Tag: M.W=150-200

Hodgson, Ernest published the artcileDietary choline requirements, phospholipids, and development in Phormia regina, Name: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Comparative Biochemistry and Physiology (1969), 29(1), 343-59, database is CAplus.

Twenty-six compounds were tested for their ability to support growth and development when fed, in lieu of choline, to P. regina. Sixteen supported larval growth and previous findings on structure-function relation in choline substitutes were confirmed. Only ten compounds permitted appreciable formation of puparia and only four of these permitted the emergence of normal adults. Thus, the structural requirements for postlarval development are much more rigorous than those for larval growth. No compound was as effective as choline. All compounds which support larval growth are incorporated into phospholipids analogous to phosphatidylcholine, indicating that the cytidine pathway for phospholipid synthesis is relatively nonspecific. Isopropylaminoethanol is a growth inhibitor when fed to P. regina larvae.

Comparative Biochemistry and Physiology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Name: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yoon, Taeyoung published the artcileThe design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists, Application In Synthesis of 209919-30-2, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(3), 891-896, database is CAplus and MEDLINE.

The design, synthesis and structure-activity relationships of a series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core on CRF-1 receptor binding were investigated.

Bioorganic & Medicinal Chemistry Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C2H5BF3K, Application In Synthesis of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Moggio, Loredana published the artcileSolid-Phase Synthesis of Cyclic PNA and PNA-DNA Chimeras, SDS of cas: 33697-81-3, the publication is Organic Letters (2006), 8(10), 2015-2018, database is CAplus and MEDLINE.

A new and versatile online automated solid-phase approach to obtain cyclic PNA and cyclic PNA-DNA chimeras in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic mols. by standard peptide and phosphoramidite-based chem. has been achieved.

Organic Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Paolino, D. published the artcilePolyaspartylhydrazide copolymer-based supramolecular vesicular aggregates as delivery devices for anticancer brugs, Quality Control of 6249-56-5, the publication is Biomacromolecules (2008), 9(4), 1117-1130, database is CAplus and MEDLINE.

In this paper we report on three different hydrophilic copolymers based on α,β-polyaspartylhydrazide (PAHy) bearing butyric groups in the side chain (C₄) (PAHy-C₄) or a combination of butyric groups and pos. charged residues ((carboxypropyl)trimethylammonium chloride, CPTACl) (PAHy-C₄-CPTA) that were synthesized and used for the preparation of new supramol. vesicular aggregates (SVAs) containing gemcitabine as an antitumor drug. Gemcitabine-loaded SVAs containing synthesized PAHy derivatives were characterized from the physicochem. and technol. point of view and the in vitro toxicity and anticancer activity on two different human cancer cell lines, i.e., CaCo-2 (human colon carcinoma) and ARO (human anaplastic thyroid carcinoma) cells, were also evaluated. Moreover, considering that carrier-cell interaction is an important factor to achieve an improvement of anticancer drug activity, confocal laser scanning microscopy and flow cytometric experiments were carried out on the two different cancer cell lines.

Biomacromolecules published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Quality Control of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pierson, R. M. published the artcileBis-type modifiers in polymerization. I. Behavior of various disulfides in bulk styrene polymerization, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Polymer Science (1955), 221-46, database is CAplus.

Studies were made of the effectiveness in low-conversion bulk styrene polymerizations of the modifiers, bis(2-ethylhexyl) disulfide, dibenzyl disulfide, bis(chlorobenzyl) disulfide, bis[2-(2-pyridyl)ethyl] disulfide, bis(2-chloroethyl)disulfide, bis(2-hydroxyethyl)disulfide, dithiodiacetic acid, esters of bis(2-carboxyethyl)disulfide, bis(2-chloroacetoxyethyl) disulfide, diphenyl disulfide, di-ο-tolyl disulfide, bis(2,6-xylyl) disulfide, bis(2,3,5,6-tetramethylphenyl) disulfide, bis(4-carboxyphenyl) disulfide, bis(4-carbethoxyphenyl) disulfide, bis(4-hydroxymethylphenyl)disulfide, bis(2-chloromethylphenyl) disulfide, bis(2-bromomethylphenyl)disulfide, bis(2-aminophenyl) disulfide, di-2-naphthyl disulfide, di-2-benzothiazolyl disulfide, bis(isopropylxanthogen) disulfide, 4,4′-dithiodimorpholine disulfide, carbonylbis(thioglycolic acid), thiocarbonylbis(thioglycolic acid), and tetraphenylhydrazine. Alkyl disulfides, even when substituted at C’s near the SS bond, had very low transfer constants The transfer constants of aryl disulfides were much higher and could be increased by substitutions, thereby incorporating desired groups into the polymer. They cleave to give one half the mol. to each end of the polymer as was shown by comparing end-group concentrations of styrene polymers containing various types of end groups with polymers modified by thiols containing similar groups.

Journal of Polymer Science published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Bowen published the artcileDesign, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives, Recommanded Product: 3-Chlorobenzylchloride, the publication is Youji Huaxue (2020), 40(4), 978-987, database is CAplus.

A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC₆H₄, 4-FC₆H₄, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH₂C₆H₄] showed the most potent antitumor activity against PC-3 cells with IC₅₀ value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH₂C₆H₄] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH₂C₆H₄] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway.

Youji Huaxue published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C15H23BO2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Dong-Jun published the artcileDiscovery of novel indole derivatives that inhibit NEDDylation and MAPK pathways against gastric cancer MGC803 cells, SDS of cas: 620-20-2, the publication is Bioorganic Chemistry (2021), 104634, database is CAplus and MEDLINE.

A series of novel indole derivatives were synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (MGC803, EC-109 and PC-3). Among these analogs, 2-(5-methoxy-1H-indol-1-yl)-N-(4-methoxybenzyl)-N-(3,4,5-trimethoxyphenyl)acetamide (I) showed the best inhibitory activity against MGC803 cells with an IC₅₀ value of 1.59μM. Cellular mechanisms elucidated that I inhibited colony formation, induced apoptosis and arrested cell cycle at G2/M phase. Importantly, indole analog I inhibited NEDDylation pathway and MAPK pathway against MGC803 cells.

Bioorganic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boersma, Brenda J. published the artcileNeutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties, Product Details of C8H7ClO3, the publication is Free Radical Biology & Medicine (2003), 35(11), 1417-1430, database is CAplus and MEDLINE.

Soy isoflavones and other polyphenolics have a number of potentially important beneficial effects on the pro-oxidant aspects of chronic inflammation. The impact of inflammatory cell-specific metabolism of polyphenolics, which can include halogenation and nitration, on the properties of these compounds has not been examined Using either human neutrophils or differentiated human leukemia cells (HL-60) stimulated with phorbol ester to elicit a respiratory burst, the hypothesis that local generation of reactive oxygen and nitrogen species may metabolize and modify the biol. properties of the soy isoflavones was examined Coincubation of the stimulated cells with genistein or daidzein had no effect on the respiratory burst. Medium from stimulated cells in the presence of the isoflavones and NO₂^– increased the inhibition of copper-induced LDL oxidation Mass spectrometry anal. of this medium revealed that monochlorinated, dichlorinated, and nitrated isoflavones, formed through a myeloperoxidase-dependent mechanism, were present. The consumption of genistein in the presence of cells was both extensive and rapid with > 95% of the genistein converted to either the chlorinated or nitrated metabolites within 30 min. Chem. synthesized 3′-chlorogenistein and 3′-chlorodaidzein increased the inhibition of LDL oxidation by approx. 4-fold and 2-fold over genistein and daidzein, resp. These results lead to the hypothesis that inflammatory cell-specific metabolism of polyphenolics can modify the properties of these compounds at the local site of inflammation.

Free Radical Biology & Medicine published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Utkin, Ilya published the artcileSpecificity of reductive dehalogenation of substituted ortho-chlorophenols by Desulfitobacterium dehalogenans JW/IU-DC1, Category: chlorides-buliding-blocks, the publication is Applied and Environmental Microbiology (1995), 61(1), 346-51, database is CAplus and MEDLINE.

Resting cells of D. dehalogenans JW/IU-DC1 grown with pyruvate and 3-chloro-4-hydroxyphenylacetate (3-Cl-4-OHPA) as the electron acceptor and inducer of dehalogenation reductively ortho-dehalogenate pentachlorophenol (PCP), tetrachlorophenols (TeCPs), the trichlorophenols 2,3,4-TCP, 2,3,6-TCP, and 2,4,6-TCP, the dichlorophenols 2,3-DCP, 2,4-DCP, and 2,6-DCP, 2,6-dichloro-4-R-phenols, where R is -H, -F, -Cl, -NO₂, -CO₂^–, or -COOCH₃, 2-chloro-4-R-phenols (2-Cl-4-RPs, where R is -H, -F, -Cl, -Br, -NO₂, -CO₂^–, -CH₂CO₂^–, or -COOCH₃), and bromophenols (2-BrP, 2,6-DBrP, and 2-Br-4ClP). Monochlorophenols, the dichlorophenols 2,5-DCP, 3,4-DCP, and 3,5-DCP, the trichlorophenols 2,3,5-TCP, 2,4,5-TCP, and 3,4,5-TCP, and the fluorinated analog of 3-Cl-4-OHPA, 3-F-4-OHPA, are not dehalogenated. A Cl substituent in position 3 (meta), 4 (para), or 6 (2nd ortho) of the phenolic moiety facilitates ortho dehalogenation in position 2. Cl in the 5 (2nd meta) position has a neg. effect on the dehalogenation rate or even prevents dechlorination in the 2 position. In general, 2,6-DCl-4-RPs are dechlorinated faster than the corresponding 2-Cl-4-RPs with the same substituent R in the 4 position. The highest dechlorination rate, however, was found for dechlorination of 2,3-DCP, with a maximum observed 1st-order rate constant of 19.4/h-g (dry weight) biomass. There is no strong linear correlation between the logarithm of pseudo-1st-order rate constants for the dehalogenation of 2,6-DCl-4-RPs and 2-Cl-4-RPs and electronic (Hammett σ_m), hydrophobic (π), and stearic (E_s) constants of the substituent R. The substrate specificity and induction pattern found for dehalogenation with the pure culture of D. dehalogenans and the original 2,4-DCP-enrichment, derived from a methanogenic sediment, were similar, suggesting that the conditions used led to only 1 type of dechlorinating organism.

Applied and Environmental Microbiology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H6KNO4S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Manach, Claire published the artcileIdentification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts, Quality Control of 33697-81-3, the publication is Journal of Medicinal Chemistry (2021), 64(4), 2291-2309, database is CAplus and MEDLINE.

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp³-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chem. optimization and biol. profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (<50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogs followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics