Month: December 2022

Yang, De-Yong published the artcilePhotoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2021), 86(24), 18042-18055, database is CAplus and MEDLINE.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C9H22OSi, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, De-Yong published the artcilePhotoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones, Category: chlorides-buliding-blocks, the publication is Journal of Organic Chemistry (2021), 86(24), 18042-18055, database is CAplus and MEDLINE.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

Journal of Organic Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C3H6O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zeng, Jing published the artcileSelective Co/Ti Cooperatively Catalyzed Biaryl Couplings of Aryl Halides with Aryl Metal Reagents, HPLC of Formula: 6313-54-8, the publication is Organic Letters (2013), 15(20), 5342-5345, database is CAplus and MEDLINE.

Various aryl bromides or chlorides, including those bearing a free COOH, OH, CONHR, and SO₂NHR group, coupled with aryl magnesium or lithium reagents in the presence of 7.5 mol% CoCl₂/15 mol% PBu₃ and substoichiometric Ti(OEt)₄ (40 mol% to ArM) at room temperature in high yields with high chemo- and regioselectivity. This simple reaction represents the first example of Co/Ti cooperative catalysis which plays a key role in suppressing undesired homocouplings.

Organic Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xie, Yundong published the artcileThe combination of sesamol and clofibric acid moieties leads to a novel potent hypolipidemic agent with antioxidant, anti-inflammatory and hepatoprotective activity, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128121, database is CAplus and MEDLINE.

Oxidative stress and inflammation have been considered the main factors in the liver injury of clofibrate (CF). To obtain a novel antihyperlipidemic agent with antioxidant, anti-inflammation and hepatoprotection, the combination of sesamol and clofibric acid moieties was performed and achieved sesamol-clofibrate (CF-Sesamol). CF-Sesamol showed significant hypolipidemia effects in hyperlipidemia mice induced by Triton WR 1339, reducing TG by 38.8% (P < 0.01) and TC by 35.1% (P < 0.01). CF-Sesamol also displayed an alleviating effect on hepatotoxicity. The hepatic weight and hepatic coefficient were decreased. The amelioration of liver function was observed, such as aspartate and lactate transaminases (AST and ALT), alk. phosphatase (ALP) and total proteins (TP) levels. Liver histopathol. examination showed that hepatocyte necrosis, cytoplasmic loosening, nuclear degeneration and inflammatory cell infiltration reduced obviously by treatment with CF-Sesamol. Related mol. mechanisms on hepatoprotection showed that CF-Sesamol up-regulated Nrf2 and HO-1 expression and down-regulated p-NF-κB p65 expression in hepatic tissues. CF-Sesamol has significant antioxidant and anti-inflammatory effects. Plasma antioxidant enzymes such as SOD and CAT increased, anti-lipid peroxidation product MDA decreased. The expression of TNF-α and IL-6 inflammatory cytokines in liver was significantly lower than that in the CF group. The results indicated that CF-Sesamol exerted more potent antihyperlipidemic effects and definite hepatoprotective activity partly through the Nrf2/NF-κB-mediated signaling pathway.

Bioorganic & Medicinal Chemistry Letters published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C8H11BO2, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Chao published the artcileUse of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes, Formula: C6H3ClFNO2, the publication is Biochemistry (2018), 57(5), 817-826, database is CAplus and MEDLINE.

Human hepatic cytochromes P 450 (CYP) are integral to xenobiotic metabolism CYP2B6 is a major catalyst of biotransformation of environmental toxicants including polybrominated di-Ph ethers (PBDEs). CYP2B substrates tend to contain halogen atoms, but the biochem. basis for this selectivity and for species specific determinants of metabolism has not been identified. Spectral binding titrations and inhibition studies were performed to investigate interactions of rat CYP2B1, rabbit CYP2B4, and CYP2B6 with a series of phenoxyaniline (POA) congeners that are analogs of PBDEs. For most congeners, there was less than 3-fold difference between the spectral binding constants (K_S) and IC₅₀ values. In contrast, large discrepancies between these values were observed for POA and 3-chloro-4-phenoxyaniline. CYP2B1 was the most sensitive enzyme to POA congeners, so the Val-363 residue from that enzyme was introduced into CYP2B4 or CYP2B6. This substitution partially altered the protein-ligand interaction profiles to make them more similar to that of CYP2B1. Addition of cytochrome P 450 oxidoreductase (POR) to titrations of CYP2B6 with POA or 2’4’5’TCPOA decreased the affinity of both ligands for the enzyme. Addition of cytochrome b₅ (cyt b₅) to a recombinant enzyme system containing POR and CYP2B6 increased the POA IC₅₀ value and decreased the 2’4’5’TCPOA IC₅₀ value. Overall, the inconsistency between K_S and IC₅₀ values for POA vs. 2’4’5’TCPOA is largely due to the effects of redox partner binding. These results provide insight into the biochem. basis of di-Ph ether binding to human CYP2B6 and changes in CYP2B6 mediated metabolism dependent on POA congener and redox partner identity.

Biochemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ling published the artcileDiscovery of Thieno[2,3-d]pyrimidine-based KRAS G12D inhibitors as potential anticancer agents via combinatorial virtual screening, Computed Properties of 145349-62-8, the publication is European Journal of Medicinal Chemistry (2022), 114243, database is CAplus and MEDLINE.

A series of novel thieno[2,3-d]pyrimidine analogs were designed and synthesized as KRAS G12D inhibitors via combinatorial virtual screening approach. Most compounds exhibited potent antiproliferative activity on KRAS G12D mutated cancer cell lines (Panc1, SW1990 and CT26) with IC₅₀ values in the low micromolar range. Among them, I (R = 2-OCH₃-5-CF₃) showed the highest antiproliferative activity with an average IC₅₀ of 2.1μM against three KRAS G12D-mutated cells (Panc1, SW1990 and CT26). CompoundI (R = 2-OCH₃-5-CF₃) decreased the active form of KRAS (KRAS-GTP) in KRAS G12D mutated cancer cell lines (CT26 and SW1990) but not in KRAS G13D mutated cancer cells (HCT116). Moreover, I (R = 2-OCH₃-5-CF₃) down-regulated the phosphorylated Raf and Erk in CT26 and SW1990 cancer cell lines but not in HeLa cells (KRAS WT). The binding affinity of I (R = 2-OCH₃-5-CF₃) was further confirmed by the isothermal titration calorimetry (ITC) assay in which I (R = 2-OCH₃-5-CF₃) exhibited a K_D of 33 nM for binding to KRAS G12D protein. In addition, I (R = 2-OCH₃-5-CF₃) (40 mg/kg or 60 mg/kg) exhibited significant antitumor efficacy in a CT26 tumor model with a tumor growth inhibition (TGI) of 42% or 53% without causing apparent toxicity. Taken together the above results suggest that I (R = 2-OCH₃-5-CF₃) is a promising KRAS G12D inhibitor deserving further investigation.

European Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Computed Properties of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Corton, J. Christopher published the artcileTowards replacement of animal tests with in vitro assays: a gene expression biomarker predicts in vitro and in vivo estrogen receptor activity, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Chemico-Biological Interactions (2022), 109995, database is CAplus and MEDLINE.

High-throughput transcriptomics (HTTr) has the potential to support efforts to reduce or replace some animal tests. In past studies, we described a computational approach utilizing a gene expression biomarker consisting of 46 genes to predict estrogen receptor (ER) activity after chem. exposure in ER-pos. human breast cancer cells including the MCF-7 cell line. We hypothesized that the biomarker model could identify ER activities of chems. examined by Endocrine Disruptor Screening Program (EDSP) Tier 1 screening assays in which transcript profiles of the same chems. were examined in MCF-7 cells. For the 62 chems. examined including 5 chems. examined in this study using RNA-Seq, the ER biomarker model accuracy was 1) 97% for in vitro reference chems., 2) 76-85% for guideline uterotrophic assays, and 3) 87-88% for guideline and nonguideline uterotrophic assays. For the same chems., these accuracies were similar or slightly better than those of the ToxCast ER model based on 18 in vitro assays. The performance of the ER biomarker model indicates that HTTr interpreted using the ER biomarker correctly identifies active and inactive ER reference chems. As part of the HTTr screening program the approach could rapidly identify chems. with potential ER bioactivities for addnl. screening and testing.

Chemico-Biological Interactions published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Menghan published the artcileMolecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2022), 116579, database is CAplus and MEDLINE.

Four series of mol. hybrids (37 final products) of neo-tanshinlactone, a natural product extracted from Salvia miltiorrhiza Bunge, and known PD-1/PD-L1 interaction inhibitors were prepared as possible chemotherapeutic agents against triple neg. breast cancer. Screening using a homogenous time-resolved fluorescence method resulted in three lead compounds (MZ52 IC50 74 ± 4 nM; MZ58 IC50 134 ± 17 nM; MZ61 IC50 225 ± 19 nM). With less T cell cytotoxicity and effects in activating CD8+ T cells in a T cell proliferation assay and a functionality experiment, MZ58 was selected as the best candidate for animal experiments MZ58 exhibited antitumor effects in a s.c. transplantation tumor model as well as effects in reducing T cell exhaustion. In conclusion, after in vivo and in vitro experiments, we successfully acquired an effective candidate (MZ58) showing antitumor effects with low cytotoxicity toward T cells as well as the ability to activate CD8+ T cells and reduce T cell exhaustion.

Bioorganic & Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C14H12N2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yue, Fuyang published the artcileLight-Mediated Defluorosilylation of α-Trifluoromethyl Arylalkenes through Hydrogen Atom Transfer, Related Products of chlorides-buliding-blocks, the publication is Organic Letters (2022), 24(22), 4019-4023, database is CAplus and MEDLINE.

Herein, the authors report a direct, light-mediated defluorosilylation protocol for converting α-trifluoromethyl arylalkenes and alkyl silanes into γ,γ-difluoroallylic compounds via a combination of photoredox catalysis and H atom transfer. The clean, convenient protocol can be scaled to the gram level, and its mild conditions make it very suitable for late-stage functionalization of complex natural products and drugs.

Organic Letters published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C5H5ClIN, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Chongbo published the artcileSynthesis and insecticidal activities of N-(tert-butyl)-N’-(fluorobenzoyl)pyridinecarboxylic acid hydrazide derivatives, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Youji Huaxue (2016), 36(5), 1051-1059, database is CAplus.

In order to find novel diacylhydrazine derivatives which possessed high activities against pests, 20 novel N-(tert-butyl)-N’-(fluorobenzoyl)pyridinecarboxylic acid hydrazide derivatives of formula I [Py = substituted pyridine; R = H, F] were synthesized by introducing fluoro-contained Ph and pyridine into the basic structure of diacylhydrazines. Their structures were confirmed by ¹H NMR, ¹³C NMR, IR and HRMS. The bioassay results indicated that most of the compounds exhibited more than 80 % mortality against Mythimna separata at the concentration of 500 mg/L. Among these compounds, N-(tert-butyl)-N’-(2,6-difluorobenzoyl)-N-2-chloronicotinohydrazine and N-(tert-butyl)-N’-(2,6-difluorobenzoyl)-N-2,5-dichloronicotinohydrazine exhibited 100 % and 80 % mortality against Mythimna separata at 10 mg/L, resp. The LC₅₀ of compound N-(tert-butyl)-N’-(2,6-difluorobenzoyl)-N-2-chloronicotinohydrazine against Mythimna separata was 8.77 mg/L, and it showed about 0.51 times of toxicity against Mythimna separata than tebufenozide and had 1.5 times of toxicity against Plutella xylostella than tebufenozide.

Youji Huaxue published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics