterion-Catalyzed Intermolecular Bromoesterifications, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Organic Letters (2020), 22(14), 5572-5576, database is CAplus and MEDLINE.

Intermol. haloesterification is an important class of transformations. The resulting products are valuable building blocks. However, it is often necessary to use super-stoichiometric amount of acid in order to compensate the low reactivity. Herein, we report a zwitterion-catalyzed intermol. bromoesterification using acid and olefin in an equimolar ratio. Mechanistic study revealed that the charge pair in the zwitterion works synergistically in activating both NBS and carboxylic acid.

Organic Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

McKenna, Charles E. published the artcileThe facile dealkylation of phosphonic acid dialkyl esters by bromotrimethylsilane, Application In Synthesis of 866-23-9, the publication is Tetrahedron Letters (1977), 155-8, database is CAplus.

The phosphonates RP(O)(OR1)2 [I; R = CH2:CH, PhCH2, EtO(CH2)2, (EtO)2P(O)CH2, R1 = Et; R = Bz, (MeO)2P(O)CH2, R1 = Me] were dealkylated by treatment with Me3SiBr at 25° for 1-2 h to give quant. RP(O)(OSiMe3)2. Similar dealkylation of I (R = Cl3C, R1 = Et) at 61-9° for 2.7 h gave ≥99% Cl3CP(O)(OSiMe3)2. Dealkylations with Me3SiCl required higher temperatures and gave low yields. The silyl esters may be hydrolyzed to give the parent phosphonic acids.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nakasato, Satoshi published the artcileSynthesis of dialkyl trichloromethylphosphonates and their properties for additives, Computed Properties of 866-23-9, the publication is Journal of the American Oil Chemists’ Society (1970), 47(8), 283-5, database is CAplus.

Nine (C2-18) dialkyl trichloromethylphosphonates (TCMP) were synthesized by the Arbusov reaction from the corresponding trialkyl phosphite and CCl4. The reaction of (EtO)3P and CCl4 using daylight was completed in about 4 hr. However, in the preparation of the higher dialkyl TCMP the mixture of (RO)3P and CCl4 had to be refluxed 8 hr or more. These compounds were effective chelating, antistatic and flame resistant additives in a formulation of poly(vinyl chloride) as well as excellent extreme pressure additives for lubricating oil; especially the dibutyl TCMP which was effective at 0.25%.

Journal of the American Oil Chemists’ Society published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pearce-Higgins, Robert published the artcileAn Enantioselective Suzuki-Miyaura Coupling To Form Axially Chiral Biphenols, Related Products of chlorides-buliding-blocks, the publication is Journal of the American Chemical Society (2022), 144(33), 15026-15032, database is CAplus and MEDLINE.

The use of enantiopure, sulfonated SPhos (sSPhos), an existing ligand that has until now been used only in racemic form and that derived its chirality from an atropisomeric axis that was introduced through sulfonation. The attractive noncovalent interactions involving the ligand sulfonate group was responsible for the high levels of asym. induction that we obtain in the 2,2′-biphenol products of Suzuki-Miyaura coupling, and a highly practical resolution of sSPhos via diastereomeric salt recrystallization was developed.

Journal of the American Chemical Society published new progress about 1451391-17-5. 1451391-17-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is 3-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, and the molecular formula is C12H16BClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lois, Isabella published the artcileThe effect of the r_cation/r_anion ratio on the structural and chemical properties of N-chloroarenesulfonamidates, Computed Properties of 7080-50-4, the publication is Inorganica Chimica Acta (2007), 360(8), 2686-2696, database is CAplus.

A comparative structural study on sodium and potassium N-chloroarenesulfonamidates was carried out using x-ray diffraction and IR spectroscopy as exptl. techniques. As shown by crystallog. studies, the sodium ions tend to incorporate more water oxygen atoms in their coordination spheres than the potassium ions, while the potassium congeners prefer the interaction with sulfonamidate moieties. The marked dissimilarity between the compositions of the coordination spheres as well as the different tendency of the sodium and potassium salts to absorb moisture from the air were attributed to the different sizes of the sodium and potassium ions. The opposite shifts of the ν _as(SO₂) and ν(SN) bands upon dehydration were ascribed to an increased polarization of the sulfonyl group by the metal centers. Based on IR spectroscopic observations, a weakening of the N-Cl bonds is suspected in the water-free compounds, which may contribute to the known thermal instability of the dehydrated salts of N-chloroarenesulfonamides. Various sections of IR spectra as well as x-ray powder diffraction patterns proved to be suitable to identify the water-free and hydrated samples.

Inorganica Chimica Acta published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Computed Properties of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Saito, Tetsuo published the artcileSystemic inseccticidal properties of certain organic phosphorus compounds to the green peach aphid, Myzus persicae, and the tobacco cutworm, Prodenia litura, Name: Diethyltrichloromethylphosphonate, the publication is Bochu Kagaku (1966), 31(2), 77-81, database is CAplus.

Screening tests of insecticidal activity for ∼50 organophosphorus compounds used the sucking insect, green peach aphid, and the chewing insect, tobacco cutworm. The established systemic insecticides were usually highly toxic to the aphid while being less toxic to the cutworm. One of the thiophosphate esters, ((EtO)2P(S)SCH2CO2(CH2)2Cl) was toxic to the cutworm. Five phosphate esters were toxic to both insects. O,O-Di-Me dichlorohydroxyethanephosphonate and its Ac ester, O,O-di-Me trichlorohydroxyethanephosphonate and its Et Me homolog were more toxic to the cutworm than the aphid. The test plant was cabbage and the test chems. were formulated with Me2CO-C6H6-emulsifier 30:30:30% weight/weight Insecticidal activity was indicated by mortality at concentrations of 1000 ppm. or lower.

Bochu Kagaku published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics