Author: Jessica.F

Palii, G. K. published the artcileDevelopment of resistance of Candida albicans to chemotherapeutic preparations, Related Products of chlorides-buliding-blocks, the publication is Trudy Krymskogo Gosudarstvennogo Meditsinskogo Instituta (1974), 38-40, database is CAplus.

C. albicans grown in nutrient medium containing increasing concentrations of decamine [17349-05-2] and decamethoxin [38146-42-8] gradually developed resistance to these fungicides but retained their sensitivity to levorin [11014-70-3]. Morphol. and culture changes and decreased rates of carbohydrate catabolism accompanied the development of Candida resistance to decamine and decamethoxin.

Trudy Krymskogo Gosudarstvennogo Meditsinskogo Instituta published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileEffect of decamethylene-1,10-bis(N-dimethylcarbomenthoxymethylammonium) dichloride on agglutinin and complement titers under experimental conditions, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Immunologiya (Kiev) (1972), 133-6, database is CAplus.

Decamethylene-1,10-bis(dimethylcarbomenthoxymethylammonium) dichloride (I) [38146-42-8] administered s.c. to rabbits at 1 or 2 mg/kg daily for 14 days during immunization with typhoid vaccine did not inhibit the manufacture of agglutinins and increased complement titer. Similar administration of I for 14 days after termination of immunization did not affect complement or agglutinin levels of the blood.

Immunologiya (Kiev) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ofner, P. published the artcileAmidone. Some isomeric chlorodialkylaminopropanes and their reaction with diphenylmethyl cyanide, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Journal of the Chemical Society (1951), 1800-3, database is CAplus.

MeCH(NMe₂)CO₂Et is reduced by the Bouveault-Blanc procedure to 55% of MeCH(NMe₂)CH₂OH (I), b. 145-8° (picrate, orange-yellow, m. 182-3°); 20 g. I in 45 cc. C₆H₆, added (20 min.) to 23 g. SOCl₂ in 90 cc. C₆H₆ at 0°, allowed to warm to room temperature, and refluxed 1.5 h., give 59% MeCH(NMe₂)CH₂Cl.HCl (II), m. 103-4°. Me₂NCH₂CHMeOH (III) yields a picrate, orange-yellow, m. 83-4°. III (20 g.) and 23 g. SOCl₂, as above, give 73% Me₂NCH₂CHMeCl.HCl (IV), m. 190-1°. I (20 g.) in 45 cc. C₆H₆, treated with 23 g. SOCl₂ in 90 cc. C₆H₆ and the gummy residue refluxed with 150 cc. Me₂CO, gives 34% IV; the II is removed by the Me₂CO. 1-Piperidino-2-propanol (b₇₆₂ 198-201°; picrate, m. 134-5°) gives with SOCl₂ 2-chloro-1-(1-piperidyl)propane-HCl (V), m. 213-14°. 1-(1-Piperidyl)-3-propanol (m. 66-7°) with SOCl₂ gives 1-chloro-3-(1-piperidyl)propane (VI), b₁₀ 79-80°; HCl salt, m. 213-14°. The mother liquor from V or VI did not contain the other isomer. 1-Allylpiperidine (picrate, m. 72-3°) does not add HCl. The base, Me₂NCH₂CHMeCl (VII), liberated from IV by dilute NH₄OH at 0° or with 40% NaOH at room temperature, is stable and gives the same picrate, even after distillation (b₃₅ 36-7°). The base liberated from II at room temperature by 40% NaOH solution is Me₂NCHMeCH₂Cl (VIII) (Schultz, et al., C.A. 42, 4934i). VIII can be heated in an inert solvent and can be agitated in an inert solvent with NaOH or NaNH₂ without undergoing decomposition or isomerization; on distillation in vacuo, VIII is isomerized and VII and VIII can be separated by fractional crystallization of the picrates. The relative proportions of the isomers formed in the alkylation of PhCH₂CN with VII or V were determined by effecting as complete as possible a separation of the isomers giving the more sparingly soluble salts. In the dimethylamino series, the N-compounds from the more sparingly soluble salts, whereas in the analogous piperidyl series, the salts of the iso compounds have the lowest solubility In the former series at least 60% of the cyanide was formed by isolation as 6-dimethylamino-4,4-diphenyl-3-heptane-HBr and in the latter at least 45% of the isocyanide as 3-imino-5-methyl-4,4-diphenyl-6-(1-piperidyl)hexane-2HCl. Thus, the relative proportions vary according to the nature of the basic groups of the Cl base employed in the alkylation.

Journal of the Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Morita, Hirokazu published the artcileDifferential thermographic features of some crystalline biopolymers, HPLC of Formula: 6249-56-5, the publication is Biopolymers (1966), 4(2), 215-22, database is CAplus.

Thermograms are shown for globular, serum, and blood plasma proteins, calf thymus DNA, sodium triticonucleate, sodium thermonucleate, sperm DNA, yeast RNA, adenosine 3′-phosphate, adenosine 5′-phosphate, disodium adenosine triphospate, adenosine, and deoxyadenosine. A pronounced effect of moisture on the differential thermal properties of DNA was observed. Solid-state denaturation may be one of the prominent thermal effects recorded by the differential thermal analysis of proteins and nucleic acids.

Biopolymers published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mistryukov, E. A. published the artcileSynthesis and steric structure of some 1-methyl-4-phenyl-4-piperidinols, COA of Formula: C7H16ClNO2, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1961), 623-6, database is CAplus.

cf. CA 52, 20159b. PhLi from 17 g. Li treated in Et₂O with 127.6 g. 1-methylperhydro-4-pyrindone gave, after refluxing 4 h. and treating with aqueous HCl, followed by NaOH, 44% 1-methyl-4-phenylperhydro-4-pyrindole (I), b_0.3 136-46°, m. 45.5-6.5° (HCl salt m. 221-2°), along with a small amount of a base, C₂₃H₂₉NO, m. 71-2°; the mother liquors gave a base, m. 4850° (picrate decomposed at 199-200°; propionate HCl salt m. 206-7°), whose structure was not determined I formed a picrate, m. 157-7.5°. PhLi and 1-methyldecahydro-4-quinolone gave 63.7% isomeric alcs. in 62:24:14 ratio: α-form of 1-methyl-4-phenyldecahydro-4-quinolol, m. 126.5-7°; β-form, m. 112-13° (HCl salt m. 216-19°); and γ-form, m. 148-50°. Heating (CCMe₂OH)₂ with p-MeC₆H₄SO₃H in the presence of pyrogallol at 100°/100 mm. 1 h. gave H₂O and CO₂ and a residue of 2,5-dimethyl-1,5-hexadien-3-yne, b₄₀ 46-9°, and 2,5-dimethyl-5-hexen-3-yn-2-ol, b₁₃ 64-7°. Treatment of 2,5-dimethyl-1,4-hexadien-3-one and its MeOH adducts (crude mixture, Nazarov and Bukhmutskaya, CA 42, 7733e) with 39% aqueous MeNH₂ 2 days at room temperature gave, after treatment with H₂O and aqueous HCl, followed by NaOH, 40% 1,2,2,5-tetramethyl-4-piperidone, b₁₅ 90-3°, n²⁰_D 1.4620 (HCl salt m. 195.5°; picrate m. 180-80.5°). This and PhLi gave only 1 isomer of 1,2,2,5-tetramethyl-4-phenyl-4-piperidinol, m. 81-2°; HCl salt m. 201° (hydrate m. 152-3°). This piperidinol probably had equatorial Ph and Me groups at C-5. Only I showed evidence of internal H-bonding in the IR spectrum.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathieu, Didier published the artcileFlash Points of Organosilicon Compounds: How Data for Alkanes Combined with Custom Additive Fragments Can Expedite the Development of Predictive Models, Category: chlorides-buliding-blocks, the publication is Industrial & Engineering Chemistry Research (2012), 51(43), 14309-14315, database is CAplus.

A particularly simple approach to evaluate flash points (FP) from additive fragment contributions is outlined. Since it is based on a square root expression derived from examining n-alkane data, it avoids the need for nonlinear fitting procedures and for trial-and-error optimization of anal. relationship between FP and mol. descriptors. Despite a specially small number of additive contributions, the method can be applied to most organic mols. For organosilicon compounds, it exhibited some advantages vs. previously available procedures while providing very similar performance with an average absolute deviation from experiment close to 12° K, a determination coefficient R² = 0.89, and only 1 error >40° K.

Industrial & Engineering Chemistry Research published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Masamba, W. R. L. published the artcileDetection of trace amounts of chemical warfare agents in paint by gas chromatography and gas chromatography-mass spectrometry, COA of Formula: C4H8Cl2S2, the publication is Malawi Journal of Science & Technology (2001), 47-55, database is CAplus.

The chem. warfare agents pinacoly methylphosphonofluoridate (soman), bis[(2-chloroethylthio)ethyl] ether (O mustard), and tris(2-chloroethyl)amine (nitrogen mustard) and low levels of bis(2-chloroethyl) sulfide (mustard gas, H), 1,2-bis(2-chloroethylthio)ethane (Sesquimustard), and bis(2-chloroethyl) disulfide were detected by gas chromatog. and gas chromatog.-mass spectrometry in a paint sample that had been prepared by spiking soman, O mustard, and nitrogen mustard to simulate a case where chem. warfare agents were absorbed into a paint matrix. The results show that gas chromatog. and gas chromatog.-mass spectrometry can be used for the detection of such chem. warfare agents in paint samples.

Malawi Journal of Science & Technology published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, COA of Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Maristany, Jose M. Millet published the artcileDerivatives of N-methyl-4-phenylpiperidine-4-carboxylic and 2,2-diphenyl-4-dimethytaminovaleric acids, Category: chlorides-buliding-blocks, the publication is Rev. real acad. cienc. exact., fís. y nat. Madrid (1961), 59-103, database is CAplus.

N-Carboxyalkylamides of the title acids (I and II, resp.), analogs of dolatin and methadone, were prepared and tested. Derivatives of II had comparable spasmolytic activity, derivatives of I had low activity, and none had analgesic activity. The total syntheses of the chlorides (III and IV) of I and II were described with minor modifications of literature preparations Attempted condensations of III and IV with Et (V), Pr (VI), iso-Pr (VII), allyl (VIII), and Bu carbamates in the presence of Na and C₆H₆ at reflux, Na and Et₂O at reflux, EtMgBr (i.e., MgBr salt of the carbamate), Na and C₅H₅N, and alone gave poor results and the following method was adopted. To 10 g. NaH (50% dispersed in mineral oil) in 150 ml. anhydrous C₆H₆ was added 0.2 mole NH₂CO₂R in 250 ml. anhydrous C₆H₆ with cooling and stirring at a rate to maintain the temperature at 6-7°. Stirring was continued 30 min., during addition of 27.4 g. III.HCl (freshly prepared) in 150 ml. anhydrous C₆H₆, 2 hrs. more at 6-7°, 4 hrs. while the mixture warmed to room temperature, and 1 day longer. Workup yielded CH₂.CH₂.NMe.CH₂.CH₂.C(Ph)CONHCO₂R (X): (R in X, g. crude yield, m.p., and g. recovered acid given): Et, 16, 140-1.5° (Me₂CO), 9.5; Pr, 18.5, 138-9.5° (Me₂CO), 7; iso-Pr, 15, 136-8o (Me₂CO), 6; allyl, 16, 112-13.5° (Me₂CO), 8; Bu (XI), 15, 99.5-100.5° (Me₂CO) [picrate m. 163-4.5° (EtOH); HCl salt m. 108-10° (decomposition)], 6. X were very soluble in Me₂CO and EtOH, slightly soluble in Et₂O, and soluble in C₆H₅, 5% NaOH, and acids. Me₂NCHMeCH₂CPh₂CONHCO₂R (XII) were prepared similarly from 6.9 g. Na sand and 0.3 mole NH₂CO₂R (R in XII, g. pure yield, and m.p. given): Et, 10, 153-4.5° (Me₂CO); Pr, 10, 158-9° (Me₂CO); iso-Pr, 10, 140-1° (Me₂CO); allyl, 13.8, 139-9.5° (Me₂CO); and Bu (XIII), 12, 97-7.5° (Me₂CO) [picrate m. 128° (indefinite); HCl salt, liquid]. XII had the same solubilities as X, but were insoluble in dilute NaOH. XI was hydrolyzed by acid to the corresponding starting acid and by aqueous NH₃ and NaOEt in EtOH to the corresponding amide, whereas XIII was hydrolyzed by all three reagents to its corresponding amide. V (81 g.), 66 g. VI, and 60 g. VIII were prepared by heating 100 g. (NH₂)₂CO and 600 ml. of the appropriate alc. in an autoclave 60 hrs. at 160°, distilling the mixture to 150°, and distilling the residue in vacuo. Urea nitrate (200 g.) and 1 l. iso-PrOH refluxed 100 hrs. and the mixture worked up similarly gave 89 g. VII.

Rev. real acad. cienc. exact., fís. y nat. Madrid published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mao, Faming published the artcileSynthesis of reactive scarlet 3G, Category: chlorides-buliding-blocks, the publication is Ranliao Yu Ranse (2010), 47(1), 19-20, database is CAplus.

Reactive scarlet 3G was prepared from sodium 2,4-diaminobenzenesulfonate, 2,3-dibromopropanoyl chloride and γ acid by acylation, diazotization, coupling and salting-out. The two steps of acylation were studied emphatically. The complete reaction conditions were obtained by experiments: the temperature of acylation was 0-15°C, pH was controlled between 5-7.5; the molar ratio of 2, 3-dibromopropanoyl chloride and sodium 2,4-diaminobenzenesulfonate was 1.05: 1,2,3-dibromopropanoyl chloride and γ acid molar ratio was 1.05: 1. The yield of acylation was above 90%.

Ranliao Yu Ranse published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mangte, Anvita D. published the artcileSynthesis and antimicrobial evaluation of protected lactosyl isothiourea derivatives, COA of Formula: C7H7ClN2S, the publication is Asian Journal of Chemical and Environmental Research (2014), 7(1-4), 50-54, database is CAplus.

Protected lactosyl isothiourea were synthesized by nucleophilic addition of per-O-acetyl lactosyl aryl isothiourea to tolyl isothiocyanate. Structures of these compounds were confirmed on the basis of IR, NMR, Mass spectra and elemental anal. These compounds were also screened for their in vitro antimicrobial activities against bacteria S. aureus, E. coli, P. vulgaris, P. aeruginosa and fungi A. niger, Penicillium.

Asian Journal of Chemical and Environmental Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, COA of Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics