Schmidt, Stine N. published the artcileLinking algal growth inhibition to chemical activity: Excess toxicity below 0.1% of saturation, Application In Synthesis of 350-30-1, the publication is Chemosphere (2018), 880-886, database is CAplus and MEDLINE.
The first aim was to challenge this chem. activity range for baseline toxicity. Algal growth inhibition data (median effective concentrations, EC50) were compiled from two recent studies and included 108 compounds categorized as non-polar (mode of toxic action, MOA1) and polar (MOA2) narcotics. These data were linked to chem. activity by (1) plotting them relative to a regression for (subcooled) liquid solubility (SL), which served as visual reference for chem. activity of unity and (2) determining EC50/SL ratios that essentially equal median effective chem. activity (Ea50). Growth inhibition required chem. activity >0.01 for MOA1 and >0.001 for MOA2 compounds The second aim was to identify compounds exerting excess toxicity, i.e., when growth inhibition occurred at chem. activity <0.001. Of these compounds, 16 are pesticides or precursors. This study includes two methods for translating EC50 values into the chem. activity framework, each having advantages and limitations. Scientifically, this study confirms that baseline toxicity generally requires chem. activities of 0.01-0.1 and extends the application of the chem. activity approach beyond baseline toxicity, by demonstrating its utility to identify compounds that exert excess toxicity.
Chemosphere published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application In Synthesis of 350-30-1.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics