Tag: M.W=150-200

Ali, Eslam M. H.; El-Telbany, Rania Farag A.; Abdel-Maksoud, Mohammed S.; Ammar, Usama M.; Mersal, Karim I.; Zaraei, Seyed-Omar; El-Gamal, Mohammed I.; Choi, Se-In; Lee, Kyung-Tae; Kim, Hee-Kwon; Lee, Kwan Hyi; Oh, Chang-Hyun published the artcile< Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors>, Quality Control of 85740-98-3, the main research area is imidazolyl pyrimidine preparation BRAFV600E p38alpha inhibitor antitumor mol docking; BRAF(V600E); Imidazol-5-ylpyrimidine; MAPK14; Melanoma; Molecular docking; TNF-α.

In the present work, a new series of (imidazol-5-yl)pyrimidine I ( Ar = C6H5, 4-ClC6H4, 4-BrC6H4 etc.; X = F, Cl; R = OCH3, OH) was designed and synthesized as dual inhibitors of BRAFV600E and p38α kinases which are considered as key regulators in mitogen-activated protein kinase signalling pathway. The target compounds were evaluated for dual kinase inhibitory activity. The tested compounds exhibited nanomolar scale IC50 values against BRAFV600E and low to sub-micromolar IC50 range against p38α. Compound I (Ar = 4-OHC6H4; X = F; R = OH) was identified as the most potent dual BRAFV600E/p38α inhibitor with IC50 values of 2.49 and 85 nM, resp. Further deep investigation revealed that Compound I (Ar = 4-OHC6H5; X = F; R = OH) possesses inhibitory activity of TNF-α production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 value of 96.3 nM. Addnl., the target compounds efficiently frustrated the proliferation of LOX-IMVI melanoma cell line. Compound I (Ar = 4-OHC6H5; X = F; R = OH) showed a satisfactory antiproliferative activity with IC50 value of 13μM, while, compound I (Ar = 3-FC6H4; X = F; R = OCH3) exhibited the highest cytotoxicity potency with IC50 value of 0.9μM. Compound I (Ar = 3-FC6H4; X = F; R = OCH3) is 11.11-fold more selective toward LOX-IMVI melanoma cells than IOSE-80PC normal cells.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 85740-98-3 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Quality Control of 85740-98-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Barluenga, Jose; Jimenez-Aquino, Agustin; Aznar, Fernando; Valdes, Carlos published the artcile< Modular Synthesis of Indoles from Imines and o-Dihaloarenes or o-Chlorosulfonates by a Pd-Catalyzed Cascade Process>, Application In Synthesis of 35852-58-5, the main research area is palladium catalyst regioselective synthesis indole; imine preparation reaction dihaloarene halobenzenesulfonate.

A detailed study of the scope of a new Pd-catalyzed synthesis of indoles from 1,2-dihaloarenes and o-halobenzene sulfonates and imines is described. The cascade reaction comprises an imine α-arylation followed by an intramol. C-N bond-forming reaction promoted by the same Pd catalyst. The reaction with 1,2-dibromobenzene shows wide scope and allows the introduction of aryl, alkyl, and vinyl substituents at different positions of the five-membered ring of the indole. The regioselective synthesis of indoles substituted in the six-membered ring can be carried out by employing o-dihalobenzene derivatives with two different halogens, taking advantage of the different reactivities of I, Br, and Cl in oxidative addition reactions. This paper also introduces a method for the efficient cleavage of the N-t-Bu group, thus allowing for the preparation of N-H indoles through the same methodol. Finally, the reaction with o-halosulfonates has been studied. The best substrates are o-chlorononaflates, which lead to indoles in very high yield. The reaction is particularly appropriate for the synthesis of the challenging 6-substituted indoles. In view of the availability of o-chlorophenols, which are direct precursors of the chlorononaflates, this reaction represents an efficient entry into indoles substituted in the six-membered ring. The concept is illustrated by the preparation of a 4,6-disubstituted indole from naturally occurring anethole.

Journal of the American Chemical Society published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Application In Synthesis of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dashan, Irem; Balta, Demet Karaca; Temel, Binnur Aydogan; Temel, Gokhan published the artcile< Preparation of Single Chain Nanoparticles via Photoinduced Double Collapse Process>, Application In Synthesis of 1592-20-7, the main research area is chain nanoparticle photoinduced collapse.

A straightforward method is described to achieve polymeric nanoparticles by double folding of single linear chains. The side chain functional polystyrene with controlled mol. weight is converted to pendant azide and benzophenone motifs via postmodification reactions. Resulting functionalized chains undergo intramol. crosslinking upon UV illumination using simultaneous and subsequent pathways at a dilute concentration Particle size of nanoparticles can be tuned by changing the degree of crosslinking using a second folding process. Obtained single and double collapsed chains indicate higher glass transition temperatures and lower hydrodynamic radii compared to their intermediates. To our knowledge, the combination of photoinduced azide crosslinking and radical coupling processes is the first attempt to prepare double folding single polymer chains.

Macromolecular Chemistry and Physics published new progress about Crosslinking, intramolecular. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application In Synthesis of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Jiangtao; Chen, Guofei; Fang, Xingzhong published the artcile< Preparation, characterization, and properties of poly(thioether ether imide)s from isomeric bis(chlorophthalimide)s and bis(4-mercaptophenyl) ether>, Application of C8H3ClO3, the main research area is chlorophthalimide mercaptophenyl ether viscosity solubility thermal stability mech property.

A series of isomeric poly(thioether ether imide)s (PTEIs) containing both thioether and ether linkages were prepared by aromatic nucleophilic substitution reaction of isomeric bis(chlorophthalimide)s (BCPIs) with bis(4-mercaptophenyl) ether (BMPE). The inherent viscosities of synthesized polymers were found in the range of 0.41-0.86 dL g-1 in N-methyl-2-pyrrolidone at 30°C. The glass transition temperature (Tg) of the isomeric PTEIs were 210-242°C and increased by increasing the content of 3-substituted phthalimide unit in the polymer backbone. The 5% weight loss temperature values reached up to 525-539°C under nitrogen and 523-534°C in air atmospheres, resp., which indicated this kind of polyimide possessed excellent thermal stability. Flexible films could be cast from the polymer solution The PTEI films exhibited moderate mech. properties with tensile strengths of 106-127 MPa, elongations at break of 8.6-11.5%, and tensile moduli of 2.2-2.8 GPa, resp. Dynamic mech. thermal anal. results illustrated that the storage moduli (E’) of PTEI (a-e) almost completely maintained at about 2.3 GPa before reaching the corresponding Tg. It is noted that the min. melt viscosity of isomeric PTEIs (a’-e’) decreased by increasing the content of unsym. 3,4′-substituted phthalimide unit in the polymer main chain.

High Performance Polymers published new progress about Elongation at break. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nandhikonda, Premchendar; Heagy, Michael D. published the artcile< Dual Fluorescent N-Aryl-2,3- naphthalimides: Applications in Ratiometric DNA Detection and White Organic Light-Emitting Devices>, Related Products of 118-45-6, the main research area is ratiometric DNA detection dual fluorescent aryl naphthalimide; white organic light emitting device dual fluorescent aryl naphthalimide.

A ten element matrix of 5- and 6-substituted-(2,3)-naphthalimides was prepared for the appropriate placement of substituents necessary to promote dual fluorescence (DF). As prescribed by our balanced seesaw photophys. model this matrix yielded nine new DF dyes out of a possible ten compounds From this set of nine DF dyes, 4-fluoronaphthalic amide was selected as a probe for ratiometric detection of DNA and demonstration of panchromatic emission.

Organic Letters published new progress about Dyes. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Related Products of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Caswell, Lyman R.; Soo, Lily Y.; Lee, Daisy H.; Fowler, Rosemary G.; Campbell, Jo Anne B. published the artcile< Dipole moments of some 3- and 4- substituted phthalimides and phthalic anhydrides. Influence of steric and resonance effects>, Quality Control of 118-45-6, the main research area is dipole moment phthalimide phthalic anhydride.

The dipole moments of phthalimide, phthalic anhydride, and 16 derivative compounds in dioxane solution were measured and compared. The predicted moments of the derivatives were also calculated from group moments. There is good agreement between the exptl. and predicted dipole moments only for 3-methylphthalic anhydride, 3-fluorophthalimide, 4-methylphthalimide, 3-fluorophthalic anhydride, and 4-methylphthalic anhydride. The Zhdanov-Minkin equation for calculating resonance interaction moments was applied for all of the derivatives Arguments are presented for designating the numerical results of this calculation as ring polarization moments. The results of these calculations show that interaction resonance is significant only for 4-chlorophthalic anhydride. Steric and resonance effects are both small or absent as influences on the dipole moments of 3-fluorophthalic anhydride, 3-fluorophthalimide, and of all methyl derivatives Steric interaction between ortho substituents appears to be large only in the cases of 3-nitrophthalimide and 3-nitrophthalic anhydride.

Journal of Organic Chemistry published new progress about Dipole moment. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Quality Control of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fritzson, Ingela; Bedingfield, Paul T. P.; Sundin, Anders P.; McConkey, Glenn; Nilsson, Ulf J. published the artcile< N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors>, Name: Methyl 4-chloro-2-hydroxybenzoate, the main research area is substituted salicylamide recombinant human Plasmodium dihydroorotate dehydrogenase inhibitor.

In our continuing program to develop Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors, a series of N-substituted salicylamides were synthesized and their ability to selectively inhibit PfDHODH was examined The synthetic program was based on 2-hydroxy-N-(2-phenylethyl)benzamide (1) that weakly inhibits both PfDHODH and human DHODH (hDHODH). Structure activity relationships were examined for developing derivatives Selective PfDHODH inhibitors with improved potency were obtained by introducing a 2,2-diphenylethyl substitution on the salicylamidic nitrogen. Biol. activity of the most potent compounds was confirmed on parasite infected cells in vitro.

MedChemComm published new progress about Erythrocyte. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Vashisth, N.; Sharma, S. P.; Kumar, S.; Aruna published the artcile< One-Pot Green Synthesis of 2-Hydroxybenzoyl(cinnamoyl)methanes and 2-Styrylchromones Using Dual-Frequency Ultrasonication>, Synthetic Route of 17082-09-6, the main research area is styrylchromone preparation green chem ultrasound; hydroxybenzoyl cinnamoyl methane preparation heterocyclization; hydroxyacetophenone cinnamoyl chloride ultrasonication Baker Venkataraman rearrangement.

One-pot green synthesis of (2-hydroxybenzoyl)(cinnamoyl)methanes (E)-I (R1 = H, OMe; R2 = H, Me; R3 = H, OMe) has been performed by reacting 2-hydroxyacetophenones 2-OH-4-R1-5-R2C6H2C(O)CH3 with cinnamoyl chlorides (E)-4-R3C6H4CH=CHC(O)Cl using activated Ba(OH)2, followed by Baker-Venkataraman rearrangement assisted by dual-frequency ultrasonication. Cyclization of (2-hydroxybenzoyl)(cinnamoyl)methanes I using methanesulfonic acid along with dual-frequency ultrasound irradiation resulted in the formation of 2-strylchromones (E)-II in a single step.

Russian Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Yiping; Chen, Miao; Huang, Qunwu; Cui, Yong; Jin, Yanchao; Cui, Lingyun; Wen, Chen published the artcile< Experimental study of a solar-driven photo-electrochemical hybrid system for the decolorization of Acid Red 26>, Reference of 118-45-6, the main research area is Acid Red 26 dye decolorization photoelectrochem hybrid system.

This study presents a new solar-driven hybrid system that integrated a photo-electrochem. reactor with a photovoltaics (PV) panel for azo dyes decolorization and electricity generation. Full spectrum of sunlight is utilized to optimize the color removal of Acid Red 26 (AR26) in this hybrid system. Persulfate (PS, S2O2-4) was selected as the photochem. oxidant and Ti/IrO2-Ta2O5 electrode was used as the anode. Experiments were made to evaluate the efficiency of decolorization and the performance of PV panels in different reaction conditions outdoors. The results showed that the synergistic effect of two processes was observed for the AR26 decolorization. Comparing with the solar/persulfate process or the electrochem. process alone, the complete color removal time by the hybrid system decreased up to 50% and 44.4% resp. In this system, the water layer in the flow channel cooled PV panels by absorbing the far IR spectrum of sunlight, and the increased temperature of wastewater from 7°C to 16°C enhanced the decolorization efficiency of AR26. Moreover, the generated electricity by PV panels could satisfy the energy demand of electrochem. oxidation

Energy Conversion and Management published new progress about Chlorides Role: NUU (Other Use, Unclassified), USES (Uses). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Reference of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics