Month: November 2022

Yaremchuk, A. A. published the artcileSurfactant and antibacterial properties of decamethoxine, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Nauchnye Trudy – Vsesoyuznyi Nauchno-Issledovatel’skii Institut Farmatsii (1990), 106-10, database is CAplus.

Decamethoxine showed surfactant properties with critical micellar concentration at 25° of 0.63%. Correlation among surfactant properties, length between N atoms in the quaternary ammonium compound and its antimicrobial activity was observed

Nauchnye Trudy – Vsesoyuznyi Nauchno-Issledovatel’skii Institut Farmatsii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C5H6BNO2, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Priyanka, V. P. published the artcileEnhanced partitioning of tryptophan in aqueous biphasic systems formed by benzyltrialkylammonium based ionic liquids: Evaluation of thermophysical and phase behavior, Category: chlorides-buliding-blocks, the publication is Journal of Molecular Liquids (2017), 207-214, database is CAplus.

Ionic liquids (ILs) based aqueous biphasic systems (ABS) are envisioned to be promising separation and environmentally benign extraction media. In this context, novel ternary phase diagrams were determined for two ILs namely, Benzyltrimethylammonium chloride and Benzyltributylammonium chloride in presence of various potassium salts, K₃PO₄, K₂HPO₄, K₂CO₃ and KOH at 298.15 K. The influence of benzyl group substitution on the cation of IL and nature of various potassium salts on the phase behavior were analyzed. Exptl. binodal data were fitted to Merchuk’s equation and tie line compositions and tie line length were also determined Further, these IL based ABS in presence of various potassium salts have been systematically scrutinized for their efficiency to extract Tryptophan. For the better understanding of the role of thermophys. properties on phase behavior and extraction capability, d. and viscosity of coexisting phases were measured at various compositions in the temperature range from 293.15 to 328.15 K. Enhanced extraction coefficients achieved for the studied combinations of ILs and inorganic salts indicate the possible use of these ABS as efficient extraction systems. Further, the study of thermophys. properties suggested that selected ternary systems present more desirable features in terms of d. and viscosity as compared to traditional polymer based ABS.

Journal of Molecular Liquids published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lipkovskaya, N. A. published the artcilePhysicochemical properties of quercetin and rutin in aqueous solutions of decamethoxin antiseptic drug, Synthetic Route of 38146-42-8, the publication is Russian Journal of Applied Chemistry (2014), 87(1), 36-41, database is CAplus.

The effect of a cationic surfactant, Decamethoxin, on the physicochem. properties of structurally related natural flavonoids, quercetin and rutin, was studied by spectrophotometry. The spectral and protolytic properties and the solubility of quercetin and rutin strongly depend on the Decamethoxin concentration in solution The presence of Decamethoxin in the solution favors the tautomeric transition of the enol form of quercetin to the keto form.

Russian Journal of Applied Chemistry published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lipkovska, N. A. published the artcileSpectral and Acid-Base Properties of Hydroxyflavones in Micellar Solutions of Cationic Surfactants, Product Details of C38H74Cl2N2O4, the publication is Journal of Applied Spectroscopy (2014), 81(4), 644-648, database is CAplus.

It has been shown that the spectral characteristics (intensity, position of the absorption band) and the acid-base properties in a series of structurally similar hydroxyflavones depend on the concentration of the cationic surfactants miramistin and decamethoxin in aqueous solutions and the extent of their changes is more pronounced for hydrophobic quercetin than for hydrophilic rutin. For the first time, we have determined the apparent dissociation constants of quercetin and rutin in solutions of these cationic surfactants (pK_a1) over a broad concentration range and we have established that they decrease in the series water-decamethoxin-miramistin.

Journal of Applied Spectroscopy published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Product Details of C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sobol, Marcin published the artcileCytotoxicity study of novel water-soluble chitosan derivatives applied as membrane material of alginate microcapsules, Synthetic Route of 4584-49-0, the publication is Journal of Biomedical Materials Research, Part A (2013), 101A(7), 1907-1914, database is CAplus and MEDLINE.

The majority of cell encapsulation systems applied so far are based on polyelectrolyte complexes of alginate and polyvalent metal cations. Although widely used, these systems suffer from the risk of disintegration. This can be partially solved by applying chitosan as addnl. outer membrane. However, chitosan can be dissolved in water only at a low pH, which limits its use in the field of bioencapsulation. In this study, novel primary and tertiary amine chitosan derivatives have been synthesized, which may be dissolved at pH 7.0, and retain the ability to effectively form addnl. membrane on the surface of alginate beads. As aqueous solutions tertiary amines dimethylamino-1-propyl-chitosan and dimethylethylamine-chitosan with linear hydrochloride aliphatic chains had the lowest toxicity, whereas dimethylpropylamine-chitosan, diethylaminoethyl-chitosan, and diisopropylaminoethyl-chitosan with branched hydrochloride aliphatic were cytotoxic to the majority of tested cells. When applied as polyelectrolyte complexation agent on the surface of alginate beads, none of the derivates had any neg. effect on the metabolic activity of encapsulated beta-cells. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

Journal of Biomedical Materials Research, Part A published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H7N3S3, Synthetic Route of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Zhongsheng published the artcileStructure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei, COA of Formula: C7H8BClO2, the publication is RSC Medicinal Chemistry (2020), 11(8), 885-895, database is CAplus and MEDLINE.

Based on crystal structures of Trypanosoma brucei methionyl-tRNA synthetase (TbMetRS) bound to inhibitors, we designed, synthesized, and evaluated two series of novel TbMetRS inhibitors targeting this parasite enzyme. One series has a 1,3-dihydro-imidazol-2-one containing linker, the other has a rigid fused aromatic ring in the linker. For both series of compounds, potent inhibition of parasite growth was achieved with EC₅₀ < 10 nM and most compounds exhibited low general toxicity to mammalian cells with CC₅₀s > 20 000 nM. Selectivity over human mitochondrial methionyl tRNA synthetase was also evaluated, using a cell-based mitochondrial protein synthesis assay, and selectivity in a range of 20-200-fold was achieved. The inhibitors exhibited poor permeability across the blood brain barrier, necessitating future efforts to optimize the compounds for use in late stage human African trypanosomiasis.

RSC Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is 0, COA of Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Presa, Andreu published the artcileNon-Switching 1,2-Dithienylethene-based Diplatinum(II) Complex Showing High Cytotoxicity, Related Products of chlorides-buliding-blocks, the publication is Inorganic Chemistry (2016), 55(11), 5356-5364, database is CAplus and MEDLINE.

A diplatinum(II) complex was prepared from a new 1,2-dithienyl-ethene-based ligand containing N-methylimidazole groups as metal-binding units. Reaction of the ligand 1,2-bis[2-methyl-5-(1-methyl-1H-imidazol-2-yl)-3-thienyl]-cyclopentene (L2^H) with cis-dichlorobis(dimethylsulfoxido)platinum(II) generated the bimetallic complex trans-[Pt₂Cl₄(DMSO)₂(L2^H)] (1), whose DNA-interacting properties were studied using different techniques. Cytotoxicity assays with various cancer cell lines showed that this compound is active, with IC₅₀ values in the micromolar range. Surprisingly, the diplatinum(II) complex does not exhibit the anticipated photoswitching properties; indeed, UV irradiation does not lead to the photocyclization of the ligand L2^H or of the metal complex. Computational studies were performed and revealed significant differences in the electronic structure of L2^H compared with L1^H (i.e., 1,2-bis[2-methyl-5-(4-pyridyl)-3-thienyl]-cyclopentene, which exhibits photoswitching properties), in terms of the relevant MOs involved in the UV-visible absorption features, which ultimately is responsible for the inertia of L2^H toward photocyclization.

Inorganic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nadaf, Afra Quasar A. published the artcileDesign, synthesis and biological evaluation of novel N,4-diphenylthiazol-2-amine derivatives, Computed Properties of 3696-23-9, the publication is Medicinal Chemistry Research (2020), 29(3), 442-458, database is CAplus.

Novel N,4-diphenylthiazol-2-amine derivatives I (R¹ = Cl, OMe; R² = Br, NO₂; R³ = Et, i-Pr, n-Pr, s-Bu, octan-3-yl) were designed and synthesized employing Hantzsch method. The three-step reaction involved in the synthesis occurred at a faster rate with excellent yields in eco-friendly conditions. Single-crystal X-ray diffraction studies also confirmed the formation of title compds I. These compounds I were evaluated in vitro for their antimicrobial and anti-inflammatory activities. The results demonstrated that most of the tested compounds I showed potent antifungal activity. Interestingly, these compounds I also exhibited good anti-inflammatory and moderate antibacterial activity towards sensitive as well as resistant bacterial strains. In silico studies depicted their good binding affinity profile against S. aureus (PDB ID: 1AD4) and C. albicans (PDB ID: 1AI9).

Medicinal Chemistry Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Martinez-Lopez, Yoan published the artcilePrediction of aquatic toxicity of benzene derivatives using molecular descriptor from atomic weighted vectors, Application of 3-Chloro-4-fluoronitrobenzene, the publication is Environmental Toxicology and Pharmacology (2017), 314-321, database is CAplus and MEDLINE.

Several descriptors from atom weighted vectors are used in the prediction of aquatic toxicity of set of organic compounds of 392 benzene derivatives to the protozoo ciliate Tetrahymena pyriformis (log(IGC50)^-1). These descriptors are calculated using the MD-LOVIs software and various Aggregation Operators are examined with the aim comparing their performances in predicting aquatic toxicity. Variability anal. is used to quantify the information content of these mol. descriptors by an information theory-based algorithm. Multiple Linear Regression with Genetic Algorithms is used to obtain models of the structure-toxicity relationships; the best model shows values of Q² = 0.830 and R² = 0.837 using six variables. The authors’ models compare favorably with other previously published models that use the same data set. The obtained results suggest that these descriptors provide an effective alternative for determining aquatic toxicity of benzene derivatives

Environmental Toxicology and Pharmacology published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathur, Neha published the artcileViscometric behaviour and miceller studies of some biodegradable organometallic complexes in binary solvent system, Computed Properties of 3696-23-9, the publication is Research Journal of Pharmaceutical, Biological and Chemical Sciences (2014), 5(2), 989-997, 9 pp., database is CAplus.

Some nitrogen and sulfur containing aromatic ligands are ubiquitous components both for physiol. active products and important pharmaceuticals. The study of binuclear complexes of these ligands with transition metal copper(II) is highly interesting due to their significance in phys. and bioinorganic chem., material science and multi-electron redox chem. Likewise novel complexes of copper(II) palmitate with N and S donor ligands were synthesized and viscometric behavior of these complexes was studied in non aqueous benzene-methanol solvent mixture Their study helps in interpretation of solute-solvent interactions, structural insight of micelle and colloidal chem. behavior in binary systems. Study of these factors is essential as it indirectly makes them responsible for their immense applicability in wide areas of field.

Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics