Month: December 2022

Oh, Myung J. published the artcileComparison of the resist effectiveness and leveling character of α-bromoacrylamide based and 2,4-dichloro-s-triazine based dye-resist agents for wool, Name: 2,3-Dibromopropionylchloride, the publication is Dyes and Pigments (2005), 70(3), 220-225, database is CAplus.

Three dye resists based on α-bromoacrylamide and three dye resists based on dichlorotriazine were synthesized and their effectiveness and leveling properties were compared on wool. In general, the dichlorotriazine based resist agents displayed higher resist effectiveness in dyeing than their α-bromoacrylamide counterparts. However, the resists based on α-bromoacrylamide exhibited better leveling properties than those based on dichlorotriazine. The resist effectiveness was significantly improved by increasing the number of sulfonate group in the dye-resist agents and the hydrophilic character of anionic dyes applied over them.

Dyes and Pigments published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Name: 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jung, Sung-Hyun published the artcilePalladium-Catalyzed Direct Synthesis, Photophysical Properties, and Tunable Electroluminescence of Novel Silicon-Based Alternating Copolymers, Application In Synthesis of 14799-94-1, the publication is Macromolecules (2000), 33(25), 9277-9288, database is CAplus.

A new class of silicon-based alternating copolymers with a uniform π-conjugated segment regulated by organosilicon units was synthesized using the Heck reaction between distyrylsilane monomers and appropriate arylene dibromides. The incorporation of organosilicon units with the aromatic or aliphatic groups on the silicon atoms into π-conjugated systems improved their processability and interrupted the π-conjugation length. They could be spin-cast onto various substrates to give highly transparent homogeneous thin films. Their glass transition temperatures were in the range 94-127 °C. They show strong absorption bands around 356-416 nm, which corresponds to the π-π* transition of the conjugated segments. The maximum photoluminescence appeared around 440-526 nm in the blue or green emission region. Their optical properties depend on the arylene dibromides in the Heck reaction. The single-layered light-emitting diode of an Al/SiPhPPV or SiHMPPV/ITO glass exhibits a threshold voltage of 10-12 V from the I-V curve. The electroluminescence (EL) of the SiPhPPV or SiHMPPV gives an emissive peak at 450 nm. Furthermore, the multilayered light-emitting diodes of an Al/LiAl/SiPhPVK/PANI/ITO glass and an Al/LiAl/SiPhFPV or SiHMFPV/ITO glass shows a threshold voltage of 6-12 V. The EL device based on SiPhPVK exhibits the blue emissive color at 467 nm, when an operating voltage of 7 V was applied. When an operating voltage of 11 V was applied, however, the EL device emits a white color. The EL spectra of the SiPhFPV and SiHMFPV polymers, obtained at an applied voltage of 12 V, show two strong peaks in the blue emissive region as well as in the green region.

Macromolecules published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Application In Synthesis of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Creemer, Cassidy published the artcileLight-controlled self-assembly of a dithienylethene bolaamphiphile in water, Category: chlorides-buliding-blocks, the publication is Dalton Transactions (2020), 49(26), 8846-8849, database is CAplus and MEDLINE.

The self-assembly of bolaamphiphiles comprised of a central photochromic dithienylethene (DTE) chromophore was investigated in aqueous media. Irradiation at 254 nm induced a conversion from the open to closed states of the DTE chromophores. Whereas, in water, irradiation produced a photostationary state of 20 : 80 (open/closed), in methanol the ratio improved to 10 : 90 (open/closed). The open → closed transition was accompanied by the formation of 1D nanofibers during incubation in darkness.

Dalton Transactions published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fujii, Shinya published the artcileStructural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling, Formula: C6H3ClFNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(17), 127408, database is CAplus and MEDLINE.

We report here structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK (STE20/SPS1-related proline/alanine-rich kinase) inhibitors. Abnormal activation of the signal cascade of with-no-lysine kinase (WNK) with OSR1 (oxidative stress-responsive kinase 1)/SPAK and NCC (NaCl cotransporter) results in characteristic salt-sensitive hypertension, and therefore inhibitors of the WNK-OSR1/SPAK-NCC cascade are candidates for antihypertensive drugs. Based on the structure of lead compound 2, we examined the SAR of N-(4-phenoxyphenyl)benzamide derivatives, and developed compound 20l as a potent SPAK inhibitor. Compounds 201 is a promising candidate for a new class of antihypertensive drugs.

Bioorganic & Medicinal Chemistry Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fujii, Shinya published the artcileStructural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is ChemMedChem (2021), 16(18), 2817-2822, database is CAplus and MEDLINE.

Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade as a potential target, and we previously developed a screening system for inhibitors of WNK-OSR1/SPAK-NCC signaling. Herein we used this system to examine the structure-activity relationship (SAR) of salicylanilide derivatives as SPAK kinase inhibitors. Structural design and development based on our previous hit compound, aryloxybenzanilide derivative I, and the veterinary anthelmintic closantel (II) led to the discovery of compound III as a potent SPAK inhibitor with reduced toxicity. Compound III decreased the phosphorylation level of NCC in mouse kidney in vivo, and appears to be a promising lead compound for a new class of antihypertensive drugs.

ChemMedChem published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sergeev, Pavel G. published the artcileConstruction of 6-Aminopyridazine Derivatives by the Reaction of Malononitrile with Dichloro-Substituted Diazadienes, Recommanded Product: 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine, the publication is European Journal of Organic Chemistry (2020), 2020(31), 4964-4971, database is CAplus.

The reactions of 4,4-dichloro-1,2-diazabuta-1,3-dienes with malononitrile resulted in an efficient approach to highly functionalized 6-aminopyridazine derivatives isolated in up to 98%. The process was found to provide straightforward access to the interesting type of nitrogen-containing heterocycles with an exocyclic double bond. Furthermore, the possibility of subsequent functionalization of the obtained compounds via intramol. cyclization was demonstrated. As a result, condensed azaheterocycles can be prepared very efficiently in one-pot and tandem versions. Finally, the influence of structural features of all synthesized compounds on their absorption characteristics in the UV/Vis-range is also investigated.

European Journal of Organic Chemistry published new progress about 1869-22-3. 1869-22-3 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Hydrazine,Amine,Benzene, name is 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine, and the molecular formula is C15H20N2O2, Recommanded Product: 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kochetkov, N. K. published the artcileCycloserine and related compounds. VIII. Synthesis of 3-isoxazolidones, Category: chlorides-buliding-blocks, the publication is Zhurnal Obshchei Khimii (1959), 3417-24, database is CAplus.

cf. CA 54, 8777i. Halo hydroxamic acids were prepared by a general reaction of acyl chlorides with H₂NOH in aqueous medium, the products being cyclized to 3-isoxazolidones by MeOH-KOH. To 32 g. NaOH in 120 ml. H₂O was added at 0° 55.5 g. NH₂OH.HCl and the resulting solution was treated below 5° with 68.6 g. BrCH₂CH₂COCl. After 1 hr. at 0-5°, 1.5 hrs. at 15°, the mixture was heated to 60° and filtered. The filtrate after 1-2 days at -5° gave 48-50% BrCH₂CH₂CONHOH (I), m. 88-90°. Similarly were prepared: 50-5% ClCH₂CH₂CONHOH, m. 102-4°; 52-5% BrCH₂CHMeCONHOH, m. 98-100°; 61% PhCHBrCH₂CONHOH, m. 85-90°; 65% ClCMe₂CH₂CONHOH, an oil; PhCH:CPhCONHOH (from PhCHBrCHPhCOCl), 50%, m. 147-9°; BrCH₂CHBrCONHOH, 55-60%, m. 151-3°: 50-60% ClCH₂CHClCONHOH, m. 95-7°. I (6.8 g.) in 15 ml. MeOH was treated with 40 ml. 2N MeOH-KOH and heated 40 min., yielding after filtration and evaporation and treatment of the residue with Et₂O 80-5% K salt of 3-isoxazolidone, decomposed 213-15°, which with aqueous AgNO₃ gave the Ag salt, decomposed 166-8°. The K salt treated with absolute EtOH-HCl gave 70% 3-isoxazolidone, m. 69-70°. Similarly, were prepared: 70% K salt of 4-methyl-3-isoxazolidone, decomposed 151-3° (free base decomposed 72-4°); 70% K salt of 5-phenyl-3-isoxazolidone, decomposed 285-7° (free base m. 121-3°); 50% K salt of 5,5-dimethyl-3-isoxazolidone, m. 122-5° (Ag salt, decomposed 166-8°; free base, an unpurifiable oil). The K salt of 3-isoxazolidone and BzCl in dioxane gave 47% N-benzoyl-3-isoxazolidone, m. 123-4°, also formed from the Ag salt in 40% yield. Similarly were prepared: 51% N-(p-nitrobenzoyl)-3 isoxazolidone, m. 178-80°, and 40% N-carbomethoxy-3-isoxazolidone, m. 106-8°.

Zhurnal Obshchei Khimii published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Platonov, Dmitry N. published the artcileIonic Cyclopropenium-Derived Triplatinum Cluster Complex [(Ph₃C₃)₂Pt₃(MeCN)₄]²⁺(BF₄^–)₂: Synthesis, Structure, and Perspectives for Use as a Catalyst for Hydrosilylation Reactions, Formula: C9H20Cl2Si, the publication is Organometallics (2021), 40(23), 3876-3885, database is CAplus.

This study presents a methodol. for the synthesis of the ionic cyclopropenium-derived triplatinum cluster complex [(Ph₃C₃)₂Pt₃(MeCN)₄]²⁺(BF₄^–)₂ and its analog with the replacement of one of the BF₄^– anions with a Cl^– anion, which represents a chain coordination polymer in crystalline form. The structures of the complexes were studied by several physicochem. methods, primarily x-ray diffraction using synchrotron radiation and ¹⁹⁵Pt NMR spectroscopy in solution with measurement and anal. of the ¹⁹⁵Pt-¹⁹⁵Pt and ¹³C-¹⁹⁵Pt spin-spin coupling constants A high catalytic activity of the synthesized Pt₃ complex was observed in hydrosilylation reactions. The catalytic efficiency of the complex is comparable to that of Karstedt’s catalyst and in some cases even higher.

Organometallics published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Balinge, Kamlesh Rudreshwar published the artcileFacile access to polymer supported zinc-salen complex: highly efficient heterogeneous catalyst for synthesizing hydantoins, thiohydantoins and Schiff bases in aqueous medium, Application In Synthesis of 3696-23-9, the publication is Research on Chemical Intermediates (2018), 44(3), 2075-2097, database is CAplus.

The synthesis of polymer supported zinc-salen complex (PS-Zn-salen) is described. The mononuclear zinc(II)-salen complex was characterized by Fourier-transform NMR spectroscopy, energy-dispersive X-ray spectroscopy, Fourier transform IR spectrophotometry (FT-IR), thermogravimetric anal., SEM, surface area and pore size distribution by Brunauer-Emmett-Teller. The synthesized PS-Zn-salen complex used as a recyclable heterogeneous catalyst for the efficient synthesis of hydantoins, thiohydantoins and Schiff bases in an aqueous medium. The isolated yields of hydantoins, thiohydantoins and Schiff bases achieved up to 89, 95 and 94%, resp. In spite of conventional heterogeneous catalysts, current PS-Zn-salen complex shows thermal stability up to 280 °C. Moreover, the catalyst could be recovered easily by simple filtration and reused for next run with slightly declining its activity up to six successive runs. The FT-IR spectrum of recycle catalyst after 6th run confirmed that the catalyst was stable during the course of a reaction. The leaching of metal from the PS-Zn-salen is negligible, which was confirmed by AAS and hot filtration test.

Research on Chemical Intermediates published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Attimarad, Mahesh Veerabhadra published the artcileMicrowave assisted synthesis, pharmacological activities, and molecular docking studies of ethyl 2-[2-substituted-4-(thiophenyl) thiazolyl] acetates, Application In Synthesis of 3696-23-9, the publication is Iranian Journal of Pharmaceutical Research (2017), 16(4), 1379-1395, database is CAplus.

Two series of Et 2-[2-anilino-4-(2-thienyl)thiazol-5-yl]acetates I [R = 3-MeC₆H₄, 4-MeOC₆H₄, 4-BrC₆H₄, etc.] and Et 2-[2-(2-benzylidenehydrazino)-4-(2-thienyl)thiazol-5-yl]acetates II [R¹ = 2-HOC₆H₄, 4-ClC₆H₄, 4-Me₂NC₆H₄] were synthesized and screened for their anti-inflammatory, analgesic and antioxidant activities. In-vivo test results showed that the compounds I [R¹ = 4-FC₆H₄, 4-ClC₆H₄, 3-Cl-4-FC₆H₃, 2,4-Cl₂C₆H₃, 4-BrC₆H₄] exhibited good anti-inflammatory and analgesic activities, similar to that of indomethacin and aspirin, resp. Compounds II showed better anti-oxidant activity than compounds I when compared to ascorbic acid. Further, a mol. docking study was performed to predict the possible binding modes on cyclooxygenase-1 (COX-1) and COX-2 for compounds I and II. Good correlation was observed between the anti-inflammatory activity of the compounds I and II and the results of the binding modes in COX-2.

Iranian Journal of Pharmaceutical Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics