Month: November 2022

Amani, A. published the artcileCrystal structure of 2,2-diphenyl-4-dimethylaminopentanenitrile, C₁₉H₂₂N₂, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Zeitschrift fuer Kristallographie – New Crystal Structures (2005), 220(4), 549-550, database is CAplus.

The title compound was synthesized by reaction of 1-dimethylamino-2-chloropropane hydrochloride and diphenylacetonitrile in the presence of NaOH as a base. Crystallog. data and at. coordinates are given. Its crystal structure is built up by only the C₁₉H₂₂N₂ mols. within which all bond lengths are almost in normal ranges. C6 atom is substituted with two Ph groups and the C8-C6-C14 angle is 108.2(4)°. The C7-C6-C14 angle of 104.3(2)° and C2-C1-C16 angle of 110.8(2)° deviate slightly from the ideal value of 109.5°. The planes of the two Ph rings on C6 are oriented differently to each other with one in a horizontal and the other in a vertical manner. The arrangement of two mols. in the unit cell is in a manner that intermol. π-π stacking interactions between two horizontal Ph groups are achieved. These interactions were not observed for the vertical Ph groups.

Zeitschrift fuer Kristallographie – New Crystal Structures published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

del Olmo, Esther published the artcileAntimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds, Quality Control of 33697-81-3, the publication is European Journal of Medicinal Chemistry (2011), 46(11), 5379-5386, database is CAplus and MEDLINE.

The synthesis of several series of imidazo[2,1-a]isoindol-5-ol derivatives and the results of their evaluation against Plasmodium falciparum are presented and discussed. The effects of electron-withdrawing or -donating substituents on different parts of the mol., as well as those produced by the incorporation of an addnl. fused ring, were analyzed. Several compounds showed significant antimalarial activity in vitro with IC₅₀ values as low as 60 nM and a certain efficacy in vivo by reducing parasitemia in Plasmodium berghei mouse models.

European Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sokolova, A. S. published the artcileSynthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of filovirus infections, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Russian Chemical Bulletin (2019), 68(5), 1041-1046, database is CAplus.

N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A mol. modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.

Russian Chemical Bulletin published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C18H24N6O6S4, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Wei published the artcileNickel-Catalyzed One-Pot Carbonylative Synthesis of 2-Mono- and 2,3-Disubstituted Thiochromenones from 2-Bromobenzenesulfonyl Chlorides and Alkynes, Application In Synthesis of 21286-54-4, the publication is Organic Letters (2021), 23(16), 6589-6593, database is CAplus and MEDLINE.

A nickel-catalyzed one-pot carbonylation reaction of 2-bromobenzenesulfonyl chlorides I (R = H, Me, OMe; R¹ = H, OMe; RR¹ = -OCH₂O-, -O(CH₂)₂O-) with alkynes R²CCR³ (R² = Me, Ph, 2-thienyl, etc.; R³ = Ph, 3-thienyl, 2-naphthyl, etc.) for the synthesis of thiochromenones II has been established. The alkynes were suitable substrates in this carbonylative transformation, and a broad range of 2-mono- and 2,3-disubstituted thiochromenone products II were obtained in moderate to good yields with quite high functional group compatibility. Notably, this procedure presents the first example of nickel-catalyzed carbonylative synthesis of thiochromenones II with 2-bromobenzenesulfonyl chlorides as a promising sulfur precursor.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C7H9BO3, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qi, Xinxin published the artcileNickel-Catalyzed Thiocarbonylation of Arylboronic Acids with Sulfonyl Chlorides for the Synthesis of Thioesters, Computed Properties of 21286-54-4, the publication is Organic Letters (2020), 22(16), 6671-6676, database is CAplus and MEDLINE.

An interesting procedure for thioesters synthesis via nickel-catalyzed thiocarbonylation of arylboronic acids with sulfonyl chlorides as the sulfur source has been explored. Using Mo(CO)₆ as a solid CO surrogate and reductant, a broad range of thioesters ArC(O)SR (Ar = Ph, naphthalen-2-yl, furan-2-yl, etc., R = Et, cyclohexyl, naphthalen-1-yl, etc.) were obtained in moderate to good yields with good functional group tolerance.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qi, Xinxin published the artcilePalladium-catalyzed carbonylative transformation of aryl iodides and sulfonyl chlorides: convenient access to thioesters, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Organic Chemistry Frontiers (2020), 7(6), 885-889, database is CAplus.

A palladium-catalyzed carbonylative transformation of aryl iodides RI (R = Ph, naphthalen-2-yl, thiophen-3-yl, etc.) and sulfonyl chlorides R¹S(O)₂Cl (R¹ = 4-methylphenyl, i-Pr, cyclohexyl, etc.) has been studied. Both aryl and alkyl sulfonyl chlorides were all successfully transformed into the desired thioesters RC(O)SR¹ with sulfonyl chlorides as the sulfur source. Mo(CO)₆ played a dual role as both CO surrogate and reductant in this reaction.

Organic Chemistry Frontiers published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yongzhu published the artcilePalladium-catalyzed reductive desulfonative aminocarbonylation of benzylsulfonyl chlorides with nitroarenes towards arylacetamides, Computed Properties of 939-99-1, the publication is Organic Chemistry Frontiers (2022), 9(8), 2079-2083, database is CAplus.

A new palladium-catalyzed reductive desulfonative aminocarbonylation reaction with benzylsulfonyl chlorides RCH₂S(O)₂Cl (R = Ph, 3,4-dimethylphenyl, 2,4-dichlorophenyl, etc.) as C(sp³) electrophiles has been developed. Using nitroarenes R¹NO₂ (R¹ = Ph, quinolin-8-yl, 2H-1,3-benzodioxol-5-yl, etc.) as readily accessible and stable nitrogen surrogates, a wide range of arylacetamides RCH₂C(O)NHR¹ were easily prepared in high yields with very good functional group compatibility. Mo(CO)₆ plays a dual role as both a CO source and reductant. Moreover, a late-stage modification of natural products was also achieved via this aminocarbonylation strategy.

Organic Chemistry Frontiers published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Computed Properties of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yongzhu published the artcilePalladium-catalyzed reductive desulfonative aminocarbonylation of benzylsulfonyl chlorides with nitroarenes towards arylacetamides, Product Details of C7H6Cl2, the publication is Organic Chemistry Frontiers (2022), 9(8), 2079-2083, database is CAplus.

A new palladium-catalyzed reductive desulfonative aminocarbonylation reaction with benzylsulfonyl chlorides RCH₂S(O)₂Cl (R = Ph, 3,4-dimethylphenyl, 2,4-dichlorophenyl, etc.) as C(sp³) electrophiles has been developed. Using nitroarenes R¹NO₂ (R¹ = Ph, quinolin-8-yl, 2H-1,3-benzodioxol-5-yl, etc.) as readily accessible and stable nitrogen surrogates, a wide range of arylacetamides RCH₂C(O)NHR¹ were easily prepared in high yields with very good functional group compatibility. Mo(CO)₆ plays a dual role as both a CO source and reductant. Moreover, a late-stage modification of natural products was also achieved via this aminocarbonylation strategy.

Organic Chemistry Frontiers published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Product Details of C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yongzhu published the artcilePalladium-catalyzed reductive desulfonative aminocarbonylation of benzylsulfonyl chlorides with nitroarenes towards arylacetamides, Name: 3-Chloro-4-fluoronitrobenzene, the publication is Organic Chemistry Frontiers (2022), 9(8), 2079-2083, database is CAplus.

A new palladium-catalyzed reductive desulfonative aminocarbonylation reaction with benzylsulfonyl chlorides RCH₂S(O)₂Cl (R = Ph, 3,4-dimethylphenyl, 2,4-dichlorophenyl, etc.) as C(sp³) electrophiles has been developed. Using nitroarenes R¹NO₂ (R¹ = Ph, quinolin-8-yl, 2H-1,3-benzodioxol-5-yl, etc.) as readily accessible and stable nitrogen surrogates, a wide range of arylacetamides RCH₂C(O)NHR¹ were easily prepared in high yields with very good functional group compatibility. Mo(CO)₆ plays a dual role as both a CO source and reductant. Moreover, a late-stage modification of natural products was also achieved via this aminocarbonylation strategy.

Organic Chemistry Frontiers published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Name: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yongzhu published the artcilePalladium-catalyzed reductive desulfonative aminocarbonylation of benzylsulfonyl chlorides with nitroarenes towards arylacetamides, HPLC of Formula: 21286-54-4, the publication is Organic Chemistry Frontiers (2022), 9(8), 2079-2083, database is CAplus.

A new palladium-catalyzed reductive desulfonative aminocarbonylation reaction with benzylsulfonyl chlorides RCH₂S(O)₂Cl (R = Ph, 3,4-dimethylphenyl, 2,4-dichlorophenyl, etc.) as C(sp³) electrophiles has been developed. Using nitroarenes R¹NO₂ (R¹ = Ph, quinolin-8-yl, 2H-1,3-benzodioxol-5-yl, etc.) as readily accessible and stable nitrogen surrogates, a wide range of arylacetamides RCH₂C(O)NHR¹ were easily prepared in high yields with very good functional group compatibility. Mo(CO)₆ plays a dual role as both a CO source and reductant. Moreover, a late-stage modification of natural products was also achieved via this aminocarbonylation strategy.

Organic Chemistry Frontiers published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics