Tag: M.W=150-200

Chen, Chao published the artcileUse of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes, Formula: C6H3ClFNO2, the publication is Biochemistry (2018), 57(5), 817-826, database is CAplus and MEDLINE.

Human hepatic cytochromes P 450 (CYP) are integral to xenobiotic metabolism CYP2B6 is a major catalyst of biotransformation of environmental toxicants including polybrominated di-Ph ethers (PBDEs). CYP2B substrates tend to contain halogen atoms, but the biochem. basis for this selectivity and for species specific determinants of metabolism has not been identified. Spectral binding titrations and inhibition studies were performed to investigate interactions of rat CYP2B1, rabbit CYP2B4, and CYP2B6 with a series of phenoxyaniline (POA) congeners that are analogs of PBDEs. For most congeners, there was less than 3-fold difference between the spectral binding constants (K_S) and IC₅₀ values. In contrast, large discrepancies between these values were observed for POA and 3-chloro-4-phenoxyaniline. CYP2B1 was the most sensitive enzyme to POA congeners, so the Val-363 residue from that enzyme was introduced into CYP2B4 or CYP2B6. This substitution partially altered the protein-ligand interaction profiles to make them more similar to that of CYP2B1. Addition of cytochrome P 450 oxidoreductase (POR) to titrations of CYP2B6 with POA or 2’4’5’TCPOA decreased the affinity of both ligands for the enzyme. Addition of cytochrome b₅ (cyt b₅) to a recombinant enzyme system containing POR and CYP2B6 increased the POA IC₅₀ value and decreased the 2’4’5’TCPOA IC₅₀ value. Overall, the inconsistency between K_S and IC₅₀ values for POA vs. 2’4’5’TCPOA is largely due to the effects of redox partner binding. These results provide insight into the biochem. basis of di-Ph ether binding to human CYP2B6 and changes in CYP2B6 mediated metabolism dependent on POA congener and redox partner identity.

Biochemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zeng, Jing published the artcileSelective Co/Ti Cooperatively Catalyzed Biaryl Couplings of Aryl Halides with Aryl Metal Reagents, HPLC of Formula: 6313-54-8, the publication is Organic Letters (2013), 15(20), 5342-5345, database is CAplus and MEDLINE.

Various aryl bromides or chlorides, including those bearing a free COOH, OH, CONHR, and SO₂NHR group, coupled with aryl magnesium or lithium reagents in the presence of 7.5 mol% CoCl₂/15 mol% PBu₃ and substoichiometric Ti(OEt)₄ (40 mol% to ArM) at room temperature in high yields with high chemo- and regioselectivity. This simple reaction represents the first example of Co/Ti cooperative catalysis which plays a key role in suppressing undesired homocouplings.

Organic Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Zhi-You published the artcileA microwave-assisted approach to N-(2-nitrophenyl)benzenesulfonamides that enhanced peroxidase activity in response to excess cadmium, HPLC of Formula: 350-30-1, the publication is Tetrahedron Letters (2019), 60(8), 626-629, database is CAplus.

A facile and efficient approach to N-(2-nitrophenyl) benzenesulfonamides was developed under microwave irradiation A series of pyrabactin analogs containing nitrophenyl scaffold was obtained in excellent yields. In addition, the method was pretty suitable to prepare flusulfamide. Significantly, the 4-bromo-N-(4-chloro-2-nitrophenyl)benzenesulfonamide could enhance POD activity in response to heavy metal stress.

Tetrahedron Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, HPLC of Formula: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cheng, Wei-Chieh published the artcileA combinatorial approach towards the synthesis of non-hydrolyzable triazole-iduronic acid hybrid inhibitors of human α-L-iduronidase: discovery of enzyme stabilizers for the potential treatment of MPS-I, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(21), 2647-2650, database is CAplus and MEDLINE.

Preparation of substituent-diverse, triazole-iduronic acid hybrid mols. by click reaction of an azido iduronic acid derivative with randomly chosen alkynes is described. Library members were screened for their ability to inhibit α-L-iduronidase, and hit mols. and analogs were then investigated for their ability to stabilize rh-α-IDUA in a thermal denaturation study. This work resulted in the discovery of the first small mols. that can be used to stabilize exogenous rh-α-IDUA protein in vitro and for the potential treatment of mucopolysaccharidosis type I (MPS I).

Chemical Communications (Cambridge, United Kingdom) published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Zhihua published the artcileDiscovery of the imidazole-derived GPR40 agonist AM-3189, COA of Formula: C7H8BClO2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(1), 15-20, database is CAplus and MEDLINE.

As a follow-up to the GPR40 agonist AMG 837, which was evaluated in clin. trials for the treatment of type II diabetes, further optimization led to the discovery of AM-3189 I. I is representative of a new class of compounds with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837.

Bioorganic & Medicinal Chemistry Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, COA of Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cai, Liangzhen published the artcileSynthesis of diarylaminofluorenes through tandem copper and palladium catalyzed coupling-cyclizing reactions, SDS of cas: 145349-62-8, the publication is Youji Huaxue (2015), 35(8), 1682-1690, database is CAplus.

A convenient method of tandem copper and palladium catalyzed coupling-cyclizing reactions was developed for the preparation of diarylaminofluorenes, I, II(R¹ = H, Me, R² = H, Me) . Methylbromotriphenylamines prepared by the copper-catalyzed reaction of substituted iodobenzenes and methylbromoanilines, coupled with chlorophenylboronic acid under palladium catalyst to obtain the chlorophenylmethyltriphenylamines (V). A series of diarylaminofluorenes could be generated in good yields through palladium-catalyzed activation of benzylic C(sp³)-H bond of compound V. It was found that the 2-diarylaminofluorenes or 3-diarylaminofluorenes could be efficiently gotten. These compounds were characterized by¹H NMR, ¹³C NMR, HRMS, IR and UV-vis.

Youji Huaxue published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, SDS of cas: 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Er-dong published the artcile2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is European Journal of Medicinal Chemistry (2019), 36-47, database is CAplus and MEDLINE.

A series of novel 2,4-disubstituted quinazolines I [R = hexyl, cyclopentyl, Ph, etc.] were synthesized and evaluated for their anti-tumor activity against five human cancer cells (MDA-MB-231, MCF-7, PC-3, HGC-27 and MGC-803) using MTT assay. Among them, compound I [R = 4-F₃CC₆H₄] showed the most potent cytotoxicity against breast cancer cells. Compound I [R = 4-F₃CC₆H₄] also significantly inhibited the colony formation and migration of MDA-MB-231 and MCF-7 cells. Meanwhile, compound I [R = 4-F₃CC₆H₄] induced cell cycle arrest at G1 phase and cell apoptosis, as well as increased accumulation of intracellular ROS. Furthermore, compound I [R = 4-F₃CC₆H₄] exerted antitumor effects in-vitro via decreasing the expression of anti-apoptotic protein Bcl-2 and increasing the pro-apoptotic protein Bax and p53. Mechanistically, compound I [R = 4-F₃CC₆H₄] markedly decreased p-EGFR and p-PI3K expression, which revealed that compound I [R = 4-F₃CC₆H₄] targeted breast cancer cells via interfering with EGFR-PI3K signaling pathway. Mol. docking suggested that compound I [R = 4-F₃CC₆H₄] could indeed bind into the active pocket of EGFR. All the findings suggest that compound I [R = 4-F₃CC₆H₄] might be a valuable lead compound for antitumor agents targeting breast cancer cells.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Diao, Peng-Cheng published the artcileDiscovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity, Formula: C7H7ClN2S, the publication is European Journal of Medicinal Chemistry (2019), 196-207, database is CAplus and MEDLINE.

To develop novel CDK2 inhibitors as anticancer agents, a series of novel pyrimidine-based benzothiazole derivatives I (R = 4-(S(O)₂NH₂), 4-(piperidin-1-yl), 3-F, etc.) and II (R¹ = H, F, Cl, Me, MeO; R² = H, Me, F; R³ = Me, NH₂) was designed and synthesized. Initial biol. evaluation demonstrated that some of target compounds displayed potent antitumor activity in vitro against five cancer cell lines. Especially, the analog II (R¹ = F; R² = H; R³ = NH₂) exhibited approx. potency with AZD5438 toward four cells including HeLa, HCT116, PC-3, and MDA-MB-231 with IC₅₀ values of 0.45, 0.70, 0.92, 1.80 μM, resp. More interestingly, the most highly active compound II (R¹ = F; R² = H; R³ = NH₂) in this study also possessed promising CDK2/cyclin A2 inhibitory activities with IC₅₀ values of 15.4 nM, which was almost 3-fold potent than pos. control AZD5438, and mol. docking studies revealed that the analog bound efficiently with the CDK2 binding site. Further studies indicated that compound II (R¹ = F; R² = H; R³ = NH₂) could induce cell cycle arrest and apoptosis in a concentration-dependent manner. These observations suggest that pyrimidine-benzothiazole hybrids represent a new class of CDK2 inhibitors and well worth further investigation aiming to generate potential anticancer agents.

European Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Weitao published the artcileSynthesis of Multisubstituted Allylic Alcohols via a Nickel-Catalyzed Cross-Electrophile Ring-Opening Reaction, SDS of cas: 620-20-2, the publication is Organic Letters (2022), 24(31), 5751-5755, database is CAplus and MEDLINE.

Herein, a nickel-catalyzed cross-electrophile ring-opening reaction of vinyl epoxides I (R¹ = Ph, 1-naphthyl, benzodioxol-5-yl, etc.; R² = H, Me, phenyl; R³ = H, Ph, furan-2-yl, thiophen-2-yl) was reported, wherein aryl iodides, alkyl iodides, and benzyl chlorides R⁴X (R⁴ = Pr, cyclohexyl, phenyl; X = I, Cl) can all serve as the electrophilic coupling partners, providing a new approach to preparing multisubstituted allylic alcs. R¹C(CH(OH)R³)=C(R²)CH₂R⁴. This new method features broad substrate scope multisubstituted allylic alcs., good step-economy, and high L/B- and E/Z selectivity as well as mild reaction conditions.

Organic Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yonghong published the artcileSodium Selenosulfate from Sodium Sulfite and Selenium Powder: An Odorless Selenylating Reagent for Alkyl Halides to Produce Dialkyl Diselenide Catalysts, Safety of 3-Chlorobenzylchloride, the publication is Synlett (2019), 30(14), 1698-1702, database is CAplus.

Na₂SeSO₃, which can be generated in situ by the reaction of Na₂SO₃ with Se power, was found to be an odorless reagent for the selenenylation of alkyl halides RX (R = Bu, cyclohexyl, 3-fluorobenzyl, etc.; X = Cl, Br) to produce dialkyl diselenides RSeSeR. By using aqueous EtOH as the solvent and avoiding the generation of a malodorous selenol intermediate, the selenylation reaction with Na₂SeSO₃ is much more environmentally friendly than conventional methods. Owing to the cheap and abundant starting materials and selenium reagents, the novel synthetic method reduces the production costs of dialkyl diselenides as organoselenium catalysts, thereby advancing practical applications of organoselenium-catalysis technologies.

Synlett published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics