Month: December 2022

Padmaja, A. published the artcileSynthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles, Product Details of C7H13ClNNaO5S, the publication is European Journal of Medicinal Chemistry (2011), 46(10), 5034-5038, database is CAplus and MEDLINE.

A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles I(X= O, S, R = H, Me, Cl) and II(X= O, S, R¹ = R² = H, cl; X= O, S, R¹ = Me, R² = MeO) and isoxazoles III(X= O, S, R¹ = R² = H, cl; X= O, S, R¹ = Me, R² = MeO) were prepared from the synthetically vulnerable intermediate E-styrylsulfonylacetic acid Me ester and studied their antioxidant activity.

European Journal of Medicinal Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Product Details of C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nielsen, Alexander L. published the artcileMechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration, Quality Control of 42074-68-0, the publication is RSC Chemical Biology (2021), 2(2), 612-626, database is CAplus and MEDLINE.

Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biol. functions in the cell and has been considered a drug target in relation to both neurodegenerative diseases and cancer. Therefore, access to well-characterized and robust tool compounds is essential for the continued investigation of the complex functions of this enzyme. Here, we report a collection of chem. probes that are potent, selective, stable in serum, water-soluble, and inhibit SIRT2-mediated deacetylation and demyristoylation in cells. Compared to the current landscape of SIRT2 inhibitors, this is a unique ensemble of features built into a single compound We expect the developed chemotypes to find broad application in the interrogation of SIRT2 functions in both healthy and diseased cells, and to provide a foundation for the development of future therapeutics.

RSC Chemical Biology published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Quality Control of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Di Carmine, Graziano published the artcileSynthesis of functionalized imidazolidine-2-thiones via NHC/base-promoted aza-benzoin/aza-acetalization domino reactions, Name: 1-(4-Chlorophenyl)thiourea, the publication is Organic & Biomolecular Chemistry (2017), 15(41), 8788-8801, database is CAplus and MEDLINE.

A strategy for the synthesis of biol. relevant 5-hydroxy-imidazolidine-2-thione derivatives I [R¹ = i-Pr, 4-pyridinyl, 2-ClC₆H₄, etc.; R² = i-Pr, Ph, 2-FC₆H₄, 4-ClC₆H₄, 3-MeC₆H₄, 3-BrC₆H₄; R³ = cyclohexyl, Ph, 2-MeC₆H₄, 2-FC₆H₄, 4-ClC₆H₄; X = S] and imidazolidine-2-one I [R¹ = Ph; R² = 4-ClC₆H₄; R₃ = Bn; X = O] was presented. A novel class of α-sulfonylamines had been suitably prepared (46-81% yield) as precursors of formal benzylidenethiourea acceptors; these were generated in situ and intercepted by N-heterocyclic carbene (NHC)-activated aldehydes affording open-chain aza-benzoin-type adducts, which in turn underwent an intramol. aza-acetalization reaction in a one-pot fashion. A thiazolium salt/triethylamine couple proved to be the more effective system to trigger the domino sequence giving the target heterocycles in good yields (45-97%) and diastereoselectivities (up to 99 : 1 dr). The multigram scale synthesis and elaboration of a selected 5-hydroxy-imidazolidine-2-thione compound I [R¹ = 4-ClC₆H₄, R² = R³ = Ph] was also described.

Organic & Biomolecular Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Name: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gupta, Atul published the artcileSynthesis of 3-phenyl-4-phenylvinylbenzopyranones and the corresponding 2,2-dimethylbenzopyrans with structural similarity to estradiol, as estrogen receptor ligands, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Medicinal Chemistry (2007), 3(5), 446-454, database is CAplus and MEDLINE.

7-Methoxy-3-phenyl-4-phenylvinylbenzopyran-2-ones I [R¹R² = oxo, R⁴ = (CH₂)₂R⁵, CH(Me)CH₂NMe₂, R⁵ = 1-pyrrolidinyl, 1-piperidinyl, NMe₂, NEt₂] and the corresponding 2,2-dimethylbenzopyrans I [R¹ = R² = Me] substituted with different alkylamino residues were synthesized. Except compound I [R¹R² = oxo, R⁴ = CH(Me)CH₂NMe₂], all compounds showed high levels of estrogen agonistic activity (>81 %) whereas, compounds I [R¹R² = oxo, R⁴ = (CH₂)₂R⁵, CH(Me)CH₂NMe₂, R⁵ = 1-piperidinyl, NMe₂, NEt₂] and I [R¹ = R² = Me, R⁴ = (CH₂)₂R⁵, R⁵ = 1-pyrrolidinyl] showed significant estrogen antagonistic activity (>20 %). X-Ray anal. of I [R¹R² = oxo, R⁴ = (CH₂)₂NEt₂] showed its structural resemblance to endogenous estrogen, 17β-estradiol. Estrogenic and anti-estrogenic activities of these derivatives demonstrate their estrogen receptor (ER) binding ability. The lack of hydroxyl groups at appropriate positions resulted in poor relative binding affinity (RBA).

Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chandra published the artcile3-(4-Methoxyphenyl)-5-methylisoxazole-4-carboxylic acid, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Acta Crystallographica, Section E: Structure Reports Online (2013), 69(3), o388, database is CAplus and MEDLINE.

In the title compound, C₁₂H₁₁NO₄, the dihedral angle between the benzene and isoxazole rings is 42.52(8)°. The carboxylic acid group is close to being coplanar with the isoxazole ring [dihedral angle = 5.3(2)°]. In the crystal, inversion dimers linked by pairs of O-H···O hydrogen bonds generate R₂²(8) loops.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Savel’eva, E. I. published the artcileStudy of the composition of gas emissions from bitumen-salt materials including mustard gas degradation products, Product Details of C4H8Cl2S2, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg) (1999), 72(9), 1501-1506, database is CAplus.

The method of steady-state vapor-phase anal. was used to investigate the composition of th gas emissions from the bitumen-salt materials, including products OK decontamination of mustard gas with mixture of monoethanolamine and ethylene glycol. Gas chromatog.-mass spectrometry were for analyzing the components. Homologous series of alkyldithianes and ethanolthiomopholines were noted in the gas emissions of the detoxication products of mustard gas with ethanolamine. All these compounds with the exception of 1,4-dithiane were characteristic of destruction of mustard gas. At the same time. 1.4-dithiane, the most stable product of transformation of mustard gas, may serve as an unusual indicator for ascertaining illegal use of the mustard gas.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg) published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Product Details of C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Padmavathi, V. published the artcileSynthesis of novel bis heterocycles: bis pyrroles, pyrrolyl pyrazolines and pyrrolyl isoxazolines, Product Details of C7H13ClNNaO5S, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2008), 47B(11), 1707-1712, database is CAplus.

The Michael acceptors, 1-arylsulfonyl-2-styrylsulfonylethenes were used as synthons to develop bis pyrroles, pyrrolyl pyrazolines and pyrrolyl isoxazolines by 1,3-dipolar cycloaddition of tosylmethyl isocyanide, nitrile imines and nitrile oxides.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Product Details of C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Swain, Asim Kumar published the artcilePyrene-Fused [7]Helicenes Connected Via Hexagonal and Heptagonal Rings: Stereospecific Synthesis and Chiroptical Properties, Product Details of C10H15ClO3S, the publication is Journal of Organic Chemistry (2022), 87(2), 993-1000, database is CAplus and MEDLINE.

In this manuscript, stereospecific synthesis of C2- and C1-sym. pyrene fused [7]helicene compounds I and II, resp. was portrayed. Compounds I and II were synthesized via one-pot Suzuki coupling-C-H activation and two-step Suzuki coupling-Scholl reaction, resp., with complete retention of configuration. The synthesized mols. differ in the fusing mode of [7]helicene units with pyrene via six- and seven-membered rings for compounds I and II, resp. There was a significant difference in the functional properties and enantiomerization barrier of both compounds because of their distinct mol. symmetry as well as fusing mode to pyrene moiety. The heptagon containing mol. II showed remarkable photophys. and chiroptical properties with commendable configurational stability compared to compound I and pristine [7]helicene as well as its [5]helicene congener.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C8H8O2, Product Details of C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Suryadevara, Praveen Kumar published the artcileDialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents, Computed Properties of 350-30-1, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(23), 6492-6499, database is CAplus and MEDLINE.

New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound I as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound I is highly efficacious in the acute model of the disease. However, compound I has a high mol. weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC₅₀ <1 nM) against T. cruzi in culture. The halogenated derivatives II (where R² = Cl, R³ = Me or H; R² = F, R³ = H) display excellent activity against T. cruzi amastigotes, with reduced mol. weight and lipophilicity, and exhibit suitable physicochem. properties for an oral drug candidate.

Bioorganic & Medicinal Chemistry Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C3H6F3N, Computed Properties of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghosh, Soumen published the artcileHFIP-Assisted Single C-F Bond Activation of Trifluoromethyl Ketones using Visible-Light Photoredox Catalysis, HPLC of Formula: 5860-95-7, the publication is Angewandte Chemie, International Edition (2022), 61(9), e202115272, database is CAplus and MEDLINE.

A visible light photoredox catalytic method for the selective cleavage of single strong C-F bond in trifluoromethyl ketones was reported. Single electron reduction of trifluoromethyl ketones generates difluoromethyl radicals which was engaged in intermol. C-C bond formation with N-methyl-N-arylmethacrylamides to furnish fluorine-containing oxindole derivatives in good yields. The reaction shows excellent chemoselectivity with good functional group tolerance under mild conditions. 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) as a solvent plays a critical role for the selective single C-F bond cleavage. High-level DFT calculations are depicted to shed light on the mechanism.

Angewandte Chemie, International Edition published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, HPLC of Formula: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics