Author: Jessica.F

Kovtunyak, N. A. published the artcileEffect of decamethoxin, decamine and levorin on the content of cholesterol, phospholipids and triglycerides in the liver of white rats, Synthetic Route of 38146-42-8, the publication is Farmakologiya i Toksikologiya (Moscow) (1983), 46(5), 72-5, database is CAplus.

I.m. injection, of quaternary ammonium compounds (decamethoxin (I) [38146-42-8] and decamine  [522-51-0]) and levorin  [11014-70-3] changed the content of cholesterol  [57-88-5], phospholipids, and triglycerides in the liver of rats. Decamethoxin decreased the content of phospholipids and cholesterol and raised the concentration of triglycerides. Decamine decreased the level of phospholipids and raised the content of cholesterol and triglycerides, while levorin minimized the content of phospholipids, cholesterol, and triglycerides.

Farmakologiya i Toksikologiya (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Moeller, Carsten published the artcileDiscovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies, HPLC of Formula: 7080-50-4, the publication is ChemMedChem (2018), 13(21), 2271-2280, database is CAplus and MEDLINE.

Progesterone plays an important role in the female reproductive system. However, there is also evidence that gynecol. disorders/diseases such as uterine fibroids and endometriosis are progesterone-dependent. Steroidal and non-steroidal selective progesterone receptor modulators (SPRMs) have shown potential for the treatment of such diseases. Steroidal SPRMs, including mifepristone and ulipristal acetate, have proven effective in clin. trials. However, several steroidal SPRMs containing a dimethylamino substituent have been associated with elevated liver enzymes in patients. An earlier drug discovery program identified lonaprisan as a highly selective SPRM that did not show drug-related change in liver enzyme activity. Building on data obtained from that work, here we describe the research program that culminated in the discovery of a novel steroidal SPRM, vilaprisan, which combines an extremely high potency with very favorable drug metabolism and pharmacokinetic properties. Vilaprisan has entered clin. development and is currently undergoing phase 3 clin. trials.

ChemMedChem published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, HPLC of Formula: 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Prosyanik, A. V. published the artcileAsymmetric unbridged nitrogen. 20. New data on derivatives of 1-alkoxyaziridine-2-carboxylic acids, Application of 2,3-Dibromopropionylchloride, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1980), 212-15, database is CAplus.

Treatment of BrCH₂CHBrCO₂R (R = Me, Et, CHMe₂, CMe₃) with R¹ONH₂ (R¹ = Me, Et, Me₂CH) and Et₃N gave R¹ONHCH₂CHBrCO₂R, which cyclized upon heating in Et₃N-MeCN to give I, the trans isomer being formed predominantly. Similarly prepared were II (same R¹) with the trans isomer predominant or exclusive. III (trans/cis = 3:1) was also obtained. The N inversion barriers in I–III were 130-138 kJ/mol at 120°.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bonafoux, Dominique F. published the artcileAminopyridinecarboxamide-based inhibitors: Structure-activity relationship, Formula: C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry (2010), 18(1), 403-414, database is CAplus and MEDLINE.

Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1β stimulated synovial fibroblasts. The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors with improved cellular activity.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Binaschi, Monica published the artcileAntiproliferative and Differentiating Activities of a Novel Series of Histone Deacetylase Inhibitors, COA of Formula: C13H9ClN2O4, the publication is ACS Medicinal Chemistry Letters (2010), 1(8), 411-415, database is CAplus and MEDLINE.

Histone deacetylases are promising mol. targets for the development of antitumor agents. A novel series of histone deacetylase inhibitors of the hydroxamic acid type were synthesized for structure-activity studies. Thirteen tricyclic dibenzo-diazepine, -oxazepine, and -thiazepine analogs were studied and shown to induce variable degrees of histone H3/H4 and tubulin acetylation in a cellular model of myeloid leukemia sensitive to all-trans retinoic acid (ATRA). Multiparametric correlations between acetylation of the three substrates, tumor cell growth inhibition, and ATRA-dependent cytodifferentiation were performed, providing information on the chem. functionalities governing these activities. For two analogs, antitumor activity in the animal was demonstrated.

ACS Medicinal Chemistry Letters published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, COA of Formula: C13H9ClN2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lysenko, V. P. published the artcilePhosphorus-containing sulfoxonium ylides. IV. Ylides containing substituents with trivalent phosphorus, Synthetic Route of 5034-06-0, the publication is Zhurnal Obshchei Khimii (1979), 49(6), 1230-5, database is CAplus.

Reaction of Me₂S(O):CH₂ with FP(OEt)₂ gave Me₂S(O):CHP(OEt)₂ which reacts with S, RX (R = Me, Et; X = halo) and Cl₃CCHO to give Me₂S(O):CHR¹ (R¹ = P(S)(OEt)₂, P(O)R(OEt), P(O)(OEt)OCH:CCl₂ resp.). Reaction of Me₂S(O):CH₂ with Cl₃PX¹ (X¹ = -, O, S) gave X¹P[CH₂S⁺(O)Me₂]₃ 3Cl^–.

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lysenko, V. P. published the artcilePhosphorus-containing sulfoxonium ylides. II. Properties of ylides stabilized by phosphorus(V), Name: trimethyloxosulphonium chloride, the publication is Zhurnal Obshchei Khimii (1978), 48(5), 978-84, database is CAplus.

Me₂S⁺(O)CH₂P(Y)(OR)₂ X^– (Y = O, NSO₂C₆H₄Me-p, R = Et, Pr, Ph; X = Cl, 2,4,6-(O₂N)₃C₆H₂O, F₃CCO₂) were prepared in 81-92% yields by treating Me₂S⁺(O)C^–HP(Y)(OR)₂ (I) with HX. Reaction of I with PhNCO, Ac₂O, and p-R¹C₆H₄CHO (R¹ = H, NO₂) gave Me₂S⁺(O)C^–R²P(O)(OR)₂ (R² = CONHPh, Ac, CH(OH)C₆H₄R¹–p) resp. Reaction of Me₂S⁺(O)C^–HP(OEt)₂ with RN₃ (R = Ph, p-MeC₆H₄SO₂) and N₂C(CO₂Et)₂ gave Me₂S⁺(O)C^–HP(:X)(OEt)₂ (X = NR, NN:C(CO₂Et)₂] resp.

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Name: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pavlova, A. S. published the artcileSynthesis of combinatorial libraries of amides, sulfonamides and ureas from 2-acylated derivatives of benzo[d]thiazole-2,5-diamine, Synthetic Route of 61551-49-3, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2010), 53(7), 11-15, database is CAplus.

Four 2-(acylamino)-5-aminobenzo[d]thiazoles (acyl = MeCO, EtCO, PhCO, 4-MeC₆H₄CO) were efficiently synthesized in 3 steps by cyclocondensation of 1-chloro-2,4-dinitrobenzene with thiourea followed by acylation of the intermediate 2-amino-5-nitrobenzothiazole and hydrogen reduction of the nitro group on Pd catalyst in DMF. The products were successfully used in the solution-phase parallel synthesis of combinatorial libraries of 5-amide-, 5-sulfonamide- and 5-urea-functionalized 2-(acylamino)benzothiazoles by reactions with carboxylic acids/CDI, sulfonyl chlorides and isocyanates, resp.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Synthetic Route of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Poltavskii, V. P. published the artcileChanges in mitotic regimen of permanent amniotic human cell cultures (line Ai) exposed to decamethoxin, Computed Properties of 38146-42-8, the publication is Antibiotiki (Moscow) (1975), 20(6), 506-9, database is CAplus.

Decamethoxin [38146-42-8] (0.1-10 μg/ml) added to cultures of a permanent line of amniotic human cells suppressed mitotic activity and arrested cells in telophase. At 50-500 μg/ml, decamethoxin caused cell destruction and at 1000 μg/ml had a fixation effect.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Computed Properties of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Newby, James A. published the artcileDesign and Application of a Low-Temperature Continuous Flow Chemistry Platform, Name: (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, the publication is Organic Process Research & Development (2014), 18(10), 1211-1220, database is CAplus.

A flow reactor platform technol. applicable to a broad range of low temperature chem. is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor.

Organic Process Research & Development published new progress about 944129-07-1. 944129-07-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester,, name is (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H7BClFO3, Name: (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics