Month: December 2022

Gao, Dingding published the artcileOne-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C-H Activation and Relay Diels-Alder Reaction, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Organic Letters (2020), 22(11), 4300-4305, database is CAplus and MEDLINE.

An efficient one-pot synthesis of multisubstituted 9,10-dihydrophenanthrenes from easily available 2-arylazaarenes and cyclohexadienone-tethered terminal alkynes (1,6-enynes) has been successfully achieved. This domino reaction proceeded smoothly through Cp*Rh(III)-catalyzed C-H activation, direct protonation of alkenyl-Rh intermediates, intramol. Diels-Alder reaction, alkene isomerization, subsequent ring-opening aromatization, and acetylation. This strategy was pot-economical and tolerated a wide range of functional groups. Moreover, the potent anticancer activities against HepG2 cells were observed for these artificial 9,10-dihydrophenanthrene derivatives

Organic Letters published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Fei published the artcilePhotostimulus-Responsive Large-Area Two-Dimensional Covalent Organic Framework Films, Quality Control of 219537-97-0, the publication is Angewandte Chemie, International Edition (2019), 58(45), 16101-16104, database is CAplus and MEDLINE.

Using an external stimulus to modulate the electronic structure of covalent organic frameworks (COFs) is very important because such a response will endow them with addnl. functions. A two-dimensional (2D) COF, constructed from a photo-responsive unit (1,2-bis(5-formyl-2-methylthien-3-yl)cyclopentene), can reversibly switch its elec. conductivity 200 times from low state (the open form) to high state (the closed form) upon irradiation with UV light and reversible with visible light. This reversible phenomenon can be monitored through a circuit containing a light-emitting diode (LED). Photoinduced ring-closing/opening reactions do not destroy the integrity of the frameworks, and both processes follow logarithmic carrier generation with time. Moreover, the correlation between COFs electronic properties and changes in photoinduced kinetics and absorption curves has been demonstrated.

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C3H8N2S, Quality Control of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Sheng published the artcileA Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes, Product Details of C8H7ClO3, the publication is Journal of the American Chemical Society (2012), 134(43), 18116-18124, database is CAplus and MEDLINE.

Protein tyrosine phosphatases (PTPs) constitute a large family of signaling enzymes that control the cellular levels of protein tyrosine phosphorylation. A detailed understanding of PTP functions in normal physiol. and in pathogenic conditions has been hampered by the absence of PTP-specific, cell-permeable small-mol. agents. We present a stepwise focused library approach that transforms a weak and general non-hydrolyzable pTyr mimetic (F₂Pmp, phosphonodifluoromethyl phenylalanine) into a highly potent and selective inhibitor of PTP-MEG2, an antagonist of hepatic insulin signaling. The crystal structures of the PTP-MEG2-inhibitor complexes provide direct evidence that potent and selective PTP inhibitors can be obtained by introducing mol. diversity into the F₂Pmp scaffold to engage both the active site and unique nearby peripheral binding pockets. Importantly, the PTP-MEG2 inhibitor possesses highly efficacious cellular activity and is capable of augmenting insulin signaling and improving insulin sensitivity and glucose homeostasis in diet-induced obese mice. The results indicate that F₂Pmp can be converted into highly potent and selective PTP inhibitory agents with excellent in vivo efficacy. Given the general nature of the approach, this strategy should be applicable to other members of the PTP superfamily.

Journal of the American Chemical Society published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C10H20O2, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Jin published the artcileFolic Acid-Conjugated Pyropheophorbide a as the Photosensitizer Tested for In Vivo Targeted Photodynamic Therapy, Recommanded Product: 2-Chlorotrityl chloride, the publication is Journal of Pharmaceutical Sciences (2017), 106(6), 1482-1489, database is CAplus and MEDLINE.

Photodynamic therapy (PDT) is a highly localized and minimally invasive cancer treatment modality with many important advantages, but the lack of ideal photosensitizers (PSs) greatly restricts its clin. utility. To develop new PSs with highly efficient singlet oxygen production and high tumor-localizing ability to reduce damage to healthy adjacent tissues, we conjugated folic acid (FA) with pyropheophorbide a (Pyro), a potent PS with a very high singlet oxygen quantum yield and a high extinction coefficient In the present work, we describe the synthesis and PDT evaluation of this FA-Pyro conjugate both in vitro and in vivo. This conjugation increased the accumulation of Pyro inside the tumors and improved the efficiency of PDT, resulting in eradication of s.c. xenograft KB (human mouth epidermal carcinoma) tumors after only 1 or 2 applications of external near IR light irradiation This outstanding PDT outcome in a tumor-bearing mouse model and the simple synthesis of the conjugate should have very good practical potential for clin. application.

Journal of Pharmaceutical Sciences published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C8H14O2, Recommanded Product: 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Yong published the artcileSynthesis of 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl) benzene, Safety of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Huaxue Shiji (2017), 39(11), 1237-1240, 1243, database is CAplus.

In this work, 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone was synthesized by reaction of Et trifluoroacetate with the Grignard reagent, which was obtained by reaction of 3,5-dichlorobromobenzene, magnesium and diisobutyl aluminum hydride. 1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone was then reacted with methyltriphenylphosphonium iodide in the presence of potassium t-butoxide to give the desired product 1,3-dichloro-5-(3, 3, 3-trifluoroprop-1-en-2-yl) benzene. Above two compounds were confirmed by IR, MS, UV, ¹HNMR and ¹³CNMR. The synthetic route has the advantages of simple operation, mild reaction condition, cheap and easy access to raw materials, green environmental protection and low cost.

Huaxue Shiji published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C33H22N4, Safety of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Zhi-You published the artcileA microwave-assisted approach to N-(2-nitrophenyl)benzenesulfonamides that enhanced peroxidase activity in response to excess cadmium, HPLC of Formula: 350-30-1, the publication is Tetrahedron Letters (2019), 60(8), 626-629, database is CAplus.

A facile and efficient approach to N-(2-nitrophenyl) benzenesulfonamides was developed under microwave irradiation A series of pyrabactin analogs containing nitrophenyl scaffold was obtained in excellent yields. In addition, the method was pretty suitable to prepare flusulfamide. Significantly, the 4-bromo-N-(4-chloro-2-nitrophenyl)benzenesulfonamide could enhance POD activity in response to heavy metal stress.

Tetrahedron Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, HPLC of Formula: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Luo, Qianfu published the artcileSynthesis and characteristics of dithienylethenes with purine and pyrimidine substituents, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Dyes and Pigments (2015), 602-608, database is CAplus.

Five new dithienylethenes decorated with purine and pyrimidine derivatives have been conveniently synthesized via a facile one-pot process. All new compounds were characterized by ¹H NMR, ¹³C NMR, UV-visible spectroscopy and high-resolution mass spectrometry. Their photophys. properties and photochromic behavior were investigated in detail. These compounds exhibit reversible photochromism with good photocyclization/photocycloreversion quantum yields and considerable molar extinction coefficients The result shows that the introduction of purine and pyrimidine derivatives into the dithienylethene unit has a remarkable effect on their performance, such as photoinduced fatigue resistance, photocyclization/photocycloreversion quantum yields and molar extinction coefficient

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jin, Piaopiao published the artcileBinding porphyrins gated dithienylethene bridge, Formula: C15H14Cl2S2, the publication is Dyes and Pigments (2016), 151-158, database is CAplus.

Porphyrins strapped with photochromic dithienylethene have been prepared for photochem. double-throw gated switch. The strapped porphyrins performed totally different but reversible binding capacity and fluorescence intensity when irradiated by different lights. The photochromism of the dithienylethene bridge was effectively gated by porphyrin ring through binding or unbinding Zn²⁺. The central Zn²⁺ in the porphyrin ring was employed as a lock, external H⁺ as a key, which can alternately turn on/off the photochromic switch of the dithienylethene bridge. The porphyrins’ gate for binding/unbinding Zn²⁺ was reversibly regulated by dithienylethene switch with different irradiation lights. These distinctive properties might be utilized to multi-controlled mol. switches or logic gates.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Yan-Xiang published the artcileSynthesis and identification of novel berberine derivatives as potent inhibitors against TNF-α-induced NF-κB activation, Name: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Molecules (2017), 22(8), 1257/1-1257/14, database is CAplus and MEDLINE.

Twenty-three new berberine (BBR) analogs containing substituents on ring D, I [R¹ = OMe, NH₂, cyclopropanecarbonyloxy, (4-nitrophenyl)sulfonyloxy, etc., R² = OMe, (adamantan-1-yl)acetoxy, (adamantane-10-carbonyloxy)], were synthesized and evaluated for their activity for suppression of tumor necrosis factor (TNF)-α-induced nuclear factor (NF)-κB activation. Structure-activity relationship (SAR) anal. indicated that suitable tertiary/quaternary carbon substitutions at the 9-position or a rigid fragment at position 10 might be beneficial for enhancing their anti-inflammatory potency. Among them, compounds I [R¹ = (1-methylcyclohexane-1-carbonyl)oxy, 2-(bicyclo[2.2.1]heptan-2-yl)acetoxy, (2′-propylpentanoyl)oxy, (p-tert-butylbenzoyl)oxy, R² = OMe] exhibited satisfactory inhibitory potency against NF-κB activation, with an inhibitory rate of around 90% (5 μM), much better than BBR. A preliminary mechanism study revealed that all of them could inhibit TNF-α-induced NF-κB activation via impairing IκB kinase (IKK) phosphorylation as well as cytokines interleukin (IL)-6 and IL-8 induced by TNF-α. Therefore, the results provided powerful information on further structural modifications and development of BBR derivatives into a new class of anti-inflammatory candidates for the treatment of inflammatory diseases.

Molecules published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C8H6ClN, Name: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, De-Yong published the artcilePhotoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones, Application of 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Journal of Organic Chemistry (2021), 86(24), 18042-18055, database is CAplus and MEDLINE.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

Journal of Organic Chemistry published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C21H37BO, Application of 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics