Author: Jessica.F

Holy, A. published the artcilePhosphorylation of nucleosides with trichloromethylphosphonic acid derivatives, HPLC of Formula: 866-23-9, the publication is Tetrahedron Letters (1972), 157-8, database is CAplus.

Ribonucleosides were phosphorylated selectively, to give the 2′-phosphate derivative, with Et trichloromethylphosphonate (I) when the ribonucleoside contained the cis-2′,3′-diol group. Treatment of uridine (over-night) with I in HCONMe2 containing Et3N gave 67% of the corresponding uridine nucleotide. Similarly prepared were the nucleotides of cytidine, adenosine, and 6-azauridine in 23, 45, and 3% yield, resp. Thymidine and 2′,3′-O-isopropylideneuridine did not give the nucleotides as they could not form a cyclic intermediate. -(α-L-Lyxofuranosyl)adenine, in which two cyclic intermediates were conformationally allowed, gave 95% of a nucleotide mixture containing 2- and 3-isomeric phosphates and the 3,5-cyclic phosphate in 23, 37, and 35% yield, resp.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, HPLC of Formula: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Herbain, Maurice published the artcileA biologic test of antilipemic heparin derivatives, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Clinica Chimica Acta (1960), 204-7, database is CAplus and MEDLINE.

cf. Velluz, et al., CA 53, 10555g, 19898g. Rabbits were fed a diet containing saturated fats and 200 mg./kg./day cholesterol for a period of 30 days. Those animals in which serum total cholesterol levels reached 8 g./l. or more were selected for testing. The ratio of β-lipoprotein lipide/total lipide exceeded 0.70 compared to a control value of 0.35. After removal of cholesterol from the diet for 24 hrs., 5 mg./kg. heparin or other antilipemic agent was injected intravenously and total and β-lipoprotein lipides (the latter were precipitated with dextran) were estimated at 6, 10, and 14 hrs. When the test was carried out with N-dimethylbenzoyl-N-desulfoheparin, its antilipemic activity was found to be slower but more intense than that of heparin.

Clinica Chimica Acta published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hansen, Bertil published the artcilePreparation of thiocholine esters. II. Esters of α- and β-methylthiocholine, Category: chlorides-buliding-blocks, the publication is Acta Chemica Scandinavica (1959), 159-62, database is CAplus.

cf. CA 52, 14538g. α-Methyl- and β-methylthiocholine halide esters of benzoic and the lower fatty acids were prepared in good yield from Me₂NCHMeCH₂SH (I), b₈₈ 71°, n²⁵_D 1.4538, d₂₅ 0.8693, and HSCHMeCH₂NMe₂ (II), b₇₀ 78.5°, n²⁵_D 1.4684, d₂₀ 0.9046, resp., by esterification with Ac₂O and quaternization with MeI. The α-Me esters were also prepared from 1,2-propylene sulfide by adding the acid bromide and then quaternizing with Et₃N. The II was synthesized (Renshaw, et al., CA 32, 7412¹) from Me₂NCH₂CHMeCl.HCl (III), m. 185°, and (H₂N)₂CS. An attempt to prepare I similarly from MeCHNMe₂CH₂Cl.HCl and (H₂N)₂CS gave only II; addition of Me₂NH to propylene sulfide, b₁ 74-6° (prepared in 58% yield from propylene oxide and (H₂N)₂CS, in Et₂O gave I as the only product. Esters of MeCHBrCH₂SH prepared were: 73% acetate, b₆ 72-3°; 66% propionate, b₉ 93-6°; 53% butyrate, b₈ 99.5-100.5°; and 53% valerate, b₁₀ 125-6.5°. Esters of α-methylthiocholine bromide: 63% acetate, m. 187°; 63% propionate, m. 154°; 54% butyrate, m. 170°; and 67% valerate, m. 179°. Also prepared were the acetate, b₁₁ 64.5-6°, propionate, b₁₂ 67-81°, butyrate, b₉ 80-8°, isobutyrate, b₁₀ 85-94°, valerate, b_0.07 53-60°, and benzoate, b_0.01 88-96°, of I, and the acetate, b₁₁ 76-82°, propionate, b₁₀ 78-88°, butyrate, b_1.8 74-85°, isobutyrate, b₁₂ 86-92°, valerate, b_0.3, and benzoate, b_0.03 120-5°, of II. α-Methylthiocholine bromide acetate, m. 188°, and the following β-methylthiocholine bromide esters (acetate, m. 168°, 67% butyrate, m. 164°, and 32% isobutyrate, m. 140°), α-methylthiocholine iodide esters (50% acetate, m. 164°, 61% propionate, m. 155°, 62% butyrate, m. 130°, 82% isobutyrate, m. 158°, 62% valerate, m. 152°, and 54% benzoate, m. 136°), and β-methylthiocholine iodide esters (70% acetate, m. 150°, 65% propionate, m. 132°, 67% butyrate, m. 164°, 32% isobutyrate, m. 140°, 31% valerate, m. 74°, and 76% benzoate, m. 194°) were prepared III refluxed 65 h. with (H₂N)₂CS in absolute EtOH gave 52% S-(1-dimethylamino-2-propyl)isothiuronium chloride hydrochloride, m. 154° (PrOH).

Acta Chemica Scandinavica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Griffin, C. E. published the artcileReaction of trichloromethyl radicals with triethyl phosphite, Category: chlorides-buliding-blocks, the publication is Chemistry & Industry (London, United Kingdom) (1958), 415, database is CAplus.

CCl₄ and (EtO)₃P at 80° give 80-5% Cl₃CP(O)(OEt)₂ (I). The reaction is inhibited by hydroquinone but traces of Bz₂O₂ give a 4-fold increase in reaction rate (89% yield at 80°). Irradiation of the reaction mixture at room temperature with a Hanovia ultraviolet lamp gives 80% I; under similar conditions BrCCl₃ and (EtO)₃P give 88% I. No reaction is observed in the dark at room temperature (30 days). These results confirm the chain process proposed by Kamai and Kharrasova (C.A. 52, 3666a). I b₁₇ 137-8°, n²¹_D 1.4612; partial hydrolysis with PhNH₂ in PhMe at 110° gave the anilinium salt of monoethyl trichloromethanephosphonate, m. 181.6-2.2° (MeOH-PhMe).

Chemistry & Industry (London, United Kingdom) published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Griffin, C. E. published the artcilePhosphoryl stretching frequency correlation for phosphonic acid derivatives, Computed Properties of 866-23-9, the publication is Chemistry & Industry (London, United Kingdom) (1960), 1058-9, database is CAplus.

A plot of Σ σ* (Taft substituent constants) vs. γ_PO (as films in CS₂ or CCl₄) for 19 phosphonates [RP(O)XY] (I) gave a linear relationship; a least squares treatment of the data gave γ_PO = 16.80 Σσ* + 1198. The following I were studied (X = Y = OEt) (R given): Me, Et, Pr, Bu, n-C₆H₁₃, CH₂:CH, CH₂:CHCH₂, PhCH₂, Ph, ClCH₂, Cl₂CH, CCl₃ (II), BrCH₂, HOCH₂, AcCH₂. Also I (R, X, and Y given): Me, OMe, OMe; Me, OEt, NMe₂; Me, NMe₂, NMe₂ (III); Ph, H, OEt. The average deviation between calculated and observed frequencies was ±4 cm.^-1; the only significant deviation occurred with II and III, and may have arisen through disturbance of the normal inductive effects of the substituents by field effects. Major deviations from the linear relationship also occurred with frequency values obtained in the presence of H-bonding solvents. The following σ* values were tentatively assigned: (CH₂)₂CO₂Et, 0.39; (CH₂)₃CO₂Et, 0.39; NEt₂, 0.68.

Chemistry & Industry (London, United Kingdom) published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gramstad, Thor published the artcileStudies of hydrogen bonding. Part XXXIII. Dipole moments of phosphoryl compounds and their hydrogen-bonded complexes with phenol, Application In Synthesis of 866-23-9, the publication is Acta Chemica Scandinavica (1992), 46(11), 1087-91, database is CAplus.

The dipole moments of 33 phosphoryl compounds and of their hydrogen-bonded complexes with phenol have been determined in CCl₄ at 20°. In general there is no correlation between the dipole moments and the O-H stretching frequency shift accompanying the complexation of phenol with the phosphoryl compounds A smooth correlation is observed, however, for some series of closely related phosphoryl compounds The influence of the various substituents on the dipole moment is discussed. The vectorially calculated dipole moments of the complexes were smaller than the corresponding dipole moments obtained exptl. The vectorial difference, Δμ, is greatest for phosphoryl compounds containing the N-P:O and C₆H₅-P:O groups.

Acta Chemica Scandinavica published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gramstad, Thor published the artcileHydrogen bonding. XII. Correlation of the complexing ability of organophosphorus compounds with the Taft σ^* constant, Safety of Diethyltrichloromethylphosphonate, the publication is Spectrochimica Acta (1964), 20(4), 729-31, database is CAplus.

cf. CA 56, 15544b; 58, 1333a; 59, 13792b. The relation of the Taft substituent constant (Σσ^*) is linear with respect to log K^20°_association and the shift of the OH stretching vibration fundamental (Δv_OH) for 22 organophosphorus compounds in mixed solutions with phenol, ethanol, and α-naphthol in CCl₄. Σσ^* is also linear with respect to log K^20°_association for the organophosphorus compounds with iodine in CCl₄ solution, and with the wavelength shift of the visible absorption band of iodine from near 518 mμ. The relation between Σσ^* and P:O stretching frequencies in cm.^-1 (v_PO) is not linear for these organophosphorus compounds in CCl₄ solution, contrary to previous reports (Griffin, CA 55, 1415h). However, some of G.’s determinations of v_PO were on pure films, and these compounds are associated in the pure state.

Spectrochimica Acta published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gramstad, Thor published the artcileHydrogen bonding. VII. Hydrogen-bond association of phenol and pentachlorophenol with carbonyl compounds and ethers, SDS of cas: 866-23-9, the publication is Spectrochimica Acta (1963), 497-508, database is CAplus.

cf. Acta Chem. Scand. 16, 2368(1962); CA 58, 1333b. The thermodn. data for the 1:1 association of PhOH with 8 esters, 3 acid fluorides, 16 ketones, 14 aldehydes, and 15 ethers in CCl₄ solution were determined The frequency shifts, δv_OH, of the O-H band of PhOH which accompanies the formation of the H bond with various types of proton acceptors (N,N-disubstituted amides, esters, ketones, aldehydes, ethers, and organo-P compounds) are proportional to the corresponding enthalpies of association This relation is not applicable to other proton donors studied. The entropy of association (-ΔS) for the various systems is, in relation to δv_OH, in order of increasing values as follows: organo-P compounds-PhOH <N,N-disubstituted amides-PhOH < esters-PhOH < ketones-PhOH < aldehydes-PhOH < ethers-PhOH < tertiary amines and pyridines-PhOH. The influence of inductive and mesomeric effects on the H-bond association is discussed.

Spectrochimica Acta published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gramstad, Thor published the artcileStudies of hydrogen bonding. II. Intermolecular hydrogen bond association between organophosphorus compounds and methanol, α-naphthol, and pentachlorophenol, respectively, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Acta Chemica Scandinavica (1961), 1337-46, database is CAplus.

cf. ibid. 14, 1485(1960). -The K_association ΔH, ΔF, and ΔS values of the equilibrium reaction between organophosphorus compounds and MeOH, α-naphthol (I), and C₆Cl₅OH (II) were determined by infrared measurements. Data were given for the dimeric hydrogen-bond association between 16 organophosphorus compounds and MeOH, I, and II in CCl₄. A comparison of thermodynamic data of H bonds in CS₂ and CCl₄ was made for the compounds PhOH.Ph₃PO and C₆Cl₅OH.Ph₃PO. The following observations were made: (1) the absorption bands due to H-bonding are for each system lowered in frequency, broadened in contour, and enhanced in integrated intensity as the base strength of the proton acceptor increases; (2) the ease with which the H donors studied form H bonds in CCl₄ with the organophosphorus compounds used is, in order of decreasing association constant, I > phenol > II > MeOH; (3) the sequence of the variation ΔH, ΔS with Δv for each system is, in order of decreasing slope, MeOH > phenol > I > II. For the system organophosphorus compounds-MeOH interaction on H bonding is predominantly due to the solvation effect around the H bonded complex; with I both the solvation and the solvent-proton donor effects come into play and with II the solvent-proton donor effect predominates.

Acta Chemica Scandinavica published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gradecka, Lucja published the artcileQualitative and quantitative studies of technical diethylsafranine, Name: 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, the publication is Biuletyn Informacyiny: Barwniki, Srodki Pomocnicze (1983), 27(3), 56-7, database is CAplus.

The purity of samples of tech. diethylsafranine (I) [4569-86-2] (used as an inhibitor in electrorefining of Cu) was determined by chromatog. on a silica gel-filled column using 9:1:1:1 BuOH-EtOH-AcOH-H₂O mixture as solvent and eluent, and spectrophotometric determination of the concentration of eluted, pure I at wavelength 560 nm utilizing the calibration curve.

Biuletyn Informacyiny: Barwniki, Srodki Pomocnicze published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Name: 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics