Tag: M.W=150-200

Kelgtermans, Hans published the artcileA Fragment-Based Approach toward Substituted Trioxa[7]helicenes, HPLC of Formula: 350-30-1, the publication is Organic Letters (2012), 14(20), 5200-5203, database is CAplus and MEDLINE.

A series of novel substituted trioxa[7]helicenes have been successfully prepared by a one-pot palladium catalyzed C-H arylation reaction starting from readily prepared dibenzofuran fragments. The dinitro-substituted helicene I was analyzed by X-ray crystallog. revealing the occurrence of two distinct enantiomers in the asym. unit, which forms interesting supramol. motifs in the crystal, based on weak H-bonding interactions.

Organic Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, HPLC of Formula: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kelgtermans, Hans published the artcileSynthesis of Functionalized Dioxa-aza[7]helicenes Using Palladium Catalyzed Arylations, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is Organic Letters (2012), 14(6), 1500-1503, database is CAplus and MEDLINE.

Despite the recent reports on transition-metal catalyzed cycloisomerization strategies toward helicenes, the amount of palladium catalyzed routes remains rather scarce. Within this letter the successful preparation and characterization of novel dioxa-aza[7]helicenes using palladium mediated coupling reactions is presented.

Organic Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shostenko, A. G. published the artcileRadiational reaction of methyldichlorosilane with ethylene, Application In Synthesis of 14799-94-1, the publication is Khimiya Vysokikh Energii (1976), 10(2), 189-91, database is CAplus.

Radiochem. yields (mols./100 eV) were determined for MeSiCl2(C2H4)nH (n = 1, 2, 3), produced in the title reaction, at different reactant ratios. The activation energies of chain transfer and chain growth were practically equal.

Khimiya Vysokikh Energii published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H8BNO4, Application In Synthesis of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Duo published the artcileMethanesulfinylation of Benzyl Halides with Dimethyl Sulfoxide, Recommanded Product: 3-Chlorobenzylchloride, the publication is Journal of Organic Chemistry (2020), 85(4), 2752-2758, database is CAplus and MEDLINE.

A phenyltrimethylammonium tribromide-mediated nucleophilic substitution/oxygen transformation reaction of benzyl halides with DMSO has been developed. In this transition-metal-free reaction, DMSO acts as not only a solvent but also a “S(O)Me” source, thus providing a convenient method for the efficient and direct synthesis of various benzyl Me sulfoxides.

Journal of Organic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Szafran, M. published the artcileDifferences in proton-proton coupling constants of N⁺-CH₂-CH₂ protons of some betaines, N⁺-(CH₂)_2-3-COO^–, and their complexes in aqueous solution, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of Molecular Structure (2001), 555-564, database is CAplus.

Synthesis and ¹H NMR spectra in D₂O of 4 betaines and 19 betaine complexes with mineral acids containing 2 or 3 CH₂ groups in the tether, N⁺-(CH₂)_n-COO^–, n=2,3, and diverse volume of the pos. charged groups are reported. In compounds containing three CH₂ groups in the tether and three substituents at the nitrogen atom or α, α’-disubstituted pyridine ring, a characteristic multiplet for an AA’MM’X₂ spin system is observed This is consistent with preference for trans conformation (68-85%). In the spectra of compounds with two CH₂ groups in the tether or three CH₂ groups and unsubstituted pyridine ring, the multiplet changes to a triplet and gives apparent A₂X₂ and A₂M₂X₂ spectra, resp., consistent with no significant conformational preference. Both the number of CH₂ groups in tether and the bulkiness of the charged groups are responsible for the observed differences of N⁺CH₂ multiplicity and reflect changes in conformational preferences. According to the PM3 calculations, in the gas phase a gauche-like conformer is more stable than the trans, but in aqueous solution it is reverse.

Journal of Molecular Structure published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C24H12, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Parry, Geraint published the artcileNovel auxin transport inhibitors phenocopy the auxin influx carrier mutation aux1, Quality Control of 33697-81-3, the publication is Plant Journal (2001), 25(4), 399-406, database is CAplus and MEDLINE.

The hormone auxin is transported in plants through the combined actions of diffusion and specific auxin influx and efflux carriers. In contrast to auxin efflux, for which there are well documented inhibitors, understanding the developmental roles of carrier-mediated auxin influx has been hampered by the absence of specific competitive inhibitors. However, several mols. that inhibit auxin influx in cultured cells have been described recently. The physiol. effects of two of these novel influx carrier inhibitors, 1-naphthoxyacetic acid (1-NOA) and 3-chloro-4-hydroxyphenylacetic acid (CHPAA), have been investigated in intact seedlings and tissue segments using classical and new auxin transport bioassays. Both mols. do disrupt root gravitropism, which is a developmental process requiring rapid auxin redistribution. Furthermore, the auxin-insensitive and agravitropic root-growth characteristics of aux1 plants were phenocopied by 1-NOA and CHPAA. Similarly, the agravitropic phenotype of inhibitor-treated seedlings was rescued by the auxin 1-naphthaleneacetic acid, but not by 2,4-dichlorophenoxyacetic acid, again resembling the relative abilities of these two auxins to rescue the phenotype of aux1. Further investigations have shown that none of these compounds block polar auxin transport, and that CHPAA exhibits some auxin-like activity at high concentrations While results indicate that 1-NOA and CHPAA represent useful tools for physiol. studies addressing the role of auxin influx in planta, 1-NOA is likely to prove the more useful of the two compounds

Plant Journal published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Barry, A. J. published the artcileReaction of olefins and chlorohydrosilanes, Recommanded Product: Dichloro(hexyl)(methyl)silane, the publication is Journal of the American Chemical Society (1947), 2916, database is CAplus.

Organic Si compounds have been prepared by heating an unsaturated organic compound and R_xSiCl_y under pressure at temperatures from 160° (slow reaction) to 400° (rapid reaction). Thus 406 g. HSiCl₃ and 756 g. octadecene, heated to 300° during 2.5 hrs., give 94% octadecyltrichlorosilane, b_2-3 185-99°. PrMeSiCl₂, b₇₄₇ 123-4°, results in 72% yield on heating 345 g. MeSiHCl₂ and 128 g. C₃H₆ 12 hrs. at 300°. The following new compounds were thus prepared: sec-butyltrichlorosilane, b₇₃₆ 145-6°; (2-methylpentyl)trichlorosilane, b₅₀ 98°; 3-(2,2,4-trimethylpentyl)trichlorosilane (from diisobutylene), b₂₀ 94-6°; hexadecyltrichlorosilane, b_7.5 194-6°; butenyltrichlorosilane, b₄₀ 64°; trichlorosilyl(trichlorosilylethyl)cyclohexane, b₆ 161°; hexenyltrichlorosilane, b₅₀ 103-40°; bis(trichlorosilyl)hexane, b₁₀ 148-53°; propyltribromosilane, b₇₅₆ 183°; ethylmethyldichlorosilane, b₇₄₄ 100°; butylmethyldichlorosilane, b₇₄₄ 147.5-8°; hexylmethyldichlorosilane, b₇₄₃ 192°; methyloctyldichlorosilane, b₂₀ 100-16°; methyloctadecyldichlorosilane, b₆ 200-10°; cyclohexylmethyldichlorosilane, b₇₄₅ 204°; phenylpropyldichlorosilane, b_44-7 140-4°; diethylpropylchlorosilane, b₇₄₂ 164-6°; methylphenylpropylchlorosilane, b₃₀ 124-6°; diphenylpropylchlorosilane, b₁₀ 174-6°.

Journal of the American Chemical Society published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Recommanded Product: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thakur, Alok S. published the artcileSynthesis and Anticonvulsant Effect of Novel Thiazolidinedione Containing Benzene-sulfonylurea and Sulfonylthiourea Derivatives, HPLC of Formula: 3696-23-9, the publication is Central Nervous System Agents in Medicinal Chemistry (2016), 16(2), 152-157, database is CAplus and MEDLINE.

A newer series of 1-(4-substitutedphenyl)-3-(4-((2,4-dioxothiazolidin-5-lidene)methyl)phenyl sulfonyl)urea/thiourea (4a-l) were synthesized for their anticonvulsant activity. The activity is attributed to its potential to restrain astrocytic Na+, 2HCl, and K+ co-transport similar to torasemide which has sulfonylurea in its structure. Torasemide having the similar action as the furosemide that obstructs kainic acid-induced elec. discharges observed from cortex and it has neuroprotective agents, for instance antagonizing the N-methyl-D-aspartate (NMDA) and non-NMDA receptors for evaluating antiepileptic activity. The structures of new derivatives were established by elemental anal. and spectroscopic techniques viz. FTIR, 1H NMR and LC-MS. The all twelve derivatives were assessed for anticonvulsant activity at three different doses at 30, 100 and 300 mg/kg body weight into maximal electroshock (MES) and s.c. pentylenetetrazole (sports) models. Compounds 4c and 4e were formed to be most active among all the derivatives for both the models of anticonvulsant activity. Beside these compounds 4g, 4i and 4k also possessed the prominent anticonvulsant activity devoid of any neurotoxicity. The sulfonylurea and sulfonylthiourea both were proved to be effective anticonvulsant pharmacophore. Other structure activity relationships were established by considering the aspect of substitution in the lead.

Central Nervous System Agents in Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C24H12, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thakur, M. R. published the artcileSynthesis, characterization and investigation of novel benzoyl protected glycosyl 1-formamidino-3-aryl formamidino thiocarbamides for antimicrobial activity, Application In Synthesis of 3696-23-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2016), 55B(10), 1248-1253, database is CAplus.

In the present investigation, a series of novel benzoyl protected glycosyl 1-formamidino-3-aryl formamidino thiocarbamides have been synthesized by interaction of various benzoyl protected glycosyl bromides and 1-aryl-formamidino-3-formamidino thiocarbamides. The required benzoyl protected glycosyl bromides have been synthesized by benzoylation followed by bromination and 1-aryl-formamidino-3-formamidino thiocarbamides have been synthesized by interaction of aryl thiocarbamides and cyanoguanidine. All the newly synthesized compounds have been characterized by usual chem. transformations, elemental anal., IR, 1H NMR and mass spectral studies. These compounds have been investigated for their potential against several human pathogenic bacteria and fungi for their antibacterial and antifungal activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi and Penicilium notatum, Aspergillus niger resp. Some of the synthesized compounds show very promising activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C12H23N3S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ansari, Mohammed M. published the artcileSynthesis antimicrobial and anticancer evaluation of 1-aryl-5-(o-methoxyphenyl)-2-s-benzyl isothiobiurets, SDS of cas: 3696-23-9, the publication is International Journal of Medicinal Chemistry (2014), 352626/1-352626/6, database is CAplus and MEDLINE.

A series of S-benzyl aryl thiourea were condensed with o-methoxy phenylisocyanate to yield resp. isothiobiuret derivatives I [R = H, 4-CH₃, 4-Cl, 2-CH₃, 2-Cl, 3-Cl]. The newly synthesized compounds I were evaluated for their antibacterial, antifungal and anticancer activity.

International Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics