Tag: M.W=150-200

Freidlina, R. Kh. published the artcileThermal telomerization of olefins with silanes, Application In Synthesis of 14799-94-1, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1960), 662-8, database is CAplus.

cf. CA 52, 6165d. Heating 11.5 g. MeSiHCl₂ and 4.3 g. C₂H₄ in an ampul in an autoclave 3 hrs. at 320-40° gave mixed MeEtSiCl₂ and MeBuSiCl₂ in yields of 42-80% and 17-28%, resp. The use of a bare steel autoclave tended to lower the yield of MeEtSiCl₂ and raise that of BuMeSiCl₂. Similarly, Ph₃SiH and C₂H₄ in hexane 12 hrs. at 300° gave Ph₃SiEt, m. 68-70°, and Ph₃SiBu, m. 81-2°, along with some (Ph₃Si)₂O, m. 224°. Reaction of MeSiHCl₂ and propylene in the presence of a catalytic amount of H₂PtCl₆ in iso-PrOH in 1 hr. at room temperature gave MePrSiCl₂, which with MeMgBr gave known Me₃SiPr. In the telomerization of MeSiHCl₂ with C₂H₄ at 300°, the increased proportion of the olefin tended to lower steadily the yield of MeSiCl₂Et and MeSiCl₂(CH₂CH₂)₂H, while the yield of MeSiCl₂(CH₂CH₂)₃H remained substantially constant and that of MeSiCl₂(CH₂CH₂)₃H rose rapidly. Elevation of the temperature from 285° to 350° increased the yield of MeSiCl₂Et and decreased that of telomers with n over 3, while the intermediate telomer yield remained substantially constant

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Application In Synthesis of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Heo, Seunga published the artcileBoosting photoredox catalysis using two-dimensional electride as persistent electron donor, Formula: C8H6ClF3, the publication is ACS Applied Materials & Interfaces (2021), 13(36), 42880-42888, database is CAplus and MEDLINE.

Electrides, which have excess anionic electrons, are solid-state sources of solvated electrons that can be used as powerful reducing agents for organic syntheses. However, the abrupt decomposition of electrides in organic solvents makes controlling the transfer inefficient, thereby limiting the utilization of their superior electron-donating ability. Here, we demonstrate the efficient reductive transformation strategy which combines the stable two-dimensional [Gd₂C]²⁺·2e^– electride electron donor and cyclometalated Pt(II) complex photocatalysts. Strongly localized anionic electrons at the interlayer space in the [Gd₂C]²⁺·2e^– electride are released via moderate alcoholysis in 2,2,2-trifluoroethanol, enabling persistent electron donation. The Pt(II) complexes are adsorbed onto the surface of the [Gd₂C]²⁺·2e^– electride and rapidly capture the released electrons at a rate of 10⁷ s^-1 upon photoexcitation. The one-electron-reduced Pt complex is electrochem. stable enough to deliver the electron to substrates in the bulk, which completes the photoredox cycle. The key benefit of this system is the suppression of undesirable charge recombination because back electron transfer is prohibited due to the irreversible disruption of the electride after the electron transfer. These desirable properties collectively serve as the photoredox catalysis principle for the reductive generation of the benzyl radical from benzyl halide, which is the key intermediate for dehalogenated or homocoupled products.

ACS Applied Materials & Interfaces published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haberfield, Paul published the artcileProximate charge effects. 8. Ion pair formation as an assembly process in ester aminolysis, Computed Properties of 6249-56-5, the publication is Journal of Organic Chemistry (1990), 55(4), 1334-8, database is CAplus.

The rate of aminolysis of p-nitrophenyl hexanoate by benzylamine in 95.3 mol % dioxane-water was compared to the rate of this reaction when the n-pentyl group in the ester was replaced by a Me₃N⁺(CH₂)₃ group, and the benzyl group in the amine by a ^–O₃SCH₂CH₂ group. The second-order rate constant of the first reaction was 4.21 × 10^-3 L mol^-1 s^-1, the first-order rate constant for the reacting ion pair was 1.88 × 10^-2 s^-1, yielding an effective molarity of 4.47 mol L^-1 as the measure of the rate acceleration caused by this preassembly of the reactants by electrostatic attraction. Further evidence for the intermediacy of an ion pair in the reaction between the oppositely charged reactants was the observation of a special salt effect, the addition of an inert salt causing a decrease in the aminolysis rate.

Journal of Organic Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Computed Properties of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Unterhalt, B. published the artcileSynthesis of methadone-nitrile as well as isomethadone-nitrile, and related compounds, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Scientia Pharmaceutica (2000), 68(3), 229-234, database is CAplus.

R₂NCH₂CHMeCl [R₂ = Me₂, (CH₂)₅, (CH₂)₂O(CH₂)₂, (CH₂)₄] are reacted with Ph₂CHCN under phase-transfer conditions to give a mixture of the corresponding nitriles R₂NCHMeCH₂CPh₂CN and R₂NCH₂CHMeCPh₂CN. Both R₂NCH₂CHPhCl and R₂NCHPhCH₂Cl [R₂ = Me₂, (CH₂)₅, (CH₂)₂O(CH₂)₂, (CH₂)₄] led to resp. R₂NCH₂CHPhCPh₂CN.

Scientia Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C10H2F12NiO4, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wood, Gordon W. published the artcileMethyl transfer in field desorption mass spectrometry of ammonioalkanecarboxylate hydrochloride salts, COA of Formula: C7H16ClNO2, the publication is Organic Mass Spectrometry (1983), 18(1), 42-5, database is CAplus.

Field desorption mass spectra of simple N,N,N-trimethylammoniocarboxylate hydrochloride salts and their N,N,N-perdeuteriotrimethylammonium analogs are reported in which Me transfer was observed Mechanisms for this and other fragmentation and rearrangement processes are dependent on anode heating current. Addition of the protonating agent p-MeC₆H₄SO₃H suppressed most ions except the protonated mol. ion.

Organic Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C18H35NO, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Huaisheng published the artcileDiscovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent, Application of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(9), 1647-1651, database is CAplus and MEDLINE.

A series of natural products-based Ph sulfone derivative and their property-based analogs were investigated as potential growth inhibitors of Trypanosoma brucei. Trypanosoma brucei is a kinetoplastid protozoan parasite that causes trypanosomiasis. In this work, the authors found that nopol- and quinoline-based Ph sulfone derivative were the most active and selective for T. brucei, and they were not reactive towards the active thiol of T. brucei’s cysteine protease rhodesain. A thiol reactive variant of the quinoline-based Ph sulfone was subsequently investigated and found to be a moderate inhibitor of rhodesain. The quinoline-based compound that is not reactive towards rhodesain can serve a template for phenotypic-based lead discovery while its thiol-active congener can serve as template for structure-based investigation of new antitrypanosomal agents.

Bioorganic & Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C24H12, Application of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Di Fabio, Giovanni published the artcileA versatile synthetic approach for the development of libraries of 5′,3′-bis-conjugated oligonucleotides, Quality Control of 33697-81-3, the publication is Nucleic Acids Symposium Series (2008), 52(1), 299-300, database is CAplus and MEDLINE.

A symposium. A versatile approach to develop libraries of diverse 5′,3′-bis-conjugated oligonucleotides (ODNs) is here described. The usage of ad hoc derivatized solid supports, to which the first nucleoside unit is attached through a phosphate linkage, opens easy synthetic access to a large variety of hybrid bis-conjugated oligomers. The G-quadruplex forming d(^5′TGGGAG^3′) sequence, as a potential anti-HIV agent, has been here used as a model system.

Nucleic Acids Symposium Series published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

D’Onofrio, Jennifer published the artcileNovel cyclic phosphate-linked oligosaccharides (CyPLOSs) covalently immobilized on solid supports for potential cation scavenging, SDS of cas: 33697-81-3, the publication is European Journal of Organic Chemistry (2007), 3849-3858, database is CAplus.

For potential cation scavenging both from water and from organic solvents, a synthetic procedure for functionalization of a Tentagel solid support with novel cyclic phosphate-linked oligosaccharide (CyPLOS) analogs I (R = TBDMS, H) is described. To establish the feasibility of the synthetic strategy, the cyclic dimer was the model compound selected to be incorporated onto the solid support. This functionalization was achieved through a stepwise solid-phase synthesis of the linear dimer, obtained by standard phosphoramidite protocols, followed by a synthesis of the cyclic mol. on the resin. The key intermediate was a suitably derivatized sugar phosphoramidite building block II, with the secondary hydroxy functions masked as TBDMS ethers. This proved to be an orthogonal protection with respect to the DMT ether, fully compatible with the phosphoramidite and the phosphotriester chem. used for the oligomerization and the cyclization process onto the solid support, resp. Conditions for the total unmasking of the hydroxy groups of the cyclic dimer, not affecting the integrity of the cyclic structure nor its linkage with the solid matrix, have been optimized. Gel-phase ³¹P NMR spectroscopy has been used extensively here to monitor the efficiency of the reactions carried out on the solid support.

European Journal of Organic Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Dachuan published the artcileDesign, synthesis and biological evaluation of benzo[d]thiazole with dimethylpyrazole derivatives, Safety of 3-Chlorobenzylchloride, the publication is Asian Pacific Journal of Cancer Prevention (2019), 20(11), 3487-3495, database is CAplus and MEDLINE.

A series of new benzothiazole derivatives containing dimethylpyrazole I [R = H, n-pentyl, benzyl, etc.] were synthesized and evaluated for their anticonvulsant activity, neurotoxicity and cytotoxicity by using the maximal electroshock (MES), rotarod neurotoxicity (TOX) and MTT colorimetric assay. Among the compounds studied, four compounds I [R = Bu, n-pentyl, 2-fluorobenzyl, 2,6-dichlorobenzyl] showed better anticonvulsant than the others at 300 mg/kg and they also showed anticonvulsant activity at the dose of 100 mg/kg. All the synthetic compounds I showed lower neurotoxicity and little cytotoxicity, so that the compounds, which with better activities, also had higher protective index. In particular, the compound I [R = 2-fluorobenzyl] showed better activity with an ED₅₀ value of 160.4 mg/kg and higher protective index (PI) values of 2.74 in the MES test than the standard drugs sodium valproate, which used as pos. controls in this study. After that the compound I [R = 2-fluorobenzyl] demonstrated antagonistic activity against seizures induced by pentylenetetrazol, which proved compound I [R = 2-fluorobenzyl] may be exert activity through effecting GABAergic neurotransmission.

Asian Pacific Journal of Cancer Prevention published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Dachuan published the artcileDesign, synthesis and biological evaluation of benzo[d]thiazole with dimethylpyrazole derivatives, COA of Formula: C8H6ClF3, the publication is Asian Pacific Journal of Cancer Prevention (2019), 20(11), 3487-3495, database is CAplus and MEDLINE.

A series of new benzothiazole derivatives containing dimethylpyrazole I [R = H, n-pentyl, benzyl, etc.] were synthesized and evaluated for their anticonvulsant activity, neurotoxicity and cytotoxicity by using the maximal electroshock (MES), rotarod neurotoxicity (TOX) and MTT colorimetric assay. Among the compounds studied, four compounds I [R = Bu, n-pentyl, 2-fluorobenzyl, 2,6-dichlorobenzyl] showed better anticonvulsant than the others at 300 mg/kg and they also showed anticonvulsant activity at the dose of 100 mg/kg. All the synthetic compounds I showed lower neurotoxicity and little cytotoxicity, so that the compounds, which with better activities, also had higher protective index. In particular, the compound I [R = 2-fluorobenzyl] showed better activity with an ED₅₀ value of 160.4 mg/kg and higher protective index (PI) values of 2.74 in the MES test than the standard drugs sodium valproate, which used as pos. controls in this study. After that the compound I [R = 2-fluorobenzyl] demonstrated antagonistic activity against seizures induced by pentylenetetrazol, which proved compound I [R = 2-fluorobenzyl] may be exert activity through effecting GABAergic neurotransmission.

Asian Pacific Journal of Cancer Prevention published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, COA of Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics