Tag: M.W=150-200

Brintzinger, Herbert published the artcileOrganic sulfur chlorides. VII. Syntheses with α-chloroethylsulfur chloride, Product Details of C4H8Cl2S2, the publication is Chemische Berichte (1954), 300-14, database is CAplus.

cf. C.A. 47, 7433a. Adding 68 g. SO₂Cl₂ dropwise at -20° to 61.5 g. (EtS)₂ in 150 cc. CCl₄, adding another 123 g. SO₂Cl₂ at -15°, warming the mixture to 20°, keeping it overnight, and distilling it give 90% MeCHClSCl (I), b₂₇ 38°. Passing CHCH into 13.1 g. I in 50 cc. CCl₄ 3 h. and distilling the mixture give CHCl:CHSCHClMe, b₁₄ 75°, which decompose on standing. Adding dropwise 10.5 g. cyclohexene in 40 cc. CCl₄ to 13.5 g. I at 20° gives α-chloroethyl 2-chlorocyclohexyl sulfide (II) which decompose on distillation at 2 mm. Heating II at 150° until HCl is no longer split off and distilling off the volatile part leave a thermoplastic dark brown resin. Adding 6.6 g. cyclopentadiene in 35 cc. CCl₄ to 13.1 g. I at below 30° and fractionating the mixture give 4-chlorocyclopenten-2-yl vinyl sulfide, b₇ 65°, which polymerizes readily when the solvent is distilled off at atm. pressure; on heating it 4 h. at 120° a dark thermoplastic resin is formed. Adding dropwise 10.4 g. styrene in 30 cc. CCl₄ to 13.1 g. I at below 25° and distilling the mixture give β-chlorophenethyl vinyl sulfide (III), b₈ 135°. Heating III 50 h. at 80° gives a thermoplastic styrene soft resin, soluble in chlorinated hydrocarbons. Heating III at 160° until HCl is no longer evolved (50 h.) gives a hard black resin containing 3% Cl. Adding dropwise 26.2 g. I in 10 cc. THF (THF) to 10.4 g. cycloöctatetraene in 20 cc. THF at 20° and distilling off the THF in vacuo give what may be 2,7-dichloro-5,8-bis(α-chloroethylmercapto)bicyclo[0.2.4]oct-3-ene (IV) as a viscous yellow-red oil. Heating IV 18 h. at 100° gives a hard nonthermoplastic polymer, (C₁₂H₁₄Cl₂S₂)_x. When IV is heated 10 h. at 160° a Cl-free nonthermoplastic resin of the composition (C₁₂H₁₂S₂)_x is obtained. Adding 13.1 g. I slowly at 35° to 6.6 g. CH₂(CN)₂ in 10 cc. THF causes the evolution of HCl; distilling off the THF in vacuo leaves a red oil which soon polymerizes with the evolution of heat and HCl, giving a soft resin which, on heating 24 h. at 100°, gives a dark brown thermoplastic polymer, (C₅H₅N₂ClS)_x. Refluxing 13.1 g. I and 7.4 g. THF 28 h. and distilling the mixture give δ-chlorobutyl α-chloroethanesulfenate, CH₂Cl(CH₂)₃OSCHClMe, b₁₂ 88°, decomposing to a red oil after a few days. Adding slowly CH₂N₂ [from 10 g. MeN(NO)CONH₂] to 8.5 g. I and distilling off the ether in vacuo give ClCH₂SCHClMe, b₁ 40°, mobile oil, decomposing on standing at 20°. Shaking 26 g. I 3 h. with 25 g. Hg and warming the decanted solution with fresh Hg 0.5 h. at 50° give (CH₂ClCH₂S)₂, yellow oil, b₉ 84°. Adding 15 g. I dropwise at 5° to 40 g. dry Me₂CO, warming the mixture 0.5 h. at 35°, and fractionating it give hexakis(α-chloroethylmercapto)acetone, b₂ 70°, which, heated 10 h. at 80°, polymerizes to a hard Cl-free resin. When equal parts of I and Me₂CO are mixed, heat and HCl are evolved; the mixture, heated 5 h. at 80° and fractionated, gives hexakis(ethylmercapto)acetone, light yellow oil, b₁₅ 53°. Mixing 12 g. PhAc and 13.1 g. I and distilling off the volatile parts in vacuo give a compound, MeCHClSCHBzSCHMeCHBzSCHClMe, which splits off HCl at 20°, completely after heating at 100°, giving a hard resin of the composition (C₂₂H₂₂O₂S₃)_x. Adding 13.1 g. I to 20 g. CH₂Ac₂ at below 30° and distilling the mixture give 3-(α-chloroethylmercapto)pentane-2,4-dione (V), b₁ 82°. Shaking 8 g. V with a small excess of 10% KOH 10 min. and adding 150 cc. H₂O give (3-vinylmercapto)pentane-2,4-dione, mobile oil, b_0.5 70°. Adding 39.3 g. I in 3 portions to 10 g. CH₂Ac₂, keeping the mixture several hrs., and distilling it give tris(α-chloroethylmercapto)pentane-2,4-dione, b₁₂ 104-7°. Similarly, equimolar amounts of I and AcCH₂CO₂Et give (as primary reaction product) Et α-(α’-chloroethylmercapto)acetoacetate (VI), which, heated 15 h. at 65°, gives Et α-(vinylmercapto)acetoacetate, yellow mobile oil, b₁₈ 115°. Adding 39.3 g. I slowly to 7.2 g. MeCOEt at 30° causes a strong evolution of HCl; the mixture is heated several hrs. at 100°, giving a Cl-free polymer, (C₂₀H₂₄OS₈)_x, as a nonthermoplastic black resin. Similarly, 39.3 g. I and 7 g. MeCOCH: CH₂ give MeCOCHClMe, b₂₈ 40°, and a resin which, heated 4 h. at 100°, gives a nonthermoplastic insoluble resin of the composition (C₁₄H₁₆OS₅)_x. Adding 6.5 g. I to 8 g. carbazole in 125 cc. warm xylene, heating the mixture 1.5 h. at 60°, and concentrating the filtered black solution in vacuo give (α-N-carbazolylethyl) (N-carbazolyl) sulfide, yellow crystals, m. 212° (decomposition), and a polymer which is obtained as the main product when 8 g. carbazole and 6.5 g. I are refluxed in 125 cc. xylene 2.5 h., the cooled solution is filtered, concentrated, filtered again, and evaporated, the residue extracted with CCl₄, and the residue of the CCl₄ extract heated 1 h. at 80°/12 mm. Adding dropwise 6.5 g. I in 15 cc. AcOH to 12.1 g. PhNMe₂ in 15 cc. AcOH, stirring the mixture 1 h. at 35°, adding 22.5 g. KOH in 200 cc. H₂O, extracting with ether, distilling off the PhNMe₂ from the residue of the dried ether extract, and recrystallizing the residue 3 times from EtOH give [α-(4-dimethylaminophenyl)ethyl] 4-dimethylaminophenyl sulfide, yellow needles, m. 125°. Adding in small portions with cooling 30 g. AlCl₃ to 13.1 g. I in 100 cc. C₆H₆, keeping the mixture overnight, distilling off about 50 cc. C₆H₆, pouring the residue into iced HCl, extracting with ether, and distilling the washed (NaOH) and dried organic solution at 30°/10 mm. leave Ph α-phenethyl sulfide, yellow crystals, m. 161°. Treating 11.4 g. CO(NHPh)₂ in 250 cc. CHCl₃ several hrs. with 13.1 g. I and distilling off the CHCl₃ give N,N’-diphenyl-N,N’-bis(α-chloroethylmercapto)thiourea-2HCl, m. 132°. Adding 13.1 g. I to 22.8 g. CO(NHPh)₂ in 120 cc. THF and distilling off the THF leave a viscous yellow soft resin which is heated 1 h. at 60°/12 mm. and has the composition (C₁₅H₁₆N₂Cl₂S₂)_x, soluble in CCl₄ and ether, and giving a clear solid film. Adding dropwise 13.1 g. I to 21.1 g. diphenylguanidine in 200 cc. CHCl₃ and distilling off the CHCl₃ give a polymer, (C₁₅H₁₇N₃Cl₂S)_x, as a tough thermoplastic film-forming red resin. Adding 13.1 g. I to 9.8 g. cyclohexanone in 50 cc. CCl₄ at below 40°, keeping the mixture 48 h. at 20°, and fractionating the solution give a colorless Cl-containing oil, b₈ 45°, which readily decompose, giving a Cl-containing dark red soft resin. When I and cyclohexanone are mixed without cooling, the mixture is heated 20 h. on a water bath, and the volatile portion is distilled off a red thermoplastic hard resin of the composition (C₈H₁₂OS)_x is obtained. Treating 9.4 g. PhOH in 50 cc. CHCl₃ with 13.1 g. I, distilling off the CHCl₃, and heating the residue 5 h. at 60° give a soft resin, containing 12.4% Cl, which after heating another 5 h. at 100° gives a Cl-free hard resin of the composition (C₈H₉OS)_x.

Chemische Berichte published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Product Details of C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Beattie, Karren D. published the artcileAntibacterial and antifungal screening of natural products sourced from Australian fungi and characterization of pestalactams D-F, Product Details of C8H7ClO3, the publication is Phytochemistry (Elsevier) (2016), 79-85, database is CAplus and MEDLINE.

Eighteen natural products sourced from Australian micro- or macro-fungi were screened for antibacterial and antifungal activity. This focused library was comprised of caprolactams, polyamines, quinones, and polyketides, with addnl. large-scale isolation studies undertaken in order to resupply previously identified compounds Chem. investigations of the re-fermented culture from the endophytic fungus Pestalotiopsis sp. yielded three caprolactam analogs, pestalactams D-F, along with larger quantities of the known metabolite pestalactam A, which was methylated using diazomethane to yield 4-O-methylpestalactam A. The chem. structures of the previously undescribed fungal metabolites were determined by anal. of 1D/2D NMR and MS data. The structure of 4-O-methylpestalactam A was confirmed following single crystal X-ray diffraction anal. The antibacterial and antifungal activity of all compounds was assessed, which identified three compounds, (1S,3R)-austrocortirubin, (1S,3S)-austrocortirubin, and 1-deoxyaustrocortirubin with mild activity (100 μM) against Gram-pos. isolates and one compound, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid, with activity against Cryptococcus neoformans and Cryptococcus gattii at 50 μM.

Phytochemistry (Elsevier) published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Spagnuolo, Lauren A. published the artcileEvaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors, Formula: C6H3ClFNO2, the publication is Journal of the American Chemical Society (2017), 139(9), 3417-3429, database is CAplus and MEDLINE.

A critical goal of lead compound selection and optimization is to maximize target engagement while minimizing off-target binding. Since target engagement is a function of both the thermodn. and kinetics of drug-target interactions, it follows that the structures of both the ground states and transition states on the binding reaction coordinate are needed to rationally modulate the lifetime of the drug-target complex. Previously, the authors predicted the structure of the rate-limiting transition state that controlled the time-dependent inhibition of the enoyl-ACP reductase InhA. This led to the discovery of a triazole-containing di-Ph ether with an increased residence time on InhA due to transition state destabilization rather than ground state stabilization. In the present work, the authors have evaluated the inhibition of InhA by 14 triazole-based di-Ph ethers and used a combination of enzyme kinetics and x-ray crystallog. to generate a structure-kinetic relationship (SKR) for time-dependent binding. The authors show that the triazole motif slows the rate of formation for the final drug-target complex by up to three orders of magnitude. In addition, the authors identify a novel inhibitor with a residence time on InhA of 220 min which is 3.5-fold longer than that of the INH-NAD adduct formed by the tuberculosis drug, isoniazid. This study provides a clear example in which the lifetime of the drug-target complex is controlled by interactions in the transition state for inhibitor binding rather than the ground state of the enzyme-inhibitor complex, and demonstrates the important role that on-rates can play in drug-target residence time.

Journal of the American Chemical Society published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C14H22O2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tehrani, Maliheh Barazandeh published the artcilePhthalimide-1,2,3-triazole hybrid compounds as tyrosinase inhibitors; synthesis, biological evaluation and molecular docking analysis, Computed Properties of 620-20-2, the publication is Journal of Molecular Structure (2019), 86-93, database is CAplus.

A novel series of phthalimide-1,2,3-triazole hybrids linked to benzyl ring containing different substituents were synthesized and evaluated for their tyrosinase inhibitory activity (inhibitory activity and inhibition kinetic). It was found that compounds 2-((1-(2-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methyl)isoindoline-1,3-dione (I) and 2-((1-(2-bromobenzyl)-1H-1,2,3-triazol-4-yl)methyl)isoindoline-1,3-dione (II), exhibited the best tyrosinase inhibitory activity, with IC₅₀ values of 26.20 ± 1.55 and 26.55 ± 2.31 μM, resp. The inhibition kinetic anal. of I indicated that the compound inhibited tyrosinase in a competitive manner. Moreover, mol. docking anal. was performed to study the interactions and binding modes of the tested compounds Docking results confirmed that the active inhibitors well accumulated in the mushroom tyrosinase active site.

Journal of Molecular Structure published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C10H14O2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albert, Anastasia published the artcileCharacteristics of Low-Temperature Plasma Ionization for Ambient Mass Spectrometry Compared to Electrospray Ionization and Atmospheric Pressure Chemical Ionization, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Analytical Chemistry (Washington, DC, United States) (2012), 84(24), 10657-10664, database is CAplus and MEDLINE.

Ambient desorption/ionization mass spectrometry (ADI-MS) is an attractive method for direct anal. with applications in homeland security, forensics, and human health. For example, low-temperature plasma probe (LTP) ionization was successfully used to detect, e.g., explosives, drugs, and pesticides directly on the target. Despite the fact that the field is gaining significant attention, few attempts were made to classify ambient ionization techniques based on their ionization characteristics and performance compared to conventional ionization sources used in mass spectrometry. Relative ionization efficiencies (RIEs) for a large group of compound families were determined with LTP-Orbitrap-MS and compared to those obtained with electrospray ionization mass spectrometry (ESI-MS) and atm. pressure chem. ionization mass spectrometry (APCI-MS). RIEs were normalized against 1 reference compound used across all methods to ensure comparability of the results. Typically, LTP analyte ionization through protonation/deprotonation (e.g., 4-acetamidophenol) was observed; in some cases (e.g., acenaphthene) radicals were formed. Amines, amides, and aldehydes were ionized successfully with LTP. A benefit of LTP over conventional methods is the possibility to successfully ionize PAHs and imides. The studied model compounds could be detected by neither APCI nor ESI. LTP is a relatively soft ionization method because little fragmentation of model compounds was observed It is considered to be an attractive method for the ionization of low mol. weight compounds over a relatively wide polarity range.

Analytical Chemistry (Washington, DC, United States) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vuorinen, Anna published the artcilePotential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2, Formula: C8H7ClO3, the publication is Journal of Natural Products (2017), 80(4), 965-974, database is CAplus and MEDLINE.

17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) converts the active steroid hormones estradiol, testosterone, and 5α-dihydrotestosterone into their weakly active forms estrone, Δ⁴-androstene-3,17-dione, and 5α-androstane-3,17-dione, resp., thereby regulating cell- and tissue-specific steroid action. As reduced levels of active steroids are associated with compromised bone health and onset of osteoporosis, 17β-HSD2 is considered a target for antiosteoporotic treatment. In this study, a pharmacophore model based on 17β-HSD2 inhibitors was applied to a virtual screening of various databases containing natural products in order to discover new lead structures from nature. In total, 36 hit mols. were selected for biol. evaluation. Of these compounds, 12 inhibited 17β-HSD2 with nanomolar to low micromolar IC₅₀ values. The most potent compounds, nordihydroguaiaretic acid (1), IC₅₀ 0.38 ± 0.04 μM, (-)-dihydroguaiaretic acid (4), IC₅₀ 0.94 ± 0.02 μM, isoliquiritigenin (6), IC₅₀ 0.36 ± 0.08 μM, and Et vanillate (12), IC₅₀ 1.28 ± 0.26 μM, showed 8-fold or higher selectivity over 17β-HSD1. As some of the identified compounds belong to the same structural class, structure-activity relationships were derived for these mols. Thus, this study describes new 17β-HSD2 inhibitors from nature and provides insights into the binding pocket of 17β-HSD2, offering a promising starting point for further research in this area.

Journal of Natural Products published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C42H63O3P, Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuan, Yunyun published the artcileDesign, Synthesis, and Biological Evaluation of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan Derivatives as Peripheral Selective μ Opioid Receptor Agents, Computed Properties of 6313-54-8, the publication is Journal of Medicinal Chemistry (2012), 55(22), 10118-10129, database is CAplus and MEDLINE.

Peripheral selective μ opioid receptor (MOR) antagonists could alleviate the symptoms of opioid-induced constipation (OIC) without compromising the analgesic effect of opioids. However, a variety of adverse effects were associated with them, partially due to their relatively low MOR selectivity. A 6β-N-4′-pyridyl substituted naltrexamine derivative, NAP, I (R = 4-pyridyl) was identified previously as a potent and highly selective MOR antagonist mainly acting within the peripheral nervous system. The noticeable diarrhea associated with it prompted the design and synthesis of its analogs in order to study its structure-activity relationship. Among them, compound I (R = 2-methyl-4-pyridyl) showed improved pharmacol. profiles compared to the original lead, acting mainly at peripheral while increasing the intestinal motility in morphine-pelleted mice (ED₅₀ = 0.03 mg/kg). The slight decrease of the ED₅₀ compared to the original lead was well compensated by the unobserved adverse effect. Hence, this compound seems to be a more promising lead to develop novel therapeutic agents toward OIC.

Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C12H12N2O, Computed Properties of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuan, Yunyun published the artcileStructure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists, Name: 2-Chloroisonicotinic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5625-5629, database is CAplus and MEDLINE.

Mu opioid receptor antagonists have been applied to target a variety of diseases clin. The current study is designed to explore the structure selectivity relationship (SSR) of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP), a lead compound identified as a selective mu opioid receptor antagonist based on the previous study. Among a series of NAP derivatives synthesized, compounds 6 (NMP) and 9 (NGP) maintained comparable binding affinity, selectivity and efficacy to the lead compound Particularly, the mu opioid receptor selectivity over kappa opioid receptor of NGP was considerably enhanced compared to that of NAP. Overall, the preliminary SSR supported our original hypothesis that an alternate address’ domain may exist in the mu opioid receptor, which favors the ligands carrying a hydrogen bond acceptor and an aromatic system to selectively recognize the mu opioid receptor.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C22H18O2, Name: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nafie, Mohamed S. published the artcileControl of ER-positive breast cancer by ERα expression inhibition, apoptosis induction, cell cycle arrest using semisynthetic isoeugenol derivatives, Product Details of C7H6Cl2, the publication is Chemico-Biological Interactions (2022), 109753, database is CAplus and MEDLINE.

New semi-synthetic effective and safe anticancer agents isoeugenol derivatives were synthesized, characterized, and screened for their cytotoxic activity against MCF-7. Moreover, their selective cytotoxicity was assessed against MCF-10A. Three derivatives, 2, 8 and 10 were significantly more active than the reference drug 5-FU with IC50 values of 6.59, 8.07 and 9.63 and 30.93 μM, resp. Also interestingly, these derivatives demonstrated some degree of selectivity to cancer cells over normal cells. Furthermore, derivative 2 was subjected to other in vitro experiments against MCF-7 where it inhibited colony formation by 87.5% and lowered ERα concentration to 395.7 pg/mL compared to 1129 pg/mL in untreated control cells. In continuation of the investigation, the apoptotic activity of compound 2, was assessed where it significantly enhanced total apoptotic cell death by 9.16-fold (18.70% compared to 1.64% for the untreated MCF-7 control cells) and arrested the cell cycle at the G2/M phase. Furthermore, the mol. mechanism of apoptotic activity was investigated at both the gene (RT-PCR) and protein (western plotting) levels where upregulation of pro-apoptotic and down regulation of anti-apoptotic genes was detected. Addnl., compound 2 treatment enhanced the antioxidant (GSH, CAT, SOD) activities. Finally, in vivo experiments verified the effective anticancer activity of compound 2 through inhibition of tumor proliferation by 47.6% compared to 22.9% for 5-FU and amelioration of the hematol., biochem., and histopathol. examinations near normal. In effect, compound 2 can be viewed as a promising semi-synthetic derivative of isoeugenol with some degree of selectivity for management of breast cancer through apoptotic induction and ERα downregulation.

Chemico-Biological Interactions published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Product Details of C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Duo published the artcileMethanesulfinylation of Benzyl Halides with Dimethyl Sulfoxide, Related Products of chlorides-buliding-blocks, the publication is Journal of Organic Chemistry (2020), 85(4), 2752-2758, database is CAplus and MEDLINE.

A phenyltrimethylammonium tribromide-mediated nucleophilic substitution/oxygen transformation reaction of benzyl halides with DMSO has been developed. In this transition-metal-free reaction, DMSO acts as not only a solvent but also a “S(O)Me” source, thus providing a convenient method for the efficient and direct synthesis of various benzyl Me sulfoxides.

Journal of Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics