Month: December 2022

Sareen, V. published the artcileSynthesis of some new 2-(4-nitroanilino)-4-(4-carboxyanilino)-6-(substituted thioureido)-1,3,5-triazines, Quality Control of 3696-23-9, the publication is Heterocyclic Letters (2014), 4(1), 115-118, 4 pp., database is CAplus.

Some new 2-(4-nitroanilino)-4-(4-carboxyanilino)-6-(substituted thioureido)-1,3,5-triazines I (R = C₆H₅, 4-FC₆H₄, 4-ClC₆H₄, etc.) have been prepared by reacting 2,4,6-trichloro-1,3,5-triazine with nucleophilic reagents, 4-nitroaniline, 4-carboxyaniline and different substituted thioureas.

Heterocyclic Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Quality Control of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Golubeva, Elena N. published the artcileFormation of Active Catalysts in the System: Chlorocuprates-CCl₄-n-C₁₀H₂₂, COA of Formula: C19H34ClN, the publication is Journal of Physical Chemistry A (2009), 113(38), 10219-10223, database is CAplus and MEDLINE.

Transformations of anionic Cu^II chlorocomplexes have been studied under conditions of catalytic exchange reactions between carbon tetrachloride and n-alkanes. It was shown that chlorocuprates are just precursors and are easily reduced to the genuine catalysts, i.e., to the resp. Cu^I complexes. Both the composition and the geometric structure of the precursor (CuCl₄^2-) and, probably, the active site (CuCl₃^2-) have been investigated by several techniques (UV-vis spectroscopy, ESR, extended X-ray absorption fine structure (EXAFS), X-ray absorption near-edge structure (XANES), and static magnetic measurements). The dependence of the metathesis velocity on the [Cl^–]/[Cu] ratio was found to exhibit a maximum most likely corresponding to the highest content of trichlorocuprite CuCl₃^2-.

Journal of Physical Chemistry A published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nadirova, Maryana A. published the artcileCascade of the Hinsberg / IMDAF reactions in the synthesis 2-arylsulfonyl-3a,6-epoxyisoindoles and 4a,7-epoxyisoquinolines in water, Name: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Tetrahedron (2021), 132032, database is CAplus.

N-Furfuryl allylamines, readily accessible from corresponding furfurals or furfuryl amines, react with a broad range of aryl sulfonyl chlorides with the formation of a 3a,6-epoxyisoindoles I [Ar = Ph, 2-thienyl, Ts, etc.; R¹ = H, I, Et, etc.; R² = H, Br, Me] in one synthetic stage was reported. Usually, in boiling water, the interaction sequence involved two consecutive steps: the Hinsberg reaction and the intramol. Diels-Alder furane (IMDAF) reaction. The scope and limitations of the proposed method were thoroughly investigated, and it was revealed that the key [4+2] cycloaddition step proceeded through an exo-transition state, giving rise to the exclusive formation of a single diastereomer of the target heterocycle. The method allowed the ability to obtain N-sulfaryl-substituted 3a,6-epoxyisoindoles I and 4a,7-epoxyisoquinolines, which were potentially useful substrates for further transformations and subsequent bioscreening, in particular antimicrobial activity.

Tetrahedron published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Name: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Khan, Mohammad Rizwan published the artcileQuantitative determination of methylene blue in environmental samples by solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry: a green approach, COA of Formula: C22H23ClN4, the publication is RSC Advances (2014), 4(64), 34037-34044, database is CAplus.

Industrial effluents with dyes may contain appreciable concentrations of materials with high COD and suspended solids, posing adverse effects to both humans and aquatic life; therefore, these effluents require quant. monitoring. In the present study, an anal. method based on solid-phase extraction (SPE) and ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) has been optimized for the quant. anal. of methylene blue (MB) in environmental samples. For the extraction of MB, a variety of solvents, including formic acid, were investigated to obtain optimum recovery. MB extraction using the SPE method was best achieved using methanol with 1 M formic acid. Chromatog. separation of MB and methylene violet 3RAX (MV 3RAX, internal standard) was accomplished on an Acquity BEH C₁₈ column using water (64.99%) with formic acid (0.01%) and acetonitrile (35%) in isocratic elution mode. Chromatog. separation for both MB and MV 3RAX was achieved in <2 min with good resolution and superior peak symmetry. MB and MV 3RAX were quantified with electrospray ionization coupled with MS/MS in the multiple reaction monitoring mode. Good quality parameters were achieved for instance linearity (r² > 0.999), run-to-run and day-to-day precisions with relative standard deviations of <4%, sensitivity with a low limit of detection (LOD) of 0.1 ng mL^-1 and limit of quantification (LOQ) of 0.4 ng mL^-1 were obtained. Industrial wastewater samples (paper, textile, laundry and printing press) were analyzed, and an MB level was found in between 0.36 and 1.08 μg mL^-1 with excellent recovery rates (95-99%) depending on samples.

RSC Advances published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, COA of Formula: C22H23ClN4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zaib, Sumera published the artcileEvaluation of indole-picolinamide hybrid molecules as carbonic anhydrase-II inhibitors: Biological and computational studies, HPLC of Formula: 32333-53-2, the publication is Journal of Molecular Structure (2022), 133048, database is CAplus.

The present study reported the successful synthesis and evaluation of a series of indole-picolinamide hybrids I, II [Ar = Ph, 3-CF₃C₆H₄, 3,4-di-ClC₆H₃], III, IV and V as potent inhibitors of bovine carbonic anhydrase II, a promising therapeutic target for the treatment of neurol. disorders, osteoporosis, glaucoma, cancer and obesity. Various multistep synthetic approaches were utilized to access the desired structures having exclusive sites for chem. modifications and diverse spots for biol. interactions between the ligand and enzyme. Compound I was observed as a potent inhibitor of the bovine CA-II with an IC₅₀ value of 0.0440 ± 0.009μM. The inhibition potency was about 22-fold higher than the standard drug acetazolamide (IC₅₀ = 0.9618 ± 0.180μM). Several relevant structure-activity relationships were deduced that enlighten the crucial role of substituents as well as the key pharmacophores involved in the inhibition process. Mol. docking tools reinforced the in vitro assay results. The most active compound I was also investigated for anticancer potential using sulforhodamine B assay and results showed two-fold efficacy against HeLa cells when compared to standard drug cisplatin (IC₅₀ = 8.045 ± 3.791μg/mL and 4.128 ± 1.473μg/mL, resp.). These findings were also confirmed by flow cytometry and comet tests. Moreover, fluorescence microscopy with DAPI staining revealed apoptosis as a mechanism of cancer cell death.

Journal of Molecular Structure published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3ClINS, HPLC of Formula: 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Emami, Leila published the artcileNovel N-substituted isatin-ampyrone Schiff bases as a new class of antiproliferative agents: Design, synthesis, molecular modeling and in vitro cytotoxic activity, COA of Formula: C7H6Cl2, the publication is Journal of Heterocyclic Chemistry (2022), 59(7), 1144-1159, database is CAplus.

Thirteen novel isatin-ampyrone Schiff bases derivatives such as I [X = H, Cl; R = H, 3-F, 4-OMe, etc.] were synthesized by the reaction of isatins and benzyl halides followed by condensation with ampyrone. In vitro cytotoxic activity of these new Schiff bases against three human tumor cell lines (MCF-7, A549, and SCOV3) as well as normal breast cell line (MCF-10A) were evaluated by MTT assay. Structure-activity relationship of the tested compounds revealed that chlorine group at C-5 position of the isatin ring significantly increased the cytotoxic activity. This study generally led to introduce a highly active mol. I [X = Cl; R = 3-Cl] with IC₅₀ values of 5.12, 25.5, and 12.9μM, on MCF-7, A549, and SCOV3, resp. Furthermore, mol. docking studies of the synthesized compounds were also done to investigate their binding modes to toward VEGFR-2 and JNK3-MAP kinase as the main targets for isatin-containing anticancer agents. Binding free energy values of the compounds showed pos. correlation with their cytotoxic activities. To confirm the docking results, mol. docking simulations of potent compound I [X = Cl; R = 3-Cl] against VEGFR-2 and JNK3 MAP kinase were also performed. According to the cytotoxic results and in silico ADMET predictions together, I [X = Cl; R = 3-Cl] could be considered as a potent candidate for the future anticancer studies.

Journal of Heterocyclic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Goldberg, Frederick W. published the artcileGeneral synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor, SDS of cas: 7080-50-4, the publication is Tetrahedron (2014), 70(37), 6613-6622, database is CAplus.

The sulfoximine group has great potential as a substituent in drug discovery, as evidenced by two new clin. candidates, and can be viewed as an isosteric alternative to the commonly used sulfone. Our aim was to improve the accessibility of this group by synthesizing a diverse range of S-alkyl and N-alkyl sulfoximine building blocks with procedures that are applicable on a practical scale (>10 g). In particular, synthesis of the less well exploited N-alkyl sulfoximines and the use of dimethylsulfoximine as a versatile, com. available precursor is discussed.

Tetrahedron published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, SDS of cas: 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathew, Vinod published the artcileStudies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues, SDS of cas: 6313-54-8, the publication is European Journal of Medicinal Chemistry (2007), 42(6), 823-840, database is CAplus and MEDLINE.

Several 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole, e.g., I (R = H, Me or Ph), and their dihydro analogs were synthesized from hetero aromatic acids and hetero aromatic aldehydes, resp., by microwave-assisted and conventional methods. Synthesized compounds were studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacol. activities.

European Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathew, Vinod published the artcileSynthesis, characterization and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles and their dihydro analogues, Quality Control of 6313-54-8, the publication is E-Journal of Chemistry (2007), 4(3), 320-342, database is CAplus.

4-Amino-5-aryl, or heteroaryl, substituted-3-mercapto-1,2,4-triazoles were prepared from the corresponding aromatic carboxylic acids through a multi-step sequence. These compounds were then reacted with various aromaticand hetero aromatic acids and hetero aromatic aldehydes to give 3,6-disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles, e.g., I, and 3,6-disubstituted-5,6-dihydro-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles resp. Elemental anal., IR, ¹H NMR and mass spectral data was elucidated for the structures of all newly synthesized compounds Synthesized compounds were studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacol. activities.

E-Journal of Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathew, V. published the artcileHeterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles, SDS of cas: 6313-54-8, the publication is European Journal of Medicinal Chemistry (2006), 41(9), 1048-1058, database is CAplus and MEDLINE.

Triazolo[3,4-b]thiadiazoles I (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl; R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) are prepared in three steps from the hydrazides RCONHNH₂ (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl) and the carboxylic acids R¹CO₂H (R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) via aminomercaptotriazoles II (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl); the antiinflammatory, analgesic, antibacterial, and antifungal activities of I (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl; R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) are determined Base-mediated condensation of hydrazides RCONHNH₂ (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl) with carbon disulfide followed by condensation of the potassium arylcarbonylhydrazinocarbodithioate with hydrazine hydrate provides II (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl); condensation of II (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl) with carboxylic acids R¹CO₂H (R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) in phosphorus oxychloride provides I (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl; R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂). The activities of the prepared compounds are lower than those of the standard agents used.

European Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics