Month: December 2022

Yang, Shuqing published the artcileIsobutene oligomerization in ionic liquid, Application of N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Shiyou Lianzhi Yu Huagong (2007), 38(1), 39-42, database is CAplus.

Ionic liquid containing various anions or cations was synthesized. The catalytic performance and related reaction conditions of the oligomerization of isobutene catalyzed by ionic liquid were investigated in an autoclave. The exptl. results indicated that ionic liquid synthesized by anhydrous FeCl₃ and triethylamine hydrochloride could effectively catalyze oligomerization and had higher selectivity. The type of anion had important influence on activity and selectivity of the products, and the structure of cation also had important influence on activity. The test result showed that the product was the mixture of dimer, trimer, tetramer and pentamer without crackate. Under the reaction conditions of temperature 40 °C, reaction time 30 min, ionic liquid to olefin ratio 1.2 with 200 mL n-hexane as diluent, the conversion of isobutene reached 85%, and the concentration of dimer and trimer in oligomer was 22.87% and 57.43% resp.

Shiyou Lianzhi Yu Huagong published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C18H28B2O4, Application of N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Shuqing published the artcileOligomerization of isobutene catalyzed by AlCl₃ ionic liquids, HPLC of Formula: 23616-79-7, the publication is Shiyou Lianzhi Yu Huagong (2012), 43(5), 14-18, database is CAplus.

AlCl₃ ionic liquids having various cations and anions were synthesized. Tests for oligomerization of isobutene catalyzed by various AlCl₃ ionic liquids were conducted in an autoclave, and the effect of reaction temperature, reaction time and stirring speed was studied. Exptl. results indicated that these AlCl₃ ionic liquids exhibited good catalytic performance in isobutene oligomerization with conversion of isobutene over 95%. For ionic liquids synthesized by AlCl₃ and (C₂H₅)₃NHCl, when the mole ratio of AlCl₃ to(C₂H₅)₃NHCl was below 1, the AlCl₃ ionic liquid was inactive to isobutene oligomerization. When the mole ratio of AlCl₃ to(C₂H₅)₃NHCl was 1, the ionic liquid exhibited certain catalytic activity and its selectivity to dimers and trimers was good. When the mole ratio of AlCl₃ to (C₂H₅)₃NHCl was above 1, these ionic liquids could effectively catalyze oligomerization reactions, the conversion of isobutene reached more than 95%, yet the selectivity to dimers and trimers declined and the product distributions were continuous with certain amount of cracking byproducts. The optimal reaction conditions were as follows: a reaction temperature of 80°C, a reaction time of 30 min and stirring speed of 1300 r/min.

Shiyou Lianzhi Yu Huagong published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C9H7NO3, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Shuqing published the artcileThe Discovery of a Palladium(II)-Initiated Borono-Catellani Reaction, Related Products of chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2018), 57(24), 7161-7165, database is CAplus and MEDLINE.

Reported is a novel palladium(II)-initiated Catellani-type reaction that uses widely accessible aryl boronic acids as the substrates instead of aryl halides, thereby greatly expanding the existing scope of this powerful transformation. This borono-Catellani reaction was promoted by cooperative catalysis between Pd(OAc)₂ and the inexpensive 5-norbornene-2-carbonitrile. Practicality is the striking feature of the reaction: it is run open to air at ambient temperature and no phosphine ligand is needed. This mild, chemoselective, and scalable protocol is compatible with a large range of readily available functionalized aryl boronic acids and bromides, as well as terminating olefins (50 examples, 39-97% yields). Moreover, the orthogonal reactivity between the borono-Catellani and classical Catellani reaction was demonstrated. This work is expected to open new avenues for developing novel Catellani-type reactions.

Angewandte Chemie, International Edition published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Luan, Pengqian published the artcileAqueous chemoenzymatic one-pot enantioselective synthesis of tertiary α-aryl cycloketones via Pd-catalyzed C-C formation and enzymatic C=C asymmetric hydrogenation, Recommanded Product: 4-Chloro-2-methylphenylboronic acid, the publication is Green Chemistry (2021), 23(5), 1960-1964, database is CAplus.

An aqueous chemoenzymic cascade reaction combining Pd-catalyzed C-C formation and enzymic C=C asym. hydrogenation (AH) was developed for enantioselective synthesis of tertiary α-aryl cycloketones in good yields and excellent enantioselectivities. The stereopreference of the enzyme in AH of α-aryl cyclohexenones was studied. An enantiocomplementary enzyme was obtained by site-directed mutation.

Green Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Recommanded Product: 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhan, Bei-Bei published the artcileNickel-catalyzed ortho-halogenation of unactivated (hetero)aryl C-H bonds with lithium halides using a removable auxiliary, Computed Properties of 6313-54-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(27), 4934-4937, database is CAplus and MEDLINE.

The first example of Ni-catalyzed halogenation of (hetero)aryl C-H bonds with lithium halides (LiX, X = Br, I, Cl) using PIP as a removable directing group was reported. This protocol provided an efficient access to ortho-halogenated (hetero)arenes with operational simplicity, good functional group tolerance and large-scale synthesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C8H14O2, Computed Properties of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yue-Jin published the artcileCopper/Silver-Mediated Direct ortho-Ethynylation of Unactivated (Hetero)aryl C-H Bonds with Terminal Alkyne, Related Products of chlorides-buliding-blocks, the publication is Chemistry – A European Journal (2015), 21(1), 205-209, database is CAplus and MEDLINE.

A copper/silver-mediated oxidative ortho-ethynylation of unactivated aryl C-H bonds with terminal alkynes has been developed. The reaction uses the removable PIP [PIP = 2-(pyridin-2-yl)isopropyl] directing group and features broad substrate scope, high functional-group tolerance, and compatibility with a wide range of heterocycles, providing an efficient synthesis of aryl alkynes. E.g., Cu(OAc)₂ and Ag₂CO₃ catalyzed the ethynylation of benzene derivative (I) with CHCTIPS to give 42% II. This procedure highlights the potential of copper catalysts to promote unique synthetically enabling C-H functionalization reactions that lie outside of the current scope of precious metal catalysis.

Chemistry – A European Journal published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xin published the artcileCopper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary, Synthetic Route of 6313-54-8, the publication is Organic Letters (2014), 16(15), 3904-3907, database is CAplus and MEDLINE.

A copper-mediated C-H hydroxylation of arenes and heteroarenes using our newly developed PIP directing group has been developed. This procedure is scalable and compatible with a wide range of functional groups and heteroarenes, providing an operationally simple protocol for the synthesis of o-hydroxybenzamides. The hydroxylation of nicotinamides gave 4-oxo-1,4-dihydropyridine-3-carboxamides selectively. Preliminary mechanistic studies implicate that a basic ligand-enabled, irreversible, rate-determining CMD step is most likely involved in this process.

Organic Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Synthetic Route of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Yurong published the artcileAn alternatively metal-free synthesis of 1,3,5-triazines or 1,2,4-thiadiazoles from benzyl chlorides and benzylamines mediated by elemental sulfur, COA of Formula: C7H6Cl2, the publication is Tetrahedron Letters (2019), 60(49), 151289, database is CAplus.

An elemental sulfur mediated reaction of benzyl chlorides with benzylamines was developed, which allows the practical synthesis of valuable 1,3,5-triazines. This protocol that was metal free, ligand free, and uses inexpensive elemental sulfur as oxidant or raw material displays mild reaction conditions, a broad substrate scope and moderate to good yields. Moreover, the modified sulfur-mediated reaction system was used to synthesize 1,2,4-thiadiazoles, by simply switching the stoichiometry of sulfur powder from 0.75 equiv to 5 equivalent

Tetrahedron Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C15H12O6, COA of Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jing-Jing published the artcileDiscovery of Antimetastatic Chiral Ionone Alkaloid Derivatives Targeting HIF-1α/VEGF/VEGFR2 Pathway, Category: chlorides-buliding-blocks, the publication is ChemMedChem (2021), 16(13), 2130-2145, database is CAplus and MEDLINE.

Novel chiral ionone alkaloid derivatives were synthesized and their antimetastatic effects were evaluated in human breast cancer cells using chemotaxis assay. Compared with pos. control LY294002, a PI3 K inhibitor, seven derivatives exhibited significant inhibitory effects against cancer cell migration. Especially, the IC₅₀ for compound I was as low as 0.035±0.004μM. Further investigations on compound I revealed that it could exert inhibitory effects on the adhesion, migration and invasion of MDA-MB-231 cells. The mechanisms for the antitumor metastatic effects of I might be through the inhibition of HIF-1α/VEGF/VEGFR2/Akt pathway, which suppressed the downstream signaling mols., including Akt1/mTOR/p70S6K and Akt2/PKCζ/integrin β1 pathways. Taken together, chiral ionone alkaloid derivative I has the potential to be developed into an antitumor metastatic agent for breast cancer.

ChemMedChem published new progress about 854778-30-6. 854778-30-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (2-Chloro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H8BClO3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tan, Yun-Xuan published the artcileAn unconventional trans-exo-selective cyclization of alkyne-tethered cyclohexadienones initiated by rhodium(III)-catalyzed C-H activation via insertion relay, Application In Synthesis of 637-07-0, the publication is CCS Chemistry (2021), 3(5), 1582-1595, database is CAplus.

Different from the established trans-endo-selective cyclization of alkyne-tethered electrophiles that involve an E/Z isomerization process, herein, the authors present a novel strategy to allow trans-exo-selective arylative cyclization of 1,6-enynes. Through initiation of rhodium(III)-catalyzed C-H activation, a diverse range of N-heterocyclic directing groups, including pyridine, pyrazole, imidazo[1,2-a] pyridine, benzoxazole, benzothiazole, and purine, was feasible for the cascade transformation, exhibiting high efficiency (up to 92% yield), broad substrate scope, and excellent functional group compatibility. Moreover, the modification of natural products and pharmaceutical compounds was also demonstrated to showcase its synthetic utility. Based on d. functional theory (DFT) calculations, a key three-membered ring intermediate through the insertion relay, rather than the direct E/Z isomerization of alkenyl rhodium species, controlled the stereochem. outcome for this trans-exo-selective cyclization. The subsequent ring-opening protonation of the more favored rotamer led to exclusive trans-exo-selectivity.

CCS Chemistry published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C11H14O2, Application In Synthesis of 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics