Author: Jessica.F

Lopatnikova, E. published the artcileIntramolecular transformations of silylenes in the gas phase, Quality Control of 14799-94-1, the publication is Doklady Akademii Nauk SSSR (1983), 268(1), 108-11 [Chem.], database is CAplus.

Treatment of RCH₂CH₂SiMeCl₂ [R = (CH₂)_nH, n = 0, 1-4] with K/Na (7:1) in a tubular continuous reactor at 300-340° and 0.1-1.0 mm gave, after trapping of the products in N(l) followed by gas chromatog-mass spectrometric identification, 30-50% RCH:CH₂. A mechanism involving intramol. β-attack by silylene (RCH₂CH₂SiMe) to give a 3-membered ring and subsequent elimination of the silylene group was proposed.

Doklady Akademii Nauk SSSR published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Quality Control of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Changchun published the artcileSynthesis and fungicidal activity of (2-chloropyridin-5-yl)methyl carbamates, Safety of 3-Chloro-4-fluoronitrobenzene, the publication is Nongyaoxue Xuebao (2015), 17(1), 97-100, database is CAplus.

Eleven novel (2-ehloropyridin-S-yl)methyl carbamates were synthesized by Pd-Fe/TiO₂ catalyzed carbonylation of aromatic nitro-compounds and (2-chloropyridin-S-yl) methanol with carbon monoxide. Their structures were confirmed by ¹H NMR and MS. Preliminary fungicidal activity tests indicated that some of the target compounds exhibited certain degree of inhibiting effect against four tested strains at the concentration of 50 mg/L. The inhibition rate against Gibberella zeae was over 77.3% for compound I [(2-chloropyridin-5-yl)methyl (4-methoxyphenyl) carbamate], II [(2-chloropyridin-5-yl)methyl (2,4-dichlorophenyl) carbamate] and III [(2-ehloropyridin-S-yl)methyl (3,4-dichlorophenyl) carbamate]. Compound I showed 82.5% of inhibition rate against Physalospora piricola, that was almost equal to carbendazim. All compounds showed better fungicidal activities against Botrytis cinerea than carbendazim.

Nongyaoxue Xuebao published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Safety of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kozakiewicz, Irena published the artcileReactions of 2-(4-chloro-2-mercapto-5-methylbenzenesulfonamido)-5-methylimidazoline with some (dialkylamino)alkyl chlorides, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Annales Academiae Medicae Gedanensis (1995), 367-70, database is CAplus.

Reactions of 2-(4-chloro-2-mercapto-5-methylbenzenesulfonamido)-5-methylimidazoline with some (dialkylamino)alkyl chlorides were described. Thus, treating mercaptobenzenesulfonamido derivative I (R = H) with RCl·HCl [R = CH₂CH₂NR’₂, R’ = Me, Bu, Pr; R = (CH₂)₃NMe₂, CH₂CH₂NR”₂, NR”₂ = morpholino; R = CH₂CMe₂NMe₂, CHMeCH₂NMe₂] in Me₂CHOH containing Me₂CHONa gave 23-72% alkylated I (same R).

Annales Academiae Medicae Gedanensis published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Klevay, Leslie M. published the artcileCholesterotropic and cuprotropic chemicals, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Journal of the Science of Food and Agriculture (2020), 100(10), 4057, database is CAplus and MEDLINE.

A review. A dozen or so chems. modify both cholesterol and copper metabolism Ascorbic acid and cadmium, etc., inhibit copper metabolism and raise cholesterol. Calcium and clofibrate, etc., enhance copper and lower cholesterol. Perhaps the doses of dietary cholesterol and fructose in this experiment were too severe to permit fenofibrate to lower cholesterol in a manner similar to clofibrate. 2020 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jurga, Stefan published the artcileNuclear magnetic relaxation studies in solids, COA of Formula: C3H9ClOS, the publication is Ser. Fiz. (Uniw. im. Adama Mickiewicza Poznaniu) (1980), 58 pp., database is CAplus.

Spin-lattice relaxation times in the laboratory and in the rotating frame are reported for trimethyloxosulfonium fluoride, chloride, bromide and iodide as well as for Me₂SO and Me₂SO₂ over a wide temperature range. A model was developed that makes it possible to analyze the exptl. data on the basis of 4 independent reorientations around 3 3-fold axis and around center of gravity . The following conclusions consistent with the 2nd moment and spin-lattice relaxation results are drawn about reorientational state of cations and mols. The Me group is reorienting about its 3-fold axis at random between 3 equilibrium positions separated by 120° in all the compounds A 3-fold reorientation of all cations around the C₃ axis (designed by S → O bond) occurs. There is dynamical inequivalence of Me groups within the Me₂SO mol. and trimethyloxosulfonium chloride with 1:2 ratio. There is observed translational diffusion in Me₂SO₂. The activation energies for C₃ and C‘₃ reorientations decrease with an increase of an anion ionic radius (with exception of the iodide salt for the last motion).

Ser. Fiz. (Uniw. im. Adama Mickiewicza Poznaniu) published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, COA of Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jones, F. William published the artcileFiber-reactive insecticides for wool: organophosphorus esters of nitrogen heterocycles, Formula: C3H3Br2ClO, the publication is Journal of Agricultural and Food Chemistry (1983), 31(2), 190-4, database is CAplus.

O,O-Di-Et phosphorothionate esters and O-Et S-Pr phosphorothiolothionate esters of some pyridazine and 1,2,4-triazole compounds containing a 2-bromoacryloyl ester substituent were synthesized and screened for insecticidal activity against the wool-digesting insects Tineola bisselliella and Anthrenus flavipes. O,O-Diethyl O-[1-(2-hydroxyethyl)-5-methylthio-3-(1,2,4-triazolyl)] phosphorothiolothionate (I) was most active. These compounds were found to be hydrolytically unstable when applied to wool from a boiling acidic dye bath. The extent of this hydrolysis has been determined by the development of a method for estimating organophosphorus esters that are covalently bound to the wool.

Journal of Agricultural and Food Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Formula: C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Izzo, Patrick T. published the artcilePreparation of 1-aryl-1,2-cyclopropanedicarboximides. An application of dimethylsulfoxonium methylide, Formula: C3H9ClOS, the publication is Journal of Organic Chemistry (1963), 1713-15, database is CAplus.

1-Aryl-1,2-cyclopropanedicarboximides (I) were prepared in the presence of dimethylsulfoxonium methylide (II). Trimethylsulfoxonium chloride (III) was prepared by the method of Kuhn and Trischmann (CA 52, 14523g),m. 215-16°. III(1.5g.) added to a suspension of 0.29 g. NaH in 150 ml. tetrahydrofuran (THF), the mixture refluxed with evolution of H, stirred under reflux 45-60 min., and 0.012 mole N-methyl-2-arylmaleimide added to the solution (containing II), the mixture refluxed 2 hrs., cooled, alc. added, solvent removed in vacuo, the residue taken up in CH₂Cl₂, and the solution washed, dried, and evaporated gave I (R, R¹, m.p., % yield given): Ph, H, 55-7°, 21; Ph, Et, 113-146deg;, 81; 3,4,5-trimethoxyphenyl, H, 136-86°, 21. The structure of I was supported by infrared and ultraviolet spectra, elementary analyses, and unsaturation tests. N-Methyl-2-phenylsuccinimide (37.8 g.), 39.2 g. N-bromosuccinimide, 0.4 g. Bz₂O₂, and 800 ml. CCl₄ refluxed 24 hrs., stored 16 hrs. at room temperature, the succinimide removed, and the filtrate evaporated gave 49.2 g. 2-bromo-N-methyl2-phenylsuccinimide (IV), m. 110.5-12°. IV (7.5 g.) in 75 ml. C₆H₆ and 3 g. NEt₃ kept 1 hr. at room temperature and the product separated gave 3.7 g. N-methyl-2-phenylmaleimide (V), m. 147-8°. Arylation of maleimide with 3,4,5-trimethoxyphenyldiazonium chloride gave 27% 2-chloro-3-(3,4,5-trimethoxyphenyl)succinimide (VI), m. 207-8° (decomposition). VI (2 g.) heated 0.5 hr. with 8 ml. 2,6-lutidine gave 1.5 g. 2-(3,4,5-trimethoxyphenyl)maleimide (VII), m. 211-13°. VII (2.8 g.) in 75 ml. THF brought to reflux with 0.24 g. NaH, then treated in 45 min. under reflux with 7 g. MeI in 10 ml. THF, the mixture refluxed 1.75 hrs., evaporated, and the residue taken up in CHCl₈ gave 2 g. N-methyl-2-(3,4,5-trimethoxyphenyl)maleimide, m. 155-66deg;. V (8.9 g.) in 150 ml. CH₂Cl₂ treated in one lot with 0.054 mole MeCHN₂ in Et₂O gave 11.6 g. N,5-dimethyl-3-phenyl-1-pyrazoline-3,4-dicarboximide (VIII), m. 106-76deg; (decomposition). VIII (5.1 g.) in 50 ml. alc. was heated 0.5 hr., evapd, in vacuo, and the 4.4 g. of oil subjected to partition chromatography. Evaporation of material from the first peak gave 5% N-methyl-2-ethyl-3phenylmaleimide, m. 69-70°. The 2nd and slower moving component was obtained as the chief yield, 4 g., of N,3-dimethyl-1-phenyl-1,2-cyclopropanedicarboximide.

Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Isbell, A. F. published the artcileSynthesis of organophosphorus compounds, Formula: C5H10Cl3O3P, the publication is United States Department of Commerce, Office of Technical Services, AD [ASTIA Document] (1961), 9 pp., database is CAplus.

Monoalkylphosphonates of the type RP(O)(OR’)₂(R = R’ = Me, Et, or Bu; R = Ph, R’ = Et; R = PhCH₂, R’ = Bu) were treated with Na metal, using either PhCH₃ or excess ester as solvent. In all cases, the gas R’H was given off, yields being 0.3-0.5 moles gas/mole ester in PhCH₃ and 0.1 or less in excess ester. In addition, white solids were formed; they were insoluble in PhCH₃ but soluble in excess ester. Viscosity and non-crystalline character increased with increasing mol. weight of R. These solids were believed to consist in part of RP(O)(OR’)ONa. Other compounds studied were (MeO)₃P; (EtO)₃P; (BuO)₃PO; triethyl α,α-dimethylphosphonoacetate; triethyl phosphonoformate; BuPhP(O)OBu, and Et₂P(O)OEt. Attempts were also made to synthesize fluoroalkylphosphonic esters. F₃CCl or F₃Cl with (BuO)₂P(O)Na or (EtO)₃P gave no reaction. (EtO)₃P(O)CCl₃ heated with KF.2H₂O gave 83% CHCl₃ and a salt-like product. RP(O)(OEt)₂ (R = ClCH₂ or Cl₂CH) heated with anhydrous KF gave no reaction, but Cl₃CP(O)(OEt)₂ reacted with KF or NaF to give FP(O)(OEt)₂, (b₄₇ 88.5-89.5°); n²⁷_D 1.3710; d₂₇ 1.1399.

United States Department of Commerce, Office of Technical Services, AD [ASTIA Document] published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ilhan, Suleyman published the artcileEssential Oils from Vitex agnus castus L. Leaves Induces Caspase-Dependent Apoptosis of Human Multidrug-Resistant Lung Carcinoma Cells through Intrinsic and Extrinsic Pathways, Product Details of C10H9ClF3NO2, the publication is Nutrition and Cancer (2021), 73(4), 694-702, database is CAplus and MEDLINE.

Essential oil (EO) fractions of plants are complex mixtures of volatile compounds with broad-spectrum biol. properties. In the current study, the EO content of Vitex agnus castus L. (VAC) leaves growing in the Aegean region of Turkey was extracted and identified. Then, VAC EOs were investigated for their potential antioxidant, cytotoxic and apoptotic effects in human H69AR multi-drug resistant cancer cells. EOs were isolated by hydrodistillation and chem. composition was determined by GC-MS. Cell viability was assessed via MTT and trypan blue assays. Antioxidant activity was evaluated by measuring the total antioxidant activity and free radical scavenging activity. Apoptosis was evaluated via DNA fragmentation and caspase 3/7 activity assays. Changes in the levels of apoptotic genes were determined by RT-qPCR. The results indicated strong antioxidant activity and cytotoxic effect on H69AR cancer cells but not on HEK-293 human normal cells indicating the tumor-specific effect. VAC EOs induced caspase 3/7 activation and apoptosis through triggering both extrinsic- and intrinsic-pathways by modulating Bcl-2, Bcl-XL, Bax, Bad, FADD, Caspase-8, Caspase-9, TRAIL R1/DR4 and TRAIL R2/DR5. This study revealed that VAC EOs may be a promising candidate in the development of novel therapeutic agents for multi-drug resistant lung cancer treatment.

Nutrition and Cancer published new progress about 18585-06-3. 18585-06-3 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Amine,Benzene,Amide, name is Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate, and the molecular formula is C10H9ClF3NO2, Product Details of C10H9ClF3NO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hshieh, Fu-Yu published the artcileNote: correlation of closed-cup flash points with normal boiling points for silicone and general organic compounds, Application In Synthesis of 14799-94-1, the publication is Fire and Materials (1997), 21(6), 277-282, database is CAplus.

A correlation was developed between closed-cup flash points and normal b.ps. for organic silanes or siloxanes. In addition, a more general correlation was developed between these two properties for the general organic compounds, including silanes and siloxanes. The closed-cup flash points can be predicted using empirical equations. The standard estimation errors were 11.06 and 11.66°C for silicon-containing compounds (silanes and siloxanes) and general organic compounds (including silicon-containing compounds), resp.

Fire and Materials published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Application In Synthesis of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics