Tag: M.W=150-200

Bunnett, J. F.; Bachman, D. M.; Snipper, L. P.; Maloney, J. H. published the artcile< Chlorination of 2-thiophenecarboxylic acid>, COA of Formula: C5H2Cl2O2S, the main research area is .

2-Thiophenecarboxylic acid (I) 3 g. (0.023 mole), NaOCl 0.042 mole, and excess NaOH in 400 cc. total volume were treated at pH 11.0 and 48° with 25 cc. 6 N HCl for 6 min. The temperature rose to 53°, the pH dropped to 1.3, and a white precipitate formed. After addition of 5 cc. 6 N HCl and 107 g. NaCl, the mixture was cooled and filtered to give 1.75 g. (46%) 5-chloro-2-thiophenecarboxylic acid (II), m. 134-7°, and, after recrystallization and sublimation, m. 149-50°, did not depress the m. p. of II prepared by KMnO4 oxidation of 5-chloro-2-acetylthiophene. Similarly 1.9 g. I (0.015 mole) and 0.037 mole NaOCl gave 0.4 g. (14%) 4,5-dichloro-2-thiophenecarboxylic acid, m. 194-4.5° (from H2O) (cf. m.p. 196-7° of Steinkopf and Kohler in C.A. 32, 3391.1). Oily by-products from several runs were combined to give a considerable fraction of 2,5-dichlorothiophene (III), b. 160-5°, nD16 1.5624; 3,4-dinitro derivative m. 85-5.5°. The by-product oil from a mixture of I and 3 moles NaOCl was a mixture of chlorinated thiophenes, with III the principal constituent.

Journal of the American Chemical Society published new progress about Chlorination. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, COA of Formula: C5H2Cl2O2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hafner, Andreas; Meisenbach, Mark; Sedelmeier, Joerg published the artcile< Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s>, Recommanded Product: 4-Chloro-2-methoxybenzaldehyde, the main research area is multigram scale boronic acid chem synthesis.

The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chem. on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chem. (chem. synthesis on a time scale of <1 s) with remarkable throughput (g/min) while mitigating the risk of blockages. Organic Letters published new progress about Boronic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Recommanded Product: 4-Chloro-2-methoxybenzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Chien Han; Jheng, Jia Kai; Juang, Tzong Yuan; Abu-Omar, Mahdi M.; Hsuan Lin, Ching published the artcile< Structure-property relationship of vinyl-terminated oligo(2,6-dimethyl-1,4-phenylene ether)s (OPEs): Seeking an OPE with better properties>, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene, the main research area is vinyl terminated oligodimethylphenylene ether.

Vinylbenzyl ether-terminated oligo(2,6-dimethyl-1,4-phenylene ether) (1) has been commercialized by Mitsubishi Gas Chem. in the name of OPE-2St. OPE (1) is used in high-frequency printed circuit board due to its low-dielec. characteristic after curing. However, for thermoset of (1), there is room for property improvement in thermal mech. property, dielec. property, oxygen permeation resistance, and so on. In this work, we report the preparation of three new oligo(2,6-dimethyl-1,4-phenylene ether)s: the vinyl benzoate-terminated OPE (2), the 3,5-bis(vinylbenzyl ether)benzyl ether-terminated OPE (3), and the 3,5-bis(vinylbenzyl ether)benzoate-terminated OPE (4), and compare their fundamental materials properties with the vinylbenzyl ether-terminated OPE (1). We discussed the effect of the number of vinyl groups (two or four) and the linker (benzyl ether or benzoate) on the properties of the four OPE thermosets. Through property evaluation and data analyses, we found that the thermoset of (4) show the highest Tg, modulus, oxygen permeation resistance, dimensional stability, and the lowest water absorption, and dielec. constant We also found that the toughness of thermoset of (4) can be significantly enhanced by the copolymerization with epoxy resin (HP7200) through the exchange reactions of benzoate and epoxy groups. In short, through properties comparison of four thermosets of (1-4), we demonstrate that (4) is a promising material for high-frequency printed circuit board.

European Polymer Journal published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Seo, Kyutae; Kang, Hyo published the artcile< Vertical Orientation of Liquid Crystal on Polystyrene Substituted with n-Alkylbenzoate-p-oxymethyl Pendant Group as a Liquid Crystal Precursor>, Formula: C9H9Cl, the main research area is polystyrene oxymethyl pendant liquid crystal polymer film physicochem property; anisotropic material; liquid crystal; n-alkyl-p-hydroxybenzoate; orientation layer; polystyrene.

We synthesized a series of polystyrene derivatives modified with precursors of liquid crystal (LC) mols. via polymer modification reactions. Thereafter, the orientation of the LC mols. on the polymer films, which possess part of the corresponding LC mol. structure, was investigated systematically. The precursors and the corresponding derivatives used in this study include ethyl-p-hydroxybenzoate (homopolymer P2BO and copolymer P2BO#, where # indicates the molar fraction of ethylbenzoate-p-oxymethyl in the side chain (# = 20, 40, 60, and 80)), n-butyl-p-hydroxybenzoate (P4BO), n-hexyl-p-hydroxybenzoate (P6BO), and n-octyl-p-hydroxybenzoate (P8BO). A stable and uniform vertical orientation of LC mols. was observed in LC cells fabricated with P2BO#, with 40 mol% or more ethylbenzoate-p-oxymethyl side groups. In addition, the LC mols. were oriented vertically in LC cells fabricated with homopolymers of P2BO, P4BO, P6BO, and P8BO. The water contact angle on the polymer films can be associated with the vertical orientation of the LC mols. in the LC cells fabricated with the polymer films. For example, vertical LC orientation was observed when the water contact angle of the polymer films was greater than ∼86°. Good orientation stability was observed at 150°C and with 20 J/cm2 of UV irradiation for LC cells fabricated with the P2BO film.

Polymers (Basel, Switzerland) published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kubo, Yuji; Shimada, Takuma; Maeda, Kentaro; Hashimoto, Yuta published the artcile< Thieno[1,3,2]oxazaborinine-containing aza-BODIPYs with near infrared absorption bands: synthesis, photophysical properties, and device applications>, Product Details of C9H7ClO, the main research area is thienooxazaborinine containing aza BODIPY preparation crystal structure cyclic voltammetry; fluorescence DFT thienooxazaborinine containing aza BODIPY.

As part of an ongoing study of near IR (NIR) absorbing dyes applicable to optoelectronics, thieno[1,3,2]oxazaborinine-containing aza-BODIPYs were synthesized for the first time. 3,5-Di(thiophene)-substituted N2O2-type 1 showed a NIR absorption band centered at 780 nm, with a molar absorptivity (εmax) of 5.51 × 104 M-1 cm-1 in CH2Cl2; however, it was easily hydrolyzed in solution In comparison, 3-thiophene-containing N2O-type analogs 2 and 3 had greater stability, and NIR absorption bands at 768 nm (εmax = 8.62 × 104 M-1 cm-1) and 779 nm (εmax = 6.32 × 104 M-1 cm-1), resp., in CH2Cl2. Notably, these dyes had longer absorption bands than those of all of the structurally constraining aza-BODIPYs reported thus far. CV measurements and theor. calculations indicated that this shift was the result of a higher-lying HOMO energy level generated by incorporation of thiophene into the aza-BODIPY core. As a potential device application, the 3-loaded film was prepared on indium tin oxide (ITO). The film showed a NIR absorption band at 827 nm, with a wide spectral range, and a λonset value of 897 nm; thus, its applicability as a NIR photodetector was evaluated through fabrication of a single-component device. The ITO/3 (85 nm)/Al (100 nm) device produced a photocurrent of 9.57 × 10-7 A cm-2 at a bias potential of 1 V upon illumination at 850 nm and a fluence of 130 μW cm-2. This demonstrated the potential of thieno[1,3,2]oxazaborinine-containing aza-BODIPY materials in optoelectronic applications such as NIR photodetectors.

New Journal of Chemistry published new progress about Crystal structure. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Product Details of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wan, Dong; Chen, Yong; Su, Jing; Liu, Lu; Zuo, Yuegang published the artcile< Ultraviolet absorption redshift induced direct photodegradation of halogenated parabens under simulated sunlight>, Category: chlorides-buliding-blocks, the main research area is simulation photodegradation halogenated paraben water sunlight UV Vis spectroscopy; Direct photodegradation; Estrogenic toxicity; Halogenated parabens; Mechanism; QSAR.

As disinfection byproducts of parabens, halogenated parabens are frequently detected in aquatic environments and exhibit higher persistence and toxicity than parabens themselves. An interesting phenomenon was found that UV absorption red shift (∼ 45nm) occurs after halogenation of parabens at circumneutral pH, leading to overlap with the spectrum of terrestrial sunlight. This work presents the first evidence on the direct photodegradation of seven chlorinated and brominated parabens under simulated sunlight. These halogenated parabens underwent rapid direct photodegradation, distinguished from the negligible degradation of the parent compounds The photodegradation rate depended on their forms and substituents. The deprotonation of halogenated parabens facilitated the direct photodegradation Brominated parabens exhibited higher degradation efficiency than chlorinated parabens, and mono-halogenated parabens had higher degradation than di-halogenated parabens. The pseudo-first-order rate constants (kobs) for brominated parabens (0.075-0.120 min-1) were approx. 7-fold higher than those of chlorinated parabens (0.011-0.017 min-1). A quant. structure-activity relationship (QSAR) model suggested that the photodegradation was linearly correlated with the C-X bond energies, electronic and steric effects of halogen substituents. The photodegradation products were identified using QTOF-MS analyses and a degradation pathway was proposed. The yeast two-hybrid estrogenicity assay revealed that the estrogenic activities of the photoproducts were negligible. These findings are important for the removal of halogenated parabens and predictions of their fate and potential impacts in surface waters.

Water Research published new progress about Bond energy. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Marc, Julia; Sylvestre, Julia; Bemont, Bernard published the artcile< Preparation of cyclopropane acids from γ-lactones>, COA of Formula: C10H9ClO2, the main research area is .

Cyclization of γ-chlorinated esters, readily obtained from the corresponding lactones, gave good yields of esters of cyclopropanecarboxylic acid by treatment with bases under anhydrous conditions. Thus, with tert-AmONa or PhCMe2ONa in C6H6, Cl(CH2)3CO2Et was cyclized to Et cyclopropanecarboxylate; the free acid was characterized as its S-benzylthiuronium salt, m. 161°. Similarly, the anilide of 2-methylcyclopropanecarboxylic acid, m. 109°, resulted from the Et ester of the latter, produced from MeCHCl(CH2)2CO2Et. From BzCH2CH2CO2H was obtained γ-phenyl-γ-butyrolactone, converted by SOCl2 in C6H6 to PhCHClCH2CH2CO2Et, which, boiled with Me3-COK several hrs. and the solution washed with KMnO4 to remove olefinic compounds and distilled yielded Et 2-phenylcyclopropanecarboxylate, b0.2 105-6°, m. 38° (petr. ether); hydrolysis of the ester produced the free trans acid, m. 90° (anilide, m. 145°). Analogous procedures yielded 2-(p-chlorophenyl)cyclopropanecarboxylic acid, m. 112°; p-BrC6H4 analog, m. 122°; p-MeOC6H4 analog, m. 112° (Et ester, m. 79°). The latter compounds were prepared by condensation of succinic anhydride with the aromatic derivatives, reduction to the lactones, and conversion of the latter to the cyclopropanecarboxylic acids.

Compt. rend. published new progress about Lactones. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, COA of Formula: C10H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Raju, D. Suryanarayana; Sasidhar, R. L. C.; Vidyadhara, S. published the artcile< Synthesis and characterization of some novel 5-chloro benzimidazole-2-one derivatives with specific docking studies against PPAR-γ>, HPLC of Formula: 611-19-8, the main research area is piperidinyl benzimidazolone preparation mol docking; peroxisome proliferator activated receptor gamma; benzyl halide acyl chloride alkylation acylation.

A series of 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazole-2(3H)-one derivatives I (Ar = Ph, 4-ClC6H4, 4-BrC6H4, etc.) and II have been synthesized. The compounds were docked against peroxisome proliferator activated receptor-γ (PPAR-γ) by using MCULE software. It was found that the synthesized mols. were active against PPAR-γ by their comparative docking scores with that of standard marketed drugs i.e. Rosiglitazone and Pioglitazone. In particular compounds II (Ar = 2-MeC6H4) and I (Ar = 2-MeC6H4, 4-MeC6H4) showed more binding capacity. The synthesized mols. were identified to have good binding capacity with PPAR- γ according to their docking data.

International Journal of Life Science and Pharma Research published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, HPLC of Formula: 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics