Category: chlorides-buliding-blocks

Nikhar, Sameer published the artcileDesign of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling, Formula: C7H8BClO2, the publication is European Journal of Medicinal Chemistry (2021), 113252, database is CAplus and MEDLINE.

Receptor interacting protein kinase-2 (RIPK2) is an enzyme involved in the transduction of pro-inflammatory nucleotide-binding oligomerization domain (NOD) cell signaling, a pathway implicated in numerous chronic inflammatory conditions. Herein, a pyrido[2,3-d]pyrimidin-7-one based class of RIPK2 kinase and NOD2 cell signaling inhibitors is described. For example, 33 (e.g. UH15-15) inhibited RIPK2 kinase (IC50 = 8 ± 4 nM) and displayed > 300-fold selectivity vs. structurally related activin receptor-like kinase 2 (ALK2). This mol. blocked NOD2-dependent HEKBlue NF-κB activation (IC50 = 20 ± 5 nM) and CXCL8 production (at concentrations > 10 nM). Mol. docking suggests that engagement of Ser25 in the glycine-rich loop may provide increased selectivity vs. ALK2 and optimal occupancy of the region between the gatekeeper and the αC-helix may contribute to potent NOD2 cell signaling inhibition. Finally, this compound also demonstrated favorable in vitro ADME and pharmacokinetic properties (e.g. Cmax = 5.7μM, Tmax = 15 min, t1/2 = 3.4 h and Cl = 45 mL/min/kg following single 10 mg/kg i.p. administration) further supporting the use of pyrido[2,3-d]pyrimidin-7-ones as a new structure class of RIPK2 kinase and NOD cell signaling inhibitors.

European Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lamaty, G. published the artcileAcid hydrolysis of 2-haloethylamines. I. Determination of kinetic conditions. Evaluation of the participant of the nitrogen lone pair in the loss of the halogen, Product Details of C5H13Cl2N, the publication is Bulletin de la Societe Chimique de France (1974), 2143-8, database is CAplus.

The kinetics of hydrolysis of haloamines, XCH2CH2NHR2+X- (I; R = H, Me, Et; X = Br, Cl) at 90 and 100° follow a first order rate law. Initial variations in linearity for the curve log [I] = kexp.(sec-1) are due to the competitive hydrolysis of I and its conjugate base. The rate of hydrolysis of the conjugate base is suppressed by the addition of small amounts of HClO4.

Bulletin de la Societe Chimique de France published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Product Details of C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bernardo, Paul H. published the artcileSynthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1, Recommanded Product: 3-Chloro-4-isopropoxyphenylboronic acid, the publication is Pure and Applied Chemistry (2011), 83(3), 723-731, database is CAplus.

Symposium report presented at the 18th International Conference on Organic Synthesis (ICOS) Bergen, Norway 1-6 August, 2010. A small library of pyridine-based rhodanine analogs of BH-3I-1 [i.e., 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-3-thiazolidineacetic acid] was designed, the synthesis of the target compound was achieved using amino acids as starting materials and the products thus obtained were screened against B-cell lymphoma (extra large, Bcl-XL, antiapoptotic protein, inhibitor of apoptosis proteins) and myeloid cell leukemia sequence 1 (Mcl-1) for the ability to displace 5-(carboxy)fluorescein-labeled Bak peptide (Flu-Bak). Differences in selectivity toward Bcl-XL and Mcl-1 were observed and the binding modes of selected compounds were studied further. The results may be useful in designing potent small-mol. inhibitors of Bcl-XL and Mcl-1 as well as selective Mcl-1 inhibitors.

Pure and Applied Chemistry published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Recommanded Product: 3-Chloro-4-isopropoxyphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Moldavskaya, N. A. published the artcileHydrosilylation of olefins in the presence of phosphoryl complexes of nickel(II), Recommanded Product: Dichloro(methyl)(octyl)silane, the publication is Zhurnal Obshchei Khimii (1981), 51(7), 1621-4, database is CAplus.

Hydrosilylating CH₂:CHR (R = hexyl, pentyl) with Cl₂HSiMe gave mixtures of RCH₂CH₂SiMeCl₂ and RCH₂CH₂SiMeHCl in the presence of NiL₂X₂ (L = substituted phosphine oxide, substituted phosphine, X = Br, NO₃, Cl) at 120° for 10 h at concentrations alkene:Cl₂HSiMe:nickel complex of 1:1:10^-3 mol. Catalyst effectiveness was: Ph₃PO < R¹Ph₂PO (R¹ = alkyl) < R¹₂PhPO < R¹₃PO.

Zhurnal Obshchei Khimii published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Recommanded Product: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhebentyaev, A. I. published the artcileSpectrophotometric determination of decamethoxine with eosine, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1984), 27(4), 412-14, database is CAplus.

A reproducible and highly accurate spectrophotometric determination of decamethoxine (I) [38146-42-8] consisted of adding eosin  [17372-87-1] 0.5 (10^-3 mol/L), EtOH 3, and pH 2.8 citrate buffer 5 mL to 75-100 μg I and making the volume to 25 mL with H₂O. The absorbance is measured at 555 nm. NaCl does not interfere with I determination in diluted solutions (0.01-0.05%) containing 0.9% NaCl. The Beer’s law was observed at 0.3-4 μg I/mL. Eosin and I form a 1:2 complex (5-10 min). The addition of 10-20% EtOH increased the stability of the solutions and also the absorbance. At >20% EtOH, the absorbance of the complex decreased. The absorbance is stable for >1 h. At pH 2-3.5 the solution has the highest stability.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C14H28O5S, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhebentyaev, A. I. published the artcileSpectrophotometric determination of decamethoxin, Category: chlorides-buliding-blocks, the publication is Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk (1982), 25-7, database is CAplus.

Decamethoxin was determined by spectrophotometry by measuring the absorbance of its 1:2 associate with phloxine at 530 nm in a citrate buffer (pH 1.5) in 10% EtOH. The stability constant of the associate is 2.3 × 10¹⁰. Various derivatives of quaternary ammonium hydroxides did not interfere. The detection limit is 0.4 μg/mL.

Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C24H29N5O3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhornyak, O. I. published the artcileAnalysis of the antimicrobial activity of antiseptic tablets to microorganisms, Product Details of C38H74Cl2N2O4, the publication is Anali Mechnikivs’kogo Institutu (2012), 51-54, database is CAplus.

Antimicrobial activity of antiseptic tablets septefril, sebidin, septolette, ephisol, adzhisept results have been given in this article. Research results point to great perspective of septefril, sebidin, septolette, ephisol, adzhisept antiseptic usage for treatment and prophylaxis inflammatory-purulent diseases.

Anali Mechnikivs’kogo Institutu published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C13H10O2, Product Details of C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pernot, Robert published the artcileThe reaction of ethylene with sulfur monochloride (S₂Cl₂) and with sulfur dichloride (S₂Cl₂ + Cl₂) in the preparation of bis(2-chloroethyl) sulfide (mustard gas), Safety of 1,2-Bis(2-chloroethyl)disulfane, the publication is Ann. chim. [12] (1946), 626-57, database is CAplus.

Crude mustard gas (I) as obtained in the Levinstein process is a clear yellow liquid, m. 10.5°, which does not deposit a trace of S when kept for over a year. On distillation in vacuo I gives 70% pure (ClCH₂CH₂)₂S.(II), m. 13.5°. I is only partially soluble in EtOH or ether. The m.p. is only slightly affected when byproducts are present. When 500 g. I is extracted with 500 cc. EtOH, 208 g. remains undissolved. On cooling the alc. solution, 130 g. II, m. 13.3°, crystallizes. When 500 g. I is cooled with ice-NaCl, 245 g. II, m. 12.5°, crystallizes. Distillation of 323 g. I gives 2 fractions, (a) 185 g., b₁₈ 110-15°, m. 13.3°, and (b) 40 g., b₁₈ 115-55°, m. 3.8°, the residue decomposing Redistillation of 40 g. of fraction a gives a fraction (c) 25 g., b₁₈ 110-15°, and 12 g., b₁₈ 120-35°, the latter being chiefly (ClCH₂CH₂)₂S₂ (III). Distillation of the EtOH solution gives II, but no III or (ClCH₂CH₂)₂S₃ (IV) is present. From the EtOH-insoluble part no definite product can be isolated even on distillation at 1 mm. It still contains a small amount of II which is removed by careful oxidation with H₂O₂, whereby II is oxidized to the H₂O-soluble sulfoxide while III and IV remain unchanged. The elementary composition of the residue after treatment with H₂O₂ corresponds to (ClCH₂CH₂)₂S₈ (V) which may be formed according to the following equation: 7S₂Cl₂ + 14C₂H₄ → 6 II + V. Treatment of 86 g. EtOH-insoluble product with moist NH₃ according to Felsing and Arenson (C.A. 15, 54) causes the separation of 16.5 g. S. The recovered product, now soluble in ether and C₆H₆, is free of N and has a composition corresponding to (ClCH₂CH₂)₂S₄ (VI). VI does not deposit S even after standing 6 mo. When VI is heated with S, the latter dissolves and seps. again on cooling. In an attempt to hydrolyze VI with alc. KOH no definite compound is formed. When VI is treated with Me₂CO, S is deposited with the formation of IV, m. 27°. IV is also formed when VI is treated with steam at 100 mm. An attempt to oxidize IV with BzO₂H, to transfer it into the iodine compound by heating it with NaI in a sealed tube, or to condense IV with PhONa or BzONa failed. Distillation of 50 g. IV at 1 mm. gives 40 g. yellow liquid, b₁ 120-35°. Redistillation of the latter gives 2 fractions, (d) 10 g., b₁ up to 120°, and (e) 28 g., b₁ 120-6°, containing chiefly IV, m. 26.5°. IV prepared according to Mann, et al. (C.A. 15, 2413), m. 25°; the mixed m.p. of the 2 preparations is 26°. When IV is heated with the theor. amount of S to form VI, the S dissolves but seps. again on cooling. IV when distilled at 40 mm. gives a small amount of III, b. 160-5°, which is not attacked by H₂O₂. When distilled at atm. pressure III gives a very small amount of II. These results show that III has the structure (ClCH₂CH₂S)₂ and not (ClCH₂CH₂)₂S:S, while IV has the structure ClCH₂CH₂S(:S)SCH₂CH₂Cl. When 220 g. EtOH-insoluble product is extracted 5 times with 200 cc. pure and dry Me₂CO and the Me₂CO is evaporated, 80 g. of yellow oil is obtained from which some (ClCH₂CH₂)₂SO crystallizes. The residual oil has a composition corresponding to (ClCH₂CH₂)₂S₅ (VII) and is insoluble in EtOH, petr. ether, and AcOH. Pyridine precipitates 8.5 g. S from 43 g. VII. Evaporation of the pyridine leaves an oil which on distillation at 3 mm. gives a mixture of III and IV. The Me₂CO-insoluble part (140 g.), when cooled, deposits 16 g. S. The filtrate consists of a polysulfide or a mixture of polysulfides high in S content (75.7-6.7%). The hypothesis that II is formed according to the equation S₂Cl₂ + 2C₂H₄ → II + S is not substantiated by the action of C₂H₄ upon S₅Cl₂. When 580 g. S₅Cl₂ is treated with C₂H₄, 733 g. reaction product is obtained from which 207 g. S deposits, giving 526 g. reaction product. From 342 g. S₂Cl₂, which equals 580 g. S₅Cl₂, and 142 g. C₂H₄, 484 g. reaction product is calculated while 526 g. is obtained. These results indicate that S₅Cl₂ reacts in the same way as S₂Cl₂. The following reaction mechanism is proposed: S₂Cl₂ + 3C₂H₄ gives a sesquimustard gas, (CH₂SCH₂CH₂Cl)₂ (VIII). VIII reacts with S₂Cl₂ to give 1 mol. II and ClSS₂CH₂CH₂Cl (IX); IX + C₂H₄ → IV. IV + S₂Cl₂ → Cl.S.CH₂CH₂Cl (X) + ClS₄CH₂CH₂Cl (XI); XI + C₂H₄ → II + VI, etc. SCl₂ + C₂H₄ gives 85% crude reaction product (XII), m. 5-8°. Distillation of 109.5 g. XII, m. 5.5°, gives 3 fractions: (f) 97.5 g., b₁₀ 93-6°, m. 10°; (g) 4.5 g., b₁₀ 96-105°; and 3.5 g. residue. Redistillation of 90 g. f gives a fraction, 76.5 g., b₁₂ 97-8°, m. 10°, which on redistillation gives 62.3 g., b₁₃ 101-2°, m. 10.2°, and 11.4 g., b₁₅ 102-4°, m. 11.8°. This indicates that with II other products come over. Because under the conditions used, SCl₂ can be considered to be a solution of Cl in a mixture of SCl₂ and S₂Cl₂, byproducts containing α-chlorinated compounds are formed which split off HCl with formation of ClCH:CHSCH₂CH₂Cl (XIII). II containing 8.8% XIII m. 9.9°. When SCl₂ in a 10% CCl₄ solution and C₂H₄ are allowed to react and the reaction product is distilled after the CCl₄ has been removed at 120°, II, b₁₀ 93.5-4°, m. 10.8°, is obtained. When 800 g. of the reaction product is extracted with EtOH only 31 g. insoluble product (XIV) is obtained. When Cl is passed into 250 g. XIV, the temperature rises to 45-50°. As soon as the temperature drops to room temperature the Cl current is stopped and the reaction product distilled in vacuo. Up to 70°/15 mm. the S-Cl compounds distill, and between 98° and 100° a few cc. of a turbid liquid distills. When C₂H₄ is passed at 30-40° into the residue, a vigorous reaction takes place. After the active Cl in the residue has disappeared, 303 g. of a clear red solution is obtained. Distillation of 238 g. of this solution gives 3 fractions: (h) 12.6 g., b₁₃ 40-97°; (i) 76.6 g., b₁₃ 97-107°; (j) 8.2 g., b₁₃ 107-25°. Redistillation of i gives a product, b₁₃ 98-101°, m. 8.6°. Oxidation of 4.3 g. of this product with H₂O₂ at 50° in AcOH gives 1.2 g. of a sulfoxide, m. 108°, which when mixed with the sulfoxide of II, m. 108°. These results indicate that the Cl splits the polysulfides, ClCH₂CH₂S(:S_x)S(:S_y)CH₂CH₂Cl, to give 2 mols. X, while the S is converted into SCl₂ which again reacts with C₂H₄ with excess formation of a certain amount of II. On the other hand, the Cl also reacts with X, giving rise to the formation of XIV.

Ann. chim. [12] published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Safety of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rebrova, R. N. published the artcileComparative study of the effect of decamine and decamethoxine on fungi of the genus Candida, diphtheria bacteria and pathogenic staphylococci, Formula: C38H74Cl2N2O4, the publication is Vestnik Dermatologii i Venerologii (1971), 45(11), 51-2, database is CAplus and MEDLINE.

Decamine [522-51-0] had a stronger fungistatic effect against Candida albicans than did decamethoxine (I) [38146-42-8], but I was more effective than decamine in preventing the growth of diphtheria bacteria and pathogenic staphylococci. I may be useful in treating diseases caused or complicated by diphtheria or staphylococci organisms.

Vestnik Dermatologii i Venerologii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ruefenacht, Kurt published the artcilePhosphoric acid esters and thiophosphoric acid esters with some heterocyclic substitutions. 7. Thio- and dithiophosphoric acid esters of the GS 13005 type with some analog or homolog heterocyclic rings, Product Details of C3H3Br2ClO, the publication is Helvetica Chimica Acta (1973), 56(7), 2186-204, database is CAplus.

Analogs of the pesticide GS 13005 were prepared, including pyrazolinones of the type I, (R = Cl, OH), pyrazoles II, (R = H, Me, Cl; R1 = H, Cl, Br, NO2; R2 = H, Me, iso-Pr; R3 = Cl, OH), pyridazinones III, (R = H, Cl, Br, Me, Et; R1 = H, Cl, Me; R2 = H, Cl, Me; R3 = Cl, OH), thiadiazinones IV, (R = Me, Et; R1 = Cl, OH), and their mono- and dithiophosphates. The preparation, of analogous thiadiazepinones failed, giving instead pyrazolidinone derivatives Approx. 100 compounds were prepared

Helvetica Chimica Acta published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Product Details of C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics