Category: chlorides-buliding-blocks

El-Sakka, Sahar Said published the artcileBehaviour of 4-[4-methoxy-3-methylphenyl]-4-oxobutenoic acid towards nitrogen-containing nucleophiles, SDS of cas: 3696-23-9, the publication is Journal of Chemical Sciences (Bangalore, India) (2014), 126(6), 1883-1891, database is CAplus.

A series of novel amino acid derivatives has been synthesized by the reaction of 4-[4-methoxy-3-methylphenyl]-4-oxobutenoic acid with primary and secondary amines. The treatment of amino acids with hydrazine afforded pyridazine. Phenylhydrazone was obtained from the reaction of the acid with Ph hydrazine in ethanol. On the other hand, the acid underwent heterocyclization upon the treatment with 2-aminopyridine, o-phenylenediamine, aryldithiocarbamates and thiourea derivatives to give the corresponding pyridopyrimidine, quinoxalone, 2-thioxo-1,3-thiazole and 4-hydroxy-1,3-thiazole, resp. The thiazolopyridazine derivatives were obtained from the reaction of 4-hydroxy-1,3-thiazole with hydrazine and phenylhydrazine, resp. The behavior of the 4-hydroxy-1,3-thiazole toward acetic anhydride and bromine was also studied. Some of the synthesized compounds also exhibited anti-microbial activities.

Journal of Chemical Sciences (Bangalore, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hamdy, Rania published the artcileDesign and synthesis of new drugs inhibitors of Candida albicans hyphae and biofilm formation by upregulating the expression of TUP1 transcription repressor gene, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is European Journal of Pharmaceutical Sciences (2020), 105327, database is CAplus and MEDLINE.

Here, new compounds were designed to selectively inhibit C. albicans hyphae formation without affecting human cells to afford sufficient safety. The newly designed 5-[3-substitued-4-(4-substituedbenzyloxy)-benzylidene]-2-thioxo-thiazolidin-4-one derivatives, named SR, I (R¹ = 4-Me, 4-CF₃, 3-CF₃; R² = OMe, Cl, Br) showed very specific and effective inhibition activity against C. albicans hyphae formation. SR compounds caused hyphae inhibition activity at concentrations 10-40 fold lower than the concentration required to inhibit Candida yeast and bacterial growths. The anti-hyphae inhibition activities of SR compounds were via activation of the hyphae transcription repressor gene, TUP1. Correlation studies between the expression of TUP1 gene and the activity of SR compounds confirmed that the anti-C. albicans activities of SR compounds were via inhibition of hyphae formation. The newly designed SR compounds showed 10-40% haemolytic activity on human erythrocytes when compared to 100% haemolysis by 0.1% triton employed as pos. control. Furthermore, theor. prediction of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of SR compounds confirmed their safety, efficient metabolism and possible oral bioavailability. With the minimal toxicity and significant activity of the newly-designed SR compounds, a future optimization of pharmaceutical formulation may develop a promising inhibitor of hyphal formation not only for C. albicans but also for other TUP1-dependent dimorphic fungal infections.

European Journal of Pharmaceutical Sciences published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rao, B. Vittal published the artcileSynthesis of 2,3-diphenyl-6-(p-substituted phenyl)-5H- and (or) -methyl-7H-oxofuro[3,2-g][1]benzopyrans as possible antifertility agents, HPLC of Formula: 4584-49-0, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1980), 19B(3), 232-4, database is CAplus.

Synthesis and antiimplantation activity of benzopyrans I [R = Me₂NCH₂CHMe, 3-piperidinopropyl, 2-morpholinoethyl, 3-piperazinoethyl, 2-(1-pyrrolidinyl)ethyl, Me₂NCH₂CH₂; R¹ = H, Me] are reported. I (R = Me₂NCH₂CHMe; R¹ = Me) shows significant activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, HPLC of Formula: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rao, B. Vittal published the artcileSynthesis and antifertility activity of 5-oxo-5H-benzofuro(6,5-c)[2]benzopyran and its basic ether derivatives, SDS of cas: 4584-49-0, the publication is Journal of the Indian Chemical Society (1980), 57(8), 837-40, database is CAplus.

Benzofurobenzopyranones I (R = H, aminoalkyl) were prepared from 2-BrC₆H₄CO₂H and benzenediols via 7-hydroxy-3,4-benzocoumarins and cyclization of the corresponding desyl ethers. I caused â‰?3.3% inhibition of fetal implantation at 10 mg/kg i.p. in rats.

Journal of the Indian Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Tae-Kyung published the artcileSynthesis of a novel bridge compound having hetero-bi-functional reactive groups. Part 1: its adsorption properties, HPLC of Formula: 18791-02-1, the publication is Dyes and Pigments (2005), 65(3), 261-266, database is CAplus.

A novel heterobifunctional compound containing two different reactive groups, α,β-dibromopropionylamino and dichloro-s-triazinyl groups, was synthesized. The α,β-dibromopropionylamino group had considerable reactivity towards amines or amino groups under acidic conditions and high temperature The dichloro-s-triazinyl group had reactivity towards hydroxyl groups under alk. conditions and room temperature The compound was used as a bridge to fix dyes containing amino groups (e.g. 1-amino-4-hydroxyanthraquinone) to cellulosic substrates (e.g. cotton textiles). The effects of temperature, pH, neutral salt, treatment time and concentration on chemisorption of the bridge compound to cotton fibers were investigated. The heterobifunctional compound provided the 1-amino-4-hydroxyanthraquinone-dyed cotton textile with a color strength of 14.73, while the dyed untreated textile had a color strength of 0.78.

Dyes and Pigments published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Baj, Stefan published the artcileTri-liquid system in the synthesis of dialkyl peroxides using tetraalkylammonium salts as phase-transfer catalysts, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Applied Catalysis, A: General (2010), 385(1-2), 208-213, database is CAplus.

A highly effective method to synthesize dialkyl peroxides from alkyl hydroperoxides and alkyl bromides in a liquid-liquid-liquid system using tetraalkylammonium salts as phase-transfer catalysts is reported. This process was conducted in the presence of highly concentrated aqueous KOH solutions and cyclohexane as an organic solvent. In a liquid-liquid-liquid system, the phase-transfer catalyst forms an insoluble third-liquid phase between the organic and aqueous phases that enables the catalyst to be recycled multiple times. Dialkyl peroxides were obtained in high yields and with 100% selectivity.

Applied Catalysis, A: General published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Baj, Stefan published the artcileSynthesis of peroxyesters in tri-liquid system using quaternary onium salts and polyethylene glycols as phase-transfer catalysts, HPLC of Formula: 23616-79-7, the publication is Applied Catalysis, A: General (2012), 184-189, database is CAplus.

A mild and efficient method for the synthesis of organic peroxyesters from acid chlorides and tertiary alkyl hydroperoxides in the presence of aqueous solution of inorganic base is described. The process was conducted in a tri-liquid system using quaternary onium salts and polyethylene glycols as phase-transfer catalysts. A model reaction of cumyl hydroperoxide (CHP) with butyryl chloride was investigated under a wide range of conditions. Selected peroxyesters were obtained in moderate to high yields (62-93%).

Applied Catalysis, A: General published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sousa-Pereira, Danilo published the artcileSynthetic (E)-3-phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium chloride derivatives as promising chemotherapy agents on cell lines infected with HTLV-1, Product Details of C7H7ClN2S, the publication is Molecules (2020), 25(11), 2537, database is CAplus and MEDLINE.

Synthesis of four compounds belonging to mesoionic class, (E)-3-phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium chloride derivatives (5a-d) and their biol. evaluation against MT2 and C92 cell lines infected with human T-cell lymphotropic virus type-1, which causes adult T-cell leukemia/lymphoma (ATLL), and non-infected cell lines (Jurkat) are reported. The compounds were obtained by convergent synthesis under microwave irradiation and the cytotoxicity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Results showed IC50 values of all compounds in the range of 1.51-7.70μM in HTLV-1-infected and non-infected cells. Furthermore, it was observed that 5b could induce necrosis after 24 h for Jurkat and MT2 cell lines. The exptl. (fluorimetric method) and theor. (mol. docking) results suggested that the mechanism of action for 5b could be related to its capacity to intercalate into DNA. Moreover, the preliminary pharmacokinetic profile of the studied compounds (5a-d) was obtained through human serum albumin (HSA) binding affinity using multiple spectroscopic techniques (CD, steady-state and time-resolved fluorescence), zeta potential and mol. docking calculations The interaction HSA:5a-d is spontaneous and moderate (Ka ~104 M-1) via a ground-state association, without significantly perturbing both the secondary and surface structures of the albumin in the subdomain IIA (site I), indicating feasible biodistribution in the human bloodstream.

Molecules published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C3H8N2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuan, Hai published the artcileStructural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase, Quality Control of 866-23-9, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(6), 1651-1654, database is CAplus and MEDLINE.

Low brain levels of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) lead to convulsions. Inhibition of GABA aminotransferase increases the concentration of GABA and can terminate the convulsions. Earlier we reported the synthesis of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid (2), which is 186 times more potent an inactivator of GABA aminotransferase than the epilepsy drug S-vigabatrin. The corresponding dichloromethylene analog of 2 (compound 3) has been made, but it shows only weak reversible inhibition of GABA aminotransferase. However, the tetrazole isostere of 2 (compound 4) has been found to be a time-dependent inactivator of GABA aminotransferase. Although it is 20 times less potent than carboxylic acid 2, it is 2.5 times more potent than S-vigabatrin. A calculation of the Clog P values indicates that 4 is the most lipophilic of the three, being 69 times more lipophilic than 2 and 55 times more lipophilic than S-vigabatrin, indicating potential for improved bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C26H41N5O7S, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Samet, Alexander V. published the artcileAn Efficient Synthesis of Fused 2-Aryliminothiazolines via a Solvent-Free Cyclopropyliminium Rearrangement, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is ChemistrySelect (2016), 1(10), 2373-2376, database is CAplus.

A series of (Z)-3-aryliminopyrrolo[1,2-c]thiazoles I (Ar = Ph, 4-chlorophenyl, 4-methylphenyl, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, 3-trifluoromethylphenyl) was synthesized by a base-induced dehydrobromination of 3-arylaminopyrrolo[1,2-c]thiazolium bromides II, which in turn, was obtained via an efficient solvent-free cyclopropyliminium rearrangement of the corresponding 4-cyclopropylthiazole hydrobromides III proceeding in melt at high rate and in excellent yields. Biol. evaluation using phenotypic sea urchin embryo assay showed that 2-arylamino-4-cyclopropylthiazoles IV displayed an antimitotic tubulin-unrelated activity, whereas fused-ring rearrangement products III were proposed to inhibit Ca-Zn-dependent metalloproteases.

ChemistrySelect published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics