Tag: M.W=150-200

Mohr, Lisa-Marie; Bauer, Andreas; Jandl, Christian; Bach, Thorsten published the artcile< Visible light-mediated intermolecular [2 + 2] photocycloaddition of 1-aryl-2-nitroethenes and olefins>, Synthetic Route of 5153-70-8, the main research area is aryl cyclobutane preparation intermol photocycloaddition arylnitroethene olefin.

Despite the importance of cyclobutanes there are not many direct [2 + 2] photocycloaddition reactions which can be performed with visible light in the absence of a catalyst. A notable exception is the reaction of 1-aryl-2-nitroethenes and olefins which can be performed at a wavelength of λ = 419 nm or λ = 424 nm in CH2Cl2 as the solvent. In the present study, a total of 15 1-aryl-2-nitroethenes were found to undergo a [2 + 2] photocycloaddition with 2,3-dimethyl-2-butene (28-86% yield) and a set of 12 olefins was studied in their photocycloaddition to 1-phenyl-2-nitroethene (37-88% yield). All mechanistic results are in agreement with a triplet reaction pathway and with the intermediacy of a 1,4-diradical.

Organic & Biomolecular Chemistry published new progress about [2+2] Photocycloaddition reaction. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Synthetic Route of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tang, Yan-Ling; Zheng, Xi; Qi, Yan; Pu, Xiao-Jia; Liu, Bei; Zhang, Xia; Li, Xiao-Si; Xiao, Wei-Lie; Wan, Chun-Ping; Mao, Ze-Wei published the artcile< Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors>, Application In Synthesis of 17082-09-6, the main research area is bispiperazinochalcone preparation antitumor antiinflammatory activity interleukin inhibitor; Anti-inflammatory activity; Chalcone derivatives; Cytotoxicity; IL-1β inhibitors.

In this work, a series of novel chalcone derivatives I (n = 1,2; R = H, 3-chloropropanoyl, (3,5-dichlorophenyl)carbonyl, (4-nitrophenyl)methyl, etc.) bearing bispiperazine linker have been synthesized and in vitro anti-inflammatory, cytotoxic activity and anti-inflammatory mechanism have been screened. The results indicated that most bispiperazinochalcone derivatives I displayed good inhibition of NO (IC50 < 20μM) and low cytotoxicity (CC50 > 40μM), and selectively inhibited the production of IL-1β via inhibiting NLRP3 inflammasome activation, as promising candidate compounds for the treatment of NLRP3 inflammasome-driven diseases.

Bioorganic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Afanasyev, Oleg I.; Kliuev, Fedor S.; Tsygankov, Alexey A.; Nelyubina, Yulia V.; Gutsul, Evgenii; Novikov, Valentin V.; Chusov, Denis published the artcile< Fluoride Additive as a Simple Tool to Qualitatively Improve Performance of Nickel-Catalyzed Asymmetric Michael Addition of Malonates to Nitroolefins>, COA of Formula: C8H6ClNO2, the main research area is nitroalkene dialkyl malonate nickel catalyst enantioselective Michael addition; dialkylnitroethylmalonate preparation.

Described that simple in-situ addition of the fluoride source to the asym. organometallic catalyst was improved not only activity but also enantioselectivity. Bromide-nickel diimine complexes were found to catalyze asym. Michael addition in low yields and ee, but activation with fluoride leads to a significant improvement in catalyst performance. The developed approach were applied to prepare several enantioenriched GABA analogs.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, COA of Formula: C8H6ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Capkova, Katerina; Yoneda, Yoshiyuki; Dickerson, Tobin J.; Janda, Kim D. published the artcile< Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors>, Formula: C8H7ClO2, the main research area is chlorocinnamic acid hydroxamate preparation BoNT A protease inhibitor activity; hydroxamate chlorocinnamic acid preparation structure activity relationship.

Botulinum neurotoxins are the most toxic proteins currently known. Based on a recently identified potent lead structure, 2,4-dichlorocinnamic acid hydroxamate, herein we report on the structure-activity relationship of a series of hydroxamate botulinum neurotoxin A (BoNT/A) protease inhibitors. Among them, 2-bromo-4-chlorocinnamic acid hydroxamate, e.g., I, 2-methyl-4-chlorocinnamic acid hydroxamate, and 2-trifluoromethyl-4-chlorocinnamic acid hydroxamate displayed comparable inhibitory activity to that of the lead structure.

Bioorganic & Medicinal Chemistry Letters published new progress about Biological warfare agents. 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Formula: C8H7ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verma, Astha; Grams, R. Justin; Rastatter, Brett P.; Santos, Webster L. published the artcile< Semireduction of alkynoic acids via a transition metal-free α borylation-protodeborylation sequence>, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid, the main research area is acrylic acid preparation; alkynoic acid semiredn diastereoselective.

A method for the semi-reduction of alkynoic acids through an α-borylation and subsequent protodeborylation mechanism was developed. The transition metal-free protocol is achieved through the activation of bis(pinacolato)diboron by an in-situ generated carboxylate moiety yielding aryl acrylic acids. Our studies demonstrate an unprecedented dual role for the carboxylate anion that involves the activation of the diboron reagent and a directing effect in the α-borylation.

Tetrahedron published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Pengfei; Guan, Aiying; Xia, Xiaoli; Sun, Xufeng; Wei, Siyuan; Yang, Jinlong; Wang, Junfeng; Li, Zhinian; Lan, Jie; Liu, Changling published the artcile< Design, Synthesis, and Structure-Activity Relationship of New Arylpyrazole Pyrimidine Ether Derivatives as Fungicides>, Computed Properties of 35852-58-5, the main research area is pyrimidine ether preparation fungicidal activity structure activity relationship; fungicidal activities; intermediate derivatization method (IDM); pyrimidine ether derivatives; structure−activity relationship.

To explore a novel fungicide effectively against cucumber downy mildew (CDM), a series of new arylpyrazole containing pyrimidine ether derivatives were designed and synthesized by employing the intermediate derivatization method (IDM). The structures of synthesized compounds were identified by 1H NMR, 13C NMR, elemental analyses, MS, and X-ray diffraction. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against CDM. Especially, compound I (EC50 = 1.22 mg/L) displayed significantly higher bioactivity than that of com. fungicides diflumetorim and flumorph and nearly equal effect to that of cyazofamid. The relationship between the structure and fungicidal activity of the synthesized compounds was discussed as well. The study showed that compound I was a promising fungicide candidate for further development.

Journal of Agricultural and Food Chemistry published new progress about Fungicides. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Computed Properties of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Igarashi, Susumu; Inami, Hiroshi; Hara, Hiromu; Koutoku, Hiroshi; Oritani, Hiroyuki; Mase, Toshiyasu published the artcile< A novel class of inhibitors for human and rat steroid 5α-reductases: synthesis and biological evaluation of indoline and aniline derivatives>, Name: Methyl 3-chloro-4-hydroxybenzoate, the main research area is steroid reductase inhibitor carboxyphenoxyindoline carboxyphenoxyaniline preparation.

Searching for novel nonsteroidal inhibitors of human and rat prostatic 5α-reductases led to a new series of indoline and aniline derivatives that showed potent inhibitory activities for both enzymes. Among them, 3-chloro-4-{[1-(4-phenoxybenzyl)indolin-5-yl]oxy}benzoic acid (YM-36117) showed a more potent inhibitory activity for the human enzyme than ONO-3805 with an IC50 value of 5.3 nM and a reduced rat prostatic dihydrotestosterone (DHT) concentration by oral administration. The synthesis and the structure-activity relationships of these indoline and aniline derivatives are presented.

Chemical & Pharmaceutical Bulletin published new progress about 3964-57-6. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 3-chloro-4-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zheng, Yan; Dong, Mengke; Qu, Erdong; Bai, Jin; Wu, Xiao-Feng; Li, Wanfang published the artcile< Pd-Catalyzed Carbonylative Synthesis of 4H-Benzo[d][1,3]Oxazin-4-Ones Using Benzene-1,3,5-Triyl Triformate as the CO Source>, Formula: C9H7ClO, the main research area is benzooxazinone preparation; bromoaryl amide benzene triyltriformate carbonylative cross coupling catalyst palladium; benzoxazinone; carbonylation; heterocycles; palladium; synthetic methods.

A facile synthesis of 4H-benzo[d][1,3]oxazin-4-one derivatives I [R1 = 6-F, 8-Me, 7-Cl, etc.; R2 = Me, n-Pr, t-Bu, etc.] by Pd-catalyzed carbonylative cross-coupling between N-(ortho-bromoaryl)amides and benzene-1,3,5-triyl triformate (TFBen) was developed. This procedure does not require the toxic and flammable gas CO as the carbonyl source and tolerates a wide scope of functional groups. Remarkably, 4H-benzo[d][1,3]oxazin-4-ones incorporated to natural products and drugs could be constructed by this method.

Chemistry – A European Journal published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chan, Pei Qie; Lee, Yean Kee; Abd Rahman, Noorsaadah published the artcile< Facile Intramolecular Cyclization of N-(2-Hydroxybenzoyl)hydrazones to N,N'-Diacetyl Benzo-1,3,4-oxadiazepine Derivatives>, Application In Synthesis of 22717-55-1, the main research area is diacetyl phenyl benzoxadiazepinone preparation; hydroxybenzoylhydrazone intramol cyclization sulfuric acid catalyst.

A facile synthesis of diacetyl-phenyl-benzoxadiazepinones I [R = Ph, 4-ClC6H3, 2-naphthyl, etc.; R1 = Ph, 4-MeSC6H4, 4-O2NC6H4, etc.] through sulfuric acid-catalyzed one-step intramol. cyclization of N-(2-hydroxybenzoyl)hydrazones was established and further the catalytic and substituent effects on the reactivity of this intramol. cyclization were investigated.

Asian Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application In Synthesis of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Canosa, P.; Rodriguez, I.; Rubi, E.; Negreira, N.; Cela, R. published the artcile< Formation of halogenated by-products of parabens in chlorinated water>, COA of Formula: C8H7ClO3, the main research area is paraben halogenated product formation chlorinated water; sewage raw dichloro paraben pollution.

Chem. transformations of four alkyl esters of p-hydroxybenzoic acid, parabens, in chlorinated water samples are investigated. Quantification of the parent species and identification of their reaction byproducts were performed using gas chromatog./mass spectrometry. Experiments were accomplished considering free chlorine and paraben concentrations at the mg/L and μg/L level, resp. Concentration of water samples, using solid-phase extraction, and silylation of the target species were carried out in order to improve the detectability of parent species and their possible transformation products, achieving quantification limits at the low ng/L level. Under the employed exptl. conditions, the decrease in the concentrations of parabens followed pseudo-first-order kinetics. Half-life values obtained for model ultrapure water solutions were in good agreement with those observed in tap water samples. For the first type of sample, only two byproducts were detected for each paraben. They corresponded to chlorination of the aromatic ring in one or two carbons situated in ortho positions to the hydroxyl group. Both species were also generated after the addition of parabens to chlorinated tap water. Moreover, three new transformation products were noticed for each parent compound They were identified as bromo- and bromochloro-parabens, formed due to the existence of traces of bromide in tap water sources. Experiments carried out by mixing paraben-containing personal care products with tap water, containing free chlorine, confirmed the formation of all the above described halogenated byproducts. In addition, the presence of the di-chlorinated forms of Me and Pr paraben has been detected for first time in raw sewage water samples.

Analytica Chimica Acta published new progress about Bromides Role: OCU (Occurrence, Unclassified), RCT (Reactant), OCCU (Occurrence), RACT (Reactant or Reagent). 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics