Tag: M.W=150-200

Ganesan, Divakar; Chennapuram, Madhu; Begum, Zubeda; Seki, Chigusa; Okuyama, Yuko; Kwon, Eunsang; Uwai, Koji; Tokiwa, Michio; Tokiwa, Suguru; Takeshita, Mitsuhiro; Nakano, Hiroto published the artcile< Sugar based γ-amino alcohol organocatalyst for asymmetric michael addition of β-keto esters with nitroolefins>, Application In Synthesis of 5153-70-8, the main research area is sugar amino alc organocatalyst Michael addition ketoester nitroolefin.

Sugar based γ-amino alc. was used in asym. Michael addition of β-keto esters with nitroolefins for the first time affording the corresponding several chiral Michael adducts bearing quaternary chiral carbon center in moderate to good chem. yields and stereoselectivities (up to 98%, up to dr. 95:5, up to 84% ee).

Heterocycles published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Wei; Qi, Xinxin; Wu, Xiao-Feng published the artcile< Palladium-Catalyzed Thiocarbonylation of Benzyl Chlorides with Sulfonyl Chlorides for the Synthesis of Arylacetyl Thioesters>, Safety of 1-Chloro-2-(chloromethyl)benzene, the main research area is arylacetyl thioester preparation; chloromethyl benzene sulfonyl chloride thiocarbonylation palladium catalyst.

A convenient procedure for the synthesis of thioesters RCH2C(O)SR1 (R = Ph, 3,4-dimethylphenyl, naphthalen-1-yl, thiophen-3-yl, etc.; R1 = Ph, 2,4,6-trimethylphenyl, naphthalen-1-yl, etc.) has been developed via a palladium-catalyzed thiocarbonylation of benzyl chlorides RCH2Cl with sulfonyl chlorides R1S(O)2Cl. Various arylacetyl thioesters were produced in good yields by using sulfonyl chlorides as an odorless sulfur source. Furthermore, W(CO)6 exhibited dual roles as both a solid CO surrogate and reductant here.

Advanced Synthesis & Catalysis published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P. published the artcile< Small molecule inhibitors of anthrax lethal factor toxin>, Category: chlorides-buliding-blocks, the main research area is anthrax lethal factor toxin quinoline structure activity preparation; Anthrax; Bacillus anthracis; Botulinum neurotoxin A; Desymmetrized; Hybrid compound; Lethal factor; Light chain; Matrix metalloprotease; Quinoline; Zinc metalloprotease.

This manuscript describes the preparation of new small mol. inhibitors of Bacillus anthracis lethal factor. The authors’ starting point was the sym., bis-quinolinyl compound (I) (NSC 12155). Optimization of one half of this mol. led to new LF inhibitors that were desymmetrized to afford more drug-like compounds

Bioorganic & Medicinal Chemistry published new progress about Anthrax lethal factors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wei, Haibing; Pei, Xueliang; Fang, Xingzhong published the artcile< Comparative study on polyimides from isomeric 3,3'-, 3,4'-, and 4,4'-linked bis(thioether anhydride)s>, HPLC of Formula: 118-45-6, the main research area is polyimide isomeric thioether anhydride preparation thermal mech property.

Three isomeric bis(thioether anhydride) monomers, 4,4′-bis(2,3-dicarboxyphenylthio) di-Ph ketone dianhydride (3,3′-PTPKDA), 4,4′-bis(3,4-dicarboxyphenylthio) di-Ph ketone dianhydride (4,4′-PTPKDA), and 4-(2,3-dicarboxyphenylthio)-4′-(3,4-dicarboxyphenylthio) di-Ph ketone dianhydride (3,4′-PTPKDA), were prepared through multistep reactions. Their structures were determined via Fourier transform IR, NMR, and elemental anal. Three series of polyimides (PIs) were prepared from the obtained isomeric dianhydrides and aromatic diamines in N-methyl-2-pyrrolidone (NMP) via the conventional two-step method. The PIs showed excellent solubility in common organic solvents such as chloroform, N,N-dimethylacetamide, and NMP. Their glass transition temperatures decreased according to the order of PIs on the basis of 3,3′-PTPKDA, 3,4′-PTPKDA, and 4,4′-PTPKDA. The 5% weight loss temperatures (T5%) of all PIs in nitrogen were observed at 504-519 °C. The rheol. properties of isomeric PI resins based on 3,3′-PTPKDA/4,4′-oxydianiline/phthalic anhydride showed lower complex viscosity and better melt stability compared with the corresponding isomers from 4,4′- and 3,4′-PTPKDA. In addition, the PI films based on three isomeric dianhydrides and on 2,2′-bis(trifluoromethyl)benzidine had a low moisture absorption of 0.27-0.35%. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about Absorption (water). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, HPLC of Formula: 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Yonghui; Yang, Ting; Liu, Qian; Ma, Yingli; Yang, Liuqing; Zhou, Ling; Xiang, Zhijun; Cheng, Ziqiang; Lu, Sijie; Orband-Miller, Lisa A.; Zhang, Wei; Wu, Qianqian; Zhang, Kathleen; Li, Yi; Xiang, Jia-Ning; Elliott, John D.; Leung, Stewart; Ren, Feng; Lin, Xichen published the artcile< Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists>, Application In Synthesis of 35852-58-5, the main research area is arylaryloxy thiazolyl amide preparation RORt inverse agonist immunomodulator; Crystal structure; RORγt inverse agonists; Th17 cell differentiation; Thiazole ether amides.

A novel series of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as RORγt inverse agonists was discovered. Binding mode anal. of a RORγt partial agonist (2c) revealed by co-crystal structure in RORγt LBD suggests that the inverse agonists do not directly interfere with the interaction between H12 and the RORγt LBD. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as 3m with a pIC50 of 8.0. Selected compounds in the series showed reasonable activity in Th17 cell differentiation assay as well as low intrinsic clearance in mouse liver microsomes.

Bioorganic & Medicinal Chemistry published new progress about Cell differentiation inducers. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Application In Synthesis of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ambala, Srinivas; Singh, Rohit; Singh, Maninder; Cham, Pankaj Singh; Gupta, Ria; Munagala, Gurunadham; Yempalla, Kushalava Reddy; Vishwakarma, Ram A.; Singh, Parvinder Pal published the artcile< Metal-free, room temperature, acid-K2S2O8 mediated method for the nitration of olefins: an easy approach for the synthesis of nitroolefins>, Application In Synthesis of 5153-70-8, the main research area is alkene sodium nitrate potassium persulfate TFA promoter diastereoselective nitration; nitroalkene preparation.

A simple, room temperature method for the nitration of olefins by using inexpensive sodium nitrite as a source of nitro groups in the presence of trifluoroacetic acid (TFA) and potassium persulfate (K2S2O8) under an open atm. Styrenes and mono-substituted olefins give stereo-selective corresponding E-nitroolefins under optimized conditions, however, 1,1-bisubstituted olefins give a mixture of E- and Z-nitroolefins. The optimized conditions work well with electron-donating, electron-withdrawing, un-substituted and heterocyclic styrenes and mono-substituted olefins and gave corresponding nitroolefins with good to excellent yields.

RSC Advances published new progress about Alkenes, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mushtaq, Nafeesa; Sidra, Lala Rukh; Chen, Guofei; Tang, Yongmei; Xu, Lubo; Fang, Xingzhong published the artcile< Synthesis of cardo containing asymmetric poly(ether-naphthalimide-phthalimide)s>, Synthetic Route of 118-45-6, the main research area is cardo asym polyethernaphthalimidephthalimide.

A series of cardo based asym. polyimides containing bulky rigid naphthalimide and phthalimide groups were prepared from asym. monomer bishaloimide and bisphenols by solution polycondensation. Bishalo(naphthalimide-phthalimide) monomers containing different terminal leaving groups (Cl, F, NO2) were synthesized, and the reactivity difference of these monomers was compared for the successful synthesis of polyimides. The inherent viscosities of the polyimides were in the range 0.51 – 0.60 dL g-1 in N-methyl-2-pyrrolidone at 30 °C. These polyimides demonstrated good organosoly. and mech. properties with tensile strengths of 93 – 120 MPa, tensile moduli of 3.5 – 5.3 GPa and elongations at break of 2.8% – 4.3%. The polyimides showed high glass transition temperatures (Tg) ranging from 330 to 363 °C. The 10% weight loss (T10%) of asym. polyimides reached 436 – 500 °C in nitrogen and 417 – 476 °C in air. The water uptake of the polyimides was in the range 0.35% – 0.72%. © 2017 Society of Chem. Industry.

Polymer International published new progress about Cardo polymers, polyether-polyimides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Synthetic Route of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyganowski, Piotr published the artcile< Fully recyclable gold-based nanocomposite catalysts with enhanced reusability for catalytic hydrogenation of p-nitrophenol>, Category: chlorides-buliding-blocks, the main research area is nitrophenol hydrogenation recyclable gold nanocomposite catalyst reusability.

Nanocomposite (NC) materials, which demonstrate catalytic activity under mild conditions, have garnered considerable attention due to the environmental hazards associated with aromatic nitro compounds Herein, a novel in-situ synthesis of NCs with zero-valent Au (Au°) is proposed. These materials are based on suspension copolymers with mol. reactors that enable the fabrication of Au° and the enhancement of both the catalytic activity and reusability. NCs were obtained using amino-based nanoreactors (3-14 mmol per g of a polymer) derived from polyethyleneimine (PEI), 1-(2-hydroxyethyl)piperazine (HEP), 1,4-bis(3-aminopropyl)piperazine (APP). The resultant Au@PEI, Au@HEP, and Au@APP NCs were investigated using optical microscopy, SEM, and TEM. Addnl., the physiochem. structures of both the polymeric matrix and Au° were evaluated using, i.a., FT-IR and XRD. The so-obtained NCs were used as nanocatalysts (NCats) for the catalytic hydrogenation of 4-nitrophenol (4-NP) under mild conditions. The method developed for the synthesis of NCs produced gold-based NCats with 25-37% Au° content. The synergism between the polymeric matrix and Au° enabled the hydrogenation of 4-NP within approx. 30-38 min with a rate constants of 0.071 min-1 (Au@HEP) and 0.028 min-1 (Au@APP) and, resp. The spherical millimetric morphol. of the polymeric support facilitated the facile recyclability of NCats that maintained their catalytic activity for more than 10 cycles of 4-NP reduction

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about Hydrogenation. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics