Tag: M.W=150-200

Xiong, Wenzhang; Shi, Qiu; Liu, Wenbo H. published the artcile< Simple and Practical Conversion of Benzoic Acids to Phenols at Room Temperature>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is aryl carboxylic acid chlorobenzoicacid decarboxylative oxygenation; aromatic alc preparation.

Herein, an efficient and practical approach to prepare phenols from benzoic acids via simple organic reagents at room temperature was reported. This approach was compatible with various functional groups and heterocycles and can be easily scaled up. To demonstrate its synthetic utility, bioactive mols. and unsym. hexaarylbenzenes was prepared by leveraging this transformation as strategic steps. Mechanistic investigations suggest that the key migration step involve a free carbocation instead of a radical intermediate. Considering the abundance of benzoic acids and the utility of phenols, it was anticipated that this method will find broad applications in organic synthesis.

Journal of the American Chemical Society published new progress about Aromatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bojanowski, N. Maximilian; Huck, Christian; Veith, Lisa; Strunk, Karl-Philipp; Baeuerle, Rainer; Melzer, Christian; Freudenberg, Jan; Wacker, Irene; Schroeder, Rasmus R.; Tegeder, Petra; Bunz, Uwe H. F. published the artcile< Electron-beam lithography of cinnamate polythiophene films: conductive nanorods for electronic applications>, COA of Formula: C9H7ClO, the main research area is polythiophene nanorod electron beam lithog structural electrochem property.

We report the electron-beam induced crosslinking of cinnamate-substituted polythiophene proceeding via excited state [2+2]-cycloaddition Network formation in thin films is evidenced by IR spectroscopy and film retention experiments For the polymer studied herin, the electron-stimulated process appears to be superior to photo (UV)-induced crosslinking as it leads to less degradation Electron beam lithog. (EBL) patterns cinnamate-substituted polythiophene thin films on the nanoscale with a resolution of around 100 nm. As a proof of concept, we fabricated nanoscale organic transistors using doped and cross-linked P3ZT as contact fingers in thin film transistors.

Chemical Science published new progress about Binding energy. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adler, Irving L.; Jones, Brent Marco; Wargo, Joseph P. Jr. published the artcile< Fate of 2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene (oxyfluorofen) in rats>, Application In Synthesis of 35852-58-5, the main research area is fluoromethylbenzene metabolism rat; ethoxynitrophenoxybenzene metabolism rat; nitrophenoxybenzene metabolism rat; herbicide metabolism rat.

Albino rats were dosed orally with 14C-labeled 2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene (I) [42874-03-3] for 7 consecutive days. Only trace amounts of radioactivity (2-4%) were recovered in the urine and tissues. The major route of I elimination was through the feces (∼95%). About 75% of the fecal radioactivity was as unchanged I. Other compounds present in feces were: 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenol [42874-63-5], 4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-ethoxybenzenamine [64378-95-6], N-[4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-ethoxyphenyl]acetamide [64378-96-7], and N-[4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-hydroxyphenyl]acetamide [64378-97-8].

Journal of Agricultural and Food Chemistry published new progress about Feces. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Application In Synthesis of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aldous, F. A. B.; Barrass, B. C.; Brewster, K.; Buxton, D. A.; Green, D. M.; Pinder, R. M.; Rich, P.; Skeels, M.; Tutt, K. J. published the artcile< Structure-activity relations in psychotomimetic phenylalkylamines>, Synthetic Route of 53581-86-5, the main research area is psychotomimetic phenylalkylamine; hypothermia behavior phenylalkylamine.

A series of 48 title compounds were tested for the ability to produce hypothermia in rabbits as a qual. screen for psychotomimetic activity. Addnl. tests of the ability to mimic LSD [50-37-3], mescaline [54-04-6], and DOM (2,5-dimethoxy-4-methylamphetamine [15588-95-1] in the cat EEG, as well as behavioral responses in rats, permitted a reliable quant. anal. to be made of structure-activity relations in these drugs. Trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine-HCl (I-HCl) [53581-71-8] produced the full LSD-like response and was about a third as potent as DOM.

Journal of Medicinal Chemistry published new progress about Behavior. 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Synthetic Route of 53581-86-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tsygankov, Alexey A.; Chusov, Denis published the artcile< Straightforward Access to High-Performance Organometallic Catalysts by Fluoride Activation: Proof of Principle on Asymmetric Cyanation, Asymmetric Michael Addition, CO2 Addition to Epoxide, and Reductive Alkylation of Amines by Tetrahydrofuran>, Category: chlorides-buliding-blocks, the main research area is fluoride activated organometallic catalyst preparation; asym cyanation Michael addition reductive alkylation.

The well-known transition metal catalysts can be transformed into high-performance versions by the simple use of a fluoride anion source. In situ fluoride-activated catalysts are highly active catalytic species. The isolation may lead to degradation of the species or a decrease in catalytic activity. Fluoride activation of known, relatively simple catalysts resulted in the development of one of the most efficient catalytic systems for the asym. cyanation of aldehydes, asym. Michael addition, and synthesis of cyclic carbonates. Furthermore, the fluoride-assisted reductive opening of THF with amines was developed. The proposed approach can find broad applications in the enhancement of known catalytic processes and in the design of new ones.

ACS Catalysis published new progress about Alkenes, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Wenhui; Shi, Yali; Gao, Lihong; Liu, Jiemin; Cai, Yaqi published the artcile< Occurrence, fate and risk assessment of parabens and their chlorinated derivatives in an advanced wastewater treatment plant>, COA of Formula: C8H7ClO3, the main research area is fate risk assessment paraben chlorinated derivative advanced wastewater; Advanced wastewater treatment plant; Chlorinated parabens; PHBA; Parabens; Risk assessment.

Parabens, p-hydroxybenzoic acid (PHBA) and chlorinated derivatives, were simultaneously determined in wastewater and sludge samples along the whole process in an advanced wastewater treatment plant (WWTP). Nine target compounds were detected in this WWTP, and methylparaben and PHBA were the dominant compounds in these samples. It is noteworthy that octylparaben with longer chain was 1st detected in this work. Mass balance results showed that 91.8% of the initial parabens mass loading was lost mainly due to degradation, while the contribution of sorption and output of primary and excess sludge was much less (7.5%), indicating that biodegradation played a significant role in the removal of parabens during the conventional treatment process. Specifically, parabens were mainly degraded in the anaerobic tank, and PHBA could be effectively removed at high rates after the advanced treatment. However, both biodegradation and adsorption accounted for minor contribution to the removal of chlorinated parabens during conventional treatment process, and they were only scantly removed by conventional treatment (33.9-40.7%) and partially removed by advanced treatment (59.2-82.8%). Risk assessment indicated that parabens and their chlorinated derivatives in secondary and tertiary effluent are not likely to produce biol. effects on aquatic ecosystems.

Journal of Hazardous Materials published new progress about Advanced wastewater treatment. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Scrano, Laura; Bufo, Sabino A.; D’Auria, Maurizio; Meallier, Pierre; Behechti, Akbar; Shramm, Karl Werner published the artcile< Photochemistry and photoinduced toxicity of acifluorfen, a diphenyl-ether herbicide>, Synthetic Route of 35852-58-5, the main research area is photochem photoinduced toxicity acifluorfen UV photolysis.

Photochem. studies can be helpful in assessing the environmental fate of chems. Photochem. reactions lead to the formation of byproducts that can exhibit different toxicol. properties from the original compound For this reason the photochem. behavior of the herbicide acifluorfen (5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid) in the presence of different solvents was studied. Photochem. reactions were carried out using a high-pressure mercury arc and a solar simulator. Kinetic parameters and quantum yields were determined The identification of photoproducts was performed by mass spectrometry and [1H] NMR. Nitrofluorfen, hydroxy-nitrofluorfen, 2-chloro-4-(trifluoromethyl)-phenol, 5-trifluoromethyl-5′-nitrodibenzofuran, and other derivatives were identified. The photochem. reactions were also carried out in the presence of either a singlet or a triplet quencher, and in the presence of either a radical initiator or a radical inhibitor. Substances used as inhibitors of the excited levels T1 and S1 showed that photodegradation of acifluorfen begins from a singlet state S1 through a π,π* transition. The role of free radicals in the photodegradation of acifluorfen was determined and a radical mechanism was proposed. Toxicity tests against Daphnia magna Strauss showed that acifluorfen was not toxic at a concentration of 0.1 mM; however, photoproducts formed after 36 h of UV exposure of the herbicide induced a remarkable toxicity to the test organism.

Journal of Environmental Quality published new progress about Daphnia magna. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Synthetic Route of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Swain, Baijayantimala; Angeli, Andrea; Singh, Priti; Supuran, Claudiu T.; Arifuddin, Mohammed published the artcile< New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation>, Safety of (E)-Cinnamoyl chloride, the main research area is aryl oxo chromenyl acrylamide preparation carbonic anhydrase inhibitor human; dioxidobenzooxathiinyl aryl acrylamide preparation carbonic anhydrase inhibitor human; Carbonic anhydrase; Coumarin; Hypoxia tumor; Phenylacrylamide; Sulfocoumarin; XII isoform; hCA IX.

Two novel series of phenylacrylamide linked coumarins I [R = H, Me; Ar = Ph, 4-FC6H4, 4-MeOC6H4, etc.] and sulfocoumarins II [Ar1 = 4-FC6H4, 3-F3CC6H4, 4-NCC6H4, etc.] were synthesized and evaluated against four physiol. relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I, hCA II, hCA IX and hCA XII for their inhibitory action. Compounds I and II when screened for carbonic anhydrase inhibitory activity, they showned selective inhibition toward the tumor associated isoforms hCA IX and XII over CA I and II, with inhibition constants in the submicromolar to low nanomolar range. Compound I [R = H; Ar = 4-FC6H4] and II [Ar1 = 4-NCC6H4] exhibited significant inhibition with low nanomolar potency against hCA IX, whereas I [R = H; Ar = 3,4-(OMe)2C6H3] was effective against hCA XII. Compounds I [R = H; Ar = 4-FC6H4, 3,4-(OMe)2C6H3] and II [Ar1 = 4-NCC6H4] might be considered as lead mols. for future development of cancer therapeutics based on a novel mechanism of action.

Bioorganic & Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Safety of (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lu, Tong; Dong, Ling; Pan, Hongmei; Wu, Xuedan; Chen, Xia; Gu, Chengwen; Tao, Naili; Wang, Ao; Zhang, Kehua; Jin, Jie published the artcile< Design and synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives via click reactions>, Computed Properties of 611-19-8, the main research area is quinoxalinyl triazolyl sinomenine preparation.

The synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives at the 4-OH via click reactions was accomplished, and a total of 16 novel sinomenine double N-heterocyclic derivatives are obtained in 74%-95% yields. The C-ring is first transformed into a 1,2-diketone structure under the action of hydrochloric acid, and then reacted with o-phenylenediamine to obtain a C-ring quinoxaline-substituted structure. The 4-OH of sinomenine reacted with chloropropyne to give an alkynyl sinomenine, and then reacts with sodium azide and various benzyl chlorides to give the target compounds All the synthesized derivatives were characterized by Fourier-transform IR spectrometry, high resolution mass spectrometry, 1H NMR, and 13C NMR spectroscopy.

Journal of Chemical Research published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Computed Properties of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yan, Jingling; Wang, Zhen; Gao, Lianxun; Ding, Mengxian published the artcile< Synthesis and properties of polyimides from isomeric bis(dicarboxylphenylthio)diphenyl sulfone dianhydrides>, Recommanded Product: 5-Chloroisobenzofuran-1,3-dione, the main research area is isomeric tetracarboxylic dianhydride polyimide polysulfone preparation property; permeability permselectivity oxygen nitrogen polyimide polysulfone.

4,4′-Bis(3,4-dicarboxyphenylthio)diphenyl sulfone dianhydride(4,4′-PTPSDA) and 4,4′-bis(2,3-dicarboxyphenylthio)diphenyl sulfone dianhydride(3,3′-PTPSDA) were synthesized from chlorophthalic anhydrides and bis(4-mercaptophenyl)sulfone. Their structures were determined via IR spectra, 1H NMR and elemental anal. A series of polyimides were prepared from isomeric PTPSDAs and aromatic diamines in 1-methyl-2-pyrrolidinone (NMP) via the conventional two-step method. Polyimides based on 4,4′-PTPSDA and 3,3′-PTPSDA have good solubility in polar aprotic solvents and phenols. The 5% weight-loss temperatures of isomeric polyimides were near 500 °C in N2. DMTA and DSC analyses indicated that the glass-transition temperatures of polyimides from 3,3′-PTPSDA are higher than those of polyimides from 4,4′-PTPSDA. The wide-angle X-ray diffraction showed that all polyimides are amorphous. The polyimides from 3,3′-PTPSDA showed higher permeability but lower permselectivity compared with those from 4,4′-PTPSDA.

Polymer published new progress about Elongation at break. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Recommanded Product: 5-Chloroisobenzofuran-1,3-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics