Tag: M.W=150-200

Xie, Dengbing; Zhang, Songlin published the artcile< Selective Reduction of Quinolinones Promoted by a SmI2/H2O/MeOH System>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is dihydroquinolinone preparation; quinolinone selective reduction.

The selective reduction of quinolin-2(1H)-ones promoted by a SmI2/H2O/MeOH system is reported for the first time. The reaction is effectively carried out to afford 3,4-dihydroquinoline-2(1H)-ones under mild conditions in a one-pot fashion with good to excellent yields.

Journal of Organic Chemistry published new progress about Chemoselectivity. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Rongrong; Yao, Ganbing; Xu, Hui; Zhao, Hongkun published the artcile< Solid-Liquid Equilibrium and Phase Diagram for the Ternary 4-Chlorophthalic Anhydride + 3-Chlorophthalic Anhydride + Ethyl Acetate System>, Application of C8H3ClO3, the main research area is phase diagram ternary system chlorophthalic anhydride isomer ethyl acetate; solubility ternary system chlorophthalic anhydride isomer ethyl acetate.

The mutual solubility for ternary system of 4-chlorophthalic anhydride + 3-chlorophthalic anhydride + Et acetate was measured exptl. at different temperatures Four isothermal phase diagrams of the system were constructed based on the measured solubility At each temperature, there existed two pure solid phases, pure 4-chlorophthalic anhydride and pure 3-chlorophthalic anhydride, which were identified by the Schreinemakers’ wet residue method. When temperature decreases, the crystallization regions of 4-chlorophthalic anhydride and 3-chlorophthalic anhydride increase. At a certain temperature, the crystallization region of 4-chlorophthalic anhydride is smaller than that of 3-chlorophthalic anhydride.

Journal of Chemical & Engineering Data published new progress about Phase diagram. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chakraborty, Subhasish K.; Chakraborty, Savitri; Bhattacharyya, Anjan; Chowdhury, Ashim published the artcile< Photolysis of oxyfluorfen in aqueous methanol>, Synthetic Route of 35852-58-5, the main research area is UV sunlight oxyfluorfen methanol photolysis.

Photolysis of oxyfluorfen, an herbicide of the nitrodiphenyl ether class, was studied in aqueous methanol under UV and sunlight. UV irradiation was carried out in a borosilicate glass photoreactor (containing 250 ppm oxyfluorfen in 50% aqueous methanol) equipped with a quartz filter and 125 W mercury lamp (maximum output 254 nm) at 25 ± 1°C. Sunlight irradiation was conducted at 28 ± 1°C in borosilicate Erlenmeyer flasks containing 250 ppm oxyfluorfen in 50% aqueous methanol. The samples from both the irradiated conditions were withdrawn at a definite time interval and extracted to measure oxyfluorfen content by gas chromatog.-flame ionization detector for rate study. The half-life values were 20 h and 2.7 days under UV and sunlight exposure, resp. Photolysis of oxyfluorfen yielded 13 photoproducts of which three were characterized by IR spectrophotometer and 1H NMR and 13C NMR spectroscopy. The rest of the photoproducts were identified by gas chromatog.-mass spectrometry (GC-MS) and thin layer chromatog. (TLC). An ionization potential 70 eV was used for electron impact-mass spectrometry (EI-MS) and methane was used as reagent gas for chem. ionization-mass spectrometry (CI-MS). Two of the photoproducts were also synthesized for comparison. The main phototransformation pathways of oxyfluorfen involved nitro reduction, dechlorination, and hydrolysis as well as nucleophiles displacement reaction.

Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes published new progress about Chemical ionization mass spectrometry. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Synthetic Route of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Xiu; Wang, Zhenhua; Ishida, Takumi; Nishihara, Yasushi published the artcile< Methoxylation of Acyl Fluorides with Tris(2,4,6-trimethoxyphenyl)phosphine via C-OMe Bond Cleavage under Metal-Free Conditions>, Computed Properties of 17082-09-6, the main research area is methyl ester preparation; methoxylation acyl fluoride methoxyphenylphosphine.

Aryl fluorides (prepared from the corresponding aryl chlorides) underwent methoxylation reactions with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) (in the absence of added metal catalysts or reagents) in toluene to yield Me esters.

Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Computed Properties of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Steinkopf, Wilhelm; Kohler, Werner published the artcile< Thiophene series. XXXVIII. Chlorine derivatives of thiophene and the limited usefulness of mixed melting points with the isomeric thiophene derivatives>, Application In Synthesis of 31166-29-7, the main research area is .

The fraction of 2-chlorothiophene (I) b. 130-6° yields a chloromercuri derivative (II), m. 223-4°; distillation with 10% HCl gives 86% of pure I, b. 127-8.3° (corrected), m. -70° to -69°, nD19 1.55058. II and I in KI give 67% of 5-chloro-2-iodothiophene, b14 95-6°, m. -25° to -24° (corrected). Refluxing I with yellow HgO in AcOH for 4 h. gives the 3,4,5-tri(acetoxymercuri) complex, transformed by NaCl into the corresponding Cl derivative and this in turn by I in KI into 80% of 2-chloro-3,4,5-triiodothiophene m. 126°; this also results by the action of I upon I in the presence of Hg(OAc)2. I and Br give 80-5% of the 3,4,5-tri-Br derivative, m. 91°. With ClSO3H at -10°, 8 g. I yields 2.4 g. of the 5-sulfonyl chloride, m. 28°. I is separated from III by means of the II derivative, since III does not react with HgCl2. 2,5-Dichlorothiophene (III), b. 161-2°, m. -43.4° (corrected), nD19 1.56077, is purified through the 3,4-bis(chloromercuri) derivative (IV), m. 314-15° (prepared with HgO in AcOH, followed by NaCl). IV and I-KI give the 3,4-di-I derivative (V), m. 83°, and, as an Et2O-insoluble fraction, 2,5,2′,5′-tetrachloro-3,3′-diiodo-4,4′-mercurydithienyl, m. 238°. III and Br give 80% of the 3,4-di-Br derivative, m. 65°. I and AcCl in petr. ether with AlCl3 give 16% of 2,5-dichloro-3-acetothienone, m. 39°. VI, transformed into the Grignard reagent with EtMgBr and reacted with CO2, gives a very small yield of 2,5-dichlorothiophene-3,4-dicarboxylic acid, sublimes about 200°; melting with m-C6H4(OH)2 and ZnCl2 gives a strong green fluorescence. The trichlorothiophene fraction, b. 203-7°, with HgO in AcOH, yields 80% of 2,3,5,2′,3′,5′ -hexachloro-4,4′-mercurydithienyl (VII), m. 242-3°, which has a pale violet color in UV light. VII and HgCl2 in Me2CO yield 89% of 2,3,5-trichloro-4-chloromercurithiophene, m. 211-12°; heating with HCl gives 77% of 2,3,5-trichlorothiophene (VIII), b. 207.7-9.2° (corrected), m. -3.5°, nD19.3 1.58515. The 4-bromomercuric derivative of VIII m. 207° (quant. yield from VII) and has a pale blue-violet color in UV light. VIII gives 90% of the 4-Br derivative, m. 50.5-1.5°, and a quant. yield of the 4-I derivative, m. 51°; both are soluble in 33% oleum with a deep bluish green color. Crude VIII and AcCl with AlCl3 in petr. ether yield 6.5% of 2,3,5 trichloro-4-acetothiophene, m. 80°. VIII and HNO3 in concentrated H2SO4 give the 4-NO2 derivative, m. 70°. Chlorination of 2,5-dibromo-3-iodo-4-thiophenic acid in AcOH yields 2,3,5-trichloro-4-thiophenic acid, m. 176-7°. The 4-sulfonyl chloride of VIII m. 57-8°. The action of EtMgBr upon tetrachlorothiophene gives 2,3,4-trichlorothiophene (IX), b. 209.2-10.2° (corrected), m. -0.5°, nD19.1 1.58588, purified through the 5-chloromercuri derivative (X), m. 211° (18% yield). With HgO in AcOH IX yields 50-5% 2,3,4,2′,3′,4′-hexachloro-5-mercurydithienyl, m. 242-3°, color in UV light bright violet; this also results from X and NaI in Me2CO; with HgBr2 there results a nearly quant. yield of the 5-bromomercuri derivative of IX, m. 207°. X, I and KI give a quant. yield of the 5-I derivative of IX, m. 50-1°, easily colored red by light; the 5-Br derivative, m. 50.5°, results from X and Br-H2O-KBr or from IX and Br2. IX and AcCl with AlCl3 give 59% of 2,3,4-trichloro-5-acetothienone, m. 80°, shows a bright yellow color in UV light. The 5-NO2 derivative of IX, pale yellow, m. 70°. The 5-sulfonyl chloride m. 55-6° (59% yield). 2,3-Dibromo-5-thiophenic acid and Cl2 in AcOH give 2,3-dichloro-5-thiophenic acid, m. 196-7°, sublimes at 120°; boiling with Hg(OAc)2 in AcOH for 3 h. gives 2,3-dichloro-4,5-bis(acetoxymercuri)thiophene (XI), which, transformed into the chloromercuri derivative (XIA), and distilled with HCl, gives 2,3-dichlorothiophene (XII), b. 173-4°, m. -26.2° (corrected), nD21 1.56650; 5-chloromercuri derivative, m. 269-70°; 5-I derivative, m. 27°; 5-Br derivative (XIII), b. 212-14°, m. 6°. 2,3-Dichloro-5-acetothienone, m. 68° (47% yield). XIII and HgO in AcOH, refluxed 5 h., the product treated with NaCl and then with NaI, give 2,3,2′,3′-tetrachloro-5,5′-dibromo-4,4′-mercurydithienyl, m. 238-9°. XII and HNO3 in Ac2O give 37% of the 5-NO2 derivative, pale yellow, m. 55-6°. The 5-sulfonyl chloride (XIV), pale yellow, m. 55-6° (81%). XI or XIA with KI-I gives the 4,5-di-I derivative of XII, m. 72°; XII and Br2 gives 88% of the 4,5-di-Br derivative, m. 67.5°. Heating XIV with a slight excess of 15% NaOH and reduction of the filtrate with 2.5% Na-Hg give 8.4% of 3-chlorothiophene (XV), b. 136-7° (corrected), m. -62°, nD22 1.55322; 2-chloromercuri derivative, m. 137-8°; 2,5-bis(chloromercuri) derivative, decomposes 275°. 3,3′-Dichloro-2,2′-mercurydithienyl, m. 174-5°. XII and EtMgBr, followed by CO2, give 2.8% of 3-chloro-2-thiophenic acid, m. 175-6°. Heating XV with Hg(OAc)2 in AcOH for a short time, then gradually adding I, gives 85% of 3-chloro-2,4,5-triiodothiophene, m. 121°; 2,4,5-triBr derivative, m. 91° (90% yield). The mother liquor from the preparation of XV appears to contain 4-chlorothiophene-2-sulfonic acid, for with PCl5 there results 10% of 2,4-dichlorothiophene, b. 174-5°, m. -34°, nD21.7 1.56866; 3,5-di-Br derivative, m. 72° (85%). Treating 2,5-thioxene with Cl in CCl4 and the residual oil reacted with Br2 give 60% of 3,4 – dichloro – 2,5 – bis(dibromomethyl)thiophene (XVI), m. 112°; in boiling CCl4 Cl2 gives the bis(dichloromethyl) analog, m. 80°. XVI and CaCO3 in H2O, heated 8 h., give 95% of 3,4-dichlorothiophene-2,5-dialdehyde, pale yellow, m. 194°; alk. H2O2 gives a small amount of 3,4-dichlorothiophene-2-aldehyde, with 0.5 mol. H2O, m. 72°, the principal product being the 2,5-dicarboxylic acid (XVII), m. 314-15° (decomposition). XVII, transformed into the 2,5-bis(acetoxymercuri) and then into the chloromercuri derivative and distilled with dilute HCl, yields 65% of 3,4-dichlorothiophene, b. 184.5-5.5°, m. 1°, nD19.6 1.58206; 2 -chloromercuri derivative, m. 206-7°; 2,5-bis(chloromercuri) derivative, m. 347-9°; 2,5-di-I derivative, m. 106°; 2,5-di-Br derivative, m. 75°. AcCl gives 88% of 3,4-dichloro-2-acetothienone, m. 56°. 3,4-Dichloro-2,5-bis(dibromomethyl)thiophene and Na2CO3 give a poor yield of 3,4-dichloro-2-hydroxymethylthiophene-5-carboxylic acid, m. 220-1°. 2,4,5-Tribromo-3-thiotolene and Cl2 in CCl4 give 3,4-dichloro-2,5-bis(dichloromethyl)thiophene, which yields with EtOH-KOH 2,4,5-trichloro-3-thiotolene, b23 115-16°, m. -18° (corrected), nD21.5 1.56617. 2,4,5-Triiodo-3-thiotolene and Cl2 in CHCl3 (with cooling), followed by EtOH-KOH, give 3-methyl-2,2,3,4,4,5,5-heptachlorotetrahydrothiophene, m. 217-18.5°. Exhaustive chlorination of thiophene or 2-thiophenic acid in AcOH gives 2,3,3,4,5(or 2,2,3,4,5)pentachloro-2,3-dihydrothiophene, b13 122-6°. 2,5-Thioxene and Br2 in CS2 give 85% of 3,4-dibromo-2,5-bis(dibromomethyl)thiophene, m. 132°; Cl2 gives a quant. yield of the dichloromethyl analog, m. 103°; CaCO3 in H2O gives 3,4-dibromothiophene-2,5-dialdehyde, pale yellow, m. 227°; aqueous KMnO4 gives 45% of the 2,5-dicarboxylic acid, m. 317-18°; long treatment with Cl2 in AcOH gives 49% of the acid. 2,3-Dibromo-5-thiophenic acid gives with Hg(OAc)2 in AcOH, followed by formation of the chloromercuri salt and distillation with dilute HCl, 2,3-dibromothiophene, b. 218.6-19.6°, m. -17.5°, nD22.8 1.63039. 2-Thiotolene and Br2-H2O give the tetra-Br derivative, m. 115-17°. The mixed m. ps. of isomeric thiophene derivatives are discussed and illustrated by several examples, showing that this method cannot be used to distinguish the higher halogenated derivatives Certain thiophene and selenophene derivatives have approx. the same m. ps. and mixed m. ps. The possibility of using luminescent anal. for distinguishing between these derivatives is also discussed.

Justus Liebigs Annalen der Chemie published new progress about Melting point. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, Application In Synthesis of 31166-29-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Mengmeng; Yang, Liming; Yang, Hui; An, Guanghui; Li, Guangming published the artcile< Visible Light Mediated C(sp3)-H Alkenylation of Cyclic Ethers Enabled by Aryl Ketone>, Related Products of 5153-70-8, the main research area is alkenyl ether diastereoselective preparation; ether nitroalkene visible light mediated alkenylation pentacenetetrone photocatalyst.

C-H Alkenylation of cyclic ethers (THF, 1,4-dioxane) using the readily available nitroalkenes as the alkenylating reagents which gave α-alkenyl ethers Ar(CH:CH)nR [Ar = Ph, 2-naphthyl, 2-thienyl, etc.; R = 1,2-dimethoxyethane, tetrahydrofuran-2-yl, 1,4-dioxan-2-yl] with high E-selectivity was developed. The mechanism study revealed that alkenylation proceeded through a proton coupled electron transfer (PCET) process with a de-nitration.

ChemCatChem published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Related Products of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huang, Xiao-hua; Huang, Wei; Zhou, Yong-feng; Yan, De-yue published the artcile< Synthesis and characterization of highly soluble aromatic polyimides>, Formula: C8H3ClO3, the main research area is heat resistant soluble aromatic polyimide polythioether polysulfone.

Two highly soluble aromatic polyimides were prepared from 4,4′-diamino-3,3′-di-tert-butyldiphenylmethane (MBTBA) and 3,3′,4,4′-diphenyl sulfide tetracarboxylic dianhydride (DTDA) or 3,3′,4,4′-diphenyl sulfone tetracarboxylic dianhydride (DSDA). Both polymers showed excellent solubility in common solvents, such as chloroform, THF and dioxane, at room temperature The number-average mol. weight was 6.0 × 104 and 8.3 × 104 according to gel permeation chromatog. relative to polystyrene standards, and the polydispersity index was 1.80 and 1.82, resp. The glass-transition temperatures were 286° and 314° (or 315° and 358°) as measured by differential scanning calorimetry (or dynamic mech. anal.). The 5% weight loss temperature of both polymers was near 490° in N2 atm. as determined using thermogravimetric anal. The results indicated that the tert-Bu pendent groups reduced the interactions among the polymer chains, and the thioether or sulfone moiety provided flexibility, thus improving the solubility in organic solvents without the loss of thermal stability. Transparent and flexible films of the polyimides were obtained via solution casting. The MBTBA-DTDA membrane had higher storage modulus than the MBTBA-DSDA membrane.

Chinese Journal of Polymer Science published new progress about Complex modulus, tan δ. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Formula: C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, DaEun; Jin, Chowon; Kang, Hyo published the artcile< Vertical Alignment of Liquid Crystal on Sustainable 2,4-Di-tert-butylphenoxymethyl-Substituted Polystyrene Films>, Related Products of 1592-20-7, the main research area is butylphenoxymethyl substituted polystyrene film liquid crystal; 2,4-di-tert-butylphenol; liquid crystal; orientation layer; polystyrene; vertical.

We synthesized sustainable 2,4-di-tert-butylphenoxymethyl-substituted polystyrenes (PDtBP#, # = 88, 68, 35, and 19, where # is molar percent contents of 2,4-di-tert-butylphenoxymethyl moiety), using post-polymerization modification reactions in order to study their liquid crystal (LC) alignment behaviors. In general, LC cells fabricated using polymer film with higher molar content of 2,4-di-tert-butylphenoxymethyl side groups showed vertical LC alignment behavior. LC alignment behavior in LC cell was related to the surface energy of the polymer alignment layer. For example, when the total surface energy value of the polymer layer was smaller than about 29.4 mJ/m2, vertical alignment behaviors were observed, generated by the nonpolar 2,4-di-tert-butylphenoxymethyl moiety with long and bulky carbon groups. Orientation stability was observed at 200°C in the LC cells fabricated using PDtBP88 as the LC alignment layer. Therefore, as a natural compound modified polymer, PDtBP# can be used as a candidate LC alignment layer for environmentally friendly applications.

Polymers (Basel, Switzerland) published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Related Products of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Song, Renyuan; Yu, Xiaofeng; Liu, Muxin; Hu, Xiaoling; Zhu, Shengqing published the artcile< Anion Exchange Affinity-Based Controllable Surface Imprinting Synthesis of Ultrathin Imprinted Films for Protein Recognition>, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene, the main research area is molecularly imprinted polymer anion exchange immobilization template protein recognition; anion exchange affinity-based interaction; immobilization template; protein recognition; surface-initiated photoiniferter-mediated polymerization.

Anion exchange affinity-based controllable surface imprinting is an effective approach to overcome low imprinting efficiency and high non-specific binding capacity. The template proteins were first immobilized on the anchored tetraalkylammonium groups of the nanoparticles via anion exchange affinity-based interactions, enabling monolayer sorption using a low template concentration The combined use of surface-initiated photoiniferter-mediated polymerization to precisely control the imprinted film thickness, allowing the formation of homogeneous binding cavities, and the construction of effective binding sites resulted in a low non-specific binding capacity and high imprinting efficiency. The obtained imprinted films benefited from the anion exchange mechanism, exhibiting a higher imprinting factor and faster binding rate than the reference material. Binding tests revealed that the binding strength and selective recognition properties could be tuned to a certain extent by adjusting the NaCl concentration Addnl., in contrast to the harsh template elution conditions of the covalent immobilization approach, over 80% of the template mols. were readily removed from the imprinted films using supersonic elution with an aqueous mixture of NaCl and HAc. Introducing template immobilization by anion exchange interactions to the synthesis of imprinted materials may provide a new approach for effective biomacromol. imprinting.

Polymers (Basel, Switzerland) published new progress about Anion exchange. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics