Tag: M.W=150-200

Pedroso, Enrique published the artcileSolid-phase synthesis of circular oligonucleotides, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Methods in Molecular Biology (Totowa, NJ, United States) (2005), 101-125, database is CAplus and MEDLINE.

A protocol for the straightforward preparation of small circular oligodeoxyribonucleotides (2-28 nt) is reported. The assembly of the oligonucleotide chain (standard phosphoramidite chem.) and cyclization by the phosphotriester method take place on a tailor-made nucleotide-derivatized solid support. Although cyclization yields are moderate, the procedure exploits a synthesis design that allows selective cleavage of the circular oligonucleotide from the support, which facilitates isolation of the target mol. by simple filtration.

Methods in Molecular Biology (Totowa, NJ, United States) published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Farrera-Sinfreu, Josep published the artcileSolid-Phase Combinatorial Synthesis of a Lysyl-tRNA Synthetase (LysRS) Inhibitory Library, SDS of cas: 33697-81-3, the publication is Journal of Combinatorial Chemistry (2008), 10(3), 391-400, database is CAplus and MEDLINE.

The solid-phase combinatorial synthesis of a new library with potential inhibitory activity against the cytoplasmic lysyl-tRNA synthetase (LysRS) isoform of Trypanosoma brucei is described. The library has been specifically designed to mimic the lysyl adenylate complex. The design was carried out by dividing the complex into four modular parts. Proline derivatives (cis-γ-amino-L-proline or trans-γ-hydroxy-L-proline) were chosen as central scaffolds. After primary screening, three compounds of the library caused in vitro inhibition of the tRNA aminoacylation reaction in the low micromolar range.

Journal of Combinatorial Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Khalaf, Juhienah published the artcileDesign, Synthesis, and Diversification of 3,5-Substituted Enone Library, SDS of cas: 209919-30-2, the publication is ACS Combinatorial Science (2011), 13(4), 351-356, database is CAplus and MEDLINE.

This paper describes the synthesis of a 300 member library of 3,5-substituted enones, e.g., I. The synthesis starts with six different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a variety of aromatic and vinyl boronic acids. Addnl. a small series of triazoles, e.g., II, were synthesized by a Sonogashira coupling reaction dipolar cycloaddition sequence. The library was analyzed by principal component anal. to examine its diversity.

ACS Combinatorial Science published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, SDS of cas: 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thomas, James B. published the artcileIdentification of an Opioid κ Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)piperidine, Formula: C8H7ClO3, the publication is Journal of Medicinal Chemistry (1998), 41(26), 5188-5197, database is CAplus and MEDLINE.

A three-component library of compounds was prepared in parallel using multiple simultaneous solution-phase synthetic methodol. The compounds were biased toward opioid receptor antagonist activity by incorporating (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine (a potent, nonselective opioid pure antagonist) as one of the monomers. The other two monomers were N-substituted or unsubstituted Boc-protected amino acids and a range of substituted aryl carboxylic acids and were selected to add chem. diversity. Screening of these compounds in competitive binding experiments with the κ opioid receptor selective ligand [³H]U69,593 led to the discovery of a novel κ opioid receptor selective ligand, RTI-5989-29 (I). Addnl. structure-activity relationship studies suggested that I possesses lipophilic and hydrogen-bonding sites that are important to its opioid receptor potency and selectivity. These sites appear to exist predominantly within the κ receptor since the selectivity arises from a 530-fold loss of affinity of I for the μ receptor and an 18-fold increase in affinity for the κ receptor relative to the μ-selective ligand, (+)-N-[trans-4-phenyl-2-butenyl]-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine. The degree of selectivity observed in the radioligand binding experiments was not observed in the functional assay. According to its ability to inhibit agonist stimulated binding of [³⁵S]GTPγS at all three opioid receptors, I behaves as a μ/κ opioid receptor pure antagonist with negligible affinity for the δ receptor.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C17H37NO3, Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Donovan, William H. published the artcileUsing theoretical descriptions in structure activity relationships: retention indexes of sulfur vesicants and related compounds, Name: 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1996), 83-9, database is CAplus.

The authors have conducted a theor. linear solvation energy relation (TLSER) investigation of gas chromatog. (GC) retention indexes for a series of 37 organosulfur compounds on three different columns, deriving regression equations based on descriptors obtained using the MNDO, AM1 and PM3 Hamiltonians. In all cases, satisfactory regressions based on two or three descriptors results, with mol. volume being the most important descriptor. The results are qual. similar to those of Woloszyn and Jurs who, considering the same sulfur vesicant GC retention data set, applied an objective feature selection procedure to winnow descriptors from an initial set of 100, but were not able to treat any compounds containing sulfur-sulfur bonds. The approach was free of this restriction, allowing for consideration of all 37 compounds Only relatively small differences were obtained in the statistical quality of the regressions derived from the three Hamiltonians considered, and among the three GC columns.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Name: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jitan published the artcilePalladium-catalyzed Atroposelective Interannular C-H Arylation of Biaryl Aldehydes with Aryl Iodides Enabled by a Transient Directing Group Strategy, Application of 4-Chloro-2-methylphenylboronic acid, the publication is Advanced Synthesis & Catalysis (2022), 364(20), 3589-3599, database is CAplus.

A concise synthesis of axially chiral biaryl aldehydes through Pd/amino acid-catalyzed atroposelective interannular C-H arylation of biaryl aldehydes with aryl iodides is developed. This reaction proceeds smoothly involving excellent enantiocontrol and accomplishes with good tolerance of functional groups. Moreover, the readily accessible scale-up synthesis and further transformation of products has highlighted the potential utility of this asym. catalytic protocol.

Advanced Synthesis & Catalysis published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C20H17FO4S, Application of 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Dunqi published the artcileCopper-Catalyzed Enantioselective Radical Chlorination of Alkenes, Recommanded Product: 2-Chloro-4-methylphenylboronic acid, the publication is ACS Catalysis (2022), 12(9), 5284-5291, database is CAplus.

In this report, authors reviewed a copper-catalyzed asym. atom transfer radical addition (ATRA) reaction, which remains a great challenge since the discovery of racemic ATRA in the 1940s. This enantioselective radical chlorination of acrylamides was developed, where three reagents, including Togni-I and TMSCl, PhICF₃Cl, and CX₃SO₂Cl, were employed as the radical sources and chlorine source, affording a series of chlorinated carbon-centered quaternary compounds in good yields with excellent enantioselectivity. Notably, the well-designed bulky chiral ligand plays a key role in the successful enantioselective radical chlorination process.

ACS Catalysis published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H7IN2O, Recommanded Product: 2-Chloro-4-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Jian-Fang published the artcileCocrystal of {Ti₄} and {Ti₆} Clusters with Enhanced Photochemical Properties, Application In Synthesis of 6313-54-8, the publication is Inorganic Chemistry (2017), 56(5), 2367-2370, database is CAplus and MEDLINE.

A supramol. cocrystal {Ti₄ + Ti₆} has been prepared through the combination of isolated {Ti₄} and {Ti₆} clusters. The combined {Ti₄ + Ti₆} complex displayed better solar-driven photocatalytic dye degradation activity than the individual {Ti₄} and {Ti₆} compounds

Inorganic Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H13NO2, Application In Synthesis of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Z. L. published the artcileSynthesis and antitumor evaluation of 5-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(tert-butyl)-N-arylthiazol-2-amines, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is MedChemComm (2016), 7(9), 1768-1774, database is CAplus.

A series of novel N-aryl-5-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(tert-butyl)thiazol-2-amines (C1-C31) were synthesized and evaluated for their antitumor activities against HeLa, A549 and MCF-7 cell lines. Some tested compounds showed potent growth inhibition properties with IC₅₀ values generally below 5 μM against the three human cancer cells lines. Compound C27 showed potent activities against HeLa and A549 cell lines with IC₅₀ values of 2.07 ± 0.88 μM and 3.52 ± 0.49 μM, resp. Compound C7 (IC₅₀ = 2.06 ± 0.09 μM) was the most active compound against A549 cell line, while compound C16 (IC₅₀ = 2.55 ± 0.34 μM) showed the best inhibitory activity against the MCF-7 cell line. The preliminary mechanism of the inhibitory effect was investigated via further experiments, such as morphol. anal. by dual AO/EB staining and Hoechst 33342 staining, and cell apoptosis and cycle assessment by FACS anal. The results illustrated that compound C27 could induce apoptosis and cause both S-phase and G2/M-phase arrests in HeLa cell line. Therefore, compound C27 could be developed as a potential antitumor agent.

MedChemComm published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is 0, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Donzel, Maxime published the artcileBioinspired Photoredox Benzylation of Quinones, SDS of cas: 939-99-1, the publication is Journal of Organic Chemistry (2021), 86(15), 10055-10066, database is CAplus and MEDLINE.

3-Benzylmenadiones were obtained in good yield by using a blue-light-induced photoredox process in the presence of Fe(III), oxygen, and γ-terpinene acting as a hydrogen-atom transfer agent. This methodol. is compatible with a wide variety of diversely substituted 1,4-naphthoquinones as well as various cheap, readily available benzyl bromides with excellent functional group tolerance. The benzylation mechanism was investigated and supports a three-step radical cascade with the key involvement of the photogenerated superoxide anion radical.

Journal of Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics