Tag: M.W=150-200

Xiao, Chunsheng published the artcileSide chain impacts on pH- and thermo-responsiveness of tertiary amine functionalized polypeptides, SDS of cas: 4584-49-0, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2014), 52(5), 671-679, database is CAplus.

The systemic investigation of the structural impacts of side chains on the pH- and thermo-responsiveness of tertiary amine functionalized poly(L-glutamate)s (TA-PGs) was carried out. The TA-PGs polymers were effectively synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition click reaction of azido tertiary amines with poly(γ-propargyl-L-glutamate) (PPLG). Turbimetric measurements were performed to characterize the pH- and temperature-induced phase transition of TA-PGs in aqueous solution, which suggested a structural dependence of the properties on the N-substituted groups and the “linkers” between 1,2,3-triazole ring and the tertiary amine groups in the side chains. In detail, the pH responsive properties of TA-PGs were basically determined by the hydrophobicity of the N-substituted groups in the side chains and the pH transition point (pH_t) decreased as the increasing hydrophobicity of the N-substituted groups, while the temperature-responsiveness of TA-PGs were affected by either the N-substituted groups or the “linkers.” TA-PGs with a moderate N-substituted amine group (e.g., DEA, PR, and PD) or a branched “linker” (e.g., iso-propylene and 2-methylpropylene group) were more likely to express the LCST-type phase transition tuned by pH variation. These structure-property relationships revealed in this study would help to develop the applications of TA-PGs in smart drug delivery systems. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C7H5ClN2S, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shen, Ni published the artcileDirect amide synthesis via Ni-mediated aminocarbonylation of arylboronic acids with CO and nitroarenes, Name: 3-Chloro-4-fluoronitrobenzene, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(91), 13709-13712, database is CAplus and MEDLINE.

An alternative and unconventional approach of an aminocarbonylation reaction to access aryl amides from readily available and low-cost arylboronic acids and nitroarenes was described. Nickel metal served as both reductant and catalyst in this direct aminocarbonylation. This protocol exhibited a good functional group compatibility and allows a variety of aryl amides to be synthesized, including several drug-like mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C3H6F3N, Name: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Su, Yuan-Hsiao published the artcileSolution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries, Synthetic Route of 33697-81-3, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(5), 1320-1324, database is CAplus and MEDLINE.

The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed that fenbufen but not ethacrynic acid Bu amide members displayed the cytotoxicities to tumor cells substantially, including two human cell lines (MCF7 and A549) and two murine cell lines (C26 and TRAMP-C1). Three fenbufen analogs, e.g. I, II and III, were found to have a good anti-tumor activity comparable to cisplatin.

Bioorganic & Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C14H12N2S, Synthetic Route of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Garcia-Barrantes, Pedro M. published the artcileLead optimization of the VU0486321 series of mGlu₁ PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(8), 1869-1872, database is CAplus and MEDLINE.

This Letter describes the further lead optimization of the VU0486321 series of mGlu₁ pos. allosteric modulators (PAMs), focused on addressing the recurrent issue of plasma instability of the phthalimide moiety. Here, the authors evaluated a number of phthalimide bioisosteres, and ultimately identified isoindolinones as the ideal replacement that effectively address plasma instability, while maintaining acceptable mGlu₁ PAM potency, DMPK profile, CNS penetration and mGluR selectivity.

Bioorganic & Medicinal Chemistry Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, Ho-Taek published the artcileSurface Modulation of Magnetic Nanocrystals in the Development of Highly Efficient Magnetic Resonance Probes for Intracellular Labeling, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of the American Chemical Society (2005), 127(28), 9992-9993, database is CAplus and MEDLINE.

High-quality biocompatible magnetic iron oxide (Fe₃O₄) nanocrystals were developed through a ligand exchange process of hydrophobically capped nanocrystals with hydrophilic mols. By simple modulation of the nanocrystal surface ligand charge properties, the authors have been able to prepare magnetic nanocrystals with excellent intracellular labeling capabilities that efficiently label a variety of cell types without the need for addnl. transport facilitating agents. The excellent intracellular labeling capability of the newly developed cationic WSIO has further led to successful MRI monitoring of the migration of neural stem cells in rat spinal cord. The magnetic nanocrystals developed here have great potential in applications for labeling of various cell types and also the monitoring of cell-based medical treatments and cancer metastasis.

Journal of the American Chemical Society published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C2H3N3, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ni, Nanting published the artcileInhibition of quorum sensing in Vibrio harveyi by boronic acids, Safety of (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, the publication is Chemical Biology & Drug Design (2009), 74(1), 51-56, database is CAplus and MEDLINE.

Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chems. called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathol. relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. Here, the authors describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC₅₀ values in the low to sub-micromolar range in whole cell assays.

Chemical Biology & Drug Design published new progress about 1072952-42-1. 1072952-42-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, and the molecular formula is C7H7BClFO2, Safety of (5-Chloro-2-fluoro-4-methylphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wall, Joseph S. published the artcileSpectrophotometric determination of betaines and other quaternary compounds as their periodides, HPLC of Formula: 6249-56-5, the publication is Anal. Chem. (1960), 870-4, database is CAplus.

The method of Appleton, et al. (CA 48, 3437a), for the determination of choline, through the absorbance of its periodide at 365 mμ, was modified for the determination of other quaternary N compounds (e.g. betaine, trigonelline, carnitine, stachydrine, and γ-butyrobetaine) as each was separated from an extract of corn grain by ion-exchange chromatography (cf. following abstract). Certain N compounds (such as nicotinic acid, histidine, adenine, and thiamine), which give precipitates with I, may occur in some eluates but they do not interfere in this method. As many as 50 tubes of anal. samples containing 10-100 γ of a compound can be handled. The roles of pH, I concentration, temperature, time, and presence of chloride ions on the yield of the isolated periodide were studied.

Anal. Chem. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C4Br2N2O4S, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Peng published the artcileNovel promising 4-anilinoquinazoline-based derivatives as multi-target RTKs inhibitors: Design, molecular docking, synthesis, and antitumor activities in vitro and vivo, Quality Control of 939-99-1, the publication is Bioorganic & Medicinal Chemistry (2019), 27(20), 114938, database is CAplus and MEDLINE.

4-Anilinoquinazoline derivatives I [R = 2-OBn, 3-OBn, 4-OBn, 2-O(4-NO₂Bn), etc.; n = 0, 1, 2] were designed and synthesized using a binding model with multi-target receptor tyrosine kinases and assessed their antitumor activity against five human tumor cell lines (HepG2, A549, MCF-7, DU145, SH-SY5Y). The majority of the compounds inhibited the proliferation of all the cancer cell types, with some compounds displaying selective inhibition. Compounds I [R = 3-OBn, n = 0], I [R = 4-O(4-NO₂Bn), n = 0] and I [R = 2-OBn, n = 1] displayed IC₅₀ values of 7.588, 8.619 and 6.936μM, resp., for A549 cells, which were much lower than that of Gefitinib (14.803μM). Compound I [R = 3-O(4-CF₃Bn), n = 1] displayed an IC₅₀ value of 2.756μM for DU145 cells. The representative compound I [R = 3-O(4-CF₃Bn), n = 1] had unexceptionable broad-spectrum inhibition for all cancer cell types, and demonstrate inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2), platelet-derived growth factor receptor beta (PDGFR-β), and epidermal growth factor receptor (EGFR) with IC₅₀ values of 46.4, 673.6 and 384.8 nM, resp., which were similar to those of Sorafenib for VEGFR-2 and PDGFR-β (140.6 and 582.7 nM, resp.). Mol. docking results supported the mol. level assay results. Data for production of reactive oxygen species and assessment of matrix metalloproteinase corroborated the strong anti-proliferative effect of compound I [R = 3-O(4-CF₃Bn), n = 1]. The compound also displayed robust antitumor efficacy and relativity lower toxicity in a xenograft model. These attributes were similar to those of Sorafenib.

Bioorganic & Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H15NO, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fan, Ao published the artcilePhosphonium ionic liquids as highly thermal stable and efficient phase transfer catalysts for solid-liquid Halex reactions, SDS of cas: 350-30-1, the publication is Catalysis Today (2012), 198(1), 300-304, database is CAplus.

Trihexyl (tetradecyl) phosphonium tetrafluoroborate was found to be an active catalyst for the introduction of fluoride by nucleophilic aromatic substitution. With a decomposition temperature above 300 °C, this ionic liquid is suitable for reactions at high temperatures The addition of 1 mol% of the ionic liquid relative to KF increased the initial rate for the fluorination of 1,2-dichloro-4-nitrobenzene six-fold compared to the uncatalyzed reaction. The highest reaction rate was observed at 20 mol% ionic liquid relative to KF. Ease of handling without the need for stringent drying conditions and reuseability make this ionic liquid a useful phase transfer catalyst.

Catalysis Today published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, SDS of cas: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qian, Bo published the artcileIron-Catalyzed Carboamination of Olefins: Synthesis of Amines and Disubstituted β-Amino Acids, SDS of cas: 1263414-46-5, the publication is Journal of the American Chemical Society (2017), 139(37), 13076-13082, database is CAplus and MEDLINE.

Intermol. carboamination of olefins with general alkyl groups is an unsolved problem. Diastereoselective carboamination of acyclic olefins represents an addnl. challenge in intermol. carboaminations. We have developed a general alkylamination of vinylarenes and the unprecedented diastereoselective anti-carboamination of unsaturated esters, generating amines and unnatural β-amino acids. This alkylamination is enabled by difunctional alkylating reagents and the iron catalyst. Alkyl diacyl peroxides, readily synthesized from aliphatic acids, serve as both alkylating reagents and internal oxidizing agents. A computational study suggests that addition of a nitrile to the carbocation is the diastereoselectivity-determining step, and hyperconjugation is proposed to account for the highly diastereoselective anti-carboamination.

Journal of the American Chemical Society published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, SDS of cas: 1263414-46-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics