Tag: M.W=150-200

Chen, Jinjin; Chang, Dan; Xiao, Fuhong; Deng, Guo-Jun published the artcile< Three-Component Ordered Annulation of Amines, Ketones, and Nitrovinylarenes: Access to Fused Pyrroles and Substituted Indoles under Metal-Free Conditions>, Category: chlorides-buliding-blocks, the main research area is fused pyrrole indole preparation; cyclocondensation cyclic ketone amine nitrostyrene; cyclohexanone arylamine nitrostyrene cyclocondensation aerobic aromatization iodine catalyst.

Ketones, primary amines such as aniline, and β-nitrostyrenes such as (E)-PhCH:CHNO2 underwent cyclocondensation reactions in toluene at 150° to yield fused pyrroles such as I [R = Me, Et, n-Pr, BuCH2, t-Bu, EtCMe2, Ph, 4-HOC6H4, EtO2C, AcNH, BocNH; X = (CH2)n, CHR, Me2C; n = 1, 2, 3, 7]. Thermal cyclocondensation of cyclohexanones, arylamines, and nitrostyrenes followed by aromatization with O2 and DMSO in the presence of I2 yielded indoles in 50-75% yields.

Journal of Organic Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Rui; Yang, Xiao; Ge, Yicen; Song, Jintong; Zheng, Xueli; Yuan, Maolin; Li, Ruixiang; Chen, Hua; Fu, Haiyan published the artcile< Visible-Light-Induced Oxazoline Formations from N-Vinyl Amides Catalyzed by an Ion-Pair Charge-Transfer Complex>, Synthetic Route of 17082-09-6, the main research area is oxazoline preparation photochem green chem; vinyl amide alc anhydride cyclization alkoxylation heteroarenium iodide catalyst.

Visible-light photoredox catalysis plays an important role in various reactions which are inaccessible under typical thermal conditions. Distinctly different from common visible-light photoredox catalysis which often involves transition-metal complexes, conjugated organic dyes, or electron donor-acceptor complexes, herein, the use of ion-pair charge-transfer (IPCT) complex-induced visible-light photoredox catalytic reactions are described, wherein the cyclization-methoxylation of N-vinyl amides in methanol was achieved under irradiation with blue LEDs. The reaction employs a heteroarenium iodide as the photocatalyst and can be extended to cyclization-alkoxylation, -acyloxylation, and -hydroxylation. This protocol provides an eco-friendly synthetic route to a wide range of oxazoline derivatives Mechanistic investigations with UV-visible spectroscopy and control experiments confirm the existence of the IPCT absorption band in the visible region for the heteroarenium iodide, which is responsible for the observed reactivity.

ACS Catalysis published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mu, Wen-Wen; Li, Peng-Xiao; Liu, Yue; Yang, Jie; Liu, Guo-Yun published the artcile< The potential role of the 5,6-dihydropyridin-2(1H)-one unit of piperlongumine on the anticancer activity>, HPLC of Formula: 17082-09-6, the main research area is piperlongumine dihydropyridin anticancer activity.

Piperlongumine (PL), a potent anticancer agent from the plant long pepper (Piper longum), contains the 5,6-dihydropyridin-2(1H)-one heterocyclic scaffold and cinnamoyl unit. In this paper, we synthesized a series of PL analogs and evaluated their cytotoxicity against cancer cells for the sake of exploring which pharmacophore plays a more potent role in enhancing the anticancer activities of PL. These results illustrated that the position effect, not the electronic effect, of substituents plays a certain role in the cytotoxicity of PL and its analogs. More important, the 5,6-dihydropyridin-2(1H)-one unit, a potent pharmacophore in enhancing the antiproliferative activities of PL, could react with cysteamine and lead to ROS generation, and then bring about the occurrence of ROS-induced downstream events, followed by cell cycle arrest and apoptosis. This work suggests that introducing a lactam unit containing Michael acceptors may be a potent strategy to enhancing the anticancer activity of drugs.

RSC Advances published new progress about Antiproliferative agents. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hazeldine, Stuart T.; Polin, Lisa; Kushner, Juiwanna; Paluch, Jennifer; White, Kathryn; Edelstein, Matthew; Palomino, Eduardo; Corbett, Thomas H.; Horwitz, Jerome P. published the artcile< Design, Synthesis, and Biological Evaluation of Analogues of the Antitumor Agent, 2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid (XK469)>, Recommanded Product: 5-Chloroquinoxalin-2-ol, the main research area is chloroquinoxalinyloxyphenoxypropionic acid structure antitumor; quinoxalinyloxyphenoxypropionic acid antitumor preparation.

2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) I is among the most highly and broadly active antitumor agents to have been evaluated and scheduled to enter clin. trials in 2001. The mechanism or mechanisms of action of I remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogs of I and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions: I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety-to determine the resultant in vitro and in vivo effects of chem. alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of I showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-{4-[(2-quinoxalinyl)oxy]phenoxy}propionic acid, generated the most highly and broadly active antitumor agents. A Me, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of I was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of I (region III), i.e., CONH2, CONHMe, CONMe2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 55687-19-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H5ClN2O, Recommanded Product: 5-Chloroquinoxalin-2-ol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jiajia; Xia, Yuanzhi; Lee, Sunwoo published the artcile< Coupling of amides with ketones via C-N/C-H bond cleavage: a mild synthesis of 1,3-diketones>, Application In Synthesis of 17082-09-6, the main research area is diketone preparation; amides ketone coupling.

A variety of aryl and alkyl-substituted tertiary amides reacted with ketones in the presence of LiHMDS and a variety of primary and secondary amides in one pot to gave the corresponding 1,3-diketone products R1C(O)CH(R3)C(O)R2 [R1 = octyl, Ph, 4-MeC6H4, etc.; R2 = t-Bu, Ph, 2-BrC6H4, etc.; R3 = H, Me, n-Pr, hexyl] in good to excellent yields via C-N cleavage of amides and deprotonation of ketones. The reaction was conducted at room temperature under transition-metal-free conditions. N-Tosyl-, N-triflyl-, N-mesyl-, and N-Boc-substituted tertiary amides including N-benzoyl saccharin and N-benzoyl succinimide showed good activity in the reaction. The broad scope, good functional group tolerance of substrates and gram-scale synthesis showed the great importance and potential of this protocol in organic synthesis and industrial manufacture

Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Zhong-Hua; Wang, Xin-Yan; Huang, Kun-Lin; He, Ming-Yang; Chen, Sheng-Chun published the artcile< Heterogeneous catalytic carboxylation of terminal alkynes with CO2 over a copper(II)-based metal-organic framework catalyst>, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid, the main research area is heterogeneous catalytic carboxylation terminal alkyne copper metal framework catalyst.

Developing efficient, inexpensive and robust heterogeneous catalysts for CO2 conversion is greatly important. In this study, a new stable copper(II)-based metal-organic framework [Cu(Fbtx)2Br2]n (denoted as CZU-7, CCDC-2165700, Fbtx = 1,4-bis(1,2,4-triazole-1-ylmethyl)-2,3,5,6-tetrafluorobenzene) was synthesized via a facile and fast microwave heating method. CZU-7 exhibits a two-dimensional layer structure with the 44-sql topol. This material was demonstrated to be an efficient heterogeneous catalyst for the direct carboxylation of 1-ethynylbenzene with CO2, and various propiolic acids were synthesized in moderate to good yields under optimized reaction conditions. Moreover, the catalyst could be easily recovered and reused five times without significant loss of catalytic activity.

Catalysis Communications published new progress about Carboxylation. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tryniszewski, Michal; Barbasiewicz, Michal published the artcile< Gram-Scale Preparation of Acyl Fluorides and Their Reactions with Hindered Nucleophiles>, HPLC of Formula: 17082-09-6, the main research area is acyl fluoride preparation reaction with hindered nucleophile; aqueous bifluoride acyl chloride halogen exchange.

A series of acyl fluorides was synthesized at 100 mmol scale using phase-transfer-catalyzed halogen exchange between acyl chlorides and aqueous bifluoride solution The convenient procedure consists of vigorous stirring of the biphasic mixture at room temperature, followed by extraction and distillation Isolated acyl fluorides (usually 7-20 g) display excellent purity and can be transformed into sterically hindered amides and esters when treated with lithium amide bases and alkoxides under mild conditions.

Synthesis published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bhatt, Divya; Chae, Soyeon; Kim, Hun Young; Oh, Kyungsoo published the artcile< One-Pot Synthesis of N-Hydroxypyrroles via Soft α-Vinyl Enolization of (E)-β-Chlorovinyl Ketones: A Traceless Arylsulfinate Mediator Strategy>, Quality Control of 17082-09-6, the main research area is hydroxypyrrole preparation one pot; beta chlorovinyl ketone sodium arylsulfinate alpha enolization tandem.

A traceless arylsulfinate mediator strategy has been developed to switch the reaction course of β-chlorovinyl ketones with N-hydroxyamine. The soft α-vinyl enolization of (E)-β-chlorovinyl ketones was conducted in the presence of sodium arylsulfinate to give transient alkenyl sulfones that in turn reacted with NH2OH to give novel access to N-hydroxypyrroles. The mechanistic studies revealed the initial formation of oxazine intermediates that rearranged to thermodynamically stable aromatic products, N-hydroxypyrroles, under microwave-assisted heating conditions.

Organic Letters published new progress about Enolization. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Quality Control of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Guo, Yong; van Ravensteijn, Bas G. P.; Kegel, Willem K. published the artcile< Dimple Colloids with Tunable Cavity Size and Surface Functionalities>, COA of Formula: C9H9Cl, the main research area is dimple colloid tunable cavity size surface functionality.

Dimple colloids with well-defined cavities were synthesized by a modified dispersion polymerization The key step in the procedure is the delayed addition of crosslinkers into the reaction mixture By systematically studying the effect of the delayed addition time and the concentration of the crosslinker on the resulting particle morphol., we identified the dominating driving force that underlies dimple formation. The delayed addition of crosslinkers results in colloids with a core-shell morphol. consisting of a core rich in linear polymers and a crosslinked shell. This morphol. was confirmed by selectively etching non-crosslinked material using DMF. With polymerization proceeding, consumption of monomers present in the swollen particles leads to contraction of the particles, which is larger for the core composed of linear polymers compared to the stiffer crosslinked shell. To accommodate this decrease in volume, the outer crosslinked shell has to buckle, resulting in a well-defined dimple. Furthermore, we extended the procedure to incorporate functional monomers, yielding chem. modifiable dimple particles. Subsequently, we showed that by leveraging the core-shell structure, these dimple particles can be used to prepare dumbbell-shaped colloids with one hollow and one solid lobe. These partially hollow anisotropic particles assemble into strings with well-defined orientations in an a.c. elec. field.

Macromolecules (Washington, DC, United States) published new progress about Colloids. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Koyama, Hiroo; Boueres, Julia K.; Miller, Daniel J.; Berger, Joel P.; MacNaul, Karen L.; Wang, Pei-ran; Ippolito, Marc C.; Wright, Samuel D.; Agrawal, Arun K.; Moller, David E.; Sahoo, Soumya P. published the artcile< (2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents>, Product Details of C7H4ClF3O, the main research area is chromanecarboxylate preparation PPARalpha hypolipidemic SAR.

A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonism. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound I exhibited robust lowering of total cholesterol levels in hamster and dog animal models.

Bioorganic & Medicinal Chemistry Letters published new progress about Glycerides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Product Details of C7H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics