Tag: M.W=150-200

Hu, Xiaojun; Zhou, Bingwei; Jin, Hongwei; Liu, Yunkui; Zhang, Liming published the artcile< Bifunctional phosphine ligand-enabled gold-catalyzed direct cycloisomerization of alkynyl ketones to 2,5-disubstituted furans>, COA of Formula: C9H7ClO, the main research area is disubstituted furan preparation phosphinyl gold catalyst; alkynyl ketone cycloisomerization.

An efficient synthesis of 2,5-disubstituted furans I (R1 = H, 4-Me, 4-F, etc.; R2 = Pr, C6H5, Bn, etc.) directly from alkynyl ketones has been developed via tandem gold(I)-catalyzed isomerization of alkynyl ketones to allenyl ketones and cycloisomerization. The key to the success of this chem. is the use of a biphenyl-2-ylphosphine ligand featuring a critical remote tertiary amino group.

Chemical Communications (Cambridge, United Kingdom) published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carrillo-Arcos, Ulises A.; Rojas-Ocampo, Jonathan; Porcel, Susana published the artcile< Oxidative cyclization of alkenoic acids promoted by AgOAc>, Computed Properties of 22717-55-1, the main research area is benzodioxinone preparation; oxidative cyclization alkenoic acid silver acetate.

Alkenoic acids derived from salicylic acid and analogs undergo an unexpected oxidative cyclization process triggered by AgOAc leading to 4H-benzo[d][1,3]dioxin-4-ones. The process is affected by the substitution on the aryl and the allyl units.

Dalton Transactions published new progress about Carboxylic acids, unsaturated Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ji, Shunli; Gao, Hongbin; Xia, Xingya; Zheng, Feng published the artcile< A new HPLC-UV derivatization approach for the determination of potential genotoxic benzyl halides in drug substances>, Related Products of 611-19-8, the main research area is benzyl halide antipyrine oroxylin A genotoxicity HPLCUV derivatization method.

Benzyl halides, widely used as alkylation reagents in drug synthesis, are potential genotoxic impurities (PGTIs) required to be controlled at trace levels. However, the existing anal. methods for benzyl halides often suffer from matrix interferences or low derivatization efficiency of benzyl chlorides. In this paper, a simple derivatization HPLC-UV method was developed for the anal. of these residual trace benzyl halides in drug substances. 1-(4-Nitrophenyl) piperazine (4-NPP) was selected as a new derivatization reagent because it shifted well the benzyl halides derivatives away to the near visible range (392 nm), which could minimize the matrix interferences from the drug substances and related impurities. Meanwhile, potassium iodide (KI) was used to convert the mixed benzyl halides into benzyl iodides before derivatization. The derivatization parameters were also optimized using the design of experiments (DoE) for achieving the best reaction efficiency. The results showed that the new approach had high specificity and sensitivity, and the LOQs were 7-9 μg g-1 relative to 5 mg mL-1 antipyrine and 17.5-22.5 μg g-1 relative to 2 mg mL-1 oroxylin A. The method is a valuable alternative for the determination of residual benzyl halides in the drug substances.

RSC Advances published new progress about Benzyl halides Role: ANT (Analyte), ANST (Analytical Study). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Related Products of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gao, Changlu; Zhang, Suobo; Gao, Lianxun; Ding, Mengxian published the artcile< Microwave-assisted synthesis of high-molecular-weight poly(ether imide)s by phase-transfer catalysis>, Synthetic Route of 118-45-6, the main research area is polyether polyimide polycondensation phase transfer catalysis polymerization microwave.

A facile and rapid polycondensation reaction of disodium bisphenol A with bis(chlorophthalimide)s was preformed with a domestic microwave oven in o-dichlorobenzene by phase-transfer catalysis. The polymerization reactions, in comparison with conventional heating polycondensation, proceeded rapidly and were completed within 25 min. The polymerizations gave the corresponding poly(ether imide)s with inherent viscosities of 0.55-0.92 dL g-1. The effects of various factors on the polymerization, such as the amount of the catalyst, the reaction time, and the microwave power were studied. The properties of the polymers were briefly characterized.

Journal of Applied Polymer Science published new progress about Glass transition temperature. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Synthetic Route of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yamaguchi, Miyuki; Katsumata, Haruka; Manabe, Kei published the artcile< One-Pot Synthesis of Substituted Benzo[b]furans from Mono- and Dichlorophenols Using Palladium Catalysts Bearing Dihydroxyterphenylphosphine>, Application of C8H7ClO3, the main research area is Sonogashira Suzuki Miyaura coupling chlorophenol alkyne boronic acid; palladium dihydroxyterphenylphosphine XPhos catalyst benzofuran preparation.

A dihydroxyterphenylphosphine bearing cyclohexyl groups on the phosphorus atom (I, Cy-DHTP) was found to be a powerful ligand for the palladium-catalyzed one-pot synthesis of substituted benzo[b]furans from 2-chlorophenols and terminal alkynes. E.g., in presence of PdCl2(MeCN)2, I, and LiOCMe3, Sonogashira cross-coupling of 2-chlorophenol and PhCH2CH2CCH gave 82% benzo[b]furan derivative (II). This catalyst system was also applicable to the sequential one-pot synthesis of disubstituted benzo[b]furans from dichlorophenols via the Suzuki-Miyaura cross-coupling of chlorobenzo[b]furan with boronic acids. The use of two ligands, I and XPhos, is the key to promoting the reactions. Mechanistic studies suggest that the Pd-Cy-DHTP catalyst is the active species in the Sonogashira cross-coupling step, while the Pd-XPhos catalyst accelerates the Suzuki-Miyaura cross-coupling step.

Journal of Organic Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application of C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Williams, F. J.; Donahue, P. E. published the artcile< Reaction of thiophenoxides with nitro- and halo-substituted phthalic anhydrides>, Quality Control of 118-45-6, the main research area is phthalic anhydride nitro halo substitution; substitution nitrophthalic anhydride; thiophenol substitution nitrophthalic anhydride.

A wide variety of thioether-substituted phthalic anhydride derivatives e.g. I (R = H, Me, Cl, OH) and II (R = H, Me, Cl, MeO) were synthesized from the reaction of thiophenoxides with nitro- or halosubstituted phthalic anhydrides. These reactions were carried out at room temperature and gave no indication of attack by the S nucleophile at the carbonyl groups of the anhydride. This is in direct contrast with the room-temperature reactions of phthalic anhydride with phenoxide nucleophiles, in which the nucleophile attacks only the carbonyl groups. The reaction involving the S nucleophile works well using either preformed salts of the thiophenols or by generating the nucleophile in situ with amine or inorganic salts used as bases. The choice of the base system determines the speed of the reaction, which can vary from <5 min to 3 h at 25 C. The halo derivatives are preferred over the nitro derivatives to minimize side reactions. Journal of Organic Chemistry published new progress about Cyclocondensation reaction, intramolecular. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Quality Control of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xiao, Peihong; Tang, Zhixing; Wang, Kai; Chen, Hua; Guo, Qianyou; Chu, Yang; Gao, Lu; Song, Zhenlei published the artcile< Chemoselective Reduction of Sterically Demanding N,N-Diisopropylamides to Aldehydes>, COA of Formula: C8H7ClO2, the main research area is aldehyde preparation sterically demanding diisopropylamide chemoselective reduction.

A sequential one-pot process for chemoselectively reducing sterically demanding N,N-diisopropylamides to aldehydes has been developed. In this reaction, amides are activated with EtOTf to form imidates, which are reduced with LiAlH(OR)3 [R = t-Bu, Et] to give aldehydes by hydrolysis of the resulting hemiaminals. The non-nucleophilic base 2,6-DTBMP remarkably improves reaction efficiency. The combination of EtOTf/2,6-DTBMP and LiAlH(O-t-Bu)3 was found to be optimal for reducing alkyl, alkenyl, alkynyl, and 2-monosubstituted aryl N,N-diisopropylamides. In contrast, EtOTf and LiAlH(OEt)3 in the absence of base were found to be optimal for reducing extremely sterically demanding 2,6-disubstituted N,N-diisopropylbenzamides. The reaction tolerates various reducible functional groups, including aldehyde and ketone. 1H NMR studies confirmed the formation of imidates stable in water. The synthetic usefulness of this methodol. was demonstrated with N,N-diisopropylamide-directed ortho-metalation and C-H bond activation.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, COA of Formula: C8H7ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Im, Jeong Kyun; Jeong, Ilju; Yang, ByeongDo; Moon, Hyeon; Choi, Jun-Ho; Chung, Won-jin published the artcile< N-Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism>, Application of C8H3ClO3, the main research area is dimethoxyphthalazine trichloroisocyanuricacid ring contraction bicyclization; phthalimide preparation.

An unprecedented N-chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic anal., the assisting role of n-Bu4NCl as an exogenous nucleophile was identified and the optimized reaction conditions were applied to a range of 1,4-dimethoxyphthalazine derivatives Also, an improvement of overall efficiency was demonstrated by the use of a labile O-silyl group. A bicyclization/ring-opening mechanism inspired by the Favorskii rearrangement was proposed and supported by the DFT calculations Furthermore, the efforts on scope expansion as well as the evaluation of other electrophilic promoters revealed that the newly developed ring contraction reactivity was a unique characteristic of 1,4-dimethoxyphthalazine scaffold and TCICA.

Synthesis published new progress about Chlorination. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liou, Yan-Cheng; Karanam, Praneeth; Jang, Yeong-Jiunn; Lin, Wenwei published the artcile< Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/O-Acylation/Wittig Pathway>, Application In Synthesis of 17082-09-6, the main research area is benzofuran preparation para quinone methide reactant; one pot phospha addition acylation Wittig reaction.

An efficient synthesis of functionalized benzofurans is achieved under mild and metal-free conditions from stable para-quinone methides by treatment with phosphine, acyl chloride, and a base. This one-pot phospha-1,6-addition/O-acylation/Wittig reaction is also demonstrated under catalytic conditions with similar efficacy.

Organic Letters published new progress about Acylation. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Venkatesan, Aranapakam M.; Dos Santos, O.; Ellingboe, John; Evrard, Deborah A.; Harrison, Boyd L.; Smith, Deborah L.; Scerni, Rosemary; Hornby, Geoffrey A.; Schechter, Lee E.; Andree, Terrence H. published the artcile< Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity>, HPLC of Formula: 22717-55-1, the main research area is serotonin antagonist SERT reuptake inhibitor depression antidepressant; indole benzofuran derivative SAR preparation.

Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT1A receptor affinities. Their design, synthesis and structure-activity relationships are described.

Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, HPLC of Formula: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics