Tag: M.W=150-200

Dubuffet, T.; Loutz, A.; Lavielle, G. published the artcile< An efficient large scale synthesis of coumarins by a dealkylative boron-mediated ring closure of 3-(ortho-methoxyaryl)propenoic esters>, HPLC of Formula: 53581-86-5, the main research area is coumarin synthesis; methoxyarylpropenoic ester preparation dealkylative boron mediated ring closure; methoxycinnamate ortho preparation dealkylative boron mediated ring closure.

Various substituted coumarins, e.g. I (R = H, 5-OH, 5-OMe, 6-OH, 8-OH, 6-Br, 7-Cl-6-Br, 6-Cl, 7-Cl, 8-Cl, 6-NO2, 7-F, 6-F), were prepared via a dealkylative boron-mediated ring closure of ortho-methoxycinnamates,e.g. II (R = H, 6-OMe, 5-OMe, 3-OMe, 5-Br, 5-Br-4-Cl, 5-Cl, 4-Cl, 3-Cl, 5-NO2, R1 = Me; R = 4-F, 5-F, R1 = Et).

Synthetic Communications published new progress about Cyclization (dealkylative). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, HPLC of Formula: 53581-86-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fang, Xin; Ma, Qiang; Zhang, Kai-Xia; Yao, Song-Yun; Feng, Yi; Jin, Yong-Sheng; Liang, Shuang published the artcile< Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities>, Category: chlorides-buliding-blocks, the main research area is benzothiophenone preparation antiplatelet aggregation antioxidant; Phthalide derivative; antioxidation; antiplatelet aggregation.

Benzothiophenone derivatives I [R1 = R2 = R3 = H, Cl; R4 = Et, n-Pr, i-Pr, (CH2)3CH3, (CH2)4CH3; R5 = H, OH] were designed and synthesized. In vitro antiplatelet aggregation activity screening showed that compound I [R1 = H, R2 = Cl, R3 = H, R4 = Et, R5 = H] could significantly inhibit platelet aggregation induced by arachidonic acid, compared with edaravone (p < 0.01). Meanwhile, oxidative damage models using SH-SY5Y and PC12 cells induced by H2O2 were built to evaluate the antioxidant activity of the benzothiophenone derivatives In SH-SY5Y cells, compared with aspirin, compound I [R1 = R2 = R3 = H, R4 = (CH2)3CH3, R5 = OH] significantly increased the relative cell survival rate (p < 0.05). Compared with edaravone, compound I [R1 = R2 = R3 = H, R4 = (CH2)3CH3, R5 = OH] (p < 0.01) and compound I [R1 = Cl, R2 = R3 = H, R4 = Et, R5 = H] (p < 0.05) significantly increased the relative cell survival rate. In PC12 cells, compound I [R1 = R2 = R3 = H, R4 = (CH2)3CH3, R5 = OH] (p < 0.01), compound I [R1 = Cl, R2 = R3 = H, R4 = Et, R5 = H] (p < 0.01) and compound I [R1 = H, R2 = Cl, R3 = H, R4 = n-Pr, R5 = OH] (p < 0.05) remarkably increased the cell survival rate compared with edaravone. The present study identified lead structures to develop potential anti-ischemic stroke agents. Journal of Asian Natural Products Research published new progress about Antioxidants. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

McClelland, Robert A.; Seaman, N. Esther; Duff, James M.; Branston, R. E. published the artcile< Kinetics and equilibrium in the ammonolysis of substituted phthalimides>, Quality Control of 118-45-6, the main research area is ammonolysis phthalimide substituent effect; hydrolysis phthalimide kinetics mechanism; cyclization phthalamide kinetics mechanism.

The basic hydrolysis kinetics of the title compounds (I; R = H, 4-NO2, 4-Cl, 4-Me3C, 3-NO2, 3-Me, 3-Me3Si), to phthalamic acids, show that it involves 2 mechanisms, one of which is first order each in I and OH- and one of which (important in very concentrated MeOH) is first order in I and second order in OH-. The ammonolysis kinetics of I (R ≠ 3-Me, 3-Me3Si) show that the mechanism involves a rate-determining breakdown of the anionic form of the tetrahedral intermediate derived by the addition of NH3 to I; the ammonolysis is reversible. The phthalamide hydrolyzes to the phthalamic acid via cyclization to an intermediate I, which is observed in concentrated base, where its formation from phthalamide is more rapid than its subsequent hydrolysis. Rate constants for the cyclization (the microscopic reverse of the ammonolysis) together with those for ammonolysis provide the equilibrium constant for the ammonolysis reaction. The ammonolysis kinetics of I (R = 3-Me) show that it is reversibly converted to the phthalamide and simultaneously undergoes an irreversible hydrolysis. The ammonolysis of I (R = 3-Me3Si) occurs more quickly than hydrolysis but the equilibrium is so unfavorable that even in concentrated NH3 only a small amount of the phthalimide is formed.

Canadian Journal of Chemistry published new progress about Ammonolysis. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Quality Control of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Boddiboyena, Ramesh; Reddy, G. Nagendra; Seelam, Nareshvarma; Sarma, Monima; Gudisela, Mura reddy published the artcile< Design, synthesis, anticancer evaluation, molecular docking, and in silico ADME analysis of novel chalcones incorporated indole-pyrimidine derivatives as promising anticancer agents>, Application In Synthesis of 27841-33-4, the main research area is indolepyrimidine antitumor mol docking.

A novel library of aryl rings attached chalcone derivatives of indole-pyrimidines (10a-j) were designed, synthesized, and evaluated for anticancer activities against four human cancer cell lines such as PC3, DU-145 (prostate), A549 (lung), and MCF-7 (breast) by employing MTT method. The results of the MTT assay showed that all the synthetic compounds had some tumor cell growth inhibitory activities with IC50 values range from 0.01±0.005 μM to 14.6 ± 6.32 μM, and standard drug with values 1.97 ± 0.45 μM to 3.08 ± 0.135 μM, resp. Among them, compounds (10a, 10b, 10c, 10d, and 10e) displayed remarkable activities, and out of which compounds 10a and 10d were found to be the most promising with potential anti-cancer activity. Mol. docking studies of the compounds were carried out against SARM (PDB ID: 3V49) and the docking results exclusively proposed binding modes in the active site of SARM. Among all, 10a, 10b, 10d, 10 h and 10j showed comparable dock score, 10a and 10b (-142.89 and -145.13) displayed pronounced interactions when compared with co-crystal ligand (-143.40). Finally, in silico predictions of ADME and pharmacokinetic parameters indicated that all these compounds could be considered as drug candidates with oral bioavailability.

Chemical Data Collections published new progress about Antitumor agents. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Application In Synthesis of 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lou, Qin-Xin; Li, Jing-Yu; Yang, Shang-Dong published the artcile< Iridium(III)-Catalyzed C-H Functionalization of Triarylphosphine Oxides with Diazo Dicarbonyl Compounds: Synthesis of α-Aryl 1,3-Dicarbonyl Derivatives>, Application In Synthesis of 17082-09-6, the main research area is arylated dicarbonyl compound preparation iridium catalyst; triarylphosphine oxide diazo dicarbonyl compound arylation; di ketone acyl chloride acetamidobenzenesulfonyl azide diazotization.

A novel (pentamethylcyclopenta-1,3-dienyl)iridium(III)-catalyzed direct C-H functionalization of triarylphosphine oxides with diazo dicarbonyl compounds through carbene insertion has been developed. This strategy provides a simple and efficient route to the construction of α-arylated 1,3-dicarbonyl compounds I (R1 = Me, Ph, 4-FC6H4, etc.; R2 = Ph, 3-MeC6H4, 2-thienyl, etc.; R3 = t-Bu, Ph, 2-naphthyl, etc.; R4 = Me, OEt, t-Bu, etc.; R = H, 4-Me, 5-OMe, etc.) which are important building blocks in pharmaceutical chem.

Synlett published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Prasadarao, K.; Lusirani Susuma, A. J.; Mohan, S. published the artcile< Synthesis, characterization and antibacterial activity of few chalcones>, Electric Literature of 53581-86-5, the main research area is chlorohydroxyacetophenone aldehyde Claisen Schmidt condensation; chalcone preparation antibacterial.

A series of chalcones were synthesized by condensing 4-chloro-2-hydroxyacetophenone with aldehyde derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen-Schmidt condensation. The synthesized compounds were characterized by means of their IR, 1H-NMR spectral data and elemental anal. All these compounds were tested for their antibacterial activity by agar well diffusion method.

International Journal of Pharma and Bio Sciences published new progress about Antibacterial agents. 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Electric Literature of 53581-86-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Duan, Y. T.; Parmar, T. H.; Sangani, C. B.; Shah, A. S.; Ameta, R. K. published the artcile< 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-Oxide Hexafluorophosphate (HATU)/Hydroxybenzotriazole (HOBT)-based One-Pot Cyclization of N-Substituted 2-Arylbenzimidazole Derivatives>, SDS of cas: 85740-98-3, the main research area is benzoic acid methyl phenylenediamine HATU HOBT cyclocondensation green chem; phenyl methylbenzimidazole preparation.

A simple one-pot synthesis of N-methyl-phenylbenzimidazoles was developed from substituted benzoic acids and N-methyl-o-phenylenediamine in the presence of 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate/hydroxybenzotriazole (HATU/HOBT) and N,N-diisopropylethylamine in DMF at 100° C, featuring good to excellent yields and easy workup. The protocol was scaled to gram quantities, and no chromatog. purification was required.

Russian Journal of Organic Chemistry published new progress about Benzimidazoles Role: SPN (Synthetic Preparation), PREP (Preparation). 85740-98-3 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 85740-98-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sang, Dayong; Yue, Huaxin; Zhao, Zhengdong; Yang, Pengtao; Tian, Juan published the artcile< Anchimerically Assisted Selective Cleavage of Acid-Labile Aryl Alkyl Ethers by Aluminum Triiodide and N,N-Dimethylformamide Dimethyl Acetal>, Synthetic Route of 16766-30-6, the main research area is anchimerically assisted chemoselective cleavage aryl alkyl ether; aluminum iodide DMF dimethyl acetal aryl alkyl ether cleavage.

Aluminum triiodide is harnessed by N,N-dimethylformamide di-Me acetal (DMF-DMA) for the selective cleavage of ethers via neighboring group participation. Various acid-labile functional groups, including carboxylate, allyl, tert-butyldimethylsilyl (TBS), and tert-butoxycarbonyl (Boc), suffer the conditions intact. The method offers an efficient approach to cleaving catechol monoalkyl ethers and to uncovering phenols from acetal-type protecting groups such as methoxymethyl (MOM), methoxyethoxymethyl (MEM), and tetrahydropyranyl (THP) chemoselectively.

Journal of Organic Chemistry published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Synthetic Route of 16766-30-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nasiri Oskooie, Maryam; Pooresmaeil, Malihe; Namazi, Hassan published the artcile< Design and synthesis of vinylic glycomonomers and glycopolymer based on α-D-glucofuranose moieties>, Electric Literature of 1592-20-7, the main research area is vinylic glycomonomer glycopolymer glucofuranose moiety synthesis.

Carbohydrates are valuable and safe sources for the synthesis of biopolymers. Today, synthetic polymers having saccharides as pedant groups are one of the great interests in biochem. and the medicinal field. In this work, with the aim of preparing the new glyco-copolymer, firstly isopropylidene derivative of α-D-glucofuranose was synthesized from the reaction of acetone with the glucose in the presence of sulfuric acid as catalyst. Then the obtained compound sep. reacted with acryloyl chloride and ρ-(chloromethyl)styrene monomers to produce related vinylic type glycomonomers. The synthesized glycomonomers were purified using column chromatog. Characterization of the synthesized vinylic glycomonomers was carried out using elemental anal., fourier transform IR, Carbon-13NMR and proton NMR spectroscopy. In the next step, the obtained glycomonomers were copolymerized in 1:1 ratio via a fast and easy free radical polymerization technique. The obtained copolymer showed good solubility in various solvents such as THF, chloroform, Et acetate, and some of the other organic solvents. Finally, water-soluble glyco-copolymer was obtained via partial hydrolysis. The structure of the isolated copolymers determined using the 1H NMR, gel permeation chromatog., and FT-IR spectroscopy.

Journal of Polymer Research published new progress about Biocompatible materials. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Electric Literature of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hammoud, Fatima; Giacoletto, Nicolas; Nechab, Malek; Graff, Bernadette; Hijazi, Akram; Dumur, Frederic; Lalevee, Jacques published the artcile< 5,12-Dialkyl-5,12-dihydroindolo[3,2-a]carbazole-Based Oxime-Esters for LED Photoinitiating Systems and Application on 3D Printing>, Quality Control of 17082-09-6, the main research area is carbazole ester lead emitting diode potoinitiating tree dimentional printing.

In order to expand the application of oxime-esters (OXEs) and to introduce a one-component photoinitiating system of high performance in visible light photopolymerization, a series of 5,12-dialkyl-5,12-dihydroindolo[3,2-a]carbazole-based oxime-esters with visible light absorption abilities is designed and synthesized. Notably, when irradiated with light-emitting diodes at 405 nm, the proposed structures can undergo a direct cleavage of the NO bond followed by decarboxylation, generating free radicals capable to efficiently initiate free radical photopolymerizations (FRP). Furthermore, the new OXEs showed good thermal initiation abilities and can be used as dual photo and thermal initiators. An interesting structure/reactivity/efficiency relationship can be obtained by comparing the reactivity of the different radicals generated upon photoexcitation at identical chromophore but also by comparing the photoinitiating ability of the hexyl derivatives (1)-(10) with that of Me derivatives (1′)-(10′) characterized by a lower solubility than the previous series in resins. Chem. mechanisms are studied through different techniques including real-time Fourier transform IR spectroscopy, UVvisible absorption spectroscopy, fluorescence (time-resolved or steady-state) as well as mol. modeling calculations To finish, OXEs are incorporated in new photosensitive 3D printing resins, furnishing 3D objects with a remarkable spatial resolution

Macromolecular Materials and Engineering published new progress about Absorption. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Quality Control of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics