Category: chlorides-buliding-blocks

Pachl, Petr published the artcileStructure-Based Optimization of Bisphosphonate Nucleoside Inhibitors of Human 5′(3′)-deoxyribonucleotidases, Application of Diethyltrichloromethylphosphonate, the publication is European Journal of Organic Chemistry (2018), 2018(37), 5144-5153, database is CAplus.

Cellular 5′-nucleotidases, enzymes regulating nucleotide/nucleoside pools, are capable of dephosphorylating phosphomonoesters of important nucleoside analog drugs, thus decreasing their therapeutic efficacy. Human cytosolic (cdN) as well as mitochondrial (mdN) variants of this enzyme represent interesting targets for development of inhibitory compounds In this work, bisphosphonate nucleoside derivatives were designed by using a structure-based approach. A second phosphonate group was attached onto a base moiety and by optimization of the linker an increased inhibitor potency towards mdN and cdN was attained. The best compound exhibited inhibition of both enzymes in a nanomolar range, making it the most potent inhibitor of these enzymes prepared to date. In addition, the compounds showed selectivity towards the cdN variant. A series of crystal structures were solved for several inhibitors in the complex with mdN or cdN that provided a structural basis for understanding the inhibition profile of bisphosphonate compounds

European Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hanessian, Stephen published the artcileDesign, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P₂/P₃ core motifs, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(6), 1972-1976, database is CAplus and MEDLINE.

Guided by available X-ray crystal structure data on the serine protease thrombin, a series of pyridin-2-one derivatives, e.g., I·HCl, were designed and synthesized having diverse functionality at the P₁ and P₃ sites. Potent in vitro activity against thrombin, with excellent selectivity over trypsin was found for selected analogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Exner, O. published the artcileThe inductive effect. IV. Transmission of the inductive effect through the furan and thiophene nuclei, Formula: C5H10Cl3O3P, the publication is Collection of Czechoslovak Chemical Communications (1964), 29(9), 2016-22, database is CAplus.

cf. CA 61, 562g. The apparent dissociation constants of substituted (R = H, Me, OH, OMe, OPh, SH, SO₂Ph, NMe₃Cl) 5-methylpyromucic (I) and 5-methylthiophene-2-carboxylic (II) acids were determined in 80% Me Cello-solve. The relative sensitivity to substitution in both series is believed to represent the value of the mobility of the π-electrons and indirectly the measure of the aromatic character of the skeleton which decreases in the order benzene > thiophene > furan.

Collection of Czechoslovak Chemical Communications published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akapo, S. O. published the artcileInfluence of temperature and mobile phase composition on retention properties of oligomeric bonded phases in reversed-phase liquid chromatography (RPLC), Safety of Dichloro(methyl)(octyl)silane, the publication is Chromatographia (1997), 44(3/4), 135-144, database is CAplus.

The effect of temperature and mobile phase composition (methanol-water) on the retention behavior of an oligomeric series of n-octylsilyl bonded phases in reversed-phase liquid chromatog. was investigated. Plots of In k against 1/T (van’t Hoff plot) and the enthalpy of transfer (ΔH°) yields linear relationships under the conditions studied. The ΔH° values of the aromatic hydrocarbons and n-alkyl benzoates are higher than those of the polar compounds due to their higher level of interaction with the stationary phase. A linear plot of ΔH° vs. ΔS° suggest that the retention process, which is essentially controlled by non-specific (dispersive) interactions between the solutes and the bonded ligands, is identical for all cases evaluated. The existence of similar retention mechanisms is confirmed by the constant value of the enthalpy-entropy compensation temperature of the columns for a given class of compounds As expected, decreasing the methanol content (% volume/volume) of the mobile phase results in increased eluate retention times. The methylene and Ph selectivities are found to be independent of the carbon content of the stationary phases and varied only with the eluent composition In addition to their high stability under aggressive mobile phase conditions as previously reported, the results of this study generally showed that the solute retention process on oligomeric phases are similar to those exhibited by the conventional reversed phases.

Chromatographia published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Safety of Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akapo, S. O. published the artcileSyntheses of stationary phases for reversed-phase HPLC: comparison of the fluidized bed technique with the organic solvent process, Recommanded Product: Dichloro(methyl)(octyl)silane, the publication is Journal of Chromatographic Science (1994), 32(3), 86-92, database is CAplus.

Chem. bonded stationary phases were prepared by fluidized bed and conventional organic solvent (toluene) bonding processes, resp., using mono-, di-, and trifunctional n-octylchlorosilanes. Solid-state ¹³C CPMAS NMR spectroscopic studies show that the surface structure of the fluidized bed packings consists only of the expected silane skeleton. In addition to the silane signals, the organic solvent packings give unexpected -OMe absorbance at ∼50 ppm, which arises from a possible side reaction between the methanol washings and the residual chlorine atoms. Chromatog. studies show that the fluidized bed packings possess higher plate numbers and superior retention characteristics for hydrocarbon solutes. This is probably caused by their higher carbon load and homogeneous distribution of the alkyl ligands on the silica surface as a result of better accessibility of the silane mols. to the surface silanol groups. In comparison with the organic solvent process, the fluidized bed technique produces a more reproducible packing regardless of the functionality of the silanizing agent.

Journal of Chromatographic Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Recommanded Product: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akapo, S. O. published the artcilePreparation, structure, and chromatographic properties of different silica-based octylsilyl bonded phases, Product Details of C9H20Cl2Si, the publication is Journal of Chromatographic Science (1990), 28(4), 186-93, database is CAplus.

The preparation, using the fluidized bed technique, of a series of silica-based octylsilyl bonded phases with or without silica deactivation prior to silanization with mono-, di- or trifunctional chlorosilane is described. The surface structures of the bonded phases are determined by ²⁹Si and ¹³C cross-polarization and magic angle spinning NMR. Furthermore, the retention behavior of the phases is investigated with polar and nonpolar solutes, and data are correlated in terms of the bonding procedure and the functionality of the silanizing agent. Mass loading experiments for a single solute on selected packings give a maximum load of about 140.0 and 70.0 μg/g of packing for large and small particles, resp., irresp. of the silanizing agent.

Journal of Chromatographic Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sagar, Sneha R. published the artcilePharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer’s disease, Formula: C7H7ClN2S, the publication is Bioorganic Chemistry (2019), 102992, database is CAplus and MEDLINE.

Alzheimer’s disease (AD) is the most prevalent disease of old age leading to dementia. Complex AD pathogenesis involves multiple factors viz. amyloid plaque formation, neurofibrillary tangles and inflammation. Herein we report of a new series of quinoxaline-bisthiazoles as multitarget-directed ligands (MTDLs) targeting BACE-1 and inflammation concurrently. Virtual screening of a library of novel quinoxaline-bisthiazoles was performed by docking studies. The most active mols. from the docking library were taken up for synthesis and characterized by spectral data. Compounds 8a-8n showed BACE-1 inhibition in micro molar range. One of the compounds, 8n showed BACE-1 inhibition at IC₅₀ of 3 ± 0.07 μM. Rat paw edema inhibition in acute and chronic models of inflammation were obtained at 69 ± 0.45% and 55 ± 0.7%, resp. Compound 8n also showed noteworthy results in AlCl₃ induced AD model. The treated rats exhibited excellent antiamnesic, antiamyloid, antioxidant, and neuroprotective properties. Behavioral parameters suggested improved cognitive functions which further validates the testimony of present study. Moreover, compound 8n was found to have inherent gastrointestinal safety. This new string of quinoxaline-bisthiazoles were identified as effective lead for the generation of potent MTDLs and compound 8n was found to showcase qualities to tackle AD pathogenesis.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sharma, Shivani published the artcileA review on characteristics and analytical methods of pitavastatin: a potent statin drug, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2021), 10(5), 1761-1772, database is CAplus.

A review. The distinctive solutions are utilized within the treatment of hyperlipidemia join the fibric corrosive subordinates such as clofibrate, fenofibrate; bile corrosive sequestrants e.g. colestipol; cholesterol retention inhibitors e.g. ezetimibe; HMG CoA reductase inhibitors e.g. lovastatin, rosuvastatin, simvastatin and pitavastatin. Pitavastatin is novel medicate utilized within the treatment of hyperlipidemia. It must be given in single or in mixture with distinctive antihyperlipidemic specialists. Pitavastatin may be a exceptionally strong specialist called HMG CoA reductase inhibitors, or ”quot;statins.” Pitavastatin lower the levels of low-d. lipoprotein, or LDL and triglycerides within the blood, whereas expanding levels of high-d. lipoprotein, or HDL. An colossal number of techniques counting Tall Execution Fluid chromatog. (HPLC), UV-Visible spectroscopy are utilized for the assurance pitavastatin. There are different explanatory strategies utilized for sedate examination and these strategies have been approved agreeing to ICH rules (Q1A R2). Hence, this procedure can be securely utilized for standard pitavastatin quality control tests.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C14H10O4, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gutch, Pranav K. published the artcileN,N-dichloro poly(styrene-co-divinyl benzene) sulfonamide polymeric beads: an efficient and recyclable decontaminating reagent for sulfur mustard, Synthetic Route of 1002-41-1, the publication is Journal of Polymer Materials (2011), 28(3), 431-442, database is CAplus.

An efficient and operationally simple method is developed for chem. decontamination of sulfur mustard. A new chlorine bearing reagent N,N-dichloropoly (styrene-co-divinyl benzene) sulfonamide was developed to deactivate the sulfur mustard in aqueous (acetonitrile: water) medium. This decontamination reaction was monitored by gas chromatog. and the products were analyzed by GC-MS. This reagent has advantage over earlier reported reagents in terms of effectiveness, stability, non toxicity, cost, ease of synthesis, recyclability (collected after filtration, rechlorinated and used for further reaction) and instantaneous decontamination of sulfur mustard at room temperature

Journal of Polymer Materials published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Synthetic Route of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghosh, Biswajit published the artcileMolecular Interactions of Some Bioactive Molecules Prevalent in Aqueous Ionic Liquid Solutions at Different Temperatures Investigated by Experimental and Computational Contrivance, Category: chlorides-buliding-blocks, the publication is Fluid Phase Equilibria (2022), 113415, database is CAplus.

The solute -solvent interaction between ionic liquids (ILs) and amino acids (AA) in aqueous media plays a significant role for the optimization of a number of important biotechnol. processes. L-Valine and L-Proline (two solute mols.) interact with an ionic liquid (Benzyltributylammonium chloride) in aqueous medium. Based on the different parameters such as apparent molar volume, viscosity B-coefficient, molar refraction, molar conductance at different temperatures and different concentrations from d., viscosity, refractive index, conductance measurements have been used to explain the mol. level interactions which was supported by NMR and UV-Vis studies. Using Masson equation, the exptl. slopes and the limiting apparent molar volumes are obtained which explain the solute-solute and solute-solvent interactions. Hepler’s technique and dB/dT values have been used to examine the structure-making and structure-breaking nature of the solutes in the solvents. Viscosity parameters, A and B obtained from Jones-Doles equation explained the solute-solute and solute-solvent interactions in the solution Lorentz-Lorenz equation has used to calculate the molar refraction. The specific conductance also explained the interaction properties. Further the findings have been supported by NMR study of the solutions and also considerable amount of theor. anal. has been done which was in good agreement with the exptl. result. The behavior of many other bio-mols. can be explained by considering amino acids as model and the mechanism has been extended to elucidate the behavior of other (biol.) systems. In our findings we were emphasized on the nature of solute-solvent interactions and the presence of structural effect on the solvent in solution to analyze the mol.-level interactions prevalent in the systems.

Fluid Phase Equilibria published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics