Month: December 2022

Zhang, Puwen published the artcile7-Aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2008), 16(13), 6589-6600, database is CAplus and MEDLINE.

Novel 7-aryl benzo[1,4]oxazepin-2-ones were synthesized and evaluated as non-steroidal progesterone receptor (PR) modulators. The structure activity relationship of 7-aryl benzo[1,4]oxazepinones was examined using the T47D cell alk. phosphatase assay. A number of 7-aryl benzo[1,4]oxazepinones such as 10j and 10v demonstrated good in vitro potency (IC₅₀ of 10-30 nM) and selectivity (over 100-fold) at PR over other steroidal receptors such as glucocorticoid and androgen receptors (GR and AR). Several 7-aryl benzo[1,4]oxazepinones were active in the rat uterine decidualization model. In this in vivo model, compounds 10j (I) and 10u (II) were active at 3 mg/kg when dosed orally.

Bioorganic & Medicinal Chemistry published new progress about 915763-60-9. 915763-60-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (3-Chloro-5-cyanophenyl)boronic acid, and the molecular formula is C20H18BrN3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nadaf, Afra Quasar A. published the artcileSynthesis, characterization, crystal structure and hirshfeld surface analysis of alkyl substituted N,4-diphenyl thiazole-2-amine., Computed Properties of 3696-23-9, the publication is Chemical Data Collections (2019), 100297, database is CAplus.

The present work describes the synthesis of alkyl substituted N,4-di-Ph thiazole-2-amines (I) and (II) through a three step pathway. Further, the structures were confirmed by single crystal X-ray diffraction studies which revealed that compound I crystallizes in triclinic system with P-1 space group whereas compound II crystallizes as monoclinic with P2₁/c space group. The asym. unit consists of only one mol. in both the structures. The study of torsional angles of compound I and compound II indicated that S1 and C4 are cis to each other whereas N2 and C4 are trans. A detailed anal. of intermol. hydrogen bonding interactions has been performed. Also their C-H···π and π···π stacking interactions have been explored using Hirshfeld surface anal. and their 2D fingerprint plots. The most significant contributions in both the compounds are due to H···H interactions which also account for their stability.

Chemical Data Collections published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hemetsberger, H. published the artcileBehavior of chemically bonded alkylmethyldichlorosilanes to silica gel in reversed-phase high-performance liquid chromatography, Recommanded Product: Dichloro(methyl)(octyl)silane, the publication is Chromatographia (1977), 10(12), 726-30, database is CAplus.

Hydrocarbon-bonded stationary phases were prepared by reacting CH₃(CH₂)_nSiMeCl₂, where n = 7, 10, 14, and 17, with silica and were investigated and compared with phases obtained by the reaction of silica with alkyltrichlorosilanes. The reversed-phase chromatog. of halobenzenes with aq MeOH as mobile phase showed a linear relationship between the capacity ratios k‘ and the amount of C in the phases in all cases. The alkylmethyl phases were superior to the alkyl phases; capacity ratios and selectivities were increased and the efficiencies, with one exception, were higher. The improved properties are discussed in relation to residual silanol groups on the stationary phase surface.

Chromatographia published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Recommanded Product: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

DeShong, Philip published the artcileIntermolecular and intramolecular azomethine ylide [3 + 2] dipolar cycloadditions for the synthesis of highly functionalized pyrroles and pyrrolidines, Safety of 2,3-Dibromopropionylchloride, the publication is Journal of Organic Chemistry (1985), 50(13), 2309-15, database is CAplus.

N-Alkyl and N-arylaziridines carrying a single carboxy ester function, e.g., I, undergo thermally induced electrocyclic ring opening to produce azomethine ylides, which subsequently react with acetylenes or olefins to yield substituted pyrroles, e.g., II, or pyrrolidines, e.g., III, resp. The [3 + 2] dipolar cycloaddition reaction can be performed in either an intermol. or intramol. mode and displays high regioselectivity and stereoselectivity with a variety of dipolarophiles. The yield of cycloadducts depends on the electronic characteristics and the substitution pattern of the dipolarophile, and on the mode of cycloaddition employed. In the intermol. reaction, the yield of adducts is poor unless the dipolarophile is activated. Intramol. cycloadditions with monosubstituted olefins or acetylenes give adducts in yields of 45-70%. Although the yields of adducts in these instances are moderate, the starting materials are readily prepared and the method is an effective means for the assembly of a structurally complex heterocyclic system with high regiochem. and stereochem. control of peripheral substituents. When the dipolarophilic component is disubstituted, the cycloaddition gives synthetically useful yields if the dipolarophile carries an electron-withdrawing functionality.

Journal of Organic Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Safety of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Patel, Daksha published the artcileThe cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biomaterials (2010), 32(4), 1167-1176, database is CAplus and MEDLINE.

A new class of nanoparticle-based dual-modality positron emission tomog./magnetic resonance imaging (PET/MRI) contrast agents has been developed. The probe consists of a superparamagnetic iron oxide (SPIO) or manganese oxide core coated with 3,4-dihydroxy-D,L-phenylalanine (dl-DOPA). The chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to DOPA termini. The DOTA modified nanoparticles allow chelation of copper for PET imaging. These surface functionalized nanoparticle-based probes have been characterized by various anal. techniques. The cell-labeling efficacy, cytotoxicity and relaxivity of these nanoparticles have been evaluated and compared with the same properties of one of the most commonly utilized MRI contrast agents, Feridex. Evidently, this new nanoparticle has a great potential for use in cell tracking with MRI and PET in the absence of transfecting agent. It is noteworthy that there is a sharp increase in r₂ relaxivity of these nanoparticles on coordination with Cu²⁺ ions. Thus these iron oxide nanoparticles can also be explored as the smart magnetic resonance (MR) sensor for the detection of micromolar changes in copper concentration for neurodegenerative diseases such as Alzheimer’s disease, Menkes and Wilson’s diseases, amyotrophic lateral sclerosis and prion diseases.

Biomaterials published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Agelis, George published the artcileFacile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as angiotensin II AT1 receptor blockers, Computed Properties of 42074-68-0, the publication is Molecules (2013), 7510-7532, database is CAplus and MEDLINE.

In the present work, a facile and efficient route for the synthesis of a series of N-substituted imidazole derivatives is described. Docking studies have revealed that N-substituted imidazole derivatives based on (E)-urocanic acid may be potential antihypertensive leads. Therefore, new AT1 receptor blockers bearing either the benzyl or the biphenylmethyl moiety at the N-1 or N-3 position, either the (E)-acrylate or the propanoate fragment and their related acids at the C-4 position as well as a halogen atom at the C-5 position of the imidazole ring [I; R = CH:CHCO₂H, CH:CHCO₂Me, CH₂CH₂ CO₂H, CH₂CH₂CO₂Me] and [II; X = H, R = CH:CHCO₂R¹ or CH₂CH₂CO₂R¹, R¹ = H, Me, Q; X = Cl, Br, or iodo, R = CH₂CH₂R¹, R¹ = H or Q] were synthesized. The newly synthesized analogs were evaluated for binding to human AT1 receptor. The biol. results showed that this class of mols. possesses moderate or no activity, thus not always confirming high docking scores. Nonetheless, important conclusions can be derived for their mol. basis of their mode of action and help medicinal chemists to design and synthesize more potent ones. An aliphatic group as in losartan seems to be important for enhancing binding affinity and activity.

Molecules published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Computed Properties of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hagemann, Justin P. published the artcileDesigner ligands. Part 4. Synthesis of acyclic and macrocyclic platinum group metal-specific ligands, Quality Control of 1002-41-1, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1999), 341-348, database is CAplus.

Synthetic pathways to a range of novel, polydentate, sulfur-containing, mono-amide ligands, e.g. mercaptoacetanilides I (R = H, MeO), designed to coordinate platinum group metals, have been developed. Access to the tetradentate systems was facilitated by the extensive use of disulfide linkages as a protection strategy.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Quality Control of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sato, Masakazu published the artcileSynthesis and evaluation of novel thiazolidine derivatives as thromboxane A₂ receptor antagonists, Related Products of chlorides-buliding-blocks, the publication is Chemical & Pharmaceutical Bulletin (1994), 42(3), 521-9, database is CAplus and MEDLINE.

3-Benzoyl or 3-phenylsulfonyl-2-substituted thiazolidine derivatives were prepared, and evaluated for their thromboxane A₂ (TXA₂) receptor-antagonizing effect on (15S)-15-hydroxy-11α,9α-(epoxymethano)prostathiazolidine derivative, 3-benzoyl-2-(4-hydroxy-3-methoxyphenyl)thiazolidine, showed mild TXA₂ receptor antagonist activity. Modification of the compound led to 2-chloro-4-[3-(4-chlorophenylsulfonyl)thiazolidin-2-ylmethyl]phenoxyacetates I (X = H, Cl; R² = H, OMe, halo; n = 0-2), one of which showed TXA₂ receptor antagonist activity.

Chemical & Pharmaceutical Bulletin published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Suzuki, Nobutaka published the artcilePhotochemical type I and II elimination reactions of dialkyl (trichloromethyl)phosphonates, Computed Properties of 866-23-9, the publication is Bulletin of the Chemical Society of Japan (1980), 53(5), 1421-4, database is CAplus.

Irradiation of CCl₃P(O)(OR)₂ (I; R = Et, Pr, CH₂CHMe₂) in MeCN gave the corresponding monoesters and olefins via photochem. type-II elimination. In addition, products via type-I elimination were obtained from I (R = Me, CH₂CHMe₂).

Bulletin of the Chemical Society of Japan published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H6BNO2, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tamao, Kohei published the artcileCoupling of (amino)alkylchlorosilanes with lithium: new access to symmetrical di- and tetrafunctional alkyldisilanes, Product Details of C7H16Cl2Si, the publication is Organometallics (1993), 12(2), 580-2, database is CAplus.

Homocoupling reactions of amino- and diaminoalkylchlorosilanes with Li metal proceed readily in THF at room temperature to form the corresponding sym. diamino- and tetraaminoalkyldisilanes, resp., in high yields, which are transformed into chloroalkyldisilanes by the action of acyl chloride or dry HCl and into ethoxyalkyldisilanes by ethanolysis under mild conditions. The following are the compounds prepared in this study: XR¹R²SiSiR¹R²X where R¹ = R² = Me, X = Et₂N and Cl; R¹ = R² = iso-Pr, X = Et₂N and Cl; R¹ = Me,R² = n-hexyl, X = Et₂N, Cl and EtO, and X₂MeSiSiMeX₂ where X = Et₂N and EtO.

Organometallics published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C38H74Cl2N2O4, Product Details of C7H16Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics